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    Natural Sciences

    The Immunology Podcast

    A podcast featuring conversations with immunologists from around the globe. Brought to by STEMCELL Technologies.

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    Latest Episodes:
    Ep. 16: “T Cell Regulation” Featuring Dr. Dario Vignali Oct 26, 2021
    Show notes

    Dario Vignali

    Guest:

    Dr. Dario Vignali is the Frank Dixon Chair in Cancer Immunology and Vice Chair and Professor of Immunology at University of Pittsburgh School of Medicine. His lab studies various aspects of T cell regulation, and recently generated a new mouse model to target conventional CD4 T cells.

    Featured Products and Resources:

    • Keep current with the latest in immune regulation research.
    • Use EasySepTM to isolate highly purified immune cells in as little as 8 minutes.

    The Immunology Science Round Up

    Dual Targeting for B Cell Leukemia – CAR T therapy targeting both CD19 and CD22 showed clinical activity and low toxicity in a Phase I trial, but strategies to further improve CAR T cell persistence are needed.

    Microbial Fitness in the Intestine – Researchers showed that microbial exposure leads to the selection of antigen-specific intestinal plasma cells with a diverse Ig gene repertoire.

    Less Is More for COVID-19 Vaccine Dosage – A 1000-fold lower prime dose of an adenovirus-based SARS-CoV-2 vaccine followed by a standard boost dose elicited superior immune responses compared to two standard doses.

    IL-33 in Inflammation Resolution – IL-33 induces metabolic reprogramming, which controls the differentiation of alternatively activated macrophages that contribute to the resolution of inflammation and tissue repair.

    Image courtesy of Dr. Dario Vignali

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    Ep. 15: “Tuning the Immune Response” Featuring Dr. Anil Bhushan Oct 12, 2021
    Show notes

    Anil Bhushan

    Guest:

    Dr. Anil Bhushan is a Professor at the University of California, San Francisco School of Medicine and Co-Founder of Deciduous Therapeutics, an aging therapeutics company developing a novel class of immune-modulatory therapies. His lab focuses on understanding how the immune system senses and tunes its response to senescent cells in disease and aging, and was one of the first to show the role of clearing senescent cells in models of type 1 diabetes.

    Featured Products and Resources:

    • Stay current with STEMCELL Science News
    • Explore the STEMCELL Immunology Learning Center

    The Immunology Science Round Up

    Natural Resistance to SARS-CoV-2 – While some individuals express a prenylated version of the OAS1 gene that inhibits SARS-CoV-2, researchers found that others express a version that does not detect SARS-CoV-2.

    A New Target for Cancer Immunotherapy – Using in vivo CRISPR screens, scientists identified new immune targets regulating the tumor microenvironment, and revealed that knocking out the E3 ubiquitin ligase Cop1 in cancer cells enhances anti-tumor immunity.

    Cognate Recognition of Microbial Antigens – Researchers speculate that dominant proinflammatory T cell clones might provide a therapeutic target in human inflammatory bowel disease.

    Immune Escape in Colorectal Cancer – Using new models of colorectal cancer with defined neoantigens, scientists described a mechanism of early T cell dysfunction in immunotherapy refractory tumors and strategies to overcome it.

    Image courtesy of Dr. Anil Bhushan

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    Ep. 14: “Neuroimmunology and Behavior” Featuring Dr. Michael Burton Sep 28, 2021
    Show notes

    Michael Burton

    Guest:

    Dr. Michael Burton is an Assistant Professor at the University of Texas in Dallas. His lab studies the complex interactions between the immune and nervous systems that lead to pain, depression, and sickness.

    Featured Products and Resources:

    • STEMCELL Technologies is hiring!
    • Use EasySepTM to isolate highly purified immune cells in as little as 8 minutes.

    The Immunology Science Round Up

    Nanoparticle Vaccines for SARS-CoV-2 Variants – Researchers showed that a receptor-binding domain nanoparticle vaccine generated neutralizing antibodies against multiple SARS-CoV-2 variants and related animal coronaviruses.

    An Early Wave of Memory B Cells – Scientists studied the cell fate decisions that take place upon B cell activation.

    Combining Cancer Vaccines and T Cell Transfer – Combining a cancer vaccine with adoptive autologous T cell transfer led to improved immune responses in multiple myeloma patients.

    Preserving T Cell Stemness – An IL-2 partial agonist can promote CD8+ T cell expansion without driving differentiation.

    Image courtesy of Dr. Michael Burton

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    Ep. 13: “Pathogens, Autoantigens, and Antigens” Featuring Dr. Frances Lund Sep 14, 2021
    Show notes

    Frances Lund

    Guest:

    Dr. Frances Lund is the Charles H. McCauley Professor and Chair of the Department of Microbiology at the University of Alabama at Birmingham. Her lab showed that B cells not only make antibodies, but also produce cytokines that modulate the microenvironment. She currently studies the many roles of B cells, how to target B cells gone bad, and nasal vaccines for respiratory illnesses.

