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    Natural Sciences

    The Immunology Podcast

    A podcast featuring conversations with immunologists from around the globe. Brought to by STEMCELL Technologies.

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    Latest Episodes:
    Ep. 26: “Viruses and Glycoproteins” Featuring Dr. Florian Krammer Mar 29, 2022
    Show notes

    Florian Krammer

    Guest:

    Dr. Florian Krammer is a Professor of Vaccinology at Icahn School of Medicine at Mount Sinai. His lab focuses on understanding broadly-reactive immune responses against the surface glycoproteins of RNA viruses such as influenza, with the goal to develop better vaccines and novel therapeutics. He talks about his lab’s shift to COVID-19 research, strategies for vaccine development, and how we can prepare for future pandemics.

    Featured Products and Resources:

    • Keep current with the latest in immunology of infectious disease news.
    • Explore scientific resources for your immunology research at the STEMCELL Technologies immunology learning center.

    The Immunology Science Round Up

    The Microbiome’s Effects on CAR T Therapy Outcomes – Exposure to broad spectrum antibiotics prior to CAR T therapy was associated with worse survival and increased neurotoxicity.

    Identifying Genes That Improve T Cell Proliferation – Researchers tested over 12,000 genes and identified positive regulators of T cell functions.

    Fungi in Inflammatory Bowel Disease – Scientists identified fungal strains that induce intestinal inflammation in patients with ulcerative colitis.

    Neuroimmune Communication via Cerebrospinal Fluid – Cerebrospinal fluid gains direct access to the skull bone marrow niches and regulates immune responses.

    Image courtesy of Dr. Florian Krammer

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    Ep. 25: “Immunology and Industry” Featuring Drs. Andy Kokaji and Hannah Lee Mar 15, 2022
    Show notes

    Andy Kokaji and Hannah Lee

    Guest:

    Dr. Andy Kokaji is a Senior Director of Immunology, and Dr. Hannah Lee is a Senior Director of Product Management, at STEMCELL Technologies. They discuss their career paths and how they develop and commercialize products to support scientists worldwide.

    Featured Products and Resources:

    • Keep current with the latest in human immunology news.
    • STEMCELL is hiring!

    The Immunology Science Round Up

    mRNA Boosters Increase Antibodies but Not Side Effects – A Moderna booster vaccine elicited neutralizing titers that were statistically significantly higher than the peak titers detected after the primary vaccination series.

    B Cells in Unexpected Places – Researchers showed that glycan-mediated B cell suppression plays a key role in establishing fetomaternal tolerance in mice.

    A Data Analysis Tool to Predict Disease Outcomes – Scientists identified immune cell types associated with increased risk of death from COVID-19.

    Tertiary Lymphoid Structures in Renal Cell Cancer – Researchers used spatial transcriptomics to examine B cell responses within tertiary lymphoid structures.

    Image courtesy of Drs. Andy Kokaji and Hannah Lee

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    Ep. 24: “Autoimmune Disease” Featuring Dr. Jennifer Gommerman Mar 01, 2022
    Show notes

    Jennifer Gommerman

    Guest:

    Dr. Jennifer Gommerman is a Professor of Immunology at the University of Toronto. Her team has uncovered a novel gut-brain axis that regulates neuroinflammation and is examining the role of B lymphocytes in Multiple Sclerosis (MS) patients and in animal models of MS. More recently, she has been studying the antibody response to SARS-CoV-2 in saliva samples from patients with COVID-19.

    Featured Products and Resources:

    • Keep current with the latest immune regulation research.
    • Explore scientific resources for your immunology research at the STEMCELL Technologies immunology learning center.

    The Immunology Science Round Up

    Neutralizing Antibody Responses to Omicron – SARS-CoV-2-specific immunity wanes over time after two mRNA vaccine doses.

    Determining T Cell Fate – Researchers identified T cell antigen receptor sequence features that promote regulatory T cell fate.

    Fungi in the Gut – Mucosa-associated fungi protect mice against intestinal injury and infection via interleukin-22-dependent mechanisms.

    T Cells in Glioblastomas – T cell dysfunction in the glioblastoma microenvironment is mediated by myeloid cells releasing interleukin-10.

    Image courtesy of Dr. Jennifer Gommerman

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    Ep. 23: “Dendritic Cells and the Immune System” Featuring Dr. Caetano Reis e Sousa Feb 15, 2022
    Show notes

    Caetano Reis e Sousa

    Guest:

    Dr. Caetano Reis e Sousa is the Assistant Research Director and Senior Group Leader at the Francis Crick Institute. His lab studies the molecular pathways that trigger dendritic cells into action. He talks about the mechanisms of dendritic cell cross-presentation, RNA interference, and dendritic cell progenitors in influenza.

    Featured Products and Resources:

    • Differentiate Human Monocytes into Dendritic Cells with ImmunoCult™ Dendritic Cell Culture Kit
    • The STEMdiff™ Monocyte Kit generates millions of monocytes ready for downstream assays or further development into macrophages or dendritic cells.

