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    Natural Sciences

    The Immunology Podcast

    A podcast featuring conversations with immunologists from around the globe. Brought to by STEMCELL Technologies.

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    Latest Episodes:
    Ep. 73: “T Cell Receptors” Featuring Dr. James Allison Feb 27, 2024
    Show notes

    Guest:

    Dr. James Allison is the Regental Professor and Chair of the Department of Immunology, Olga Keith Wiess Distinguished University Chair for Cancer Research, Director of the Parker Institute for Cancer Research, Executive Director of the Immunotherapy Platform, and Director of the James P. Allison Institute at MD Anderson Cancer Center.

    Dr. Allison has spent a distinguished career studying the regulation of T cell responses and developing strategies for cancer immunotherapy. He earned the 2018 Nobel Prize in Physiology or Medicine, which he shared with Dr. Tasuku Honjo, “for their discovery of cancer therapy by inhibition of negative immune regulation.” His current work seeks to improve immune checkpoint blockade therapies currently used by clinicians and identify new targets to unleash the immune system in order to eradicate cancer. He talks about the hunt for the T cell receptor and working to bring CTLA-4 blockade into the clinic. He also discusses what’s next for immunotherapy, including future investigations into myeloid cells, and playing the harmonica in a band.

    Featured Products and Resources:

    • Register now for IMMUNOLOGY2024™!
    • Enter to win a free lab coat and learn about mentorship in science.

    The Immunology Science Round Up

    Overcoming Antibacterial Resistance – A new antibiotic targets multi-drug-resistant bacteria by binding to ribosomes.

    Tregs in Visceral Adipose Tissue – Visceral adipose tissue harbors two distinct Treg cell populations: one enriched in males and one enriched in females.

    How IL-23 Fuels Tumor Growth – A subset of Tregs are responsible for the tumor-promoting effect of IL-23.

    Smoking and the Immune System – Smoking affects adaptive immune responses for years after quitting.

    Image courtesy of Dr. James Allison

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    Ep. 72: “IMMUNOLOGY2024™: Innovations in Immunology” Featuring Dr. Akiko Iwasaki, Francisco Gomez-Rivera, and Dr. Jason Augustine Feb 13, 2024
    Show notes

    Guests:

    Dr. Akiko Iwasaki is the Sterling Professor of Immunobiology and Molecular, Cellular, and Developmental Biology at Yale University and President of the American Association of Immunologists. Francisco Gomez-Rivera is an Immunology Program Graduate Student Candidate at the University of Michigan, and Dr. Jason (Swinburne) Augustine is a retired Research Microbiologist/Immunologist at the US Environmental Protection Agency. They talk about the upcoming IMMUNOLOGY2024™ meeting in Chicago, Illinois from May 3-7, 2024. They discuss key sessions to attend, what they’re looking forward to at the meeting, and advice for attendees.

    Featured Products and Resources:

    • Check out the program for the IMMUNOLOGY2024™ meeting.
    • Get updates about new mentorship content.

    The Immunology Science Round Up

    Bacteria in Gastric Cancer – Streptococcus anginosus promotes gastric tumorigenesis via direct interactions with gastric epithelial cells.

    CAR T Cells for Aging – Senolytic CAR T cells safely eliminate senescent cells in young animals.

    Microbiota and Tuft Cell Biology – Microbiota calibrate type 2 immunity in the intestine by controlling tuft cell differentiation.

    Sex Differences in Autoimmunity – Autoantibodies to the Xist ribonucleoprotein characterize female-biased autoimmune diseases.

    Images courtesy of Dr. Akiko Iwasaki, Robert Lisak, Francisco Gomez-Rivera, and Dr. Jason (Swinburne) Augustine

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    Ep. 71: “The Neuroscience of HIV” Featuring Dr. Dionna Williams Jan 30, 2024
    Show notes

    Guest:

    Dr. Dionna Williams is an Acting Associate Professor in the Department of Pharmacology & Chemical Biology at Emory University. Their research focuses on the effects of HIV infection on the brain. She talks about how HIV affects immune cells in the brain and how this can lead to neuropsychiatric symptoms. They also discuss therapeutic approaches, factors that affect how drugs can reach the brain, and moving their lab to Atlanta.

    Featured Products and Resources:

    • Sign up now for IMMUNOLOGY2024™, happening May 3-7 in Chicago.
    • Get Updates about New Mentorship Content

    The Immunology Round Up

    A Long Covid Blood Signature – Active Long Covid is accompanied by a blood protein signature marked by increased complement activation and thromboinflammation.

    T Cells in Guillain–Barré Syndrome –Autoreactive T cells that target myelin antigens in the peripheral nerves are present in patients with the demyelinating form of Guillain–Barré syndrome.

    A CAR-NK Cell Clinical Trial – Researchers identified features of donated cord blood associated with improved response to CAR-NK cell therapy for B cell malignancies.

    Cas9-Packaging Enveloped Delivery Vehicles – Researchers developed an antibody-directed strategy for delivering genome engineering tools to specific cell types.

    Image courtesy of Dr. Dionna Williams

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    Ep. 70: “Public Outreach” Featuring Drs. Akiko Iwasaki and Aimee Bernard Jan 16, 2024
    Show notes

    Guests:

    Dr. Akiko Iwasaki is the Sterling Professor of Immunobiology and Molecular, Cellular, and Developmental Biology at Yale University and President of the American Association of Immunologists (AAI), and Dr. Aimee Bernard is an Assistant Professor of Immunology and Microbiology at the University of Colorado. Dr. Iwasaki has a very active presence on X, where she shares about COVID-19 research. Dr. Bernard is also active on social media through her TikTok account, and co-hosts a podcast, Help! Make It Make Sense.

