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Solving the Puzzle with Dr. Datis Kharrazian — Health & Fitness
Solving the Puzzle with Dr. Datis Kharrazian

Solving the Puzzle with Dr. Datis Kharrazian is based on more than 20 years of Dr. Kharrazian’s experience working with autoimmune and brain health patients throughout the U.S. and Europe, exhaustive review of the scientific research, and protocols he has innovated through trial and error in working with complex patient cases.

Dr. Kharrazian discusses evidence-based models incorporating diet, nutrition, and lifestyle — protocols hard won through decades of working with tough, complex patient cases.

His goal is to help teach you effective models for so-called “mystery” symptoms and conditions so you can regain control of your health and life.

Hashimoto’s: Solving the Puzzle, is a new online course from Dr. Kharrazian, who is the originator of evidence-based strategies for managing autoimmune Hashimoto’s hypothyroidism. This course has the most complete and current information for managing Hashimoto’s available.

You can find more information at drknews.com.

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

Hosted on Acast. See acast.com/privacy for more information.

Copyright: © Datis Kharrazian

Latest Episodes:

Episode 87: Clinical Strategies for Tackling Fatigue Through Mitochondrial Health May 20, 2026

Show notes

In today’s episode, we dive into the “clinical faces of fatigue.” Join Datis Kharrazian as we explore why some individuals never fully recover from illnesses or injuries, the intricate link between mood and brain energy, and why two patients with similar medical conditions like anemia can have vastly different experiences of fatigue.

We’ll unravel how mitochondrial dysfunctions, both inherited and acquired, lie at the heart of chronic fatigue, depression, fibromyalgia, and other conditions often resistant to simple solutions. You’ll discover why bagfuls of supplements aren’t enough, and how real recovery requires understanding and addressing the unique bioenergetic roadblocks each patient faces, ranging from oxidative stress and poor sleep to blood sugar imbalances and exposure to environmental toxins.

Register for Chronic Fatigue and Pain Syndromes Clinical Strategies and Treatment Applications at https://pages.kharrazianinstitute.com/chronic-fatigue-and-pain-syndromes

To become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required.

00:00 Factors affecting mitochondrial function

03:55 Optimizing patient bioenergetics basics

09:27 Mitochondria and cell evolution

12:33 Focus on acquired mitochondrial dysfunctions

14:23 Mitochondrial ATP production process

20:22 Ketogenic diet and energy pathways

21:15 Ketogenic diet for chronic fatigue

27:02 Exploring functional medicine resources

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

Hosted on Acast. See acast.com/privacy for more information.

Episode 86: Oral and Injectable Peptides for Recovery May 05, 2026

Show notes

In this episode, functional medicine clinician Dr. Rajka Milanovic Galbraith dive into the world of peptides for recovery, exploring both oral and injectable options. She breaks down the latest clinical insights on popular peptides like BPC157, KPV, Lorazatide, TB4, and PeptiStrong, sharing case studies and practical strategies for supporting gut health, autoimmune recovery, muscle maintenance, and post-injury healing. Whether you're a healthcare practitioner, a certified nutritionist, or simply looking for ways to optimize your health, this episode bridges complex science with practical solutions you can implement today.

Enroll now in: Precision Protocols Unlocked: Guide to Nutrigenetics & Peptide Mastery, with Rajka Milanovic Galbraith, MD

⚡ Learn to integrate genetics, micronutrients, and peptides into patient care.

📅 May 23, 2026

🌐 https://pages.kharrazianinstitute.com/galbraith-peptides

00:00 Benefits and side effects of oral bpc

04:37 Addressing complex digestive issues

08:35 Managing gut inflammation

11:53 Using Pepti Strong for healing

15:15 Discussing growth hormone peptides

17:55 Growth hormone and cognitive function

20:38 Recognizing and managing drug reactions

26:00 Using peptides for post-op recovery

29:11 Podcast outro and resources

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

Hosted on Acast. See acast.com/privacy for more information.