    Featured Products and Resources:

    • Keep current with the latest in infectious disease research.
    • Explore scientific resources for your immunology research at the STEMCELL Technologies immunology learning center.

    The Immunology Science Round Up

    A COVID-19 Vaccine Targeting CD40 – Researchers fused a CD40 monoclonal antibody to a SARS-CoV-2 protein, which stimulated dendritic cells and boosted the immune response of monkeys already exposed to the virus.

    A T Cell Cancer Vaccine – Scientists generated a therapeutic cancer vaccine by genetically modifying T cells to deliver antigens and adjuvant signals to lymphoid tissues.

    Dendritic Cells in Intestinal Immunity – Intestinal dendritic cells have local specializations that depend on the microenvironment.

    Stress and the Immune System – Psychological stress primes monocytes to an inflammatory state.

    Image courtesy of Dr. Frances Lund

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    Ep. 12: “The Power of Cell Therapy” Featuring Dr. Jeffrey Bluestone Aug 31, 2021
    Show notes

    Jeffrey Bluestone

    Guest:

    Dr. Jeffrey Bluestone is the CEO and President of Sonoma Biotherapeutics, a San Francisco and Seattle-based company leveraging the properties of regulatory T cells to create living cell therapies that restore the immune system back to its balanced, fully functioning state. He discusses the company’s research and mission to create therapies that are long-lasting, highly efficacious, and have the potential to slow or prevent autoimmune disease progression and prolong healthy life.

    Featured Products and Resources:

    • Keep current with the latest in cell therapy research.
    • Explore tools and resources for your immunology research at ECI 2021

    The Immunology Science Round Up

    Linking Neutrophil Death and Lupus – Researchers showed that neutrophils from either lupus-prone mice or patients with systemic lupus erythematosus undergo ferroptosis.

    Alterations in Red Blood Cells Contribute to Lupus – Scientists found that lupus may be triggered by a defective process in the development of red blood cells.

    TCF-1 Regulates Distinct Treg Cell Functions – Researchers discovered how the transcription factor TCF-1 in Tregs modulates polyps formation in colon cancer.

    mRNA Vaccines Produce Strong Immune Response – Scientists showed that mRNA vaccines that protect against COVID-19 produce a robust T cell response.

    Image by Steve Babuljak, courtesy of Dr. Jeffrey Bluestone

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    Ep. 11: “Adoptive T Cell Transfer” Featuring Dr. Christopher Klebanoff Aug 17, 2021
    Show notes

    Christopher Klebanoff

    Guest:

    Dr. Christopher Klebanoff is a Principal Investigator and Attending Physician at the Memorial Sloan Kettering Cancer Center. His research focuses on cell-based cancer immunotherapies, T cell receptors, and the therapeutic targeting of shared cancer neoantigens. Using single-cell sequencing, biophysical measurements of T cell receptor affinity, genetic engineering, and structural immunobiology, the Klebanoff lab aims to adapt adoptive T cell transfer for advanced solid tumors.

    Featured Products and Resources:

    • Human Immunology News
    • CAR T Cell Wallchart

    The Immunology Science Round Up

    Dual Targeting of Tregs – A CTLA-4 antibody combined with a signal regulatory protein modulates both “eat me” and “do not eat me” signals to deplete regulatory T cells in the tumor microenvironment.

    A Cell-Free Assay for SARS-CoV-2 Neutralizing Antibodies – Researchers developed a multiplex assay to assess neutralizing antibodies to SARS-CoV-2 variants of concern in convalescent plasma.

    T Cells and Oral Vaccines in Environmental Enteric Dysfunction – Scientists developed a mouse model for environmental enteric dysfunction and found impaired CD4+ T cell responses in the small intestine, which reduced oral vaccine efficacy.

    Vertical Transfer of Maternal Immune Cells – Maternal microchimeric cells promote fetal immune development and are linked to a lower number of respiratory infections in early life.

    Photo Reference: Courtesy of Dr. Christopher Klebanoff

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    Ep. 10: “Viral Pathogens” Featuring Dr. James Crowe Aug 03, 2021
    Show notes

    James Crowe

    Guest:

    Dr. James Crowe is the Director of the Vanderbilt Vaccine Center. Their group uses a very broad array of techniques including molecular and cellular biology, state-of-the-art imaging and flow cytometry, bioinformatics, and bioengineering approaches to attack the scientific problems that are of interest to them: major human pathogens.

    Featured Products and Resources:

    • Immunology of Infectious Disease News
    • Immunology Learning Center

    The Immunology Science Round Up

    COVID-19 Vaccine Effectiveness against the Delta Variant – The Pfizer and Astrazeneca vaccines are highly protective against the delta variant of COVID-19 after two doses.

