Physionic

Latest Episodes:

Everything Coronavirus: How long until you show symptoms? Is a 14 day quarantine enough? How to workout in quarantine? Mar 18, 2020

Show notes

In this episode, we will dedicate the entire podcast talking about the coronavirus (COVID-19) - how long until you show symptoms of the infection? Is a standard 14 day quarantine efficient? And, if you're stuck at home without workout equipment, how do you still make fitness progress with in resistance training?
Coronavirus video (with images and data): https://youtu.be/aNqL76phkik
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The Athlete's Paradox: The Similarity between Obesity and Athletes; Muscle & Strength, and More Mar 11, 2020

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In this episode, I cover the microbiome, as well as muscle and its relation and impact on strength gain, as well as the ever confusing "Athlete's Paradox".
Microbiome: 1:48
Muscle & Strength: 10:07
Athlete's Paradox: 16:40

Longer Pregnancy & Genetics Changes; BioInk Printing Skin; Nuances in reading Studies; Coronavirus is Local... Mar 04, 2020

Show notes

In this episode, I cover a broad range of topics from pregnancy length and its affect on children's genetics, as well as a new technology that makes printing skin a new therapy possible. Finally, I answer a question/concern a commenter had over why scientists waste their time with "obvious questions".
1:48 - Pregnancy
Merid, S.K., Novoloaca, A., Sharp, G.C. et al. Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age. Genome Med 12, 25 (2020). https://doi.org/10.1186/s13073-020-0716-9
10:37 - Printing Skin
Richard Y Cheng, Gertraud Eylert, Jean-Michel Gariepy, Sijin He, Hasan Ahmad, Yizhou Gao, Stefania Priore, Navid Hakimi, Marc G Jeschke, Axel Günther. Handheld instrument for wound-conformal delivery of skin precursor sheets improves healing in full-thickness burns. Biofabrication, 2020; 12 (2): 025002 DOI: 10.1088/1758-5090/ab6413
17:03 - Science Wasting Time

High Protein Diets implicated in Artery Plaques; Air Pollution & Heart Attacks; Ranting on Selective Bias Feb 26, 2020

Show notes

In this episode, I discuss a paper looking at high protein diets and their impact on atherosclerosis, as well as air pollution and its correlation with heart attacks, and the final half is me ranting on how selective people get to fit their biases.
Poor Sleep & Obesity (2:09)
https://www.sciencedaily.com/releases/2020/02/200217085214.htm
High Protein (7:34)
https://www.sciencedaily.com/releases/2020/01/200123152614.htm
Air Pollution (12:58)
https://www.sciencedaily.com/releases/2020/02/200214134717.htm
Selective Bias Rant (16:15)

Phospholipase on Muscle Growth; Autophagy in Cancer and a Mystery Ally; New Antibiotic Feb 19, 2020

Show notes

In this episode, we will be diving extensively into a powerful muscle promoting mechanism known as phospholipase. Following that, we dive into a potential treatment for cancer using an unlikely ally. Finally, I discuss research out of McMaster University developing a new style of antibiotic.
Phospholipase (1:18)
https://www.youtube.com/watch?v=EtV3yWw0hz8&t=3s
Cancer & Unlikely Ally (19:20)
Xue Zhang, Tingting Zhang, John N. Davis, Andrea Marzi, Anthony M. Marchese, Michael D. Robek, Anthony N. van den Pol. Mucin-like domain of Ebola virus glycoprotein enhances selective oncolytic actions against brain tumors. Journal of Virology, 2020; DOI: 10.1128/JVI.01967-19
Antibiotic: (25:15)
https://www.sciencedaily.com/releases/2020/02/200212131523.htm

How does your Body fix Mutations?, Heart Rate Variability, Caffeine causes Migraines? Feb 12, 2020