Episode 85: Transforming Autism Care with Nutrigenetics and Methylation Pathways Apr 29, 2026

Show notes

In this episode, Rajka Milanovic Galbraith, MD, dives into nutrigenetics and its transformative impact on mental health and chronic conditions. Using real-life patient stories, Dr. Galbraith illustrates how genetic insights and targeted nutrient support can unlock profound change. We’ll explore personalized approaches from thought leaders like Amy Yasko, Ben Lynch, William Walsh, and Bob Miller, discussing practical protocols for methylation, balancing minerals, and managing inflammation.

Enroll now in: Precision Protocols Unlocked: Guide to Nutrigenetics & Peptide Mastery, with Rajka Milanovic Galbraith, MD

⚡ Learn to integrate genetics, micronutrients, and peptides into patient care.

📅 May 23, 2026

🌐 https://pages.kharrazianinstitute.com/galbraith-peptides

00:00 Balancing neurochemicals in children

04:16 Starting folate and B12 supplementation

07:00 Discussing William Walsh's approach

10:41 Understanding methylfolate tolerance

15:31 Patients help promote our practice

18:54 Genetic mutations and food sensitivity

23:19 Learning about methylation pathways

23:58 Evaluating a child's diet and genes

29:56 Discussing toxic exposures and genetics

31:06 Podcast resources and final thoughts

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

Hosted on Acast. See acast.com/privacy for more information.

Episode 84: Exploring Oxidative Stress, GST Genes, and Hormonal Detox Strategies Apr 21, 2026

Show notes

In this episode, we dive into the world of oxidative stress, GST gene patterns, and hormone genetics, uncovering how these factors influence chronic illness and overall health. You'll hear about innovative testing strategies, gene patterns seen in chronically unwell patients, and real-world case studies that illustrate the practical steps clinicians can take to restore health and balance.

Whether you're a healthcare professional seeking to advance your knowledge or an individual looking to understand the science behind fatigue, hormone imbalance, and detoxification, this episode bridges the gap between complex genetics and actionable solutions.

Enroll now in: Precision Protocols Unlocked: Guide to Nutrigenetics & Peptide Mastery, with Rajka Milanovic Galbraith, MD

⚡ Learn to integrate genetics, micronutrients, and peptides into patient care.

📅 May 23, 2026

🌐 https://pages.kharrazianinstitute.com/galbraith-peptides

00:00 Identifying high hydrogen peroxide symptoms

03:06 Addressing brain fog and fatigue

08:11 Combating jet lag with supplements

12:01 Understanding hormone breakdown genetics

13:36 Finasteride side effects and solutions

19:18 Importance of Selenium and Zinc

21:10 Initial treatment and Dutch test results

25:50 Podcast resources and disclaimers

26:53 End of the episode reminder

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

Hosted on Acast. See acast.com/privacy for more information.

Episode 83: The Functional Anatomy of Pain Apr 14, 2026

Show notes

In this episode with Dr. Datis Kharrazian, we dive into the mechanisms that underlie pain, exploring key terms like nociception, hyperalgesia, allodynia, and sensitization. You'll learn how pain signals travel through first, second, and third order neurons, why some injuries result in referral pain, and how chemical mediators and the sympathetic nervous system amplify pain perception.

We’ll break down how the brain interprets, localizes, and emotionally responds to pain, revealing the roles of the somatosensory cortex, amygdala, insular cortex, and other regions. Discover why pain isn’t always proportional to tissue damage and how psychological and physiological variables, including mood and limbic system activation, shape your experience. Whether you're a healthcare professional, nutritionist, or someone managing chronic pain, this episode bridges scientific insight with practical understanding, helping you see pain from a whole new perspective.

Register for Chronic Fatigue and Pain Syndromes Clinical Strategies and Treatment Applications at https://pages.kharrazianinstitute.com/chronic-fatigue-and-pain-syndromes

To become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required.

⁠

For Certified Functional Nutrition education for both practitioners and lay people, visit https://afnlm.com/⁠

00:00 Understanding types of pain

04:57 How mood affects pain perception

08:02 Why visceral pain feels external

12:04 How pain signals are amplified

15:58 How pain is blocked

19:44 How the brain processes pain

22:12 Understanding central pain syndromes

26:01 Explaining brain pathways for pain

30:06 Podcast outro and resources

31:09 Closing message and reminder

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

Hosted on Acast. See acast.com/privacy for more information.

