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    Natural Sciences

    The Immunology Podcast

    A podcast featuring conversations with immunologists from around the globe. Brought to by STEMCELL Technologies.

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    Latest Episodes:
    Ep. 43: “Respiratory Viral Infections” Featuring Dr. Jie Sun Dec 06, 2022
    Show notes

    Jie Sun

    Guest:

    Dr. Jie Sun is the Harrison Professor of Medicine at the University of Virginia. His lab studies respiratory immunology under homeostasis and disease conditions. He talks about how long COVID compares to other post-viral conditions, and his lab’s work investigating mucosal immunity from mRNA vaccines.

    Featured Products and Resources:

    • Abstract Submission Is Open for IMMUNOLOGY2023™!
    • Studying COVID-19 with Air-Liquid Interface Cultures

    The Immunology Science Round Up

    Cardiac Autoimmunity – C-Met+ T cells are selectively increased in the circulation and in the myocardium of patients with inflammatory cardiomyopathies.

    A Universal Flu Vaccine – Scientists developed an mRNA–lipid nanoparticle vaccine encoding hemagglutinin antigens from all 20 known influenza A virus subtypes and influenza B virus lineages.

    mRNA Export Rates and Gene Expression – The nuclear export efficiency of innate immune mRNAs varies such that for many genes, only a small fraction of the newly synthesized pre-mRNA reaches the cytoplasm.

    Dendritic Cells for Long-Term Tumor Control – Expanding cross-presenting dendritic cells enhances oncolytic virotherapy.

    Image courtesy of Dr. Jie Sun

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    Ep. 42: “Immune Mechanisms After Stroke” Featuring Dr. Arthur Liesz Nov 22, 2022
    Show notes

    Arthur Liesz

    Guest:

    Dr. Arthur Liesz is a Professor of Experimental Neurology at the University of Munich. The Liesz lab is interested in the interplay between the brain and the immune system after stroke. He talks about the inflammatory response to stroke, including T cell-modulated microglial activation. He also talks about stroke aftermath, including T cells that remain in the brain and the redistribution of function during recovery.

    Featured Products and Resources:

    • Keep Current with the Latest in Neural Cell News.
    • Explore Free Immunology Wallcharts.

    The Immunology Science Round Up

    The Microbiome and Metabolome – Researchers dissected the interplay between the gut microbiome and host genome.

    Personalized T Cell Therapy – Scientists isolated and cloned multiple T cell receptors recognizing mutational neoantigens.

    An Ancestral Tuberculosis Effector Promotes Dissemination – Researchers linked an unusual tuberculosis outbreak with high rates of dissemination and skeletal disease to a specific effector.

    A Broadly Neutralizing Influenza Vaccine – Co-immunization with hemagglutinin stem immunogens derived from influenza A viruses elicited cross-group protection.

    Image courtesy of Dr. Arthur Liesz

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    Ep. 41: “Autoimmunity and Cancer Immunotherapy” Featuring Dr. Vijay Kuchroo Nov 08, 2022
    Show notes

    Vijay Kuchroo

    Guest:

    Dr. Vijay Kuchroo is the Samuel L. Wasserstrom Professor of Neurology at Harvard Medical School. His major research interests include the role of co-stimulation in autoimmune diseases, as well as cell surface molecules and regulatory factors that regulate the induction of T cell tolerance and dysfunction. He talks about the conditions necessary to differentiate Th17 cells and their role in autoimmunity. He also discusses his group’s discovery of Tim-3, an inhibitor receptor on T cells which is now being exploited for cancer immunotherapy.

    Featured Products and Resources:

    • Resources for Your T Cell Therapy Research
    • Read interviews where immunologists tell their stories, discuss their research, and voice their thoughts and opinions on current topics in immunology.

    The Immunology Science Round Up

    Disrupting Calcium Homeostasis – Researchers showed that inherited variants in ITPR3 alter physiologically relevant Ca2+ signaling responses, driving defects in immune responses.

    Light Chain Coherence in Antibodies – Among naturally occurring antibodies that have adapted to particular antigens, those with similar heavy chains usually have similar light chains.

    Anti-CTLA-4 Antibodies Reprogram the Tumor Microenvironment – Scientists used single-cell RNA sequencing to dissect the immune response to anti-CTLA-4 blockade.

    An Intranasal Booster for Sarbecoviruses – Researchers used a SARS-CoV-2 intranasal spike booster to elicit mucosal immune memory within the respiratory tract.

    Image courtesy of Dr. Vijay Kuchroo

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    Ep. 40: “Bacterial Pathogens” Featuring Drs. Kristin Patrick and Robert Watson Oct 25, 2022
    Show notes

    Kristin Patrick and Robert Watson

    Guests:

    Dr. Kristin Patrick is an Assistant Professor and Dr. Robert Watson is an Associate Professor at Texas A&M University. Their joint lab investigates innate immune regulation during bacterial infection. They talk about gasdermin D and cell death in tuberculosis, and how running a lab together helps them prioritize mentorship.

