The Human Upgrade: Biohacking for Longevity & Performance

Latest Episodes:

How Urolithin A Helps Create Super T-Cells & Boosts Immunity – Dr. Anurag Singh : 999 Nov 22, 2022

Show notes

Timeline Nutrition sponsored this podcast.

IN THIS EPISODE OF THE HUMAN UPGRADE™… immunologist Anurag Singh, M.D., Ph.D., MBA, Chief Medical Officer at Amazentis, joins the show to talk about urolithin A’s connection between inflammation, aging and your mitochondria.

Urolithin A activates mitophagy and renews your mitochondria. “It takes all the cellular garbage that has been accumulating over the aging process,” Dr. Singh explains. “It revs it up, so it recharges. And so now, you're cleaning your metabolic waste products much more efficiently and they become the building blocks. This is mitochondrial biogenesis, and that means newer, healthy mitochondria coming in.”

This new conversation takes an exciting turn into immunity and your immune system’s two lines of defense: innate and adaptive. You’ll learn:

how inflammation plus aging (AKA inflammaging) contributes to a weakened immune system and a growing incidence of cancer as you age;
how inflammaging and cancer are connected to mitochondrial dysfunction specifically during the aging process; and
how to approach your immune health differently with this new knowledge.

A new study recently published in Immunity looks at how immune cells fight cancer better with a focus on immune modulation, immune cell exhaustion and immune responses. “A lot of urolithin A is anti-inflammatory, but a lot of it is immune modulation," Dr. Singh says. "So, it takes a rewiring of the immune system and makes it more conducive to stopping harmful immune responses.”

Watch this episode on YouTube!

SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: To learn more about the benefits of urolithin A, go to https://www.timelinenutrition.com and use code UPGRADE10 to get 10% off the plan of your choice.

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Battling Pathogens and Building Immunity Begins In Your Gut – Dr. Robynne Chutkan : 998 Nov 18, 2022

Show notes

IN THIS EPISODE OF THE HUMAN UPGRADE™… Robynne Chutkan, M.D., joins the show to talk about a topic that’s foundational to biohacking—resilience. More specifically, resilience that starts in the gut. You’ll learn:

how your microbiome continually evolves and why that matters to the state of your gut and body functions.
how to strengthen the antiviral defenses located in your gut.
why your body’s own ability “to resist, heal, and recover from viruses is vastly superior” to pharmaceuticals.
what to do before taking antibiotics to protect your gut, as well as what you can do to rehab your microbiome after antibiotic use.

“Being on the winning team when battling viruses isn’t because of good luck, or coincidence, or variations in viral virulence,” Dr. Chutkan explains in her newest book, “The Anti-Viral Gut: Tackling Pathogens from the Inside Out.” "It’s due to differences in us, the hosts, and our defenses, and those differences are what determine your outcome. Put another way: it’s less about the potency of the pathogen and more about the health of the host.”

Dr. Chutkan is a Yale- and Columbia-educated integrative gastroenterologist who’s been advancing knowledge and education about gut health for decades. Nearly 20 years ago she founded the Digestive Center for Wellness to help people get to the root issue of their digestive issues and improve their gut health.

Watch this episode on YouTube!

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How Sleep Tech Improves Your Performance – Matteo Franceschetti : 997 Nov 15, 2022

Show notes

Eight Sleep sponsored this podcast.

IN THIS EPISODE OF THE HUMAN UPGRADE™… you’ll learn about the intimate relationship between performance and sleep and how you can hack both with a combination of tech and lifestyle.

Matteo Franceschetti joins the show to talk about high performance—something he experienced in athletics, business and life. He was a competitive athlete in his native Italy and a race car driver across Europe. He started two clean-tech companies on two continents. He also worked at the top tier of the international legal world

The one thing he didn’t excel at was sleep. So, he co-founded Eight Sleep nearly a decade ago to hack sleep in all the ways that fuel human potential, performance and energy.

