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Solving the Puzzle with Dr. Datis Kharrazian — Health & Fitness
Solving the Puzzle with Dr. Datis Kharrazian

Solving the Puzzle with Dr. Datis Kharrazian is based on more than 20 years of Dr. Kharrazian’s experience working with autoimmune and brain health patients throughout the U.S. and Europe, exhaustive review of the scientific research, and protocols he has innovated through trial and error in working with complex patient cases.

Dr. Kharrazian discusses evidence-based models incorporating diet, nutrition, and lifestyle — protocols hard won through decades of working with tough, complex patient cases.

His goal is to help teach you effective models for so-called “mystery” symptoms and conditions so you can regain control of your health and life.

Hashimoto’s: Solving the Puzzle, is a new online course from Dr. Kharrazian, who is the originator of evidence-based strategies for managing autoimmune Hashimoto’s hypothyroidism. This course has the most complete and current information for managing Hashimoto’s available.

You can find more information at drknews.com.

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

Hosted on Acast. See acast.com/privacy for more information.

Copyright: © Datis Kharrazian

Latest Episodes:

Episode 97: Key Steps to Help Patients Navigate Complex Functional Medicine Protocols Jul 29, 2026

Show notes

In this episode, we establish effective priorities and clear communication with patients to reduce overwhelm, improve compliance, and achieve better outcomes, especially when managing chronic health, gut, brain, or autoimmune conditions.

We’ll explore strategies for setting mutually agreed priorities, communicating the reasons and duration for supplements and lab tests, and factoring in the mind-body connection, including habits, attitudes, and self-talk that impact results.

Enroll now in: Attitudes, Limbic System, and Mind-Body Influence on Functional Medicine Outcomes, with David Musnick, MD at https://pages.kharrazianinstitute.com/musnick-mind-body

TIMESTAMPS:

00:00 Assessing patient hope and understanding

06:01 Prioritizing Symptoms on First Visit

09:26 Discussing lab test costs upfront

11:38 Discussing food allergy testing options

15:12 Scheduling and preparing follow-up visits

20:05 Discussing Patient Supplement Guidance

22:52 Discussing patient supplement instructions

24:31 Timing and staging supplements

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

Hosted on Acast. See acast.com/privacy for more information.

Episode 96: Diet, Sleep & Circadian Rhythm for Fatigue Syndromes Jul 22, 2026

Show notes

In this episode we dive into the metabolic and lifestyle foundations that drive chronic fatigue, ME/CFS, and energy dysfunction. Blood sugar stabilization is covered in depth, from managing hypoglycemia and insulin resistance to the role of ketogenic nutrition in difficult cases that have not responded to other approaches. We also look at hydration and electrolyte balance as an underappreciated piece of cellular energy production, and walk through practical sleep strategies including weighted blankets, white noise, mouth taping, and building a consistent sleep routine.

Register for Chronic Fatigue and Pain Syndromes Clinical Strategies and Treatment Applications at https://pages.kharrazianinstitute.com/chronic-fatigue-and-pain-syndromes

To become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required.

TIMESTAMPS:

00:00 Discussing blood sugar and energy levels

06:17 Ketogenic diet benefits for ME/CFS

10:16 Getting started with intermittent fasting

12:01 Intermittent fasting and autophagy benefits

15:40 Hydration and fatigue management tips

18:58 Addressing sleep hygiene basics

23:14 Benefits of weighted blankets and calming aids

27:14 Improving sleep for chronic fatigue

30:00 Promoting educational health resources

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

Hosted on Acast. See acast.com/privacy for more information.

Episode 95: The Truth About Hormone Replacement Therapy for Cardiovascular and Cognitive Health Jul 15, 2026

Show notes

In this episode, Randy Vawdrey dives into the world of hormone optimization, challenging decades of conventional wisdom that has stigmatized hormone therapy, especially for women.

You'll hear an evidence-based exploration into the role hormones like DHEA, estrogen, progesterone, and testosterone play in cardiovascular prevention, brain health, and longevity. We’ll unpack landmark studies, expose misconceptions rooted in outdated research, and share powerful stories and expert interviews that reveal how proper hormone management can transform lives.

Enroll in the Master Class: Preventive Cardiology: Comprehensive & Integrative CV Risk Reduction with Randy Vawdrey, NP-C at https://pages.kharrazianinstitute.com/vawdrey-cardio

TIMESTAMPS:

00:00 Understanding DHEA and DHEA-S

04:04 DHEA and cardiovascular health

08:05 DHEA's role in heart disease

12:24 Using DHEA for better health

14:31 Discussing hormone treatments

16:14 The impact of 2001 study

21:39 Debunking hormone replacement myths

25:19 FDA's stance on hormone therapy

27:03 Doctor's views on hormone therapy

30:21 Prescribing BHRT to older patients

35:13 Closing remarks and resources

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

Hosted on Acast. See acast.com/privacy for more information.

