Mastering Nutrition

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For how long does methionine from a meal support methylation? | Masterjohn Q&A Files #235 Jul 15, 2021

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Plenty more at https://chrismasterjohnphd.com/support! Question: For how long does methionine from a meal support methylation? What I can say much more easily is that methionine is going to effectively run out as the fasting state emerges. Methionine has many fates, right? And so if it all goes into the methylation pool, it's going to be quickly either used for methylation or broken down in the CBS pathway. You are not going to save methionine for the fasting state.

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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Could collagen hurt absorption of iron from iron bisglycinate? | Masterjohn Q&A Files #234 Jul 14, 2021

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Plenty more at https://chrismasterjohnphd.com/support! Question: Could collagen hurt absorption of iron from iron bisglycinate? Yes, because the iron bisglycinate is probably going to be absorbed through glycine transporters rather than iron transporters.

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Combining carbs and fat, LDL-C, calcification, and atherosclerosis | Masterjohn Q&A Files #233 Jul 13, 2021

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Plenty more at https://chrismasterjohnphd.com/support! Question: Combining carbs and fat, LDL-C, calcification, and atherosclerosis Generally speaking, if someone is overweight and hyperglycemic, then they're probably going to get a lot of benefit from trying to separate their carbs and fat, whereas if someone has amazing body composition and a totally healthy blood glucose level while they're eating a mixed diet, then I think it's kind of pointless. I would say that for blood lipids, generally, if macronutrients are going to affect your blood lipids, that's probably involving your fasting blood lipids, which is what's usually measured. If changing your macronutrients around is going to affect those, I think it's probably going to be in the context of some level of insulin resistance or overweightness, really insulin resistance or it would just be one of several ways to get there with carbohydrates generally pumping the sort of VLDL production and triglyceride content.

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Could low-normal phosphorus be from my calcium intake? | Masterjohn Q&A Files #232 Jul 12, 2021

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Question: Could low-normal phosphorus be from my calcium intake?Given that your calcium is coming from milk and yogurt and Traditional Foods Market brand whole bone meal to get your calcium, you're definitely consuming plenty of phosphorus, and so I don't think your dietary phosphorus is off. I wouldn't really worry about the phosphorus being low in that range. It's not low, it's on the low end of the range. I think the PTH being suppressed to 18 is great. I think the calcium doing that is great. I think that the calcium did that, even when all your calcium sources were balanced by phosphorus, sounds really good because phosphorus would do the opposite.

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Exercising in the fasted state | Masterjohn Q&A Files #231 Jul 09, 2021

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Plenty more at https://chrismasterjohnphd.com/support! Question: Exercising in the fasted state The answer is necessarily subjective because the cut-off between a fasted state and a fed state is arbitrary. It's not like there's an on switch or an off switch for the fasting-feeding cycle. There's just tens of thousands of things happening that cluster together in different ratios and proportions that proportionally shift in one or another direction, depending on how much food you've eaten and how recently.

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

What does an upregulated GGT gene do to glutathione status? | Masterjohn Q&A Files #230 Jul 08, 2021

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Access the show notes, transcript, and comments here. Question: What does an upregulated GGT gene do to glutathione status? Well, if you assume that whatever the genetic test told you is actually happening as increased GGT activity, then what it should do is break down blood glutathione and help the breakdown products get into the cell to increase intracellular glutathione. I think as to what it does to glutathione status measured in the blood, I don't know. Because on the one hand, it's probably going to break down glutathione in the blood. But in general, if you're improving glutathione status inside the cell in the liver, you're going to increase the export of glutathione.

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

A question on urinary lactate, pyruvate, and Krebs Cycle metabolites | Masterjohn Q&A Files #229 Jul 07, 2021

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Plenty more at https://chrismasterjohnphd.com/support! Question: A question on urinary lactate, pyruvate, and Krebs Cycle metabolites When the NAD+ sensitive steps of the citric acid cycle are being inhibited, that could be hypoxia, it could be high-intensity exercise, it could be taking metformin or berberine, it could be having a complex 1 disorder, and of course, I would sort of measure this against symptoms. So if you feel great, I wouldn't overinterpret this. But if you have something that feels like messed up energy metabolism, then I think it's best correlated with a deficiency in the respiratory chain, whether that's driven by oxygen, by increased demand, through high-intensity exercise, through taking complex 1 inhibitors like metformin or berberine, or through having a genetic complex 1 disorder. Thiamine is possible but if it's thiamine deficiency, then you should also see elevations in alanine as well. So I would get a plasma amino acids test, and then you could also look at the thiamine level in the blood and you could look at... HDRI has an erythrocyte transketolase activity test, and it's listed as ETKA on their requisition form.

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

High-dose EPA, triglycerides, and general health | Masterjohn Q&A Files #228 Jul 06, 2021

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Question: High-dose EPA, triglycerides, and general healthIt's definitely the case that high dose EPA lowers triglyceride levels in people with high triglycerides. And it does that by interfering with carbohydrate signaling. So carbohydrate signaling, part through glucose itself, and part through insulin, increases triglyceride synthesis and in insulin resistant people, generally the average person with insulin resistance has an amplification of that pathway and is actually hypersensitive to it while being resistant to glucose handling part of the pathway. So blood glucose and blood triglycerides increase. And if you take high-dose EPA, you will interfere with the signaling and you will lower the triglycerides.

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Are there any downsides to eating lots of nuts and seeds? | Masterjohn Q&A Files #227 Jul 05, 2021

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Question: Are there any downsides to eating lots of nuts and seeds?I would mainly be looking at phytate and PUFA, and on the PUFA front, that's polyunsaturated fatty acids, on the PUFA front, I'm not in the extreme minimize it at all costs camp, but I am in the camp of, don't really overdo it beyond what you need to get your nutrients in. So I would look at the contribution of nuts and seeds to your micronutrient intake, and if you're flying real high on the pattern of nutrients that are in the nuts and seeds way more than you need of those types of nutrients, and I think I would cut back on that. And I would be a little bit concerned about the PUFA intake, whereas if you're not hitting your magnesium target, unless you eat the nuts and seeds, then I have a very different view of that.

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

Low cystine & sulfate, mid-range methionine, high homocysteine: what to do? | Masterjohn Q&A Files #226 Jul 02, 2021

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Plenty more at https://chrismasterjohnphd.com/support! Question: Low cystine & sulfate, mid-range methionine, high homocysteine: what to do? My default position on this would be, you probably don't have a problem recycling homocysteine to methionine. And that might explain why, I'm assuming this is in the fasting state, your homocysteine is only slightly elevated. Now, if you mean by slightly elevated, if you mean slightly elevated outside of the lab's reference range, then that's very elevated. And so I would look at that a little bit differently, but especially when paired with the low cystine and sulfate levels, it sounds like you have a low rate of the transsulfuration pathway or the CBS enzyme, which is the first step in that pathway, which takes homocysteine down to cysteine, which then can be metabolized to sulfate.

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.

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