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The Immunology Podcast — Natural Sciences
The Immunology Podcast

A podcast featuring conversations with immunologists from around the globe. Brought to by STEMCELL Technologies.

Latest Episodes:

Wayne Juang — Ep. 87: “Applications of Immunology” Featuring Dr. Wayne Juang Sep 10, 2024
Show notes

Guest:

Dr. Wayne Juang is a Field Application Scientist, Immunology at STEMCELL Technologies. In his current role, he works with researchers to help optimize and troubleshoot their experiments. He discusses his path to industry and his motivation to pursue an MBA.

Featured Products and Resources:

Register now for IMMUNOLOGY2025, the world’s leading annual all-immunology meeting!

Explore scientific resources for your immunology research at the STEMCELL Technologies immunology learning center.

The Immunology Round Up

TNF Mutations and Tuberculosis – Two relatives who lack working copies of the TNF gene experienced recurrent bouts of tuberculosis, but are unaffected by other pathogens.

Fibrin and Clotting in COVID-19 – Fibrin drives inflammation and neuropathology in SARS-CoV-2 infection.

Salt in Tumors – Sodium chloride in enhances the activation state and effector functions of human CD8⁺ T cells.

Fatal Respiratory Infections – Researchers identified oleoyl-ACP hydrolase as an early driver of several severe respiratory diseases.

Image courtesy of STEMCELL Technologies

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Ep. 87: “Applications of Immunology” Featuring Dr. Wayne Juang Sep 10, 2024
Show notes

Guest:

Dr. Wayne Juang is a Field Application Scientist, Immunology at STEMCELL Technologies. In his current role, he works with researchers to help optimize and troubleshoot their experiments. He discusses his path to industry and his motivation to pursue an MBA.

Featured Products and Resources:

Register now for IMMUNOLOGY2025, the world’s leading annual all-immunology meeting!

Explore scientific resources for your immunology research at the STEMCELL Technologies immunology learning center.

The Immunology Round Up

TNF Mutations and Tuberculosis – Two relatives who lack working copies of the TNF gene experienced recurrent bouts of tuberculosis, but are unaffected by other pathogens.

Fibrin and Clotting in COVID-19 – Fibrin drives inflammation and neuropathology in SARS-CoV-2 infection.

Salt in Tumors – Sodium chloride in enhances the activation state and effector functions of human CD8⁺ T cells.

Fatal Respiratory Infections – Researchers identified oleoyl-ACP hydrolase as an early driver of several severe respiratory diseases.

Image courtesy of STEMCELL Technologies

Subscribe to our newsletter!

Never miss updates about new episodes.
Subscribe

Kipp Weiskopf — Ep. 86: “Myeloid Cells” Featuring Dr. Kipp Weiskopf Aug 27, 2024
Show notes

Guest:

Dr. Kipp Weiskopf is a Valhalla Fellow at the Whitehead Institute. His research focuses on unlocking the therapeutic potential of macrophages for the benefit of cancer patients. He talks about the role of macrophages in the tumor environment and how targeting the CD47/SIRPα axis can induce phagocytosis of cancer cells. He also discusses starting spin-off companies to advance cancer therapies.

Featured Products and Resources:

Request your free copy of the ‘Human Immune Cytokines’ Wallchart

The STEMdiff Monocyte Kit generates millions of monocytes ready for downstream assays or further development into macrophages or dendritic cells.

The Immunology Round Up

Organoids with an Immune Compartment – Researchers generated human intestinal immuno-organoids to investigate intestinal inflammation triggered by cancer-targeting biologics in patients.

Gene Repression in Tregs – The transcription factor Ikaros binds to Foxp3 to inhibit the expression of target genes in Tregs.

γδ T-Cell Antigen Receptor Structure – Scientists used cryo-electron microscopy to determine the structure of of the T-cell receptor found on the surface of γδ T cells.

Autoimmune Organ Damage – Tissue-resident NKp46⁺ innate lymphoid cells are crucial signal amplifiers of disease-associated macrophage expansion and epithelial cell injury in lupus nephritis.

Image courtesy of Dr. Kipp Weiskopf

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Ep. 86: “Myeloid Cells” Featuring Dr. Kipp Weiskopf Aug 27, 2024
Show notes

Guest:

Dr. Kipp Weiskopf is a Valhalla Fellow at the Whitehead Institute. His research focuses on unlocking the therapeutic potential of macrophages for the benefit of cancer patients. He talks about the role of macrophages in the tumor environment and how targeting the CD47/SIRPα axis can induce phagocytosis of cancer cells. He also discusses starting spin-off companies to advance cancer therapies.

