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Solving the Puzzle with Dr. Datis Kharrazian — Health & Fitness
Solving the Puzzle with Dr. Datis Kharrazian

Solving the Puzzle with Dr. Datis Kharrazian is based on more than 20 years of Dr. Kharrazian’s experience working with autoimmune and brain health patients throughout the U.S. and Europe, exhaustive review of the scientific research, and protocols he has innovated through trial and error in working with complex patient cases.

Dr. Kharrazian discusses evidence-based models incorporating diet, nutrition, and lifestyle — protocols hard won through decades of working with tough, complex patient cases.

His goal is to help teach you effective models for so-called “mystery” symptoms and conditions so you can regain control of your health and life.

Hashimoto’s: Solving the Puzzle, is a new online course from Dr. Kharrazian, who is the originator of evidence-based strategies for managing autoimmune Hashimoto’s hypothyroidism. This course has the most complete and current information for managing Hashimoto’s available.

You can find more information at drknews.com.

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

Hosted on Acast. See acast.com/privacy for more information.

Copyright: © Datis Kharrazian

Latest Episodes:

Episode 112: How Chronic Stress Worsens Eczema Nov 04, 2026

Show notes

Chronic stress doesn’t just affect mood. It drives inflammation that can make atopic dermatitis worse. This episode explains how stress signals travel through the nervous system to the skin, how polyvagal theory helps us understand a child’s stress state, and why co-regulation is one of the most powerful tools for calming both behavior and eczema.

Enroll now in: Pediatric Health from the Womb and Beyond, with Chris Magryta, MD ⚡ A Kharrazian Institute Master Class at https://pages.kharrazianinstitute.com/magryta-pediatric-health

Practitioners can start a free 7-day trial at kharrazianinstitute.com

TIMESTAMPS:

00:00 Understanding Stress and Skin Health

05:30 The role of the vagus nerve

08:52 Understanding co-regulation and perception

11:58 Addressing Behavioral Challenges in Kids

13:56 Understanding Children's Behavior Responses

17:57 Building a strong developmental foundation

21:36 Importance of practitioner mindset

22:23 Podcast resources and disclaimers

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

Hosted on Acast. See acast.com/privacy for more information.

Episode 111: The Anti-inflammatory Powers of Short Chain Fatty Acids Oct 28, 2026

Show notes

Dr. Datis Kharrazian explains short-chain fatty acids and the postbiotics your gut bacteria make from fiber. He covers how butyrate calms inflammation, repairs leaky gut, and supports immune tolerance, while acetate and propionate help with blood sugar, satiety, and GLP-1. He also discusses LPS and endotoxemia, why butyrate can help people with SIBO or dysbiosis, how to dose it, and where probiotics fit in.

Interviewed by Elaine Marshall.

Want the most comprehensive functional medicine training? Start your seven-day free trial at kharrazianinstitute.com and access over 300 hours of clinical training with Dr. Kharrazian and leading functional medicine clinicians.

If you're not a clinician, look for functional medicine patient courses at drknews.com

TIMESTAMPS:

00:00 Discussing butyrate supplements and dosage

05:13 Benefits of butyrate for gut health

07:17 Role of LPS in inflammation

10:48 Starting butyrate supplementation

13:53 Teaching seminars and butyrate insights

17:20 Flaws in microbiome research

22:12 Understanding gut health supplements

23:34 Understanding microbiome and diet diversity

27:16 Health advice disclaimer

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

Hosted on Acast. See acast.com/privacy for more information.

Episode 110: Migraines and Brain Injury Oct 26, 2026

Show notes

Migraines are more than bad headaches. Migraine attacks trigger inflammation and reduce blood flow in the brain, leading to white matter lesions and higher risks of stroke and Alzheimer’s disease. Datis Kharrazian explains how rising migraine frequency is a red flag, how conventional treatment works, and how a functional medicine approach targets triggers like hormone imbalances, insulin resistance, allergies, and poor sleep. Supplements covered include magnesium, vitamin D, omega-3s, CoQ10, and riboflavin.

Interviewed by Elaine Marshall.

Want the most comprehensive functional medicine training? Start your seven-day free trial at kharrazianinstitute.com and access over 300 hours of clinical training with Dr. Kharrazian and leading functional medicine clinicians.