    Immune Cell Mechanisms in Colitis – Researchers identified an inverse correlation between inflammatory bowel disease severity and Cox2 expression, uncovering an active immune pathway that may be targeted to reduce inflammation.

    T Cell Specificity in Melanoma – Scientists took an in-depth look at the relationship between T cell receptors and T cell phenotypes in patient-derived melanoma cell lines.

    Overcoming PD-1 Blockade Resistance in Lung Cancer – Researchers studied the transcriptional programs of neoantigen-specific tumor-infiltrating lymphocytes in PD-1 treated lung cancers.

    Photo Reference: Courtesy of Dr. James Crowe

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    Ep. 9: “Lymphocyte Activation” Featuring Dr. Marc Jenkins Jul 20, 2021
    Show notes

    Guest:

    Dr. Marc Jenkins is a Regents and Distinguished McKnight University Professor in the Department of Microbiology and Immunology and the Director of the Center for Immunology at the University of Minnesota. Dr. Jenkins discovered that CD4+ T cells require CD28 as well as TCR to produce IL-2. His lab investigates CD4+ T and B cell activation in vivo by directly tracking antigen-specific cells.

    Featured Products and Resources:

    • STEMDiffTM Monocyte Kit
    • CAR T Wallchart

    The Immunology Science Round Up

    A Pathway to Regulate T Follicular Helper Cells – Scientists identified a metabolic control pathway that regulates T follicular helper cells and humoral immunity.

    HIV Treatment and the Microbiome – Researchers found that in HIV patients treated with combined antiretroviral therapy, the composition of the microbiome fluctuates and affects the reconstitution of CD4 T cells.

    Blocking RSV Replication – A drug that hardens viral inclusion bodies inhibited respiratory syncytial virus replication in mice.

    COVID-19 Vaccine-Induced Blood Clots – Adenoviral vector vaccines can induce platelet activation that can contribute to thrombosis by producing antibodies that bind to platelet factor 4.

    Photo Reference: Courtesy of Dr. Marc Jenkins

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    Ep. 8: “Veterinary Virology” Featuring Dr. Robyn Hall Jul 06, 2021
    Show notes

    Robyn Hall

    Guests:

    Dr. Robyn Hall is a Research Scientist and Team Leader at the Commonwealth Scientific and Industrial Research Organisation. She is a veterinary virologist whose research focuses on innovative and applied solutions for improving rabbit biocontrol using rabbit caliciviruses.

    Featured Products and Resources:

    • Immunology of Infectious Disease News
    • Cell Separation E-Book

    The Immunology Science Round Up

    Coordinating an Antimicrobial Response in Leprosy – In addition to immune cells, cell types such as fibroblasts and keratinocytes can produce antimicrobial molecules in leprosy granulomas.

    Modifying RNA Splicing to Enhance Immune Recognition – Scientists used drugs that modulate splicing to induce cancer cells to produce abnormal proteins, fostering recognition by immune cells.

    Remodeling the Lymphoid Landscape – Researchers characterized three distinct subsets of lymphoid stromal cells in tonsil tissue and studied their reprogramming in follicular lymphoma.

    A One-Two Punch of Immunotherapies – Researchers found that cancer patients who do not respond well to checkpoint inhibition may respond better to drugs that deplete T follicular regulatory cells prior to anti-PD1 therapy.

    Photo Reference: Courtesy of Dr. Robyn Hall

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    Ep. 7: “The Mechanisms of Itch” Featuring Drs. Isaac Chiu and Tiphaine Voisin Jun 22, 2021
    Show notes

    Isaac Chiu and Tiphaine Voisin

    Guests:

    Dr. Isaac Chiu is an Assistant Professor of Immunology at Harvard Medical School, studying the role of the nervous system in mediating inflammation and host defense. Dr. Tiphaine Voisin is a Postdoctoral Fellow at Harvard Medical School, specializing in somato-sensation and neuro-immunology. They recently published a paper in PNAS on the role of the CysLT2R receptor in acute and chronic itch.

    Featured Products and Resources:

    • Keep current with the latest dermal research with Dermal Cell News.
    • Explore resources for your immunology research at the STEMCELL Immunology Learning Center.

    The Immunology Science Round Up

    Helper T Cell Subsets Defined by Site of Priming – Researchers showed that the site of T cell priming dictates effector phenotype and homing to remote organs.

    COVID-19 Linked to Inflammation of the Brain – Scientists found that COVID-19 can spark a severe immune response in the central nervous system, affecting immune cells in the vascular system and brain.

    From Microbes to Intestinal Innate Immunity – Microbe-derived acetate induces chromatin remodeling in intestinal cells, regulating host metabolism and innate immunity.

    A Robust Response against COVID-19 Variants – A new study shows that the Johnson & Johnson COVID-19 vaccine protects against all of the SARS-CoV-2 variants of concern.

    Photo Reference: Courtesy of Drs. Isaac Chiu and Tiphaine Voisin

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