The Human Upgrade: Biohacking for Longevity & Performance

Latest Episodes:

Menopause: What to Know, What to Ask & What to Do – Mary Claire Haver, M.D. : 1015 Jan 27, 2023

Show notes

IN THIS EPISODE OF THE HUMAN UPGRADE™… board-certified OB/GYN and “menopause warrior” Mary Claire Haver, M.D., joins the show to give women a toolkit to manage what comes before, during and after menopause.

She explains the science of women’s hormones, physiology and brain during the menopausal transition.
She breaks down the studies, risks, and age timing of Hormone Replacement Therapy.
She gives you information you can use to both help yourself and ask for help from medical professionals.
She arms you with actions that work based on what is happening to your biology and brain chemistry during the years leading up to and after menopause.

“When I talk about the menopausal toolkit, HRT is just one small part of what I counsel patients about,” Dr. Haver says. “We talk about nutrition, we talk about exercise, we talk about stress reduction, we talk about sleep, we talk about possible other pharmaceuticals. And of course, we talk about supplementation. It's like a tackle box and everything is important.”

Although Dr. Haver’s career included taking care of women at all life stages, she didn’t expect to experience the shocks of her own menopause. So, she went looking for answers and took action along the way. She changed the entire focus of her medical practice to menopause. She also channeled the power of social media to provide menopause education and reaches more than 2 million on her TikTok channel alone.

Her new book, “The Galveston Diet: The Doctor-Developed, Patient-Proven Plan to Burn Fat and Tame Your Hormonal Symptoms," lays out three specific action areas: intermittent fasting, anti-inflammatory nutrition, and fuel refocus.

Menopause is having a moment. (As Lizzo would say, “It’s About Damn Time.”) From investor-backed start-ups in a $6B market to celebrity-led wellness brands to demands for more science—women, and women medical professionals, are changing mid-life menopause dynamics.

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Dave Asprey’s NEW Book! “Smarter Not Harder: The Biohacker's Guide to Getting the Body and Mind You Want” launches Feb. 28, 2023. Pre-order yours today: IndieBound / Barnes & Noble / Apple Books / Amazon

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How to Stack Cold Water, Sauna and Breathing to Accelerate Your Metabolism – Susanna Soeberg, Ph.D. : 1014 Jan 25, 2023

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IN THIS EPISODE OF THE HUMAN UPGRADE™…Susanna Soeberg, Ph.D., a Danish researcher, international scientist and expert in cold and heat therapy for health and performance, explains how you can harness the massive benefits of cold water immersion (winter swimming), sauna, breathing, and your metabolism.

When it comes to biohacking, a few things rise to the top and make a pretty big difference in your body and brain. Through her research, Susanna discovered the minimum threshold of cold and heat exposure for health benefits. We get right into that on the show. She also works with functional breathing during cold environmental conditions and cold water immersion, especially winter swimming.

Have you been considering this biohack for awhile? Baby steps won’t get you there—prepare to go all-in with the cold. “You could take cold showers, for sure,” Susanna says, “but it's not going to activate your parasympathetic nervous system in the same way as submerging yourself into cold water.”

Earning a Ph.D. in metabolism at the University of Copenhagen set her on course to focus her expertise on ways metabolism works for and against you—and what you can do to improve your metabolic profile. She researches obesity, Type 2 diabetes and insulin management, as well as how brown and white adipose tissue (fat) function differently within the human body.

In Susanna’s new book, “Winter Swimming: The Nordic Way Towards a Healthier and Happier Life,” she describes the benefits of winter swimming and cold water immersion on your physiology, mental health, and capacity for resilience.

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Opportunity: Breath, Cold, Stress & Resilience Conference, Feb. 18, 2023. Presentations by Susanna Soeberg, James Nestor and other experts. Register here.

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How Quantum Energy Raises Your Biohacking to a New Level – Philipp Samor von Holtzendorff-Fehling : 1013 Jan 20, 2023

Show notes

Leela Quantum Tech sponsored this episode.

IN THIS EPISODE OF THE HUMAN UPGRADE™…you’ll learn why energy frequencies have such a powerful influence on human physiology. Skeptics take note: science backs this up.

Philipp Samor Von Holtzendorff-Fehling introduced quantum energy on episode #809 and its benefits on body function, cellular voltage and chakra energy. He returns to the show with exciting new research that further validates the power of this energy and its frequencies on human physiology.

“Energy and frequency—that’s where the real truth is.” Philipp says. “And that's where the real life also is.”

Leela Quantum Tech creates blocs (Infinity, Quantum, Travel), frequency cards, H.E.A.L. capsules, and other products charged with quantum energy. The products have been through single- and double-blind, randomized studies and tests. This research has measured mental and physical energy, organ function, neutralization of radioactive particles, protection against pesticides and herbicides, and much more.

Studies also explored how quantum energy affects ATP production, HRV (heart rate variability) and food allergies. You can feel and measure the effects. And dark field microscopy studies (placebo-controlled and double-blind) performed by Dr. Beverly Rubik in the U.S. and the BESA institute in Austria looked at the physical effectiveness of Leela Bloc technology.

SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Go tohttps://leelaq.com and use code DAVE10 to get 10% off.

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How Your Mitochondria Control Your Brain Energy – Chris Palmer, M.D. : 1012 Jan 18, 2023

Show notes

IN THIS EPISODE OF THE HUMAN UPGRADE™…Harvard psychiatrist, researcher and assistant professor Christopher Palmer, M.D., introduces a bold new premise about the root cause of mental illness based on decades of research.

Dr. Palmer integrated existing theories and research into one unifying theory—the brain energy theory of mental illness that’s rooted in your metabolism. Through his research, he initially pioneered using a medical ketogenic diet to treat psychiatric disorders. In this conversation, you’ll learn how he went even further to uncover the connection between mental health and metabolic disorders of the brain. That connection lies in mitochondrial dysfunction or dysregulation.

His new book, “Brain Energy: A Revolutionary Breakthrough in Understanding Mental Health and Improving Treatment for Anxiety, Depression, OCD, PTSD, and More,” also explains the increased risk for mental disorders in all metabolic conditions, including diabetes, heart attacks, strokes, pain disorders, obesity, Alzheimer’s disease, and epilepsy.

“Once you see the big picture of metabolism and all of the things that influence metabolism, you actually can see novel ways to intervene,” Dr. Palmer says. “And you can also raise some red flags about some of our current treatments.”

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Attention Span: How It’s Getting Lost & How to Get it Back – Gloria Mark, Ph.D. : 1011 Jan 13, 2023

Show notes

IN THIS EPISODE OF THE HUMAN UPGRADE™…you’ll meet Gloria Mark, Ph.D., who studies how digital media impacts people's lives. Her research specifically covers how attention is affected by, and has changed, with the rise of the digital age. She’s found that attention span now averages 47 seconds on a screen—and even that’s shrinking.

As a Chancellor’s Professor of Informatics at the University of California-Irvine researching human-computer interaction, Gloria examines how people handle multitasking, task-switching, interruptions, and emotions. Her new book “Attention Span: A Groundbreaking Way to Restore Balance, Happiness and Productivity” looks at human technology use from a psychological perspective.

“In the thousands of hours that I have studied people in the course of their daily work, I have heard a common sentiment,” Gloria says in her book. “People report that they are overworked and exhausted because they have to deal with too much information and too many messages.”

This conversation gets into the science of attention, the stress it’s causing, plus real solutions for how you can regain focus with your personal technologies. You’ll learn:

How to recognize the four main types of attention;
What consequences of constant interruption do to your stress levels and productivity;
How to achieve focus, rhythm and balance in a day filled with attention-switching;
How to structure a flow state within your day; and
What four things you can do to gain agency in the digital world.

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9th Annual Biohacking Conference: Come join like-minded people June 22-24 in Orlando, Florida, for three days of awesome! You’ll learn from dozens of experts at an amazing event that’s designed to upgrade every area of your life. https://biohackingconference.com

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Change Absolutely Everything With One Hack – Robert Waldinger, M.D. : 1010 Jan 10, 2023

Show notes

IN THIS EPISODE OF THE HUMAN UPGRADE™… you’ll meet Robert Waldinger, M.D., who leads an extraordinary scientific study on happiness that’s still going strong after eight decades. The study set out to understand human health by what made people thrive.

Since 1938, the Harvard Study of Adult Development has tracked two groups of men and their families with the goal of discovering what really makes for a good life. Along the way, thousands of questions were asked, and hundreds of measurements were taken—from brain scans to blood work. Three strong themes emerged from the study:

Social connections are really good for you. Loneliness kills.
It’s the quality of your close relationships that matters.
Good close relationships don’t just protect your body, they protect your brain.

Dr. Waldinger combined those lifelong case studies with modern psychological research in his new book, co-authored with Marc Schulz, Ph.D., “The Good Life: Lessons from the World's Longest Scientific Study of Happiness." This discussion gives you real-life tools to hack your happiness. You’ll learn things like:

how relationships improve your physical, mental and emotional health. (More than you know!)
how to evaluate the effect of your relationships on your well-being. (Don’t be dragged down.)
what social fitness is and how to practice it. (Yes, it’s a flex.)
ways to enliven and energize your relationships. (Energy totally matters.)
why casual and work relationships matter more than you think. (A surprisingly big contribution.)

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Don’t Miss This! Dr. Waldinger’s TEDtalk about the study is one of TED’s Top 10 episodes and viewed more than 43 million times.

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Upgrade Spotlight: How to Fight Zombie Cells and Win Aging – Neurohacker Collective : 1009 Jan 07, 2023

Show notes

Neurohacker Collective sponsored this episode.

IN THIS "UPGRADE SPOTLIGHT" EPISODE OF THE HUMAN UPGRADE™… you’re going to learn about the zombie cells taking up valuable space in your body and how you can clear them out with senolytics.

