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    Natural Sciences

    The Immunology Podcast

    A podcast featuring conversations with immunologists from around the globe. Brought to by STEMCELL Technologies.

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    Latest Episodes:
    Ep. 58: “Redesigning Proteins” Featuring Dr. Jamie Spangler Jul 18, 2023
    Show notes

    Jamie Spangler

    Guest:

    Dr. Jamie Spangler is an Assistant Professor at Johns Hopkins. Her lab implements a unique structure-based engineering approach to elucidate the determinants of protein activity and inform drug development. She talks about designing cytokine mimetics and how engineered cytokines could be used as therapeutics.

    Featured Products and Resources:

    • Register for IUIS 2023.
    • Activate, expand, and differentiate with cytokines, chemokines, and growth factors.

    The Immunology Science Round Up

    Microenvironment Reprogramming in Cancer Progression – Researchers developed a high-resolution tumor microenvironment atlas for gastric adenocarcinoma.

    Tregs and Cell Therapy for Parkinson’s Disease – Co-transplanting Tregs with iPSC-derived neurons improves cell survival.

    How Hepatitis C Hides from the Immune System – Flavin adenine dinucleotide capping of the hepatitis C virus protects RNA from RIG-I mediated innate immune recognition.

    Mast Cells in Antigen-Avoidance – Mast cell activation in the stomach lining releases leukotrienes to affect food avoidance behavior.

    Allergic Responses and Behavior Modification – Researchers showed that allergic sensitization drives antigen-specific avoidance behavior in mouse models of food allergy.

    Image courtesy of Dr. Jamie Spangler

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    Ep. 57: “Careers Away from the Bench” Featuring Drs. Laura Raff and Ami Ashar-Patel Jul 04, 2023
    Show notes

    Laura Raff Ami Ashar-Patel

    Guests:

    Dr. Laura Raff is Associate Director, Sales, Immunology and Dr. Ami Ashar-Patel is a Senior Account Manager, Immunology at STEMCELL Technologies. Dr. Raff has a PhD in Molecular Microbiology and Immunology from the University of Southern California and Dr. Ashar-Patel has a PhD in Biochemistry and Molecular Pharmacology from the University of Massachusetts Chan Medical School. They talk about their career transitions from academia to industry and how they support scientists’ research endeavors in their current roles.

    Featured Products and Resources:

    • Register for IUIS 2023!
    • Learn about career opportunities in biotechnology and hear advice for making the move to industry.

    The Immunology Science Round Up

    Multiplexed Screening of G-Protein-Coupled Receptors – Scientists screened 1,041 human-associated metabolites against and uncovered previously unreported endogenous, exogenous, and microbial G-protein-coupled receptor agonists.

    New Oral Polio Vaccines – Genetically engineered polio vaccine candidates reduce the likelihood of Sabin strains regaining fitness and neurovirulence.

    Fecal Transplants and Immune Checkpoint Inhibition – Fecal microbiota transfer from healthy donors promotes resolution of refractory immune checkpoint-inhibitor mediated colitis in patients with cancer.

    Macrophages in the Nervous System – Resident macrophages of the muscularis externa refine the enteric nervous system early in life.

    Images courtesy of STEMCELL Technologies

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    Ep. 56: “Epitopes and the Immune System” Featuring Dr. Alessandro Sette Jun 20, 2023
    Show notes

    Guest:

    Dr. Alessandro Sette is a Center Head, Division Head, and Professor at the La Jolla Institute of Allergy and Immunology. His lab focuses on understanding the immune response, measuring immune activity, and developing disease intervention strategies against cancer, autoimmunity, allergy, and infectious diseases. He talks about bringing a biotech mindset back to academia, cross-reactive T cell responses to SARS-CoV-2, and compiling an immune-epitope database.

    Featured Products and Resources:

    • Register for the 18th IUIS International Congress of Immunology, to be held in Cape Town from 27 November-2 December 2023.
    • Read interviews with immunologists.

    The Immunology Science Round Up

    Gut T Cells and Cancer Metastasis – A subset of CD8+ T cells from colon tumors improves control of liver tumors in a preclinical model of colorectal carcinoma.

    α2-adrenergic Receptors and Immunotherapy – α2-Adrenergic receptor agonists have very strong anti-tumor activity when used as monotherapies in multiple immunocompetent tumor models.

    Bacteria in Immune Checkpoint Blockade – Antibiotic-induced changes in gut microbiota resulted in relocation of immunosuppressive T cells from the gut to tumors.

    Base Editing CAR T Cells – Researchers investigated the safety of base-edited CAR T cells in three children with relapsed leukemia.

    Image courtesy of Dr. Alessandro Sette

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    IMMUNOLOGY2023: On the Ground Jun 06, 2023
    Show notes

    IMMUNOLOGY2023: On the Ground

    In May 2023, we attended IMMUNOLOGY2023™, the annual meeting of the American Association of Immunologists, in Washington, DC. We spoke with delegates about their research and impressions of the meeting, including their reasons for attending, what they were most looking forward to, and the most memorable research presented.