    The Immunology Science Round Up

    T Cell Responses to Omicron – T cell responses in individuals with prior infection, vaccination, both prior infection and vaccination, and boosted vaccination are largely preserved to Omicron spike and non-spike proteins.

    Curing Cancer with CAR T Therapy – Ten years after treatment, two leukemia patients remained in remission and had long-persisting CD4+ CAR T cells.

    Vimentin Helps SARS-CoV-2 Enter Endothelial Cells – Vimentin could facilitate SARS-CoV-2 infection and contribute to vascular complications associated with COVID-19.

    Probing T Cell Function with CRISPR – Researchers mapped the functional gene networks regulating interleukin-2 and interferon gamma in human T cells.

    Image courtesy of Dr. Caetano Reis e Sousa

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    Ep. 22: “Maternal Immune Cells” Featuring Dr. Francesco Colucci Feb 01, 2022
    Show notes

    Francesco Colucci

    Guest:

    Dr. Francesco Colucci is a Wellcome Investigator and Professor of Immunology at the University of Cambridge. His research focuses on natural killer (NK) and other innate lymphoid cells, as well as immunogenetics. He talks about uterine NK cells and their education, and falling in love with research as a physician.

    Featured Products and Resources:

    • Explore scientific resources for your immunology research at the STEMCELL Technologies immunology learning center.
    • Use EasySepTM to isolate highly purified immune cells in as little as 8 minutes.

    The Immunology Science Round Up

    A Link between Epstein-Barr Virus and Multiple Sclerosis – Researchers used data from millions of US military recruits to determine that Epstein-Barr infection increased the risk of multiple sclerosis.

    Nano-Sponges to Treat Inflammation – Nanodecoys coated with a macrophage membrane scavenged pro-inflammatory cytokines in autoimmune disease models.

    How Epstein-Barr Infection Triggers Multiple Sclerosis – Scientists showed that molecular mimicry between an Epstein-Barr virus protein and a neuronal molecule in Multiple sclerosis patients contributes to neuroinflammation.

    The Immunoregulatory Landscape of Tuberculosis – Researchers identified how cellular composition and immunoregulatory pathways in tuberculosis granulomas relate to peripheral immune responses.

    Image courtesy of Dr. Francesco Colucci

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    Ep. 21: “Trained Immunity” Featuring Dr. Mihai Netea Jan 18, 2022
    Show notes

    Mihai Netea

    Guest:

    Dr. Mihai Netea is a Professor of Experimental Medicine at Radboud University Nijmegen and a Professor of Immunometabolism at the University of Bonn. He discusses the mechanisms of trained immunity, transmission of immune traits across generations via epigenetics, and how some vaccines can enhance immunity to other pathogens.

    Featured Products and Resources:

    • Keep current with the latest in human immunology news.
    • Use EasySepTM to isolate highly purified immune cells in as little as 8 minutes.

    The Immunology Science Round Up

    Fc-Mediated Responses to SARS-CoV-2 – mRNA vaccination, but not infection, produced spike antibodies that maintained Fc receptor binding to SARS-CoV-2 variants of concern.

    A Nasal Vaccine for Tuberculosis – An adenovirus-vectored tuberculosis vaccine induced airway tissue-resident memory CD4 and CD8 T cells.

    Behavioral Immune Landscapes of Inflammation – Researchers used 4D live imaging to obtain behavioral descriptors of individual cells and build behavioral landscapes.

    Platelet Aggregation in Sepsis – Scientists showed that inhibiting NFAT in activated mouse and human platelets enhanced their aggregation.

    Image courtesy of Dr. Mihai Netea

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    Ep. 20: “Mucosal Immunology” Featuring Dr. De’Broski Herbert Dec 21, 2021
    Show notes

    De’Broski Herbert

    Guest:

    Dr. De’Broski Herbert is an Associate Professor of Immunology at the University of Pennsylvania. The Herbert lab is exploring the immunoregulatory and regenerative mechanisms operating at the mucosal interface. He discusses his recent paper on IL-33 sources and secretion, his postdoctoral fellowship in South Africa, and the M1/M2 macrophage paradigm.

    Featured Products and Resources:

    • Keep current with the latest in immune regulation.
    • Use EasySepTM to isolate highly purified immune cells in as little as 8 minutes.

    The Immunology Science Round Up

    TREM-2 and T Cells in SARS-CoV-2 – Researchers showed that triggering receptor expressed on myeloid cells 2 (TREM-2) expression was increased on T cells in patients with COVID-19.

    Neutralizing the Omicron Variant – mRNA vaccine boosters may increase SARS-CoV-2 neutralizing antibody titers.

    T Cells Still Recognize the Omicron Variant – Early data suggest that existing CD8+ T cell responses from previous SARS-CoV-2 infection or vaccination will likely recognize the Omicron variant of concern.

    A Nasal Vaccine for Influenza – An intranasal flu vaccine enhanced immunoglobulin A responses through lung-resident memory B cells, plasmablasts, and plasma cells in mice.

