Mastering Nutrition

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Is TMG a good source of glycine? | Masterjohn Q&A Files #225 Jul 01, 2021

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Question: Is TMG a good source of glycine?And so glycine is a methyl buffer. So it's not the default that one extra methyl group from TMG is going to make one molecule of glycine get lost, but generally if you put TMG into the system, you're going to lose methyl groups and you're going to wind up with probably the dimethylglycine going into the mitochondrion. Maybe that improves your glycine status, but I'm not so sure about that and I wouldn't rely on it. So I would just treat them completely differently.

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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Zonulin: what nutrients to look at if it's high? | Masterjohn Q&A Files #224 Jun 30, 2021

Show notes

Plenty more at https://chrismasterjohnphd.com/support! Question: Zonulin: what nutrients to look at if it's high? I think of that from my perspective, which is much more focused on nutrients and biochemistry, I'm thinking especially if you have the ION panel, which kind of takes apart my end of the spectrum, actually I would look at arachidonic acid levels because arachidonic acid in the gut is associated with lymphoid tissue, is metabolized to prostaglandin E2, which promotes immune tolerance.

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

My iron won't go up even though I'm supplementing | Masterjohn Q&A Files #223 Jun 29, 2021

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Plenty more at https://chrismasterjohnphd.com/support! Question: My iron won't go up even though I'm supplementing The top things that I would think of would be riboflavin and copper, plus inhibitors of iron absorption. So generally speaking, plant foods are strong iron absorption inhibitors. Generally, you're going to have organic acids that promote iron absorption in proportion to the amount of potassium in the vegetables that you eat, although it's also the case that polyphenols will tend to correlate. And polyphenols inhibit iron absorption, so I'm of the opinion that you shouldn't eat plant foods at the meal that you're trying to get your iron in if you have trouble getting your iron up. I would take the iron supplement with a carnivore meal. If you want to eat plant foods, eat them at some other point in the day. If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up with a 10% lifetime discount here: https://chrismasterjohnphd.com/q&a

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Vitamin K and Clotting Risk When Not on Anticoagulants | Masterjohn Q&A Files #222 Jun 28, 2021

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Plenty more at https://chrismasterjohnphd.com/support! Question: Vitamin K and Clotting Risk When Not on Anticoagulants There's essentially not a trade-off because if you're not on vitamin K antagonist anticoagulants; in theory, there shouldn't be any effect of vitamin K supplements on clotting at all. The one caveat to that is that you might be relatively vitamin K deficient now and not realize it. So it is within possibility that you're not meeting your own personal vitamin K requirement to maximize clotting, but that's very, very unlikely because in population studies, almost no one falls into this category. But if that were true, then essentially, vitamin K supplementation would bring you up to a normal level of clotting, which may or may not affect the cardiologist's assessment of whether you should be on anticoagulants.

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Do some people do well on ketosis because they have defective glucose metabolism? | Masterjohn Q&A Files #221 Mar 17, 2021

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Question: Do some people do well on ketosis because they have defective glucose metabolism?I doubt that that's the majority of people that feel good in ketosis, but certainly people with GLUT1 defects need to be on a low-glycemic index diet at least, if not a keto diet in order to not have seizures, and that's the best example of what would fit with that. People who do poorly with glucose, maybe in more moderate ways are going to do better on fat. If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life. From now through March, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations. DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

What to do when different folate markers don't line up | Masterjohn Q&A Files #220 Mar 16, 2021

Show notes

Question: What to do when different folate markers don't line upYou know, if you have high figlu on the NutrEval, which is Formiminoglutamic acid, which rises when there is Tetrahydrofolate THF, unmethylated folate, to metabolize figlu, and in that case, I would be thinking about maybe you have a B12 deficiency that is leading to the trapping of folate as the methylfolate form, so that THF isn't regenerated for that reaction. So I would absolutely never use figlu as the only marker of folate. I would look at serum folate and red blood cell folate always as the first markers of folate. So in this case, I would look at your serum folate and your red blood cell folate. So before I would get folate injections, I would be looking at all those markers to see whether there's a coherent story between all of them that are agreeing that your folate status is low despite supplements, versus a divergence story between them that is telling me that one form of folate is the one that's missing rather than a total folate. If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life. From now through March, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations. DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Can sulforaphane hurt the thyroid? | Masterjohn Q&A Files #219 Mar 15, 2021

Show notes

Question: Can sulforaphane hurt the thyroid?What I can say is that sulforaphane does generate thiocyanate ions, which do inhibit uptake of iodine into the thyroid and mammary glands. Although that is a matter of the ratio between isothiocyanate, or between thiocyanate ions and iodine. And so in principle, most uses of sulforaphane, in the context of adequate iodine shouldn't be an issue. I believe at some dose you're going to run into a problem with balancing with iodine, especially in people who have marginal iodine status, but I don't have any studies to back up what point that is. But I have seen cases of people where they got brain fog when they were taking sulforaphane and it went away when they took iodine.If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life. From now through March, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations. DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Are the PUFAs in phosphatidylcholine supplements a concern? | Masterjohn Q&A Files #218 Mar 12, 2021

Show notes

Question: Are the PUFAs in phosphatidylcholine supplements a concern?I don't think so. I think that you're looking at fairly low levels of PUFAs in there, but the way that I see it is yes, we want to restrict PUFA beyond what's needed, but what's needed is defined by what do we need to get our essential nutrients in. If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life. From now through March, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations. DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Is dairy safe for overmethylators? | Masterjohn Q&A Files #217 Mar 11, 2021

Show notes

Question: Is dairy safe for overmethylators?There's so little methylcobalamin in milk that I think that it is totally insignificant with regards to methyl groups, coming into the methylation cycle. Generally, if you're experiencing over-methylation symptoms from methylcobalamin or methylfolate, I think the big issue is partly that you don't have enough glycine in the system, very likely, and partly that your body is over-accustomed to low methyl supply and putting more suddenly into it leading into the system being adapted to a different state than the one you're putting into it. But if you find it is, you're reacting to dairy, I would be very surprised if it was the methylcobalamin, but if you're very convinced of that, then titrate up slowly with the dairy.If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life. From now through March, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations. DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Should different macronutrients be eaten at different times of day? | Masterjohn Q&A Files #216 Mar 10, 2021

Show notes

Question: Should different macronutrients be eaten at different times of day?No, I don't agree with the principle. I think you want protein spaced out at every meal. And that's because your efficiency in extracting protein for muscle synthesis is limited in any given hour or any given unit time. And so you need a lot more protein if you're going to put all your protein in one meal, then you are not going to get optimal body composition results from that. Body composition plays into every other metabolic thing we care about. If I were to shift protein around in emphasis, I would put protein bias towards the morning and biased away from night. And that would be on the basis that protein is the basis for every single neurotransmitter involved in wakefulness. If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life. From now through March, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations. DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

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