Eight Sleep mattress and mattress pad technology redesign sleep with AI and machine learning models to track your nighttime biosignals. It’s a technology that’s catching the attention of professional athletes in sports like snowboarding, CrossFit, Formula One, and many more.

SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Go to https://www.eightsleep.com/dave/ to get up to $450 off a Sleep Fit Holiday Bundle that includes the Pod 3 Cover. This is a limited-time offer. Eight Sleep currently ships within the USA, Canada, the UK, Australia and select countries in the EU.

Watch this episode on YouTube!

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Sleep Breakthroughs, Stacks & Solutions – Matt Gallant : 996 Nov 11, 2022

Show notes

BiOptimizers sponsored this podcast.

IN THIS EPISODE OF THE HUMAN UPGRADE™… you're going to get into bed with the topic of sleep. Pretty much everyone’s favorite.

In this conversation, veteran biohacker and BiOptimers co-founder Matt Gallant returns to the show with some straight talk about how to get more and better sleep. He’s spent the big bucks—about $50K he estimates—exploring, experimenting and upgrading his own sleep. He's sharing what he now knows so you can create a sleep stack that supercharges your own energy.

You’ll learn about the most common sleep disruptors and what to do about them. You’ll also learn to recognize sleep stages and how to improve your sleep pathways.

This fun show uncovers the practical sleep devices, wearables, supplements and lifestyle hacks that will lull you to sleep. So many times, you’re tired and you know you want to go to sleep—and yet—your body and mind just don’t connect. The new Sleep Breakthrough makes that connection for you. And when cortisol runs amok and falsely perks you up with a second wind, you’ll know what to do.

More and better sleep means you’ll be a higher-performing human. So, get some tonight!

SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Go to https://sleepbreakthrough.com/dave and use code DAVE10 to get an extra 10% off.

Watch this episode on YouTube!

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Sleep Better on Natural Memory Foam: https://myessentia.com/daveasprey, use code DAVE to get an extra $100 off an Essentia mattress purchase on top of Essentia’s Black Friday 25% off sale plus get two FREE organic pillows ($330 value) with mattress purchase. Through Nov. 27, 2022, only.

Cooler Temps for Deeper Sleep: https://www.chilisleep.com/, use code HUMANUPGRADE20 to save 20% on the Dock Pro Sleep System

Must-Have Magnesium: https://magbreakthrough.com/dave, use code DAVE10 to get a 10% discount

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Skincare Hacks With Meteoric Results – Andy Hnilo : 995 Nov 09, 2022

Show notes

Alitura Naturals sponsored this podcast.

IN THIS EPISODE OF THE HUMAN UPGRADE™…… you’ll learn about skincare ingredients that can either nourish or harm your skin. You’ll find out about standards in skin care products, what “clean beauty” means, and what to look for on product labels.

Andy Hnilo, founder of Alitura Naturals, joins the show to talk about skin fitness from the inside out and why using skincare products with ingredients found in nature is the way to go. That means things like pearls, meteorites, clay, CoQ10, enzymes and more.

This conversation gets into ways you can get better skin by:

choosing the right nutrient-rich specialty products you can apply topically;
pairing natural skin products with other biohacks, like red light;
making nutrition and fitness upgrades; and
exploring supplements, peptides and other wellness options.

Improving skin health also means avoiding fillers and chemicals. Toxins both in skin care products and the environment tremendously impact your skin. Acne no longer drives only teenage angst. Adult acne continues to rise, with women affected more than men.Acne affects more than 50% of women between the ages of 20 and 29 and more than 25% of women between the ages of 40 and 49. (American Academy of Dermatology 2012.)

Andy himself struggled with acne—so he knows the toll it takes from outside appearance to inner emotional roil. So, he searched for answers: “It was the products that I was using and then also what I was ingesting,” Andy says. “What I was putting into and onto my body.”

This get-smart guide to product ingredients, environmental awareness and lifestyle tips can help you find your own skin solutions.

SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Go to https://alitura.com and use code humanupgrade to save 20% sitewide.

