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    Life Sciences

    This Week in Neuroscience

    A podcast about the nervous system.

    Advertise

    Copyright: © This Week in Neuroscience is copyright 2019 by MicrobeTV, LLC

    • Apple Podcasts
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    • Spotify
    Latest Episodes:
    TWiN 46: Neuronal activity promotes glioma progression Jan 01, 2024
    Show notes

    TWiN explains research showing that interaction between glioma cells and neurons in the brain shares mechanistic features with synaptic plasticity that contributes to memory and learning in the healthy brain.

    Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS

    Links for this episode
    • MicrobeTV Discord Server
    • Glioma synapses recruit mechanisms of adaptive plasticity (Nature)
    • Timestamps by Jolene. Thanks!

    Music is by Ronald Jenkees

    Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 45: Acupuncture modulates the immune system Dec 13, 2023
    Show notes

    TWiN discusses research showing that sciatic nerve activation with electroacupuncture at the sciatic nerve controls systemic inflammation and rescues mice from polymicrobial peritonitis, by inducing vagal activation of aromatic L-amino acid decarboxylase, leading to the production of dopamine in the adrenal medulla.

    Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS

    Links for this episode
    • MicrobeTV Discord Server
    • Electroacupuncture modulates the immune system (Nat Med)
    • Electroacupuncture drives the vagal–adrenal axis (Nature)
    • Timestamps by Jolene. Thanks!

    Music is by Ronald Jenkees

    Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 44: ADHD and persistent pain Nov 02, 2023
    Show notes

    TWiN reviews a mouse model of ADHD to characterize hypersensitivity to pain, and that sensitization is further amplified in a pathological inflammatory state.

    Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS

    Links for this episode
    • MicrobeTV Discord Server
    • Pain hypersensitivity in ADHD model (PNAS)
    • Timestamps by Jolene. Thanks!

    Music is by Ronald Jenkees

    Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 43: Pavlovian opioid tolerance Oct 04, 2023
    Show notes

    TWiN discusses a study of on the pathways that control opioid analgesic tolerance, a root cause of opioid overdose and misuse, which can develop through an associative learning.

    Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS

    Links for this episode
    • MicrobeTV Discord Server
    • Associative opioid analgesic tolerance (Sci Adv)
    • Pavlovian-conditioned opioid tolerance (Sci Adv)
    • Timestamps by Jolene. Thanks!

    Music is by Ronald Jenkees

    Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 42: Therapeutic effects of psychedelic drugs Jul 18, 2023
    Show notes

    TWiN explains how psychedelic drugs such as LSD, psilocybin, and MDMA, which are being explored for treating a wide range of neuropsychiatric diseases, reopen the social reward period for critical learning.

    Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung

    Click arrow to play Download TWiN 042 (34 MB .mp3, 57 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS

    Links for this episode
    • MicrobeTV Discord Server
    • Psychedelic drugs open critical period (Nature)
    • Psychedelics reopen critical periods (News-Med)
    • LSD microdosing doesn't work (U Chicago Med)
    • Timestamps by Jolene. Thanks!

    Music is by Ronald Jenkees

    Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 41: Alzheimer's and melanin-concentrating hormone Jun 20, 2023
    Show notes

    Vivianne explains how early in Alzheimer's disease, the brain attempts to counteract the increased excitatory drive caused by amyloid deposition, and that melanin-concentrating hormone, produced during sleep, is involved in this protective response.

    Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS

    Links for this episode
    • MicrobeTV Discord Server
    • Melanin-concentrating hormone and Alzheimer's disease (Nat Neurosci)
    • Alzforum
    • Timestamps by Jolene. Thanks!

    Music is by Ronald Jenkees

    Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 40: Dopamine organizes behavior's syllables May 11, 2023
    Show notes

    Tim takes TWiN through two studies on the role of dopamine: that syllables are natural units of spontaneous behavior used by the brain to structure action, and that mesolimbic dopamine release conveys causal associations but not reward prediction errors, thereby challenging the dominant theory of reward learning.

    Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS

    Links for this episode
    • MicrobeTV Discord Server
    • Spontaneous behavior without explicit reward (Nature)
    • Dopamine release conveys causal associations (Science)
    • Timestamps by Jolene. Thanks!

    Music is by Ronald Jenkees

    Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 39: Virus-like capsids trigger paraneoplastic disease Apr 28, 2023
    Show notes

    Junjie from Jason's lab joins TWiN to discuss the observation that the cell gene PNMA2 encodes non-enveloped virus-like capsids that induce autoantibodies which underlie paraneoplastic syndrome.

    Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Junjie Xu

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS

    Links for this episode
    • MicrobeTV Discord Server
    • Virus-like capsids in paraneoplastic disease (bioRxiv)
    • Timestamps by Jolene. Thanks!

    Music is by Ronald Jenkees

    Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 38: Bacterial immunity heals sensory neurons Mar 27, 2023
    Show notes

    TWiN explains the finding that immunity to commensal bacteria promotes sensory neuron regeneration via the cytokine interleukin-17A.

    Hosts: Vincent Racaniello, Ori Lieberman, Timothy Cheung, and Vivianne Morrison

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS

    Links for this episode
    • MicrobeTV Discord Server
    • Immunity to the microbiota promotes sensory neuron regeneration (Cell)
    • Timestamps by Jolene. Thanks!

    Music is by Ronald Jenkees

    Send your neuroscience questions and comments to twin@microbe.tv

    TWiN 37: Microglia at the crossroads Jan 23, 2023
    Show notes

    TWiN reviews the field of microgial research, which has advanced in recent decades but is constrained by nomenclature that is necessary but often implies specific functions.

    Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

    Subscribe (free): Apple Podcasts, Google Podcasts, RSS

    Links for this episode
    • Microglia states and nomenclature (Nature)
    • Timestamps by Jolene. Thanks!

    Music is by Ronald Jenkees

    Send your neuroscience questions and comments to twin@microbe.tv

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