    Featured Products and Resources:

    • Register for the International Union of Immunological Societies 2023 Congress in Cape Town, South Africa from November 27 to December 2.
    • Prepare for your next conference.

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    Ep. 54: “Innate and Mucosal Immunity” Featuring Dr. Bana Jabri May 23, 2023
    Show notes

    IP 54 Bana Jabri

    Guest:

    Dr. Bana Jabri is the Sarah and Harold Lincoln Thompson Professor in the Department of Medicine and the Research Director of the Celiac Disease Center at the University of Chicago. Her research focuses on innate and mucosal immunity, particularly in celiac disease, autoimmune disorders, and inflammatory bowel disease. She talks about the mechanisms of celiac disease and new treatment options. She also discusses how the microbiome can affect immune responses in cancer.

    Featured Products and Resources:

    • Stay up-to-date with the latest in immune regulation news.
    • Download free immunology wallcharts.

    The Immunology Science Round Up

    Capsules to Study the Intestinal Environment – Scientists developed an ingestible device that collects samples from multiple regions of the human intestinal tract during digestion.

    T Cell Receptor Affinity – Repetitive pathogen exposure leads to the dominant outgrowth of T cell clones with high T cell receptor affinity to the relevant pathogen-associated antigens.

    Gut Bacterial Evolution Between Species – Analyses of metagenome-resolved genomes from humans and primate species reveal significant co-diversification of bacterial gut symbionts.

    A Pancreatic Cancer Vaccine – Researchers synthesized mRNA neoantigen vaccines in real time from surgically resected pancreatic ductal adenocarcinoma tumors.

    Image courtesy of Dr. Bana Jabri

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    IMMUNOLOGY2023: Day 5 May 16, 2023
    Show notes

    IMMUNOLOGY2023: Day 5

    In May 2023, we attended IMMUNOLOGY2023, the annual meeting of the American Association of Immunologists in Washington, DC, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the final of five special episodes from the meeting. Brenda and Jason talk about sessions on mucosal immunity, emerging pathogens, and having a successful postdoctoral experience. Highlights include Dr. Isaac Chiu‘s talk on pain and mucus production in the gut, Dr. James Crowe‘s talk on monoclonal antibody discovery, and Dr. Amy Hartman’s talk on Rift Valley fever virus.

    Featured Products and Resources:

    • Read interviews with immunologists.
    • Watch videos on career development from the NIH Office of Intramural Training & Education.

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    IMMUNOLOGY2023: Day 4 May 15, 2023
    Show notes

    IMMUNOLOGY2023 Day 4

    In May 2023, we attended IMMUNOLOGY2023, the annual meeting of the American Association of Immunologists in Washington, DC, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the fourth of five special episodes from the meeting. Brenda and Jason talk about micelles for drug delivery and how helminth infection affects susceptibility to SARS-CoV-2.

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    • Explore Free Immunology Wallcharts

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    IMMUNOLOGY2023: Day 3 May 14, 2023
    Show notes

    IP AAI 2023 Day 3

    In May 2023, we attended IMMUNOLOGY2023, the annual meeting of the American Association of Immunologists in Washington, DC, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the third of five special episodes from the meeting. Highlights include Dr. Anthony Fauci’s talk on the COVID-19 pandemic response and Dr. Doug Green’s talk on T cell activation. Jason and Brenda discuss sessions on immune responses in aging and obesity, and making better cancer vaccines.

    Featured Products and Resources:

    • Prepare for your next conference with this toolkit.

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    IMMUNOLOGY2023: Day 2 May 13, 2023
    Show notes

    IMMUNOLOGY2023: Day 2

    In May 2023, we attended IMMUNOLOGY2023, the annual meeting of the American Association of Immunologists in Washington, DC, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the second of five special episodes from the meeting. Brenda and Jason discuss sessions on peripheral neuroimmune interactions and tumor cellular therapy. Highlights include the President’s Address by Dr. Mark Davis and Dr. Barbara Rehermann’s presentation on wild mouse microbiota.

    Featured Products and Resources:

    • Explore STEMCELL Technologies’ workshops and resources at IMMUNOLOGY2023

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    IMMUNOLOGY2023: Day 1 May 12, 2023
    Show notes

    IMMUNOLOGY2023: Day 1

    In May 2023, we attended IMMUNOLOGY2023, the annual meeting of the American Association of Immunologists in Washington, DC, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the first of five special episodes from the meeting, in which Jason and Brenda summarize symposia on B and T-helper cells, and metabolic and gut microbiota. They discuss antigenic imprinting, lupus immunophenotyping and sex differences, dengue vaccines, and cytomegalovirus research.

    Featured Products and Resources:

    • Explore STEMCELL Technologies’ workshops at IMMUNOLOGY2023

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