Episode 94: The Truth About Cholesterol, CAC Scores, and Heart Attack Risk Jul 07, 2026

Show notes

In today’s episode, Randy Vawdrey dives into cardiovascular prevention with a special focus on coronary artery calcium (CAC) testing. He guides us through why traditional cardiovascular risk factors like LDL cholesterol, HDL, and BMI may not be as predictive of heart attack risk as once thought, and how CAC scores can provide a much clearer picture.

You'll hear about the latest research, practical steps for interpreting CAC scores, and the lifestyle and supplemental interventions that can help halt the progression of cardiovascular disease.

Enroll in the Master Class: Preventive Cardiology: Comprehensive & Integrative CV Risk Reduction with Randy Vawdrey, NP-C at https://pages.kharrazianinstitute.com/vawdrey-cardio

TIMESTAMPS:

00:00 Discussing cardiac risk assessment factors

05:50 Predictive value of CAC scores

07:17 Understanding Agatston scores

10:22 Boulder cardiologist's health tips

13:52 Discussing methylfolic acid and statins

16:42 Managing stress with coronary scores

20:17 Podcast sponsor shout-out and disclaimers

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

Hosted on Acast. See acast.com/privacy for more information.

Episode 93: Optimizing Omega 3 Levels for Brain and Heart Health Jul 02, 2026

Show notes

Today, we’re diving into the world of Omega 3 fatty acids with Randy Vawdrey, NP-C. He unpacks why they are so critical for brain and cardiovascular health, how dietary patterns and supplement choices can make or break your Omega 3 levels, and what the latest research tells us about optimal dosing and safety. Whether you're a clinician, health professional, or simply looking to optimize your own well-being, this episode will help you understand the science behind fatty acid ratios, how to properly interpret lab values, and the importance of choosing the right kind of supplementation.

Enroll in the Master Class: Preventive Cardiology: Comprehensive & Integrative CV Risk Reduction with Randy Vawdrey, NP-C at https://pages.kharrazianinstitute.com/vawdrey-cardio

00:00 Omega 3s and cell membranes

05:37 Rise of Seed Oils in America

07:54 Omega 6:3 ratio in veterans

12:10 Understanding omega-3 sources and protocol

16:20 Omega 3 absorption discussion

17:14 Discussing Omega 3 dosage recommendations

22:03 Discussing Omega 3 supplements

23:34 Promoting online courses and resources

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

Hosted on Acast. See acast.com/privacy for more information.

Episode 92: Understanding Chronic Pain and Fatigue Jun 23, 2026

Show notes

Today, we’re diving into the enigma of chronic pain and fatigue. Dr. Kharrazian unpacks the science and physiology behind pain, revealing that it’s not simply a sensory experience but an intricate interaction between our nerves, brain, and even our emotions. From explanations of hyperalgesia and allodynia to the crucial role the limbic system and amygdala play in amplifying or diminishing our experience of pain, this episode bridges the gap between what’s happening beneath the surface and practical strategies for those suffering from ongoing discomfort.

Register for Chronic Fatigue and Pain Syndromes Clinical Strategies and Treatment Applications at https://pages.kharrazianinstitute.com/chronic-fatigue-and-pain-syndromes

To become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required.

00:00 Understanding pain and sensitization

04:19 Understanding brain-based pain signals

08:28 Understanding referred pain mechanisms

12:02 Triggers and amplification of pain

15:07 Explaining gait control theory

17:07 How the sympathetic system works

22:08 Understanding central pain syndromes

25:06 Closing and listener resources

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

Hosted on Acast. See acast.com/privacy for more information.

Episode 91: Managing Musculoskeletal Symptoms in Menopause Jun 16, 2026

Show notes

In this episode, Leslie Fuller, ND focused on the often-overlooked musculoskeletal symptoms experienced by women during perimenopause and menopause. She discusses strategies for effective management, including nutrition, resistance training, hormone assessment, and addressing both structural and functional health. This episode offers healthcare professionals and patients evidence-based approaches to support musculoskeletal health through the menopausall transition.

