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    Natural Sciences

    The Immunology Podcast

    A podcast featuring conversations with immunologists from around the globe. Brought to by STEMCELL Technologies.

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    Latest Episodes:
    Ep. 33: “Academic Publishing” Featuring Dr. Mark Kaplan Jul 19, 2022
    Show notes

    Mark Kaplan

    Guest:

    Dr. Mark Kaplan is the Chair of the Department of Microbiology and Immunology at Indiana University School of Medicine. He is currently the Editor-In-Chief for the American Association of Immunologists’ journal ImmunoHorizons. Much of Dr. Kaplan’s work has focused on understanding the function of transcription factors in the development of T helper cell subsets. He talks about the role of T helper 9 cells in lung inflammation and γδ T cells in wound healing. He also discusses ImmunoHorizons and how it provides a home for solid immunological research that may otherwise remain unpublished.

    Featured Products and Resources:

    • Stay up-to-date with the latest papers and news in your field.
    • Read interviews with immunologists who tell their stories, discuss their research, and voice their thoughts and opinions on current topics in immunology.

    The Immunology Science Round Up

    IL-33 Secretion in Airway Inflammation – Researchers showed that in airway epithelial cells, gasdermin D pores mediate IL-33 release.

    Immune Tolerance to Food – CD4+ T cells respond to food peptides by proliferating weakly in secondary lymphoid organs of the gut–liver axis owing to the action of Tregs.

    Why Brain Injuries Lead to Seizures – Thalamic inflammation enhances seizure risk in mice after brain injury.

    B Cells in the Lungs – Influenza and SARS-CoV-2 infection generates bona fide and bystander lung-resident memory B cells.

    Image courtesy of Dr. Mark Kaplan

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    Ep. 32: “Memory T Cell Responses” Featuring Dr. Laura Mackay Jul 05, 2022
    Show notes

    Laura Mackay

    Guest:

    Dr. Laura Mackay is a Professor and Laboratory Head at the Peter Doherty Institute for Infection and Immunity at the University of Melbourne. She talks about her tissue-resident memory T cell research and her ongoing collaboration with Pfizer to identify and validate new targets for cancer therapy.

    Featured Products and Resources:

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    • Webinar: Accelerating T Cell Therapy Research

    The Immunology Science Round Up

    Breast Cancer Metastasis During Sleep – Researchers showed that most spontaneous circulating tumor cell intravasation events occur during sleep.

    Harnessing Anti-Cytomegalovirus Immunity Against Solid Tumors – Cytomegalovirus-derived peptide epitopes promote long-term antitumor immunity in murine cancer models.

    A Gut Metabolite Promotes Nerve Repair – Fasting increases production of indole-3 propionate, which enhances axonal regeneration.

    Tregs and Hair Growth – After acute hair loss, Tregs communicate with hair follicle stem cells to stimulate stem cell proliferation and hair regrowth.

    Image courtesy of Dr. Laura Mackay

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    Ep. 31: “Autoimmune Diseases and B Cell Immunity” Featuring Dr. Mark Shlomchik Jun 21, 2022
    Show notes

    Mark Shlomchik

    Guest:

    Dr. Mark Shlomchik is UPMC Endowed Distinguished Professor and Chair of the Department of Immunology at the University of Pittsburgh. He is also a Founder and Chief Scientific Officer of BlueSphere Bio, a company working to create individualized T cell therapies for the treatment of cancer. Dr. Shlomchik’s lab focuses on systemic autoimmune diseases, long-lived B cell immunity, and immunopathogenesis. He talks about the role of toll-like receptors in lupus, how his autoimmune disease research led to potential cancer therapies, and starting a biotech company with his brother.

    Featured Products and Resources:

    • Explore Free Immunology Wallcharts
    • Immunology Profiles is a venue where immunologists tell their stories, discuss their research, and voice their thoughts and opinions on current topics in immunology.

    The Immunology Science Round Up

    Antibody Escape in Omicron Subvariants – Researchers showed that the BA.4 and BA.5 SARS-CoV-2 sub-lineages contain mutations that reduce neutralization from vaccines and previous infection.

    Long COVID in the Brain – After mild respiratory COVID, mice displayed elevated CSF cytokines, impaired hippocampal neurogenesis, decreased oligodendrocytes, and myelin loss.

    Pregnancy and Intracellular Infection – Pregnancy-induced post-translational antibody modification enables protection against the prototypical intracellular pathogen Listeria monocytogenes.

    Sex-Specific Immune Responses to Tumors – Scientists demonstrated that sex-related differences in tumor burden depend on adaptive immunity.

