Immune

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Immune 64: A tangled web of wires Jan 24, 2023

Show notes

Cindy, Steph, Brianne, and Vincent do a rapid review 11 immunology papers, including a wiring diagram for the immune system, group A streptococcus vaccines, systems immunology prediction of vaccines, class switch towards IgG4 after SARS-CoV-2 mRNA vaccination, very bad B cells, monoclonal antibody to two streptococcal M protein epitopes, transcriptional atlas of response to 13 vaccines, impact of SARS-CoV-2 exposure history on T cell and IgG response, neutrophilic inflammation predisposes to RSV infection, commensals avoiding recognition, and continuous germinal center invasion contributes to diversity of immune response.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

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Tangled web of wires (Nature)
Path to group A Streptococcus vaccines (Clin Inf Dis)
Immune end-types predictive of vaccine responses (Nat Immunol)
IgG4 switch after SARS-CoV-2 mRNA vaccination (Sci Immunol)
Very bad B cells (Immunity)
Two epitope Streptococcus monoclonal (EMBO Mol Med)
Predictor of vaccine-induced antibody responses (Nat Immunol)
Impact of SARS-CoV-2 exposure history on antibody an T cell response (Cell Rep Med)
Neutrophilic inflammation and RSV infection (Science)
Commensals avoiding recognition (Sci Immunol)
Continuous germinal center invasion and immune response diversity (Cell)
Time stamps by Jolene. Thanks!

Music by Steve Neal Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Immune 63: Immune, promptly Dec 20, 2022

Show notes

Cindy, Steph, Brianne, and Vincent review some of their favorite immunology papers of 2022.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

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CAR T for SLE (Nat MEd)
Maternal gut microbiome induced IgG (Sci Immunol)
Long-primed germinal centers (Nature)
Fc mediated protection against SARS-CoV-2 VOC (bioRxiv)
Dark side of macrophages (Nat Med)
Pregnancy and antibody protection against infection (Nature)
Regulators of inflammatory response to mRNA vaccines (Nature Immunol)
Antibody effector function and protection against RSV (Cell)
Color coded antibodies (bioRxiv)
Endogenous retroviruses and inflammation (Cell)
CD8 T cells and vaccine protection against SARS-CoV-2 (Sci Immunol)
Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Immune 62: Every cell is an immune cell with De'Broski Herbert Dec 02, 2022

Show notes

De'Broski joins immune to reveal his remarkable career path and the research of his laboratory on neuroimmunology and the immune response to parasite infections.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

Guests D'Broski Herbert

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Links for this episode

Immunology of helminth infections (Ann Rev Immunology)
Neuroimmune regulatory networks (J Leuk Biol)
Every cell is an immune cell (Immunity)
Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Immune 61: Training immune cells with Julia Bohannon and Musa Mhlanga Nov 08, 2022

Show notes

From SLB22 on the Island of Hawai'i, Julia and Musa join Immune to reveal their remarkable career paths, and their research on understanding trained innate immunity.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

Guests: Julia Bohannon and Musa Mhlanga

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From the ashes (Richmond Register)
Innate immune memory (J Immunol)
Epigenetics and metabolism in trained immunity (Immunity)
Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Immune 60: Immunoeducation with Sumali Pandey and Phil Mixter Sep 22, 2022

Show notes

Somali and Phil join Immune to discuss their approaches to immunology education.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

Guest: Sumali Pandey and Phil Mixter

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Links for this episode

ImmunoReach
ASMCUE: ASM Conference for Undergraduate Educators (ASMCUE)
Upcoming ASM Webinars: free Microedu Live! discussions:
- Friday, October 14, 1:00 PM Eastern time/10:00 AM Pacific time, topic will be the assessment of learning. Register here .
- Friday, November 4, 1:00 PM Eastern time/10:00 AM Pacific time, topic will be microbiology laboratory biosafety. Register here.
Journals with relevant education resources:
- AAI ImmunoHorizons ImmunoHorizons
- Journal of Microbiology and Biology Education (ASM; open-source, see Tips & Tools for examples):Journal of Microbiology & Biology Education Table of Contents Volume 23, Issue 2 (asm.org)
- CBE Life Sciences Education CBE–Life Sciences Education (LSE) (lifescied.org)
How to tell your professional story effectively – for instruction-focused scientists (including external review): Initiative: External Peer Review of Teaching – The Teaching Academy of the Consortium of West Region Colleges of Veterinary Medicine (westregioncvm.org)
ASM Carski Award for Educators: ASM Carski Award for Undergraduate Education
Undergraduate degree program in Immunology at University of Alabama-Birmingham (only one in the USA): CAS – Undergraduate Immunology Program | UAB
3D printable antibody-antigen epitope models Antibody Epitope teaching kit by esuchman – Thingiverse
Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Immune 59: Forks in the road: Th17 cells with Mandy McGeachy Aug 19, 2022

Show notes

At Cornell University in Ithaca, NY, Mandy joins Immune to discuss her career and her research on understanding how Th17 cells develop and are influenced to be 'good' or 'bad' in their function.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

Guest: Mandy McGeachy

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Links for this episode

Th17 cytokines in health and disease (Immunity)
Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Immune 58: Gut B cells awry in ulcerative colitis Aug 03, 2022

Show notes

Immune explains a study of three cohorts of patients with ulcerative colitis which finds major perturbations within the mucosal B cell compartment, highlighting a potential role for these cells in disease pathogenesis.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

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Gut B cell dysbiosis in ulcerative colitis (Nat Med)
Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Immune 57: Bacteria, the new cure for wounds? Jun 30, 2022

Show notes

Immune reviews data showing that in mice, skin bacteria activate keratinocytes to stimulate hair follicle regeneration and wound healing.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

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Bacteria induce skin regeneration via IL-1beta (Cell Host Microbe)
Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Immune 56: Flip flops on the thymic beach with Al Singer Jun 01, 2022

Show notes

Al Singer joins immune to discuss mice that have their T cell immune system reversed, revealing the molecular basis for T cell lineage fate determination in the thymus.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

Guest: Al Singer

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T cell FlipFlop mice reveal lineage determination (Nat Immunol)
Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Immune 55: Cells that suck at their job May 03, 2022

Show notes

Immune reveals a CD8+ regulatory subset of T cell subset that suppress pathogenic T cells and are active in autoimmune diseases and infectious diseases including COVID-19.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune!

Links for this episode

KIR+CD8+ regulatory T cells (Science)
Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

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