    Featured Products and Resources:

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    The Immunology Science Round Up

    Black Death and Immune Evolution – Researchers identified loci associated with Black Death survival that are also associated with increased susceptibility to autoimmune diseases.

    How a Pathogen Inhibits Pyroptosis – A phosphatase secreted by Mycobacterium tuberculosis suppresses pyroptosis by hijacking ubiquitin.

    B Cell Antigen Receptor Structure – Scientists report the cryogenic electron microscopy structure of the mouse B cell antigen receptor assembly.

    How Pain Protects the Gut – Pain receptors regulate gut microbiota and protect tissues from inflammation.

    Image courtesy of Drs. Kristin Patrick and Robert Watson

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    Ep. 39: “Extracellular Nucleotides” Featuring Dr. Henrique Borges da Silva Oct 11, 2022
    Show notes

    Henrique Borges da Silva

    Guest:

    Dr. Henrique Borges da Silva is an Assistant Professor at the Mayo Clinic in Arizona. His main research focus is determining how extracellular nucleotides affect transcriptional, metabolic, and functional mechanisms of CD8+ T cells in response to viral infections and cancer. He talks about where extracellular ATP comes from, and how there could be a link between ATP and ADP immunological signaling and the powers of caffeine.

    Featured Products and Resources:

    • Win $300 worth of refreshments to fuel your immunology journal club!
    • Keep current with the latest in Human Immunology News.

    The Immunology Science Round Up

    Telomere Transfer in T Cells – An interaction between T cells and antigen presenting cells early in the immune response to viruses may determine how fast T cells decline.

    APOE and COVID-19 Outcomes – APOE variants associated with Alzheimer’s disease are also associated with a reduced immune response and increased mortality from COVID-19.

    Protecting the Brain from Infection – Scientists identified a new blood-endothelial barrier that separates olfactory mucosa from circulating antibodies.

    Bacterial Colonization in the Intestine – An oral bacterium associated with inflammatory bowel disease uses nitrate respiration to colonize the intestine.

    Image courtesy of Dr. Henrique Borges da Silva

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    Ep. 38: “The Urinary Bladder and Placenta” Featuring Dr. Indira Mysorekar Sep 27, 2022
    Show notes

    Indira Mysorekar

    Guest:

    Dr. Indira Mysorekar is a Professor of Medicine and Chief of Basic and Translational Research at Baylor College of Medicine. Her lab studies host–microbial interactions in the urinary bladder and the placenta. She discusses the role of the microbiome and the aging immune landscape in recurrent urinary tract infections. She also talks about her research on Zika and SARS-CoV-2 in the placenta.

    Featured Products and Resources:

    • Win $300 worth of refreshments to fuel your immunology journal club!
    • Prepare for your next conference with this toolkit.

    The Immunology Science Round Up

    Gut Bacteria and Cancer Pathogenesis – Some commensal bacteria promote the development of retrovirus-induced leukemia.

    Generating Tolerance to Microbiota – RORγ-expressing cells are responsible for the induction of Tregs in the gut.

    Antigen-Presenting Cells Promote Treg Generation – New research reveals parallel pathways for establishing tolerance to self and foreign antigens in the thymus and periphery.

    Tissue Destruction in Sjögren’s Syndrome – Sjögren’s syndrome may be caused by self-reactive CD8+ cytotoxic T cells.

    CAR T Therapy for Lupus – Anti-CD19 CAR T cell treatment led to remission of systemic lupus erythematosus in a trial of five patients.

    Image courtesy of Dr. Indira Mysorekar

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    Ep. 37: “Co-Evolution of the Human Microbiome” Featuring Drs. Ruth Ley and Sara Clasen Sep 13, 2022
    Show notes

    ruth Ley and Sara Clasen

    Guest:

    Dr. Ruth Ley is Managing Director of the Max Planck Institute for Biology Tübingen and Director of the Department of Microbiome Science. Dr. Sara Clasen is a postdoctoral fellow in the same lab. Together, they’re interested in the co-evolution of humans with their microbiomes. They use basic science to investigate the evolutionary history of gut microbes, how they have adapted to life inside humans, and how they affect human biology and health. More recently, they published a pre-print on the silent recognition of flagellins from human gut commensal bacteria by TLR5.

    Featured Products and Resources:

    • Explore immunology wallcharts.
    • Access STEMCELL’s conference toolkit.

    The Immunology Science Round Up

    Hair Follicles and Mites – Scientists show that innate type 2 immunity controls hair follicle commensalism by Domedex mites.

    The Search for a Shared Neoantigen – Using quantitative immunopeptidomics, researchers have identified a tumor stroma-specific target for T cell therapy.