Featured Products and Resources:

Request your free copy of the ‘Human Immune Cytokines’ Wallchart

The STEMdiff Monocyte Kit generates millions of monocytes ready for downstream assays or further development into macrophages or dendritic cells.

The Immunology Round Up

Organoids with an Immune Compartment – Researchers generated human intestinal immuno-organoids to investigate intestinal inflammation triggered by cancer-targeting biologics in patients.

Gene Repression in Tregs – The transcription factor Ikaros binds to Foxp3 to inhibit the expression of target genes in Tregs.

γδ T-Cell Antigen Receptor Structure – Scientists used cryo-electron microscopy to determine the structure of of the T-cell receptor found on the surface of γδ T cells.

Autoimmune Organ Damage – Tissue-resident NKp46⁺ innate lymphoid cells are crucial signal amplifiers of disease-associated macrophage expansion and epithelial cell injury in lupus nephritis.

Image courtesy of Dr. Kipp Weiskopf

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Never miss updates about new episodes.
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Ep. 85: “Reproductive Immunology” Featuring Dr. Adrian Erlebacher Aug 13, 2024
Show notes

Guest:

Dr. Adrian Erlebacher is a Professor in the Department of Laboratory Medicine at the University of California, San Francisco. His lab studies how the developmental properties of a tissue influence its ability to mount a successful immune response. He talks about immune tolerance in pregnancy and how the maternal–fetal interface affects pregnancy outcomes.

Featured Products and Resources:

Free wallchart: human immune cytokines.

Generate fallopian tube organoids with GyneCult.

The Immunology Science Round Up

Immune Cells in the Skull – The glioblastoma-linked immune-cell niche in the human skull provides an unanticipated resource and concept of acute tumor reactivity in the proximal bone marrow.

Nasal Vaccine Reactions – Nasal vaccination induces B cell expansion in the subepithelial dome of nasal-associated lymphoid tissues.

Airway Microbiota Across the Lifespan – Lifestyle factors are related to oral microbiota and environment is related to nasopharyngeal microbiota.

Tregs in the Gut – Researchers used a chemogenetic screen to reveal functional neuroimmune interactions in the gut.

Image courtesy of Dr. Adrian Erlebacher

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Ep. 85: “Reproductive Immunology” Featuring Dr. Adrian Erlebacher Aug 13, 2024
Show notes

Guest:

Dr. Adrian Erlebacher is a Professor in the Department of Laboratory Medicine at the University of California, San Francisco. His lab studies how the developmental properties of a tissue influence its ability to mount a successful immune response. He talks about immune tolerance in pregnancy and how the maternal–fetal interface affects pregnancy outcomes.

Featured Products and Resources:

Free wallchart: human immune cytokines.

Generate fallopian tube organoids with GyneCult.

The Immunology Science Round Up

Immune Cells in the Skull – The glioblastoma-linked immune-cell niche in the human skull provides an unanticipated resource and concept of acute tumor reactivity in the proximal bone marrow.

Nasal Vaccine Reactions – Nasal vaccination induces B cell expansion in the subepithelial dome of nasal-associated lymphoid tissues.

Airway Microbiota Across the Lifespan – Lifestyle factors are related to oral microbiota and environment is related to nasopharyngeal microbiota.

Tregs in the Gut – Researchers used a chemogenetic screen to reveal functional neuroimmune interactions in the gut.

Image courtesy of Dr. Adrian Erlebacher

Subscribe to our newsletter!

Never miss updates about new episodes.
Subscribe

Ep. 84: “T Cells in Inflammation and Cancer” Featuring Dr. Jeffrey Rathmell Jul 30, 2024
Show notes

Guest:

Dr. Jeffrey Rathmell is the Cornelius Vanderbilt Professor of Immunobiology at the Vanderbilt Center for Immunobiology. His research focuses on T cell metabolism in cancer. He talks about what T cells use for fuel and his work on fatty acid synthesis. He also discusses the ‘obesity paradox’ in cancer immunotherapy and his favorite parts of being a scientist and professor.

Featured Products and Resources:

The Immunology Podcast has been nominated for a People’s Choice Podcast Award!

Differentiate human monocytes into macrophages with STEMCELL’s ImmunoCult-XF Macrophage Medium.

The Immunology Round Up

A Humanized Mouse Model – A new humanized mouse mounts specific and mature antibody and autoantibody responses.