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Kickstart Autophagy: https://timelinenutrition.com/DAVE, use code ASPREY10 to get 10% off any plan

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Upgrade Spotlight: Calm the Chaos, Then Drink the Water – Analemma : 994 Nov 05, 2022

Show notes

Analemma sponsored this episode.

IN THIS EPISODE OF THE HUMAN UPGRADE™… you’re listening to a new Upgrade Spotlight series. Once a month, these shorter episodes feature guests who get right into useful information in a Q&A style. You’ll find out how to improve your energy and upgrade your performance. You’ll also get the latest knowledge about powerful tools and technologies that allow you to change your biology and the environment around you.

Introducing Analemma! During this Upgrade Spotlight with Mario Brainovic, CEO of Analemma, you’re going to find out about a tool that transforms regular water into a supercharged, full-spectrum, coherent state. The kind of water you drink absolutely influences the quality of your life. You’ll learn the science behind Analemma and what it can do for your health and energy.

Why water? You think you know the basics: stay hydrated daily, avoid plastic bottles and use a filtration system at home. Well, Analemma says water goes way beyond the basics—all the way down to your cellular level. You’re 70% water in body mass, but 99% water on a molecular level. You’re basically very clever water.

The Analemma device—similar in looks and function to a magic wand—radically changes the state of drinking water. Environmental forces cause H2O molecules in drinking water to behave chaotically. At an atomic level, water molecules crash into each other constantly. Your body’s susceptible to that influence.

“We found a way to bring order to this chaos,” Mario says. “When you swirl an Analemma through the water, what happens is that those same H2O molecules start forming a liquid crystalline structure. They start behaving harmonically. They, colloquially speaking, join hands.”

Analemma water is not exclusion zone water. It's something different. “It also is structured water, but we came to it in a very different way,” Mario says. “The key element to it is its stability.”

This conversation gets right into the science of Analemma and several studies. You’ll find out how:

a new study is measuring the rise in ATP levels (in mitochondrial energy) when people drink this water.
this water affects the human microbiome
this water reduces your biological age by one to 12 years by regenerating your cellular system, according to GlycanAge.
you get an instant balancing effect between the left and the right brain hemisphere
how a cooling affect happens on your brainwaves almost instantly when drinking this water
this water restores the biodiversity of infertile soil

SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Go tohttps://analemma-water.com and use code dave10 to save 10%.

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Sauna Big Wins: Body Detox & Depression Relief – Connie Zack : 993 Nov 03, 2022

Show notes

IN THIS EPISODE OF THE HUMAN UPGRADE™… You’ll learn about the ways using a sauna can charge your energy, help you heal physical and mental health conditions—and science that backs that up.

Sunlighten sponsored this episode.

Connie Zack joins the show to talk about the far-reaching benefits of sauna use and what’s new in the field of infrared light. For more than 22 years, Connie and her husband, Aaron, have introduced infrared light therapy to 13 countries through Sunlighten. They’re leading innovations in infrared light therapy and infrared sauna manufacturing.

This conversation covers a range of good things you’ll experience from using a sauna:

how infrared light affects the body and triggers a biochemical cascade of benefits;
how near infrared penetrates the body to interact with mitochondria;
why the real magic of infrared combines both light and heat;
what evidence connects infrared and detoxification—and why sweating wins;
why you sleep better—without feeling exhausted—when you do a sauna session before bed;
how infrared shows promising relief for those who experience depression; and
practical ways to incorporate sauna into your own stack for better sleep and higher performance.

Big takeaways for you:

Sauna for Detox: Results from a blood-urine-sweat study support infrared for detoxification, and it’s more than just thermoregulation as traditional medicine often argues.
Sauna for Depression: Chronic inflammation is associated with depression and may be a protective, inflammatory response involving thermoregulatory pathways, the immune system, serotonin system, heat shock proteins and more. Studies show that raising core body temperature can improve major symptoms of depression.

Connie’s been on the show before, so check out Saunas Use Infrared to Power Detox, Immunity & Renewal – #823 to find out how infrared sauna helps you with immunity and recovery.

SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Go to https://www.sunlighten.com/dave to save up to $600 on your sauna purchase.

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Authentic Networking: The Give & Get Starts with Real Relationships – Joe Polish : 992 Nov 02, 2022

Show notes

IN THIS EPISODE OF THE HUMAN UPGRADE™…Joe Polish, considered “the most connected person on the planet,” shares networking strategies that help you get what you want by giving people what they want.

Dave Asprey recently connected with Joe in person to talk about Joe’s new book so you can use nine genius principles to turn your business—and your personal relationships—around.

If you’re not asking “what’s in it for them?” when it comes to the people in your life—clients, colleagues, family and friends—you’re missing some important opportunities. Here are a few things you’ll learn from Joe’s new book, “What's in It for Them?: 9 Genius Networking Principles to Get What You Want by Helping Others Get What They Want,” as a how-to guide:

Deepen rapport and connect with others by identifying and reducing their suffering
Update Dale Carnegie’s insights to win the right friends and influence the right people
Overcome others’ intimidation tactics to find true appreciation in relationships
Build character for better results than capabilities can ever give on their own
Use basic marketing principles to find true love
Protect your efforts from the “takers” of the world

Joe did the hard work to heal from trauma and overcome addiction. He then spent years developing a genuine and generous approach to networking and building rapport. This approach propelled his business and led him to develop the Genius Network, one of the world’s most impactful networking groups for high-achieving entrepreneurs.

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Mini-Episode: Cool Facts Friday #28 Oct 28, 2022

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In this Episode of The Human Upgrade™...

Cool Facts are quick hits of new human and world science curated into short bursts of information just for you. This fun compilation publishes one Friday a month.

• How (and why) brain cells transfer mitochondria to one another

• How a newly discovered molecule stimulates hair growth

• How a tired brain drives poor decision-making

EPISODE SPONSOR: The Eng3 NanoVi device helps repair oxidative stress damage and support the body’s natural repair mechanisms.https://eng3corp.com/DAVE/. Learn more: The Anti-Aging Science Behind the NanoVi Device – Rowena Gates & Hans Eng – #416.

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Finding Your True North Through Yoga – Baron Baptiste : 991 Oct 27, 2022

Show notes

IN THIS EPISODE OF THE HUMAN UPGRADE™… you’ll learn how a yoga practice can be a vehicle for inner transformation. This conversation looks past the popularity of yoga as a fitness trend and into its deeper potential for human development. You’ll also learn how yoga can be a way for you to explore your whole being—from physicality to emotions to thinking.

“A yoga practice often can be the missing ingredient for people,” says renowned yoga master Baron Baptiste. “Often I hear, ‘I added yoga practice to my routine and regimen, and it just shifted everything for me.’ It's a very different way of working your body, mind and breath integration.”

Baron devotes his own life to the study and practices of human development. For more than 30 years, he’s facilitated education through yoga principles and teachings.

His power vinyasa yoga— The Baptiste Methodology—includes the physical (asana), meditation (dhyana) and inquiry (niyama).

“Iyengar was one of my primary teachers,” Baron says. “One thing I borrowed from him is the rigor to a body alignment—a True North Alignment.”

Baptiste Yoga is a systematic approach made up of 53 poses, or asanas, that are linked together by connective momentum and consist of five classical pillars: Drishti (gaze), ujjayi (breath), bandhas (foundation), tapas (heat) and vinyasa (flow).

More about Baron Baptiste: Baron began to seriously study yoga at age 12. As the son of two of America's yoga pioneers, he’s got a great life story that highlights the transformative power of yoga. He trained extensively in all the major traditions before beginning to teach yoga in Los Angeles in the late 80s and creating Baptiste Power Vinyasa Yoga in the mid-90s. He’s worked with celebrities, Olympians and professional athletes. He founded the Baptiste Power Yoga Institute that reaches people around the world. Baron’s also a New York Times bestselling author of multiple books, Emmy-award film maker and public speaker.

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