If you're not a clinician, look for functional medicine patient courses at drknews.com

TIMESTAMPS:

00:00 Brain inflammation and MRI spots

08:24 How migraines trigger pain

14:06 Using migraine tracking apps

15:55 Link between obesity and migraines

18:30 Managing migraines with supplements

22:05 Functional medicine and migraine triggers

28:15 Understanding headaches vs. migraines

32:00 Role of adrenal glands in health

35:04 Exploring training and certification options

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

Hosted on Acast. See acast.com/privacy for more information.

Episode 109: Leaky Gut & LPS: What Every Practitioner Should Know Oct 21, 2026

Show notes

In this episode, Dr. Liz Lipski covers what drives intestinal permeability, how LPS affects inflammation, autoimmunity, the brain, and the skin, which tests are most useful, and practical healing strategies like glutamine, zinc carnosine, quercetin, demulcents, and bone broth.

Enroll now in: Insights into Digestive Wellness, with Liz Lipski, PhD, FACN, CNS, IFMCP

A Kharrazian Institute Master Class at https://pages.kharrazianinstitute.com/lipski-digestive-wellness

Practitioners can start a free 7-day trial at kharrazianinstitute.com

TIMESTAMPS:

00:00 Understanding brush borders and zonulin

04:15 Causes of leaky gut

08:13 Causes of celiac disease

12:11 Understanding leaky gut and its tests

13:56 Testing lactulose and mannitol molecules

19:46 Gut health and soothing remedies

21:17 Podcast closing and resources

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

Hosted on Acast. See acast.com/privacy for more information.

Episode 108: Digestive Wellness with Dr. Liz Lipski Oct 14, 2026

Show notes

Dr. Liz Lipski discusses how to choose the right elimination diet for each patient, why gut healing should be temporary, how resilient the microbiome really is, GLP-1s and Akkermansia, and which gut tests are actually useful.

Enroll now in: Insights into Digestive Wellness, with Liz Lipski, PhD, FACN, CNS, IFMCP

A Kharrazian Institute Master Class at https://pages.kharrazianinstitute.com/lipski-digestive-wellness

Practitioners can start a free 7-day trial at kharrazianinstitute.com

TIMESTAMPS:

0:00 Introduction & the early days of functional nutrition

4:30 Gaps in medical training & "when in doubt, start with the gut"

7:00 Choosing the right elimination diet

10:30 Carnivore, SIBO & resetting the microbiome

14:00 FODMAP reintroduction & the big three: dairy, eggs, gluten

16:00 Elimination diets, orthorexia & disordered eating

19:30 GLP-1s, Akkermansia & satiety

23:00 What gut testing is actually useful

26:00 Comparing stool tests & final thoughts

29:00 Closing

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

Hosted on Acast. See acast.com/privacy for more information.

Episode 107: Digestive Enzymes and the Overlooked Signs of Pancreatic Insufficiency Oct 07, 2026

Show notes

Liz Lipski breaks down the three main types of digestive enzymes, how to test for pancreatic exocrine insufficiency using fecal elastase, and how to choose the right product for each patient. She walks through prescription options, full spectrum supplements, lipase-loaded formulas, and food-based sources, and explains why pancreatic insufficiency is so commonly missed because it presents exactly like IBS.

Enroll now in: Insights into Digestive Wellness, with Liz Lipski, PhD, FACN, CNS, IFMCP at https://pages.kharrazianinstitute.com/lipski-digestive-wellness

TIMESTAMPS:

00:00 Understanding Pancreatic Conditions

04:00 Testing for enzyme deficiency

07:13 Digestive enzymes and medical use

10:34 Protease enzymes and sensitivities

14:23 Digestive enzymes and their benefits

19:22 Enzyme naming and sensitivity options

23:15 Promoting resources for practitioners

24:13 Consult Your Healthcare Provider

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

Hosted on Acast. See acast.com/privacy for more information.

Episode 106: Ferritin, Iron Deficiency & Iron Overload Sep 30, 2026

Show notes

Ferritin is one of the most misunderstood markers on a blood test. A low-normal result doesn’t automatically mean iron deficiency, and an elevated result doesn’t necessarily mean iron overload. In this episode, Dr. Datis Kharrazian explains how ferritin reflects iron storage and inflammation, why unnecessary iron supplementation can create problems, and which tests offer clearer answers.

Interviewed by Elaine Marshall.