IL-11 Signaling in Aging – Inhibiting IL-11 extends the healthspan and lifespan of mice.

Sphinganine Synthesis in Macrophages – Sphinganine biosynthesis is a checkpoint for macrophage pattern recognition in mouse models of sepsis and melanoma.

Brain-Muscle Signaling – Researchers identified a brain-to-muscle signaling axis in Drosophila that regulates muscle performance.

Image courtesy of Dr. Jeffrey Rathmell

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Ep. 83: “Biomolecular Sensors” Featuring Dr. Shana Kelley Jul 16, 2024
Show notes

Guest:

Dr. Shana Kelley is the President of the Chan Zuckerberg Biohub Chicago and the Neena B. Schwartz Professor of Chemistry and Biomedical Engineering at Northwestern University. The Kelley research group works in a variety of areas spanning bio analytical technology development and has pioneered new methods for tracking molecular and cellular analytes with unprecedented sensitivity. She talks about developing DNA-based reagentless biosensors and commercializing new technologies.

Featured Products and Resources:

The Immunology Podcast has been nominated for a People’s Choice Podcast Award!

Activate, expand, and differentiate your cells with cytokines, chemokines, and growth factors from STEMCELL Technologies.

The Immunology Science Round Up

Tuberculosis Target Structure – Cryogenic electron microscopy structures of Mycobacterium tuberculosis ATP synthase sheds light on drug binding.

Toll-Like Receptor Signaling – Researchers engineered macrophages to delineate TLR pathway activities.

Onco-Fetal Immune Tolerance – Scientists cross-analyzed single-cell RNA sequencing data from human cancer types and the maternal-fetal interface to identify an onco-fetal immune tolerance checkpoint.

Tau Immunotherapy – Scientists loaded tau antibodies into micelles and administered them intranasally in mice.

Image courtesy of Dr. Shana Kelley

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Ep. 82: “Immunological Memory” Featuring Dr. Susan Kaech Jul 02, 2024
Show notes

Guest:

Dr. Susan Kaech is a Professor and Director of the NOMIS Center for Immunobiology and Microbial Pathogenesis at the Salk Institute. Her lab aims to understand how memory T cells are produced during infection and vaccination, how they function, and why they can fail to induce long-term immunity, particularly during chronic disease or cancer. In this episode, she talks about her research on T cell exhaustion and neuroimmunology, as well as her path from genetics to immunology.

Featured Products and Resources:

Keep current with the latest in human immunology news.

Achieve robust T cell expansion with ImmunoCult-XF.

The Immunology Round Up

Glycan Breakdown and Bacterial Function – Researchers used a large-scale screen to identify enzyme systems that represent an underappreciated mode of glycan degradation.

Cancer Risk after CAR T Therapy – Only a small percentage of patients who receive CAR T therapies develop secondary cancers, and most are not directly linked to CAR T treatment.

CD8⁺ T Cells in Hepatitis B – Hepatocellular priming induces key co-signaling receptors in dysfunctional CD8⁺ T cells.

T Cell Aging – T cell epigenetic clocks measure replicative history and can continue to accumulate well-beyond organismal lifespan.

Image courtesy of Dr. Susan Kaech

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Ep. 82: “Immunological Memory” Featuring Dr. Susan Kaech Jul 02, 2024
Show notes

Guest:

Dr. Susan Kaech is a Professor and Director of the NOMIS Center for Immunobiology and Microbial Pathogenesis at the Salk Institute. Her lab aims to understand how memory T cells are produced during infection and vaccination, how they function, and why they can fail to induce long-term immunity, particularly during chronic disease or cancer. In this episode, she talks about her research on T cell exhaustion and neuroimmunology, as well as her path from genetics to immunology.

Featured Products and Resources:

Keep current with the latest in human immunology news.

Achieve robust T cell expansion with ImmunoCult-XF.

The Immunology Round Up

Glycan Breakdown and Bacterial Function – Researchers used a large-scale screen to identify enzyme systems that represent an underappreciated mode of glycan degradation.

Cancer Risk after CAR T Therapy – Only a small percentage of patients who receive CAR T therapies develop secondary cancers, and most are not directly linked to CAR T treatment.

CD8⁺ T Cells in Hepatitis B – Hepatocellular priming induces key co-signaling receptors in dysfunctional CD8⁺ T cells.

T Cell Aging – T cell epigenetic clocks measure replicative history and can continue to accumulate well-beyond organismal lifespan.