Episode 82: Micronutrient Deficiency Signs Apr 07, 2026

Show notes

Today, we're diving into the often overlooked signs and symptoms of micronutrient deficiencies, from vitamins A, D, and K to magnesium, zinc, and beyond. You'll discover how subtle clues like gritty eyes, dream recall, muscle cramps, and even pink tongues can signal deeper nutritional gaps impacting mood, energy, and neurological health. Whether you're a practitioner seeking a sharper clinical eye or simply want to optimize your well-being, this episode supplies you with insights and tools to decode your body's signals and restore balance.

Register for the Nutrition-Focused Physical Assessment Master Class with Dr. Liz Lipski at https://pages.kharrazianinstitute.com/lipski-nutrition

To become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required.

⁠

For Certified Functional Nutrition education for both practitioners and lay people, visit https://afnlm.com/⁠

00:00 Signs of vitamin A deficiency

06:21 Vitamin E and K deficiencies

07:30 Fermented foods and vitamin K

10:48 Understanding methylation and B vitamins

16:42 Effects of vitamin B6 on sleep

18:25 Signs and symptoms of B12 deficiency

23:37 Identifying causes of muscle cramps

25:57 Recognizing magnesium deficiency signs

30:20 Signs of potassium and zinc issues

31:28 Wrapping up and resources offered

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

Hosted on Acast. See acast.com/privacy for more information.

Episode 81: How Skin Reveals Deeper Health Issues and Nutritional Imbalances Apr 01, 2026

Show notes

In this episode, we’re diving into the world of skin health, from what radiant, healthy skin should look like to the many signals our skin can send about underlying health issues. We'll explore common skin manifestations, nutritional deficiencies, and practical strategies to support skin, from dryness and discoloration to eczema, rosacea, and more. Whether you're a practitioner or someone interested in optimizing your own health, this episode bridges complex science and practical tips you can apply today.

Register for the Nutrition-Focused Physical Assessment Master Class with Dr. Liz Lipski at https://pages.kharrazianinstitute.com/lipski-nutrition

To become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required.

⁠

For Certified Functional Nutrition education for both practitioners and lay people, visit https://afnlm.com/⁠

00:00 Skin health and nutritional basics

03:56 Vitamin A and bruising

07:41 Eating healthy fats and fish

12:14 Identifying allergies and histamine response

15:07 Using food sensitivity tests

19:14 Testing for sensitivities and allergies

21:16 Food sensitivities and sweating

25:26 Talking about severe jaundice

27:59 Health effects of silver supplements

30:30 Closing and resources for listeners

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

Hosted on Acast. See acast.com/privacy for more information.

Episode 80: Dr. Darla Booth DC, AFMC, Managing Autoimmune Patients Successfully Mar 29, 2026

Show notes

In this Practitioner Spotlight episode, we sit down with Dr. Darla Booth, a seasoned chiropractor and functional medicine practitioner based in Los Gatos, California. Over the past 20 years, Dr. Booth has transitioned her practice to focus on complex functional medicine cases, with a special emphasis on autoimmunity. Join us as Dr. Booth shares how discovering autoimmune markers in her own and her daughter’s bloodwork inspired a deep dive into strategies for managing and calming autoimmune conditions. We explore the evolution of her clinical approach, the challenges of educating and supporting patients, and the power of group care and community in fostering healing.

Dr. Darla Booth, DC, AFMC specializes in helping patients with complex health issues identify their root cause, improve symptoms, and stack habits to optimize their health with functional medicine protocols. Her care complements the support patients receive through Western medicine; taking a big picture approach to health through lab work analysis, lifestyle adjustments, and nutritional support. Chiropractic and other conservative, natural care options for adults and children are Dr. Booth's specialties. She is skilled in nutritional counseling for food allergies, cranial therapy, TMJ treatment, and more.

