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The Immunology Podcast — Natural Sciences
The Immunology Podcast

A podcast featuring conversations with immunologists from around the globe. Brought to by STEMCELL Technologies.

Latest Episodes:

IUIS 2023: Day 1 Nov 29, 2023
Show notes

In 2023, we attended the 18^th International Congress of Immunology, hosted by the International Union of Immunological Societies, in Cape Town, South Africa, and recorded daily episodes discussing highlights of the conference. Here is the first of five special episodes from the meeting, in which Brenda and Jason discuss the opening ceremony of the congress as well as sessions on tuberculosis, γδ T cell receptors, and cancer immunotherapy.

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Isolate cells in as little as 8 minutes with EasySep

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IUIS 2023: Day 1 Nov 29, 2023
Show notes

In 2023, we attended the 18^th International Congress of Immunology, hosted by the International Union of Immunological Societies, in Cape Town, South Africa, and recorded daily episodes discussing highlights of the conference. Here is the first of five special episodes from the meeting, in which Brenda and Jason discuss the opening ceremony of the congress as well as sessions on tuberculosis, γδ T cell receptors, and cancer immunotherapy.

Featured Products and Resources:

Isolate cells in as little as 8 minutes with EasySep

Subscribe to our newsletter!

Never miss updates about new episodes.
Subscribe

Anjali Kusumbe — Ep. 67: “Vascular and Immune Aging” Featuring Dr. Anjali Kusumbe Nov 21, 2023
Show notes

Guest:

Dr. Anjali Kusumbe is a Group Leader and Director of the Tissue Imaging Centre at Oxford University. Her lab studies vascular changes over time with the aim of treating diseases. She talks about light sheet microscopy techniques, the aging immune system, and finding lymphatic vessels in bone.

Featured Products and Resources:

IUIS 2023 is almost here!

Enter to win $500 USD towards a cell or gene therapy conference.

The Immunology Science Round Up

Herpesvirus in CAR T Cell Therapy – A population of ‘super-expressor’ CAR T cells can contribute to the reactivation of latent human herpesvirus 6.

Autoantibodies in NF-κB2 Deficiency – Inborn errors of the alternative NF-κB pathway underlie the production of autoantibodies against type I interferons and predisposition to viral diseases.

A Rheumatoid Arthritis Atlas – Scientists built a single-cell atlas of rheumatoid arthritis synovial tissue.

Tregs After Exercise – Researchers identified Tregs as a key regulatory element that is activated in response to exercise and needed to support muscle adaptations.

Image courtesy of Dr. Anjali Kusumbe

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Ep. 66: “Immune Cell Interactions” Featuring Dr. Sophia Liu Nov 07, 2023
Show notes

Guest:

Dr. Sophia Liu is a Core Faculty Member and Early Independence Fellow at the Ragon Institute of Mass General, MIT, and Harvard. She enjoys creating new ways to measure temporally and spatially dynamic cell interactions and is particularly interested in studying T- and B-cell development. Her lab’s research focuses on immune cell interactions in tissues and dynamics across immune development and aging. She talks about the spatial mapping of T-cell receptors, what happens to the thymus during aging, and her experience starting a lab straight out of her PhD!

Featured Products and Resources:

Check out the program for IUIS 2023!

Download a free eBook on cell separation.

The Immunology Science Round Up

A Functional Coronavirus Receptor – Scientists identified a functional receptor for a coronavirus that causes the common cold.

Counting Immune Cells in the Human Body – An average individual’s immune system consists of approximately 1.8 trillion cells.

Gut Bacteria in Type 1 Diabetes – IgG2 antibodies against three gut microbial commensals are associated with time to diagnosis and clinical response to T cell-directed therapy for type 1 diabetes prevention.

Lymph Node Immune History – Tregs can form resident memory-like populations in lymph nodes after adaptive immune responses.

Image courtesy of Dr. Sophia Liu

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Siobhan Burns — Ep. 65: “Primary Immunodeficiency Disorders” Featuring Dr. Siobhan Burns Oct 24, 2023
Show notes

Guest:

Dr. Siobhan Burns is a Professor of Translational Immunology at University College London. Her group studies the underlying molecular and cellular mechanisms that give rise to primary immunodeficiency disorders. She talks about how genetic mutations affect immune function, and what inborn errors of immunity can teach us about general immunology.

Featured Products and Resources:

Check out the program for IUIS 2023!

Keep current with the latest in human immunology news.

The Immunology Science Round Up

A Cryptic Antigen in Influenza – Researchers identified a nonclassical MHC epitope that directs the T cell response against influenza.