Image courtesy of Dr. Susan Kaech

Subscribe to our newsletter!

Never miss updates about new episodes.
Subscribe

Ep. 81: “Respiratory Immunology” Featuring Dr. Priya Devarajan Jun 18, 2024
Show notes

Guest:

Dr. Priya Devarajan is an Assistant Professor at Stony Brook University. Her work focuses on immune memory and respiratory immunology. She talks about how aging affects the immune system and strategies to promote immune responses in the nose and lungs. She also discusses improving influenza vaccine responses and her experience interviewing for faculty positions.

Featured Products and Resources:

Keep current with the latest in pulmonary cell news.

Grow Functional Airway Organoids with PneumaCult.

The Immunology Science Round Up

γδ T Cells Across the Life Span – Antigenic exposures over childhood drive the functional evolution and tissue compartmentalization of γδ T cells.

Glucose Restriction and Viral Response – Glucose restriction is a physiological mechanism to bring the body into a heightened state of responsiveness to viral pathogens.

A Gene Desert Implicated in Autoimmunity – Researchers used functional genomics to identify a central regulator of human inflammatory macrophages.

Stripy T Cells – Some T cells within a population have nuclear envelope invaginations that concentrate cellular organelles.

Image courtesy of Dr. Priya Devarajan

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Ep. 81: “Respiratory Immunology” Featuring Dr. Priya Devarajan Jun 18, 2024
Show notes

Guest:

Dr. Priya Devarajan is an Assistant Professor at Stony Brook University. Her work focuses on immune memory and respiratory immunology. She talks about how aging affects the immune system and strategies to promote immune responses in the nose and lungs. She also discusses improving influenza vaccine responses and her experience interviewing for faculty positions.

Featured Products and Resources:

Keep current with the latest in pulmonary cell news.

Grow Functional Airway Organoids with PneumaCult.

The Immunology Science Round Up

γδ T Cells Across the Life Span – Antigenic exposures over childhood drive the functional evolution and tissue compartmentalization of γδ T cells.

Glucose Restriction and Viral Response – Glucose restriction is a physiological mechanism to bring the body into a heightened state of responsiveness to viral pathogens.

A Gene Desert Implicated in Autoimmunity – Researchers used functional genomics to identify a central regulator of human inflammatory macrophages.

Stripy T Cells – Some T cells within a population have nuclear envelope invaginations that concentrate cellular organelles.

Image courtesy of Dr. Priya Devarajan

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Never miss updates about new episodes.
Subscribe

Ep. 80: “Engineered Biomaterials” Featuring Dr. Erika Moore Jun 11, 2024
Show notes

Guest:

Dr. Erika Moore is an Assistant Professor in the Fischell Department of Bioengineering at the University of Maryland, where her lab is committed to engineering biomaterial models that harness the regenerative potential of the immune system. She talks about building biomaterials, rejuvenating macrophages, and treating lupus. She also discusses using the right cells in research and promoting financial literacy to make science careers more accessible.

Featured Products and Resources:

Explore scientific resources for your immunology research.

Differentiate human monocytes into macrophages with ImmunoCult-SF Macrophage Medium.

The Immunology Science Round Up

Heart Failure – Bone marrow can carry an innate immune memory of cardiac stress that may exacerbate heart failure.

Epstein Barr and B Cells – Virus-orchestrated NAD biosynthesis is a druggable metabolic vulnerability of Epstein Barr virus-driven B cell transformations.

Microbiome Modulation in Pregnancy – Bacterial conversion of corticoids into progestins may affect host physiology, particularly in the context of pregnancy.

The Circadian Rhythm and Tumor Immunosuppression – Circadian gating of tumor immunosuppression informs the timing and efficacy of immune checkpoint inhibitors.

Image courtesy of Dr. Erika Moore

Subscribe to our newsletter!

Never miss updates about new episodes.
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Ep. 80: “Engineered Biomaterials” Featuring Dr. Erika Moore Jun 11, 2024
Show notes

Guest:

Dr. Erika Moore is an Assistant Professor in the Fischell Department of Bioengineering at the University of Maryland, where her lab is committed to engineering biomaterial models that harness the regenerative potential of the immune system. She talks about building biomaterials, rejuvenating macrophages, and treating lupus. She also discusses using the right cells in research and promoting financial literacy to make science careers more accessible.

Featured Products and Resources:

Explore scientific resources for your immunology research.