    In this episode, they discuss the importance of communicating science to the public and strategies for social media. They also talk about how the AAI is working to share immunology knowledge with non-scientists through Immunology Explained.

    Featured Products and Resources:

    • Register now for IMMUNOLOGY2024™, happening May 3-7 in Chicago!
    • Stay up-to-date with the latest in cell biology news.

    The Immunology Round Up

    A New Antibiotic for Gram-Negative Bacteria – A mechanism of lipid transport inhibition has been identified for a class of peptide antibiotics effective against resistant Acinetobacter strains.

    Treg Depletion As Cancer Treatment – Researchers examined the mechanism of Treg cell depletion failure using a mouse model of Treg cell–targeted immunotherapy.

    Immunotherapy Resistance in Melanoma – Using single-cell, spatial multi-omics, scientists showed that the tumor microenvironment promotes the emergence of a complex melanoma transcriptomic landscape.

    An Immune Dictionary of Cytokine Responses – Scientists created single-cell transcriptomic profiles of more than 17 immune cell types in response to each of 86 cytokines in mouse lymph nodes in vivo.

    Images courtesy of Robert Lisak, YSM and Dr. Aimee Bernard

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    Ep. 69: IUIS 2023: On the Ground Dec 19, 2023
    Show notes

    In 2023, we attended the 18th International Congress of Immunology, hosted by the International Union of Immunological Societies (IUIS), in Cape Town, South Africa. We spoke with delegates about their research and impressions of the meeting, including their reasons for attending and the most memorable research presented. They discuss their experiences in South Africa, the meeting’s focus on infectious diseases and equitable science, and sessions by Nobel laureates.

    Featured Products and Resources:

    • Register for IMMUNOLOGY2024™, taking place May 3-7 in Chicago!
    • STEMCELL Technologies is hiring!

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    Ep. 68: “Blood Transfusions” Featuring Dr. David Gibb Dec 05, 2023
    Show notes

    David Gibb

    Guest:

    Dr. David Gibb is an Assistant Professor at Cedars-Sinai Medical Center. His lab investigates inflammatory mechanisms in patients with sickle cell disease and lupus, focusing on mechanisms regulating immune responses to red blood cell antigens following transfusion.

    Featured Products and Resources:

    • IMMUNOLOGY2024™ is happening May 3-7, 2024, in Chicago. Register now!
    • Enter to win a cell or gene therapy conference registration award.

    The Immunology Round Up

    Regulation of Lymphoid Cells – NOD1 functions in murine hematopoietic cells as a major regulator of both the generation and differentiation of lymphoid progenitors.

    The Aging Immune System – Type 2 memory CD4+ and CD8+ T cells increase with age and can produce more IL-4.

    Microglia in Cancer Metastasis – Microglia play a distinct pro-inflammatory and tumor-suppressive role in breast cancer brain metastasis.

    MAIT Cells in Mice and Humans – Environment influences MAIT cell development and function.

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    IUIS 2023: Day 5 Dec 03, 2023
    Show notes

    In 2023, we attended the 18th International Congress of Immunology, hosted by the International Union of Immunological Societies, in Cape Town, South Africa, and recorded daily episodes discussing highlights of the conference. Here is the final of five special episodes from the meeting, in which Brenda and Jason discuss sessions on integrins and ebola vaccine trials.

    Featured Products and Resources:

    • Join a live webinar on January 23, 2024, to learn more about the most recent advances in CRISPR genome editing of primary cells.

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    IUIS 2023: Day 4 Dec 01, 2023
    Show notes

    In 2023, we attended the 18th International Congress of Immunology, hosted by the International Union of Immunological Societies, in Cape Town, South Africa, and recorded daily episodes discussing highlights of the conference. Here is the fourth of five special episodes from the meeting, in which Brenda and Jason discuss sessions on the HIV/AIDS epidemic and vaccination strategies to prepare for the next pandemic.

    Featured Products and Resources:

    • Say goodbye to manual labor and hello to efficiency with RoboSep™—your ultimate solution for automated cell isolation.

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    IUIS 2023: Day 3 Dec 01, 2023
    Show notes

    In 2023, we attended the 18th International Congress of Immunology, hosted by the International Union of Immunological Societies, in Cape Town, South Africa, and recorded daily episodes discussing highlights of the conference. Here is the third of five special episodes from the meeting, in which Brenda and Jason discuss research on T cell exhaustion in chronic infections and sex differences in immune responses.

    Featured Products and Resources:

    • Achieve robust T cell expansion with high cell yield and viability using STEMCELL Technologies’ GMP-manufactured ImmunoCult™-XF.

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    IUIS 2023: Day 2 Nov 29, 2023
    Show notes

    In 2023, we attended the 18th International Congress of Immunology, hosted by the International Union of Immunological Societies, in Cape Town, South Africa, and recorded daily episodes discussing highlights of the conference. Here is the second of five special episodes from the meeting, in which Brenda and Jason discuss research on the microbiome, sepsis, and the aging immune system.

    Featured Products and Resources:

    • Perform large-volume cell processing with the Easy 250 EasySep™ Magnet.

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