Drug-Resistant Malaria Parasites – Scientists generated atovaquone-resistant malaria parasites and showed that they fail to transmit by mosquito.

Transplanting Genetically Modified Pig Kidneys into Monkeys – Scientists showed that preclinical studies of renal xenotransplantation could be successfully conducted in nonhuman primates.

Dendritic Cells to Reduce Immunosuppression After Liver Transplant – Liver transplant recipients who receive regulatory dendritic cells may require less immunosuppressive drugs.

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Ep. 64: “Brain Tumor Immunotherapy” Featuring Dr. Peter Fecci Oct 10, 2023
Show notes

Guest:

Dr. Peter Fecci is a Professor of Neurosurgery at Duke University and the Director of the Duke Center for Brain and Spine Metastasis. His research focuses on brain tumor immunology and immunotherapy, and T cell dysfunction in glioblastoma and other intracranial cancers. He talks about activating T cells to target brain tumors and his team’s work on targeting MHC-I-negative tumor cells.

Featured Products and Resources:

Register now for the International Congress of Immunology in South Africa!

Keep current with the latest in neural cell news.

The Immunology Science Round Up

A Universal Flu Vaccine Candidate – A group 2 hemagglutinin universal influenza virus vaccine candidate protects mice against group 2 influenza viruses.

Regulatory T Cells in Muscle Function – Exercise induces a highly functional and stable muscle Treg phenotype.

An Antiviral Drug and SARS-CoV-2 Mutations – Scientists identified a mutational spectrum from viruses in patients treated with molnupiravir.

Microbial Exposure and Allergic Inflammation – Increased microbial biodiversity in mice does not protect against allergic inflammation, in contrast to what would be predicted by the hygiene hypothesis.

Image courtesy of Dr. Peter Fecci

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add guest name — Ep. 63: “T Cell Tolerance” with Dr. Alice Long Sep 26, 2023
Show notes

Guest:

Dr. Alice Long is an Associate Member and Principal Investigator at Benaroya Research Institute at Virginia Mason, where her lab focuses on discovering how tolerance is lost in human autoimmunity and how therapy can restore tolerance.

Featured Products and Resources:

Attend IUIS 2023, the world’s leading conference in the field of immunology.

Keep current with Immune Regulation News

The Immunology Science Round Up

Insights into B Cell Selection – Antigen-presenting autoreactive B cells play a crucial role in tolerizing T cells and suppressing tissue-specific autoimmune inflammation.

A New Perspective for IBD Management – Researchers discovered a polymorphism encoding a defective fusion protein that is correlated with inflammatory bowel disease severity.

A Neuropeptide in Type 2 Immunity – Scientists show that neuromedin U programs eosinophils to promote mucosal immunity of the small intestine.

Intestinal Antigen Recognition and Humoral Immunity – A new study shows that antigen receptor signaling and cell death resistance control intestinal humoral response zonation.

Image courtesy of Alice Long

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Ep. 62: “T Cells in Solid Tumors” Featuring Dr. Kristin Anderson Sep 12, 2023
Show notes

Guest:

Dr. Kristin Anderson is an Assistant Professor at the University of Virginia, where her lab focuses on engineering T cells to overcome immune suppression in the tumor microenvironment. She talks about how her cancer diagnosis changed her career focus, strategies for targeting ovarian cancer, and her transition from postdoc to professor.

Featured Products and Resources:

Register now for IUIS 2023!

Support the culture of human T cells and enhance your cell therapy development by using high-performance, cGMP-manufactured ImmunoCult-XF medium.

The Immunology Science Round Up

Antibiotic Binding Site Mutations – Researchers studied the rifampicin binding site of E. coli RNA polymerase.

CRISPR Screens for Cancer – Scientists combined genome-wide CRISPR screens in target cancer cells to identify pathways that regulate γδ T cell killing and BTN3A cell surface expression.

Tissue-Resident T Cell Metabolism – Researchers explored the metabolic adaptations supporting differentiation, survival, and function of tissue-resident memory CD8⁺ T cells.

Towards a Universal CAR T Cell Therapy for Blood Cancers – Epitope-edited CAR T cells were effective against patient-derived acute myeloid leukemia, B cell lymphoma, and acute T cell leukemia.

Image courtesy of Dr. Kristin Anderson

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Ep. 62: “T Cells in Solid Tumors” Featuring Dr. Kristin Anderson Sep 12, 2023
Show notes

Guest:

Dr. Kristin Anderson is an Assistant Professor at the University of Virginia, where her lab focuses on engineering T cells to overcome immune suppression in the tumor microenvironment. She talks about how her cancer diagnosis changed her career focus, strategies for targeting ovarian cancer, and her transition from postdoc to professor.