Differentiate human monocytes into macrophages with ImmunoCult-SF Macrophage Medium.

The Immunology Science Round Up

Heart Failure – Bone marrow can carry an innate immune memory of cardiac stress that may exacerbate heart failure.

Epstein Barr and B Cells – Virus-orchestrated NAD biosynthesis is a druggable metabolic vulnerability of Epstein Barr virus-driven B cell transformations.

Microbiome Modulation in Pregnancy – Bacterial conversion of corticoids into progestins may affect host physiology, particularly in the context of pregnancy.

The Circadian Rhythm and Tumor Immunosuppression – Circadian gating of tumor immunosuppression informs the timing and efficacy of immune checkpoint inhibitors.

Image courtesy of Dr. Erika Moore

Subscribe to our newsletter!

Never miss updates about new episodes.
Subscribe

Ep. 79: “ILC2s, the Microbiome, and Fibroblasts” Featuring Dr. Kellen Cavagnero Jun 04, 2024
Show notes

Guest:

Dr. Kellen Cavagnero is a Postdoctoral Fellow at the University of California, San Diego. His PhD work focused on how fibroblasts — a cell type thought to be immunologically inert — contribute to chronic inflammatory conditions and defense against pathogens. He talks about staph infections, antimicrobial resistance, and the types and roles of fibroblasts. He also discusses his work in science communication, including his podcast, Inflammatory Content.

Featured Products and Resources:

Read more interviews with immunologists in STEMCELL’s ‘Immunology Profiles’ series.

Scale up your cell isolation with the Easy 250 EasySep Magnet.

The Immunology Science Round Up

Malaria Immunity – Scientists leveraged a human malaria infection study to investigate functional correlates of immunity.

CAR T Therapy for HIV – Anti-HIV-1 CAR-T cells armed with endogenic broadly neutralizing antibodies resulted in significant suppression of viral rebound in HIV patients.

Immunogenic Cell Death – Researchers generated a small-molecule proteolysis-targeting chimera that selectively degraded human and murine RIPK1.

Origins of Autoimmunity – NUDCD3 is required for healthy T and B cell development in humans.

Image courtesy of Dr. Kellen Cavagnero

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Never miss updates about new episodes.
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Ep. 79: “ILC2s, the Microbiome, and Fibroblasts” Featuring Dr. Kellen Cavagnero Jun 04, 2024
Show notes

Guest:

Dr. Kellen Cavagnero is a Postdoctoral Fellow at the University of California, San Diego. His PhD work focused on how fibroblasts — a cell type thought to be immunologically inert — contribute to chronic inflammatory conditions and defense against pathogens. He talks about staph infections, antimicrobial resistance, and the types and roles of fibroblasts. He also discusses his work in science communication, including his podcast, Inflammatory Content.

Featured Products and Resources:

Read more interviews with immunologists in STEMCELL’s ‘Immunology Profiles’ series.

Scale up your cell isolation with the Easy 250 EasySep Magnet.

The Immunology Science Round Up

Malaria Immunity – Scientists leveraged a human malaria infection study to investigate functional correlates of immunity.

CAR T Therapy for HIV – Anti-HIV-1 CAR-T cells armed with endogenic broadly neutralizing antibodies resulted in significant suppression of viral rebound in HIV patients.

Immunogenic Cell Death – Researchers generated a small-molecule proteolysis-targeting chimera that selectively degraded human and murine RIPK1.

Origins of Autoimmunity – NUDCD3 is required for healthy T and B cell development in humans.

Image courtesy of Dr. Kellen Cavagnero

Subscribe to our newsletter!

Never miss updates about new episodes.
Subscribe

IMMUNOLOGY2024™: On the Ground May 28, 2024
Show notes

In May 2024, we attended IMMUNOLOGY2024, the annual meeting of the American Association of Immunologists, in Chicago. We spoke with delegates about their research and impressions of the meeting, including their reasons for attending and the most memorable research presented.

Featured Products and Resources:

Prepare for your next conference.

Subscribe to our newsletter!

Never miss updates about new episodes.
Subscribe

IMMUNOLOGY2024™: On the Ground May 28, 2024
Show notes

In May 2024, we attended IMMUNOLOGY2024, the annual meeting of the American Association of Immunologists, in Chicago. We spoke with delegates about their research and impressions of the meeting, including their reasons for attending and the most memorable research presented.

Featured Products and Resources:

Prepare for your next conference.

Subscribe to our newsletter!

Never miss updates about new episodes.
Subscribe

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