    Gut Microbes Surf the IgA Cycle – New research suggests that circadian networks comprising intestinal IgA, diet, and microbiota converge to align circadian biology in the intestine and to ensure host-microbial mutualism.

    A New Way to Make CAR-T Cells – Researchers have successfully generated non-viral, gene-specific targeted CAR-T cells through CRISPR-Cas9.

    Images courtesy of Drs. Ruth Ley and Sara Clasen

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    Ep. 36: “Engineered Immune Cell Therapies” Featuring Dr. Leonardo Ferreira Aug 30, 2022
    Show notes

    Leonardo Ferreira

    Guest:

    Dr. Leonardo Ferreira is an Assistant Professor of Microbiology and Immunology at the Medical University of South Carolina. The Ferreira lab uses CARs and other engineered immune receptors to dissect how specificity, affinity, and signaling modulate the function of different T cells subsets in tolerance and immunity. He talks about how CAR Tregs could prevent transplant rejection and treat Type 1 diabetes. He also discusses mixing and matching immune cells, the freedom to pursue multiple ideas in academia, and science outreach in Bolivia.

    Featured Products and Resources:

    • Stay up-to-date with the latest in cell therapy news.
    • Download a free wallchart on the production of CAR T cells.

    The Immunology Science Round Up

    T Cell Nutrient Use – CD8+ T cells preferentially consume lactate over glucose in response to Listeria infection.

    Blocking Malaria Transmission – A stabilized malaria antigen induces transmission-blocking antibody responses.

    A New Metabolic Pathway in Inflammatory Macrophages – Research suggests that L-ornithine could improve LACC1-associated immunological dysfunctions such as arthritis or inflammatory bowel disease.

    T Cell Receptor Avidity – Scientists studied how T cell receptor avidity of tumor-specific T cells affected their anti-tumor capabilities using mouse modeling and two melanoma patients.

    Image courtesy of Dr. Leonardo Ferreira

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    Ep. 35: “Inflammatory Bowel Disease” Featuring Dr. Karen Edelblum Aug 16, 2022
    Show notes

    Karen Edelblum

    Guest:

    Dr. Karen Edelblum is an Assistant Professor of Pathology and Laboratory Medicine at Rutgers New Jersey Medical School. She discusses γδ T cells and immune-epithelial cross-talk in inflammatory bowel disease. She also talks about intravital microscopy and decorating immunology-themed cakes!

    Featured Products and Resources:

    • Stay up-to-date with the latest in intestinal cell news.
    • Use EasySep™ to isolate highly purified immune cells in as little as 8 minutes.

    The Immunology Science Round Up

    Highlights from the Gastrointestinal Tract XX Conference – Researchers presented on food tolerance and sensitization, gut cytokines and drug metabolism, the link between C. diff and colon cancer, and more.

    Programming Tissue Residency in T Cells – Researchers showed that distinct programs of tissue residency are induced in CD8+ and CD4+ tissue-resident memory T cell subsets, a difference attributable to Runx3 activity.

    How Prokaryotes Recognize Pathogens – Scientists showed that NLR-based immune pattern recognition is prevalent in bacteria and archaea.

    Image courtesy of Dr. Karen Edelblum

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    Ep. 34: “Immunology of the Nervous System” Featuring Dr. Jonathan Kipnis Aug 02, 2022
    Show notes

    Jonathan Kipnis

    Guest:

    Dr. Jonathan Kipnis is the BJC Investigator and Alan A. and Edith L. Wolff Distinguished Professor of Pathology and Immunology at Washington University in St. Louis. His lab investigates the complex interactions between the immune and nervous systems. He talks about immune activity and surveillance in the brain, and how T cell subsets affect brain function and behavior. He also discusses the brain’s immune reservoir and his lab’s work on cerebrospinal fluid-regulated immune cell mobilization.

    Featured Products and Resources:

    • Explore free immunology wallcharts.
    • Explore scientific resources for your immunology research at the STEMCELL Technologies immunology learning center.

    The Immunology Science Round Up

    Intranasal Vaccines for HIV and SARS-CoV-2 – Researchers developed vaccines that use the neonatal Fc receptor to mediate transmucosal uptake and elicit immune responses at both local and distal mucosal sites.

    How ADAR1 Mutation Leads to Autoimmune Responses – Scientists found that ZBP1-dependent signaling underlies the autoinflammatory pathology caused by the alteration of ADAR1.

    Preventing Autoinflammation – Researchers identified ADAR1 as a negative regulator of ZPB1-mediated apoptosis and necroptosis, providing insights into the pathology of Aicardi–Goutières syndrome.

    Averting Interferon Induction – ZBP1 promotes type I interferon activation and fatal pathology in mice with impaired ADAR1 function.

    The Interleukin-17 Ligand-Receptor Axis – Scientists explored the explore the structural basis for interleukin-17 family signaling.

    Image courtesy of Dr. Jonathan Kipnis

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