    Mucosal Antibody Responses to SARS-CoV-2 Vaccination – Mucosal immunoglobulin A responses to mRNA vaccination depend on pre-existing immunity.

    An Alternative Approach for Anthrax – Scientists used capsule depolymerase to remove the Bacillus anthracis bacterial capsule and promote phagocytosis and killing by human neutrophils.

    Image courtesy of Dr. De’Broski Herbert

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    Ep. 19: “Parasitic Infections” Featuring Dr. Keke Fairfax Dec 07, 2021
    Show notes

    Keke Fairfax

    Guest:

    Dr. Keke Fairfax is an Associate Professor of Microbiology and Immunology and the Director of Equity, Diversity, and Inclusion at the University of Utah. Her lab uses helminth parasite Schistosoma mansoni as a tool to understand the consequences of IL-4 induced immuno-modulation. She explains how helminth infections can reduce the efficacy of childhood vaccinations, and how mentorship and networking can help minority scientists thrive in Utah.

    Featured Products and Resources:

    • Keep current with the latest in infectious disease research.
    • Explore scientific resources for your immunology research at the STEMCELL Technologies immunology learning center.

    The Immunology Science Round Up

    Early HIV Treatment Needed to Replenish Memory T Cells – Delaying HIV treatment leads to irreversible loss of tissue-resident memory T cells and reduced protection against HPV-related cancer.

    Neoepitopes in Melanoma – Researchers found that adoptive cell therapy success is associated with an expansion of neoepitope-specific CD8+ T cells.

    Immunotherapy for Peanut Allergy – Scientists showed that patients’ responses to an oral immunotherapy for peanut allergy depends on both pre-existing CD4+ T cells and a subset of T helper cells.

    An mRNA Vaccine for Tick-Borne Diseases – Researchers developed an mRNA vaccine against the tick that transmits Lyme disease.

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    Ep. 18: “Immune Microscopy” Featuring Dr. Tri Phan Nov 23, 2021
    Show notes

    Tri Phan

    Guest:

    Dr. Tri Phan is a Senior Research Fellow at the Garvan Institute of Medical Research and a Conjoint Professor at the University of New South Wales. He runs the Intravital Microscopy Lab, which aims to understand the checks and balances that control B cell responses. His team uses two-photon microscopy to image cells in live animals, including time-lapses of over 24 hours. He talks about the physics behind this type of microscopy and how it can image deep within tissues without destroying them. We also discuss his lab’s recent Cell paper on osteomorphs, a newly discovered cell type involved in osteoclast recycling in bone, and their work on memory B cells in lymph nodes.

    Featured Products and Resources:

    • STEMCELL Technologies is Hiring!
    • The STEMdiff™ Monocyte Kit generates millions of monocytes ready for downstream assays or further development into macrophages or dendritic cells.

    The Immunology Science Round Up

    Blocking SARS-CoV-2 Replication – A Therapeutic Interfering Particle reduces SARS-CoV-2 viral load by competing for viral replication machinery.

    Pre-Existing T Cells Abort SARS-CoV-2 Infection – Health care workers who were exposed to COVID-19, but repeatedly tested negative, had pre-existing RNA-polymerase-specific T cells.

    A Self-Guarded Immune Sensing Pathway – MORC3 inhibits viral replication and its degradation by a virus unleashes a secondary antiviral response.

    T Cell States in Adoptive Cell Therapy – Host T cell reactivation drives the immune response and determines the outcome of lymphocyte infusion in leukemia patients.

    Image courtesy of Dr. Tri Phan

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    Ep. 17: “Innate Immune Receptors” Featuring Dr. Jenny Ting Nov 09, 2021
    Show notes

    Jenny Ting

    Guest:

    Dr. Jenny Ting is the William R. Kenan Jr. Distinguished Professor of Genetics at the University of North Carolina at Chapel Hill, and served as the President of the American Association of Immunologists from 2020-2021. Her lab discovered the NLR protein family, and their recent research interests include oxidative phosphorylation in HIV, the role of AIM2 in autoimmunity, and microbes that can protect from radiation.

    Featured Products and Resources:

    • Keep current with the latest in immune regulation research.
    • Use EasySepTM to isolate highly purified immune cells in as little as 8 minutes.

    The Immunology Science Round Up

    Replication Stress Response Defects in Cancer – Replication stress response defects led to single-stranded DNA accumulation in cancer cells and improved responses to immune checkpoint blockade.

    Responses to Immune Checkpoint Inhibition in Renal Cell Carcinoma – Researchers identified baseline pre-treatment T cell receptor clonality as a predictor of immunotherapy response in renal cell carcinoma.

    DNA Methylation Signatures of Immune Cells – Scientists found that adaptive and innate immune cells show distinct methylation and gene expression patterns.

    Comparing SARS-CoV-2 Variants – The Delta variant spike protein can fuse membranes more efficiently at low levels of cellular receptor ACE2 compared to other variants. Learn more about SARS-CoV-2 entry into cells in this review.

    The New York Times Coronavirus Vaccine Tracker

    Image courtesy of Dr. Jenny Ting

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