Enroll now in: Under-Recognized, Under-Treated, and Misrepresented Realities of the Perimenopause and Menopause Transition, with Leslie Fuller, ND and Jillian Moehle, ND at https://pages.kharrazianinstitute.com/fuller-moehle-perimenopause

00:00 Menopause-related musculoskeletal issues

06:32 Assessing musculoskeletal conditions

10:25 Identifying osteoporosis risk factors

13:48 Comprehensive management for inflammation repair

15:07 Discussing menopause and bone health

18:48 Future FDA approval and nutrition strategies

24:30 Effects of Isoflavones and Lignans

25:40 Calcium and vitamin D benefits

31:14 Creatine and CoQ10 for muscle health

33:42 Importance of aerobic and resistance training

38:13 Combating sarcopenia through referrals

39:17 Screening for menopausal musculoskeletal syndrome

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

Hosted on Acast. See acast.com/privacy for more information.

Episode 90: GSM Essentials for 2025: Top Treatment Updates, Safety Guidance, and Patient Impact Jun 09, 2026

Show notes

In this episode, Jillian Moehle focused on the latest evidence-based strategies for recognizing and treating Genitourinary Syndrome of Menopause (GSM). She explored newly updated guidelines from the American Urological Association, emphasizing the importance of proactive screening, a comprehensive approach to patient history, and the range of therapeutic options available, from non-hormonal treatments like moisturizers and lubricants, to hormone-based therapies including low-dose vaginal estrogen. Several points were raised, including safety considerations, the removal of the FDA black box warning on vaginal estrogen, and the crucial role of pelvic floor health in patient outcomes.

Enroll now in: Under-Recognized, Under-Treated, and Misrepresented Realities of the Perimenopause and Menopause Transition, with Leslie Fuller, ND and Jillian Moehle, ND at https://pages.kharrazianinstitute.com/fuller-moehle-perimenopause

00:00 Vaginal treatment recommendations and concerns

05:26 Discussing hormone therapy alternatives

08:13 Treatment options for vaginal health

13:16 FDA removes black box warning

15:24 Support for vaginal estrogen use

18:13 Using GoodRx and applying cream

22:00 Possible side effects and management

24:54 Impact of GSM on women's health

30:59 Podcast outro and resources sharing

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

Hosted on Acast. See acast.com/privacy for more information.

Episode 89: Why Millions of Women Were Failed by the Women’s Health Initiative Study Jun 02, 2026

Show notes

In this episode, we’re diving into the complex and often misunderstood topic of menopause and perimenopause. Despite affecting every woman who lives into late life, menopause has long been underfunded, understudied, and minimized both culturally and medically. Today, we’ll explore why clinical care for women in the menopause transition has lagged behind, examining the deep historical roots of gender bias in research, the fragmentation of women's healthcare, and the profound impact of the Women’s Health Initiative (WHI) study, which triggered decades of fear and misinformation about hormone therapy.

Enroll now in: Under-Recognized, Under-Treated, and Misrepresented Realities of the Perimenopause and Menopause Transition, with Leslie Fuller, ND and Jillian Moehle, ND at https://pages.kharrazianinstitute.com/fuller-moehle-perimenopause

00:00 Historical oversight in menopause care

06:00 Women's Health Initiative study flaws

08:29 Impact of WHI study miscalculation

10:28 Misinterpretation of breast cancer risks

13:44 Correcting hormone therapy myths

17:23 Podcast resources and educational courses

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

Hosted on Acast. See acast.com/privacy for more information.

Episode 88: Hormone Therapy, Breast Cancer, and Menopause May 28, 2026

Show notes

In today's episode, Dr. Mark Holthouse dives into the fears surrounding breast cancer and hormone replacement therapy, separating myth from evidence with a critical look at the real data. Our expert speaker unpacks the latest clinical trials and position statements, clarifying the nuanced relationship between various hormone therapies and breast cancer risk.

We’ll explore what the research says about synthetic versus bioidentical hormones, address common patient concerns, and provide actionable insights for risk assessment and individualized care.

This episode delivers an integrative approach to hormone therapy and breast cancer, bridging the gap between scientific literature and real-world practice.

To enroll in the Sex Steroid Optimization Master Class with Dr. Mark Holthouse, go to https://pages.kharrazianinstitute.com/holthouse-hormone

To become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required.

00:00 WHI study on hormone therapy

04:45 Hormone therapy risks discussion

07:58 Discussing natural vs synthetic HRT

13:11 Transdermal hormone therapy studies

17:55 Rethinking full-fat dairy for women

21:11 Time restricted eating for women

22:57 Assessing breast cancer risk

25:30 Understanding genetic risk factors

29:37 Evaluating breast cancer risk factors

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

Hosted on Acast. See acast.com/privacy for more information.

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