Show notes

In this podcast, I admittedly nerd out a bit on genetics and how our cells repair our genes when exposed to mutagens (things that cause mutations). However, with good reason, because a new paper has added some clarity to a part of the process and man is it cool! Beyond that, we will go into heart rate variability, as well as if caffeine is associated with migraines? Check it out and share!
Rad DNA Repair, 1:03
Roxanne Oshidari, Richard Huang, Maryam Medghalchi, Elizabeth Y. W. Tse, Nasser Ashgriz, Hyun O. Lee, Haley Wyatt, Karim Mekhail. DNA repair by Rad52 liquid droplets. Nature Communications, 2020; 11 (1) DOI: 10.1038/s41467-020-14546-z
Heart Rate Variability, 26:20
Giorgio Quer, Pishoy Gouda, Michael Galarnyk, Eric J. Topol, Steven R. Steinhubl. Inter- and intraindividual variability in daily resting heart rate and its associations with age, sex, sleep, BMI, and time of year: Retrospective, longitudinal cohort study of 92,457 adults. PLOS ONE, 2020; 15 (2): e0227709 DOI: 10.1371/journal.pone.0227709
Caffeine on Migraines, 31:28
https://www.sciencedaily.com/releases/2019/08/190808091422.htm
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Thoughts on Coronavirus, New Contraceptive Technology, Marijuana & Birth, and more Feb 05, 2020

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In this episode, we'll be discussing four topics:
1:47 - Coronavirus
14:46 - Contraceptive Technology
22:36 - Marijuana & Birth
28:08 - Sleep Deprivation & Hunger
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Spontaneous, life threatening, meat allergies; ageotyping; cellular asthma, and more Jan 29, 2020

Show notes

In this week's episode, we will be discussing many subjects ranging from sudden meat allergies, how asthma presents itself (cellularly), to different "styles" of aging known as ageotypes, as well as even more! Topics and time stamps listed here:
Meat Allergy (2:37): https://www.jimmunol.org/content/203/4/813
Selective Asthma (10:50): https://www.nature.com/articles/s41590-019-0496-9
Skin Pain Sensation (19:38): https://science.sciencemag.org/content/365/6454/695
Ageotypes (26:10): https://www.nature.com/articles/s41591-019-0719-5
Protein on Health (31:42): https://www.physionic.org/highproteinonhealth

Diet on Male Fertility, Non-HDL Cholesterol on Heart Disease Jan 22, 2020

Show notes

In this episode, we will go over three articles describing the affect genetics play on cardiovascular disease, as well as sleep's mitigating role. We will also discuss how non-HDL cholesterol affects heart disease risk. Finally, we briefly discuss a study on extreme sugar consumption and its impact on male fertility.
(2:28) Genetics & Sleep: Mengyu Fan, Dianjianyi Sun, Tao Zhou, Yoriko Heianza, Jun Lv, Liming Li, Lu Qi. Sleep patterns, genetic susceptibility, and incident cardiovascular disease: a prospective study of 385 292 UK biobank participants. European Heart Journal, 2019; DOI: 10.1093/eurheartj/ehz849
(11:32) Non-HDL Cholesterol: Application of non-HDL cholesterol for population-based cardiovascular risk stratification: results from the Multinational Cardiovascular Risk Consortium. The Lancet, 2019; DOI: 10.1016/S0140-6736(19)32519-X
(24:00) Sugar on Fertility: Daniel Nätt, Unn Kugelberg, Eduard Casas, Elizabeth Nedstrand, Stefan Zalavary, Pontus Henriksson, Carola Nijm, Julia Jäderquist, Johanna Sandborg, Eva Flinke, Rashmi Ramesh, Lovisa Örkenby, Filip Appelkvist, Thomas Lingg, Nicola Guzzi, Cristian Bellodi, Marie Löf, Tanya Vavouri, Anita Öst. Human sperm displays rapid responses to diet. PLOS Biology, 2019; 17 (12): e3000559 DOI: 10.1371/journal.pbio.3000559
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5 Laws of Health, Winning the War on Cancer, Creatine on Muscle Hypertrophy Jan 16, 2020

Show notes

In this episode, we take a deeper look at a recent video I released on YouTube wherein I describe 5 immutable "laws" of health. Then, we will discuss two bits on cancer research - one wonderful and one interesting. Finally, we finish off with a discussion of "does creatine increase muscle mass directly?"
6:18 - 5 Laws of Health
22:12 - War on Cancer
30:00 - Ketones and Breast Cancer
40:47 - Creatine direct affect on Muscle Hypertrophy?
Ketones on Cancer: https://www.physionic.org/overexpressingketonesonbreastcancer
5 Laws of Health: https://www.youtube.com/watch?v=US684eYHLMY&t=1s

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