To become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required.

⁠

For Certified Functional Nutrition education for both practitioners and lay people, visit https://afnlm.com/⁠

00:00 Discovering autoimmunity in bloodwork

03:56 Launching an autoimmune program

07:08 Starting group coaching sessions

11:56 Helping clients rebuild health

13:20 Addressing leaky gut in autoimmune

19:00 Understanding digestion and gut health

21:52 Creating a treatment plan

23:58 Small shifts for immune health

26:47 Prioritizing health and wellness choices

29:43 How food impacts your body

33:57 Functional medicine's credibility and impact

37:18 Using RUPA and Fullscript

39:48 Resources for practitioners and individuals

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

Hosted on Acast. See acast.com/privacy for more information.

Episode 79: Nutrition Focused Physical Assessment with Dr. Liz Lipski Mar 24, 2026

Show notes

In this episode, Dr. Liz Lipski, a leader in clinical nutrition and author of Digestive Wellness dives into the foundational practice of nutrition-focused physical assessment.

Dr. Lipski explains how simple observations like cracks in a friend’s tongue over dinner or dark circles under a child’s eyes, can become powerful clues in solving chronic and complex health puzzles. She emphasizes the importance of integrating physical assessments with patient history, lifestyle intake forms, and lab data, demonstrating how even a five-minute exam can shape the entire care plan.

Through case stories and practical examples, Dr. Lipski illustrates the vital role nutrition professionals play in the healthcare team, and why rediscovering hands-on assessment is a key to better outcomes in our modern, often rushed medical world.

Register for the Nutrition-Focused Physical Assessment Master Class with Dr. Liz Lipski at https://pages.kharrazianinstitute.com/lipski-nutrition

To become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required.

⁠

For Certified Functional Nutrition education for both practitioners and lay people, visit https://afnlm.com/⁠

00:00 "Nutrition-Focused Physical Assessment"

03:37 "Body Clues and Nutrition Insights"

09:48 "Chronic Health Needs Lifestyle Focus"

12:28 "Nutrition's Power in Healing"

17:21 "Riboflavin for Odor Relief"

19:05 "First Impressions Matter"

22:47 Cooking, Nutrition, and Self-Care

26:08 "Functional Medicine Training Hub"

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

Hosted on Acast. See acast.com/privacy for more information.

Episode 78: How Mitochondrial Dysfunction Drives Fatigue, Depression, and Chronic Pain Syndromes Mar 17, 2026

Show notes

In today’s episode, we’re diving into the impact of mitochondria on chronic conditions like fatigue, pain, and depression. You’ll hear why optimizing basic factors like sleep, movement, and stable blood sugar isn’t just “wellness” advice, but can actually be game changers for patients struggling with conditions such as leaky gut, Hashimoto’s, fibromyalgia, or neuropathic pain.

Datis Kharrazian unpacks the science behind mitochondrial bioenergetics and reveals how even the tiniest steps, like improving circadian rhythm or addressing subtle nutritional imbalances can help untangle the complex web of chronic illness. You’ll also learn about the connection between mitochondrial dysfunction, increased pain sensitivity, and how negative neuroplasticity can turn temporary pain into a lasting syndrome. Whether you’re a practitioner, a patient, or someone passionate about functional medicine, this episode will empower you to look beyond protocols and focus on the underlying mechanisms that drive recovery.

Register for Chronic Fatigue and Pain Syndromes Clinical Strategies and Treatment Applications at https://pages.kharrazianinstitute.com/chronic-fatigue-and-pain-syndromes

To become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required.

⁠

For Certified Functional Nutrition education for both practitioners and lay people, visit https://afnlm.com/⁠

00:00 Circadian Rhythm Improves Recovery

09:38 Mitochondria, Calcium, and Chronic Pain

10:46 Chronic Pain Linked to ER Stress

15:42 Mitochondrial Health Relieves Chronic Pain

17:34 "Fibromyalgia Mechanisms and Pain Reduction"

21:41 "Functional Medicine Training Resources"

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

Hosted on Acast. See acast.com/privacy for more information.

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