This Week in Neuroscience

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TWiN 56: Astrocytes help neurons remember Nov 26, 2024

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TWiN explains a study showing that while groups of neurons, form the basis for memory, astrocytes are key components of the adaptive reponse to learning experiences, and regulate the flow of information during circuit plasticity and memory recall.

Hosts: Vincent Racaniello, Jason Shepherd, and Tim Cheung

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Astrocytes and memory (Nature)
Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

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TWiN 55: A brain circuit for day/night balance Oct 28, 2024

Show notes

TWiN explains the identification of a brain circuit and periodic branch-specific neurotransmitter deployment that regulates organismal adaptation to photoperiod change.

Hosts: Vincent Racaniello, Jason Shepherd, and Tim Cheung

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Brain circuit for photoperiod adaptation (Nature)
Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

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TWiN 54: How pregnancy transforms the brain Oct 01, 2024

Show notes

TWiN explores how pregnancy leads to modifications in brain structure and function that may prepare the mother for parenting.

Hosts: Vincent Racaniello, Jason Shepherd, and Vivianne Morrison

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Pregnancy transforms the brain (Nature)
Hormone-mediated neural remodeling during pregnancy (Science)
Effects of pregnancy on brain activity (Nature Comm)
Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

Send your neuroscience questions and comments to twin@microbe.tv

TWiN 53: Slowing time by cooling the brain Jul 29, 2024

Show notes

Joseph Paton and Felipe Rodrigues join TWiN to explain how they used temperature manipulation to alter the speed of neuronal dynamics in the dorsal striatum of rats, a manipulation that selectively slowed down or sped up time perception, illuminating the mechanisms of time-based decisions.

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

Guest: Joseph J. Paton and Felipe Rodrigues

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Using temperature to analyze the neural basis of a time-based decision (Nat Neurosci)
Hot times for the dorsal striatum (Nat Neurosci)
Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

Send your neuroscience questions and comments to twin@microbe.tv

TWiN 52: Probiotic improves social behavior in children with ASD Jun 24, 2024

Show notes

Mauro Costa-Mattioli returns to TWiN to discuss the results of a placebo controlled, double blind clinical trial of a probiotic which improved social behavior but not autism severity in children with ASD.

Hosts: Jason Shepherd, Timothy Cheung, and Vivianne Morrison

Guest: Mauro Costa-Mattioli

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Probiotics for autism spectrum disorder (Cell Host Microbe)
Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

Send your neuroscience questions and comments to twin@microbe.tv

TWiN 51: Sensory processing dysfunction in autism spectrum disorders May 28, 2024

Show notes

TWiN reviews altered somatosensory reactivity, which is frequently observed among individuals with autism spectrum disorders (ASD), and in mouse models the developmental timing of aberrant touch processing can predict the manifestation of ASD-associated behaviors in mouse models.

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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Mouse models of autism spectrum disorder (Nature Neuroscience)
Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

Send your neuroscience questions and comments to twin@microbe.tv

TWiN 50: Neurological sequelae after COVID-19 Apr 29, 2024

Show notes

TWiN reviews experiments which show that SARS-CoV-2 triggers the up-regulation of synaptic components and perturbs local electrical field potential in cerebral organoids, organotypic culture of human brain explants and post-mortem brain samples from individuals with COVID-19.

Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison

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SARS-CoV-2 perturbs synaptic homeostasis (Nature Micro)
Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

Send your neuroscience questions and comments to twin@microbe.tv

TWiN 49: Mirror, mirror on the wall, who's the fairest mouse of all? Mar 25, 2024

Show notes

TWiN welcomes mice to the elite club of 'self-aware' animals, with a study demonstrating a mirror-induced self-directed behavior in mice resembling visual self-recognition.

Hosts: Vincent Racaniello, Timothy Cheung, and Vivianne Morrison

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Mice are self-aware (Neuron)
Mirror self-recognition in mice (Neuron)
Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

Send your neuroscience questions and comments to twin@microbe.tv

TWiN 48: Traumatic brain injury and retroviruses Feb 19, 2024

Show notes

TWiN describes a study that reveals activation of endogenous retroviruses in oligodenroglia from patients with traumatic brain injury.

Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung

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Activation of endogenous retroviruses in TBI oligodendroglia (Cell Rep)
Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

Send your neuroscience questions and comments to twin@microbe.tv

TWiN 47: Walking after spinal cord injury Jan 29, 2024

Show notes

TWiN explains an amazing study of a man who was paralyzed after a spinal cord injury and regained the ability to walk after implantation of a brain-spinal cord interface.

Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung

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Walking naturally after spinal cord injury (Nature)
The paralyzed rat that walked (YouTube)
Mike the headless chicken (Wikipedia)
Timestamps by Jolene. Thanks!

Music is by Ronald Jenkees

Send your neuroscience questions and comments to twin@microbe.tv

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