Want the most comprehensive functional medicine training? Start your seven-day free trial at kharrazianinstitute.com and access over 300 hours of clinical training with Dr. Kharrazian and leading functional medicine clinicians.

If you're not a clinician, look for functional medicine patient courses at drknews.com.

TIMESTAMPS:

00:00 Iron absorption and aging challenges

03:56 Misinterpreting Ferritin Levels

07:49 Understanding ferritin and hemochromatosis

13:07 Understanding health risks for MS patients

15:47 Iron storage depletion explained

17:25 Managing iron deficiency and inflammation

20:39 How the body processes iron

25:51 Learning from Christy Sutton's insights

28:09 Importance of Blood Chemistry Analysis

30:32 Promoting educational resources and courses

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

Hosted on Acast. See acast.com/privacy for more information.

Episode 105: The Future of AI in Clinical Practice Sep 23, 2026

Show notes

Sunjya Schweig looks at where AI in clinical practice is headed over the next one to three years, from AI native EMRs and ambient scribing to fully integrated clinical copilots that surface real time insights and automate routine tasks. He outlines what practitioners who build fluency now will have over those who wait, why the skill advantage compounds over time, and how to stay current without drowning in information overload.

Enroll now in: Clinical Applications of AI: A Competency-Based Masterclass for Integrative and Functional Medicine Practitioners, with Sunjya Schweig, MD at https://pages.kharrazianinstitute.com/schweig-ai-functional-medicine

TIMESTAMPS:

00:00 Discussing future AI developments

03:23 Automating patient intake with AI

09:09 AI streamlining healthcare decisions

10:57 Building expertise through micro-learning

16:45 AI fluency and customization in practice

18:53 Organizing and building with platforms

21:21 Closing and resources mention

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

Hosted on Acast. See acast.com/privacy for more information.

Episode 107: AI in a functional medicine - with Dr. Sunjya Schweig Sep 22, 2026

Show notes

Dr. Sunjya Schweig explains how AI is changing day-to-day clinical work in functional medicine. He walks through his clinic's HIPAA-compliant Claude setup and the workflow he uses to compare answers across multiple LLMs. He also makes the case for practitioners to move beyond simply querying ChatGPT and build curated AI knowledge bases for specific chronic-health protocols, patient onboarding, and other recurring clinical tasks.

The conversation also covers the tensions of this transitional period. Patients now arrive at appointments with their own AI assistants, and insurance company bots are squaring off against practitioner automation. Dr. Schweig also discusses why the future of medicine may require more in-person connection, not less.

Sunjya K. Schweig, MD, is an expert in complex chronic illnesses that require rigorous investigation and management. He has studied, taught, and practiced integrative and functional medicine for over 25 years. He founded and leads the California Center for Functional Medicine (CCFM).

Timestamps:

0:00 Intro

0:27 Interview Begins

0:55 Dr. Schweig's Background

3:04 AI Hype vs. Doom

3:51 AI in Functional Medicine

6:13 Building Knowledge Bases

8:59 Patient-Facing AI

11:51 Quality of FM Info in LLMs

15:20 The Human Element

20:46 From Consumer to Producer

24:55 Mold Project Example

29:45 Marketing with AI

34:28 Insurance & AI Battles

36:35 Younger Generation & AI

37:05 Hiring AI Help

39:06 Closing Thoughts

41:21 Outro

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

Hosted on Acast. See acast.com/privacy for more information.

Episode 104: The Next Frontier of AI in Functional Medicine Sep 16, 2026

Show notes

In this podcast Sunjya Schweig breaks down what AI agents actually are, how they differ from standard chat tools, and what they can realistically do in a clinical setting right now. He walks through the main platforms, real world use cases, and the safety protocols every practitioner needs to understand before giving an agent access to anything in their workflow.

Enroll now in: Clinical Applications of AI: A Competency-Based Masterclass for Integrative and Functional Medicine Practitioners, with Sunjya Schweig, MD at https://pages.kharrazianinstitute.com/schweig-ai-functional-medicine

TIMESTAMPS:

00:00 AI personal agents and automation tools

06:25 Using cloud-based sandbox VMs

09:07 Agentic workflow and approvals

11:39 Using AI to find specialists

13:49 Understanding AI Agents and Use Cases

18:18 Resources for Healthcare Practitioners and Patients

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

Hosted on Acast. See acast.com/privacy for more information.

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