Featured Products and Resources:

Register now for IUIS 2023!

Support the culture of human T cells and enhance your cell therapy development by using high-performance, cGMP-manufactured ImmunoCult-XF medium.

The Immunology Science Round Up

Antibiotic Binding Site Mutations – Researchers studied the rifampicin binding site of E. coli RNA polymerase.

CRISPR Screens for Cancer – Scientists combined genome-wide CRISPR screens in target cancer cells to identify pathways that regulate γδ T cell killing and BTN3A cell surface expression.

Tissue-Resident T Cell Metabolism – Researchers explored the metabolic adaptations supporting differentiation, survival, and function of tissue-resident memory CD8⁺ T cells.

Towards a Universal CAR T Cell Therapy for Blood Cancers – Epitope-edited CAR T cells were effective against patient-derived acute myeloid leukemia, B cell lymphoma, and acute T cell leukemia.

Image courtesy of Dr. Kristin Anderson

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Never miss updates about new episodes.
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Pancreatic Cancer Featuring Vinod Balachandran — Ep. 61: “Pancreatic Cancer” Featuring Dr. Vinod Balachandran Aug 29, 2023
Show notes

Guest:

Dr. Vinod Blachandran is an Attending Surgeon and Lab Head at Memorial Sloan Kettering Cancer Center. He talks about neoantigen vaccines for pancreatic cancer, what can be learned from a rare group of long-term survivors, and how surgeon-scientist mentors have influenced his career.

Featured Products and Resources:

Stay up-to-date with the latest in pancreatic cell news.

Register for IUIS 2023!

The Immunology Science Round Up

Platelet Factors in Aging – Platelet factors transfer the benefits of young blood to the aging mouse brain.

Cellular Immunity in Influenza – Adaptive T cells protect against symptomatic influenza infection.

Interactions Between the Immune System and the Gut Microbiome – T cells in the gut repertoire recognize several bacterial strains from complex defined communities.

Aryl Hydrocarbon Receptor Signaling in Lung Endothelial Cells – Aryl hydrocarbon receptor and its ligands play an important part in protecting against tissue damage following viral pathogen infection in the lung.

Image courtesy of Dr. Vinod Balachandran

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Greg Delgoffe — Ep. 60: “Immunometabolism and Cancer Immunotherapy” Featuring Dr. Greg Delgoffe Aug 15, 2023
Show notes

Guest:

Dr. Greg Delgoffe is an Associate Professor at the University of Pittsburgh. His lab studies the intersection of metabolism and immunity in cancer. He talks about the metabolism of immune cells in cancer and the effects of nutrients in the tumor microenvironment.

Featured Products and Resources:

Register for IUIS 2023!

Download a free wallchart on the production of CAR T cells.

The Immunology Science Round Up

Microbes in Diabetes Drug Responses – Researchers identified a microbiota-derived enzyme as a potential antidiabetic target.

STING Can Transport Protons – Scientists analyzed STING’s structure, hypothesizing that its transmembrane domain forms a pore capable of proton transport.

cGAS–STING in Neurodegeneration – The cGAS–STING signaling pathway is a critical driver of chronic inflammation and functional decline during aging.

T Cells Can Kill MHC-I Negative Tumor Cells – CD8⁺T cells maintain the capacity to kill tumor cells that are entirely devoid of MHC-I expression.

Image courtesy of Dr. Greg Delgoffe

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Daniel Streicker — Ep. 59: “Infectious Disease Ecology and Evolution” Featuring Dr. Daniel Streicker Aug 01, 2023
Show notes

Guest:

Dr. Daniel Streicker is a Professor of Viral Ecology at the University of Glasgow, where his lab investigates pathogen transmission between species. He talks about vampire bats as a reservoir for rabies and approaches to vaccination that could prevent transmission.

Featured Products and Resources:

Register for IUIS 2023 in Cape Town, South Africa.

Keep current with the latest infectious disease news.

The Immunology Science Round Up

Sleep Disturbance in Cardiac Disease – Sleep disruption in cardiac disease is driven by the loss of neurons that normally project from the superior cervical ganglia into the pineal gland.

Influenza Vaccine Format and Antibody Responses – Using a human tonsil organoid model, researchers tracked the differentiation and kinetics of the adaptive immune response to influenza vaccine and virus modalities.

Multipronged T Cells – Single T cells from successful immunotherapy recognize multiple cancer types.

γδ T Cells in Solid Tumors – Tumor-infiltrating γδ T cells consist of functionally distinct subsets with tumor-promoting or -restricting functions.

Image courtesy of Dr. Daniel Streicker

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