    Image courtesy of Dr. Mark Shlomchik

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    Ep. 30: “Comparative Immunology and Sharks” Featuring Dr. Hanover Matz Jun 07, 2022
    Show notes

    Hanover Matz

    Guest:

    Dr. Hanover Matz is a Postdoctoral Fellow at the University of Maryland, who recently completed his PhD under the supervision of Dr. Helen Dooley. He discusses why sharks may have evolved adaptive immune systems, the role of T cells, mucosal immunity, and antibodies, and working with sharks in the lab.

    Featured Products and Resources:

    • Keep current with the latest in immune regulation news.
    • Use Easy250 EasySep™ magnet for rapid immune cell isolation from large-volume samples.

    The Immunology Science Round Up

    Intestinal Epithelium and Response to Viral Infection – A new study has uncovered a protective role for intraepithelial Ly6A+CCR9+CD4+ T cells against enteric viral infection.

    New Mechanism to Activate Cancer-Killing T Cells – Scientists have identified a new mechanism, known as MHC-1 cross-dressing, that is effective in promoting a T cell response.

    Long Covid and Breakthrough Infections – Researchers determined that vaccination against SARS-CoV-2 before infection offers partial protection in the post-acute phase of the disease.

    Tregs in Traumatic Brain Injury – Targeted delivery of interleukin 2 boosts the number of anti-inflammatory immune cells within the brain to restrict inflammation and damage following injury or stroke.

    Image courtesy of Dr. Hanover Matz

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    Ep. 29: “Immuno-Oncology Therapeutics” Featuring Dr. Michael Alonso May 24, 2022
    Show notes

    Michael Alonso

    Guest:

    Dr. Michael Alonso is a Scientific Co-Founder, and Vice President of Immunology & Pharmacology at Bolt Biotherapeutics, a biotechnology company developing immunotherapies that activate myeloid cells. He discusses targeting tumors by covering them in “eat me” signals, considerations for moving drugs into the clinic, and building teams in biotech.

    Featured Products and Resources:

    • Read interviews with immunologists who tell their stories, discuss their research, and voice their opinions on current topics in immunology.
    • Explore scientific resources for your immunology research.

    The Immunology Science Round Up

    Trade-Offs in Cancer Mutations – Researchers developed a model of hotspot mutations that shows fundamental trade-offs between a tumor’s growth and its visibility to the immune system.

    Reversing the T Cell Immune System – To determine how T cell lineage fates are determined in the thymus, scientists generated ‘FlipFlop’ mice with a functionally reversed T cell immune system.

    Gut Microbiota and Response to Viral Infection – Suppression of gut microbiota renders mice susceptible to systemic viral infections.

    Europe Cancer Immunotherapy Meeting Highlights – Scientists discussed antigenic dominance in lung cancer, next-generation CAR T cell design, and combining CAR T cell therapy with vaccination for solid tumors.

    Image courtesy of Dr. Michael Alonso

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    “AAI 2022: Treg Modulation” Featuring Dr. Alice Long May 10, 2022
    Show notes

    Alice Long

    Guest:

    Dr. Alice Long is an Associate Member of the Center for Translational Immunology at Benaroya Research Institute at Virginia Mason. The Long lab is focused on understanding how tolerance is lost in autoimmunity, specifically as it related to type 1 diabetes. Dr. Long discusses the work she presented at the American Association of Immunologists’ annual meeting, IMMUNOLOGY2022™, on CD8 T cell exhaustion and Treg modulation.

    Featured Products and Resources:

    • Use EasySep™ to isolate highly purified immune cells in as little as 8 minutes.

    AAI 2022 Talks

    Block Symposium: Autoimmunity – CD8 T cell exhaustion is reduced in subjects with autoimmune-associated DR4 risk alleles
    Saturday, May 7, 2022 | 10:15 AM – 12:15 PM | Oregon Ballroom 203

    NextGen Transformative Immunologic Therapies for Human Disease – Treg modulation by IL-2 mutein therapy
    Sunday, May 8, 2022 | 8:00 AM – 10:00 AM | Room A107–109

    Image courtesy of Dr. Alice Long

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    “AAI 2022: Epithelial Immunity” Featuring Dr. Shruti Naik May 08, 2022
    Show notes

    Shruti Naik

    Guest:

    Dr. Shruti Naik is an Assistant Professor of Biological Sciences at New York University Langone Medical Center. She studies immunity in the epithelial tissues that line our body to understand how environmental stimuli collaborate with genetic factors to influence health and drive disease at these interfaces. She discusses the work she’s presenting at the American Association of Immunologists’ annual meeting, IMMUNOLOGY2022™, on trained immunity and immune-epithelial crosstalk in tissue repair.

