This Week in Neuroscience

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TWiN 36: Unbearable neurologists Jan 03, 2023

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TWiN answers listener questions about Alzheimer's disease, glaucoma and the microbiota, Dravet's Syndrome, schizophrenia, brain development, and chips implanted in the human brain.

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Letters read on TWiN 36
Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

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TWiN 35: Neuromodulation in treatment-resistant depression Dec 06, 2022

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Jason and Tim review the use of an implanted chronic deep brain sensing and stimulation device to carry out biomarker-driven closed-loop therapy that resulted in a rapid and sustained improvement in depression.

Hosts: Jason Shepherd and Timothy Cheung

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Closed-loop neuromodulation for depression (Nat Med)
Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

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TWiN 34: Microglia vital after spinal cord injury Sep 30, 2022

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TWiN explains how central nervous system resident macrophages known as microglia coordinate cellular interactions during spinal cord repair in mice.

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Microglia coordinate spinal cord repair (Nat Commun)
Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

Send your neuroscience questions and comments to twin@microbe.tv

TWiN 33: Viruses leaving the brain Aug 31, 2022

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TWiN describes how neurotropic viruses leave the brain via meningeal lymphatic vessels located dorsally and basally beneath the skull.

Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, and Timothy Cheung

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Meningeal lymph vessels and viral exit from brain (Nature Neuroscience)
Clearing mouse brain video (YouTube)
Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

Send your neuroscience questions and comments to twin@microbe.tv

TWiN 32: Relearning how to move after stroke Aug 02, 2022

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TWiN reviews how, in a mouse stroke model, recovery of movement is associated with the remaining cortex and the striatum coordinating their activity together.

Hosts: Ori Lieberman, Timothy Cheung, and Vivianne Morrison

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Recovery after stroke in mice (Cell Rep)
Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

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TWiN 31: HIV-1 co-receptor shapes window for memory linking Jun 29, 2022

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TWiN explains the observation that in mice, the HIV-1 co-receptor CCR5 closes the temporal window for linking different memories.

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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CCR5 and memory linking (Nature)
Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

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TWiN 30: Gut to brain spread of alpha-synuclein in Parkinson's disease May 24, 2022

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TWiN describes experiments demonstrating that gut injection of alpha-synuclein fibrils in mice converts endogenous alpha-synuclein to a pathologic form that spreads to the brain and leads to features of Parkinson's disease.

Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Gut-brain alpha-synuclein transport in PD (Neuron)
Gut has a mind of its own (Colbert Report)
Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

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TWiN 29: Astrocytes close the critical period May 02, 2022

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TWiN explains the finding that in the mouse visual cortex, astrocytes are key elements in the experience-dependent wiring of brain circuits.

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Astrocytes close the critical period (Science)
Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

Send your neuroscience questions and comments to twin@microbe.tv

TWiN 28: Oligodendrocyte performance enhancing exosomes Apr 04, 2022

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TWiN reveals how oligodendrocytes enhance axonal energy metabolism by transcellular delivery of a protein, SIRT2, that deacetylates mitochondrial proteins.

Hosts: Vincent Racaniello, Timothy Cheung, and Vivianne Morrison

Click arrow to play Download TWiN 028 (77 MB .mp3, 64 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

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Glia 101 (TWiN 19)
Oligodendrocytes enhance axonal energy metabolism (Neuron)
Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

Send your neuroscience questions and comments to twin@microbe.tv

TWiN 27: Eyes wired to the auditory cortex Mar 03, 2022

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TWiN discusses the finding that rewiring retinal projections to the auditory thalamus in ferrets leads to visually responsive cells that are typical of cells in the visual cortex.

Hosts: Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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