When these zombie cells accumulate (formally called senescent cells), they negatively impact how you age. You may experience symptoms like joint discomfort, low mental and physical energy, poor metabolic health, and diminished muscular response when you work out.

Naturopathic physician Greg Kelly joins the show from Neurohacker Collective, where he’s director of Product Development. His expertise includes nootropics, anti-aging and regenerative medicine, weight management, sleep, and the chronobiology of performance and health.

The hallmarks of aging include nine characteristics that organisms all the way up to humans share as we age, Dr. Kelly explains. One of those characteristics is senescent cells.

This discussion gets into the reasons why senescence happens, the science of senolytics, exciting new research, and new product developments that help bodies naturally eliminate senescent cells. This means a better aging process for you!

SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Go to https://neurohacker.com/dave and code ASPREY to get an additional 15% off. You can trial Qualia Senolytic for up to 100 days with a full 100% money-back guarantee.

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Sync Your Body & Mind for a More Vibrant Life – Legacy Upgrade ft. Dr. Andrew Weil : 1008 Jan 06, 2023

Show notes

IN THIS EPISODE OF THE HUMAN UPGRADE™... the new year starts off with a Legacy Upgrade conversation between Dave Asprey and Dr. Andrew Weil recorded live at True Food Kitchen in Phoenix, Arizona.

Dr. Weil’s an internationally known pioneer and leader in integrative medicine. He’s also a Harvard-trained botanist and medical doctor recognized worldwide for his views on living a healthy lifestyle, his philosophy of healthy aging, and his critique of the future of medicine and health care.

This broad discussion both hits the high points and goes deep into nutrition, aging, energy, lifestyle, and, of course, tea. Specifically, vibrant green matcha. (Or as Dave says, “It looks like green paint.”) There’s a lot of knowledge and humor shared, as well as hard-hitting truths: “One of the most toxic cultural messages here is that the value of life diminishes with aging,” Dr. Weil says.

His five pillars of good health touch on foundational elements that contribute to your core vitality and life force.

Eat right! Learn the principles of nutrition and apply them to your life
Get regular physical activity
Learn and practice methods to neutralize the harmful effects of stress
Maintain emotional and intellectual connectivity as you go through life
Attend to your spiritual well-being

More about Dr. Andrew Weil: He founded the Andrew Weil Center for Integrative Medicine at the University of Arizona. He champions the use of medicinal plants and alternative medicine, as well as the reform of medical education. He’s a clinical professor of medicine and a professor of Public Health at the University of Arizona and the author of more than a dozen books on health, wellness and optimal living.

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How to Simplify Your Intentions and Realize Love – Humble the Poet : 1007 Jan 04, 2023

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IN THIS EPISODE OF THE HUMAN UPGRADE™… Humble The Poet joins the show to talk about a unique perspective on love. You’ll learn:

what “real” love means (hint: it’s not found or earned) and how to recognize it in your life.
how to shift away from a mindset of earning more, achieving more, and gaining more attention so you can clear pathways for love to enter and flourish in your life
how to ditch restrictive “resolutions” (that fail more often than they succeed) and instead set intentions that allow you more freedom to love yourself and others.

This Canadian-born rapper, spoken-word artist, poet and international bestselling author began reciting spoken word poetry in coffee shops more than a decade ago. That creative outlet turned into an adventure that crossed genres, mediums and oceans. His style stimulates audiences with ideas that challenge conventional wisdom.

His first two books, “Unlearn” & “Things Nobody Can Teach Us” became international bestsellers.

His newest book focuses on self love, love for others, defining love in a different way, and how to ease up on expectations that may be holding you back: “How to Be Love(d): Simple Truths for Going Easier on Yourself, Embracing Imperfection & Loving Your Way to a Better Life.”

“I’m writing this because I’m desperate,” he says in the book. “Desperate to realize love, accept love, and learn how I keep f**king it up.”

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Upgrade Your Energy – Ari Whitten – Best of 2022 Dec 30, 2022

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IN THIS “BEST OF” EPISODE OF THE HUMAN UPGRADE™…

… Ari Whitten, Ph.D. (Cand.), CES, PES, explains how to double your energy through improved resilience, cell defense, nutrition and supplementation.

In his newest book, “EAT FOR ENERGY: How to Beat Fatigue, Supercharge Your Mitochondria, and Unlock All-Day Energy,” Ari explains that 5.4 million adults in the U.S. have been diagnosed with chronic fatigue syndrome (the most severe case of fatigue). However, the true fatigue epidemic affects 50 to 100 times more people with many experiencing some level of being flat-out tired as hell.

This conversation gets right into the role of mitochondria in human energy. The cause of fatigue is mitochondrial dysfunction, Ari says. The biggest factors that affect your mitochondria include:

Circadian rhythm dysregulation and poor sleep
Carrying too much body fat and too little muscle mass
Poor gut and microbiome health
Blood sugar dysregulation
Nutritional toxicities and deficiencies
Neurotransmitter and hormone imbalances

Ari recommends science-backed ways that you can get your mitochondria moving, dial in your nutrition and upgrade your brain, gut and hormones.

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