    Featured Products and Resources:

    • Easy 250 EasySep™ Magnet for Large-Scale Immunomagnetic Separation

    AAI 2022 Talks

    Back to School: A Review of Four Fast-Moving Fields – Trained immunity
    Friday, May 6, 2022 | 2:00 PM – 4:00 PM | Oregon Ballroom 204

    International Cytokine and Interferon Society (ICIS) Symposium:
    Rising Stars of Cytokine Biology
    – Immune-epithelial crosstalk in tissue repair
    Sunday, May 8, 2022 | 3:45 PM – 5:45 PM | Room B110–112

    Image courtesy of Dr. Shruti Naik

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    “AAI 2022: Peritoneal Macrophages” Featuring Dr. Gwendalyn Randolph May 06, 2022
    Show notes

    Gwendalyn Randolph

    Guest:

    Dr. Gwendalyn Randolph is the Emil R. Unanue Distinguished Professor in the Department of Immunology and Pathology at Washington University in St. Louis. Research in her lab integrates the study of monocytes, monocyte-derived cells, and dendritic cells with vascular and lymphatic vessel biology. She discusses the work she’s presenting at the American Association of Immunologists’ annual meeting, IMMUNOLOGY2022™, on the diversity, function, and mysteries of peritoneal macrophages.

    Featured Products and Resources:

    • Follow these tips to prepare for your next conference.

    AAI 2022 Talks

    Major Symposium B: Macrophage Biology, Diversity, and Inflammation – Diversity, function, and mysteries of peritoneal macrophages
    Saturday, May 7, 2022 | 8:00 AM – 11:30 AM | Portland Ballroom 254–255

    Careers in Science Lecture and Roundtables – Becoming a confident scientist and embracing your authentic self
    Sunday, May 8, 2022 | 12:30 PM – 2:00 PM | Portland Ballroom 251

    Image courtesy of Dr. Gwendalyn Randolph

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    Ep. 28: “Exploring Regulatory T Cells” Featuring Dr. Michael Rosenblum Apr 26, 2022
    Show notes

    Michael Rosenblumt

    Guest:

    Dr. Michael Rosenblum is a Professor of Dermatology at the University of California, San Francisco. His lab seeks to to understand how immune responses are regulated in tissues and how this knowledge can be exploited for therapeutic benefit. They are currently investigating how regulatory T cells (Tregs) control immune responses in tissues, as well as their “alternative” functions. He talks about early-life inflammation and type 2 helper T cells in the skin, and how Tregs can be manipulated to target autoimmune diseases and cancer.

    Featured Products and Resources:

    • Stay up-to-date with the latest in immune regulation news.
    • Download the cell separation e-book, a practical guide on everything you need to know about cell isolation techniques.

    The Immunology Science Round Up

    Tissue-Resident Memory T Cells in the Brain – After viral brain infection, tissue-resident memory T cells triggered central nervous system inflammation, promoting autoimmune reactions in mice.

    Suppressing HIV with Antibodies – Anti-HIV-1 antibodies can maintain viral suppression and may accelerate viral reservoir decay.

    Enhancing Hepatitis B Therapeutic Vaccine Responses – Natural killer cell depletion enhanced T cell responses to a chimp adenoviral vectored hepatitis B virus.

    CAR T Cell Cytotoxicity in Glioblastoma – Researchers found that interferon gamma signaling is crucial for proper engagement and killing of solid tumors by CAR T cells.

    Image courtesy of Dr. Michael Rosenblum

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    Ep. 27: “AAI 2022: Building on the Past to Meet the Moment” Featuring Dr. Gary Koretzky Apr 12, 2022
    Show notes

    Gary Koretzky

    Guest:

    Dr. Gary Koretzky is President of the American Association of Immunologists, Vice Provost for Academic Integration at Cornell University, Professor of Medicine at Weill Cornell Medicine, and Director of the Cornell Center for Immunology. He talks about how he began his career in immunology, using science to guide Cornell’s response to COVID-19, and what to expect at AAI’s Immunology 2022 meeting taking place May 6-10th.

    Featured Products and Resources:

    • Use Easy250 EasySep™ Magnet for rapid immune cell isolation from large-volume samples.
    • Tips to prepare for your next conference or networking event

    The Immunology Science Round Up

    Circular RNA Vaccines Against SARS-CoV-2 Variants – Circular RNA vaccines enable effective protection against SARS-CoV-2 in mice and monkeys.

    CD20+ T Cells in Multiple Sclerosis – Scientists found that expansion of CD20+ T cells contributes to the inflammatory process in patients with multiple sclerosis and mice with autoimmune encephalomyelitis.

    Neutrophils in Wound Healing– Neutrophils have an essential role in transferring matrix into wounds through heat shock–integrin signaling.

    Spinal Microglia Promote Pain Recovery – Scientists identified a CD11c+ spinal microglia population that appears after pain development and is essential for recovery from neuropathic pain.

    Image courtesy of Dr. Gary Koretzky

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