Immune

Latest Episodes:

Immune 44: Got IgA on the brain May 17, 2021

Show notes

On this episode of Immune, IgA-producing plasma cells mobilized from the gut play an unexpected role in suppressing neuroinflammation.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

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Intestinal IgA regulates neuroinflammation (Cell)
Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Immune 43: CAR-NK and CAR-MAC, thinking outside the CAR-T cell box Mar 24, 2021

Show notes

On this episode of Immune, Cindy provides an update on CAR-T cell therapy of cancers and introduces two new approaches that utilize NK cells and macrophages and their use in treating solid tumors.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

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CAR-T cell therapy on Immune 4
Recent CAR-T cell advances (Nat Rev Cancer)
Status of CAR-T cell therapy (CancerConnect)
CAR-MAC for cancer (Nat Biotech)
CAR-MAC for COVID-19 (bioRxiv)
Letters read on Immune 43
Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Immune 42: Evolution of SARS-CoV-2 antibody immunity with Christian Gaebler Feb 13, 2021

Show notes

Christian joins Immune to discuss the humoral memory response in a cohort of 87 individuals 1.3 and 6.2 months after infection with SARS-CoV-2.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guest: Christian Gaebler

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Evolution of antibody immunity to SARS-CoV-2 (Nature)
Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Immune 41: Zebrafish immunology with Madina Wane Jan 25, 2021

Show notes

Madina joins Immune to explain how the immune system of zebrafish gills compares to its functional counterpart in mammals, the lungs, and to discuss a zebrafish model for understanding olfactory loss during COVID-19.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guest: Madina Wane

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Black in Immuno (YouTube)
Cytokines and gill homeostasis (J Immune)
Zebrafish model of COVID-19 olfactory loss (bioRxiv)
Overview of fish vaccination (pdf)
Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Immune 40: COVID-19 nuances Dec 30, 2020

Show notes

Immune reminisces about a year in COVID-19 immunology, Steph's receiving the Pfizer vaccine, and answers to listener questions about a challenge study with common cold CoVs, T cell exhaustion, how CD4 T cells control infections, and more.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

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Immune response during common cold CoV infection (Epidem Infect)
Summary of diagnostic tests (NAS)
Letters read on Immune 40
Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Immune 39: A Tonka Truck full of salt Dec 01, 2020

Show notes

Immune catches up on COVID listener email, including discussions about long-term COVID, cross-reactive memory to SARS-CoV-2, common mucosal surfaces, the risky business of peptide mega-pools, immunodominant epitopes and much more.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

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Reflections of a COVID-19 long hauler (JAMA)
Not a cytokine storm in COVID-19 (JCIO)
Letters read on Immune 39
Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Immune 38: COVID-19 and kids with Sallie Permar Nov 28, 2020

Show notes

Sallie joins Immune to discuss her career, emphasizing the importance of a good mentor and the ability to pivot, and her research, which has focused on mother to child transmission of infectious diseases including HIV/AIDS, CMV, and more recently, COVID-19/SARS-CoV-2.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guest: Sallie Permar

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Immune correlates of protection against CMV (J Inf Dis)
Placental IgG transfer in HIV-1-infected women (Cell)
Immunization leads to HIV-1 antibody in breast milk (J Virology)
Lessons from COVID-19 in children (Clin Inf Dis)
Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Immune 37: Black in Immuno Nov 16, 2020

Show notes

Alexis, Joel, Elaine, Justine, and Evonne join Immune to discuss their careers, their research, and a platform created by a collective of Black immunologists and allies aimed at amplifying, celebrating and supporting Black voices in immunology.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guests: Alexis Mobley, Joel Babdor, Elaine Kouame, Justine Noel, Evonne Jean

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Black in Immuno
Black in Immuno week schedule
Systemic racism in higher education (Science)
Black in Microbiology (TWiM 228)
Black in Virology (TWiV 672)
Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Immune 36: Aberrant immunity in COVID-19 Oct 21, 2020

Show notes

Immune describes the striking loss of germinal centers in lymph nodes and spleen in patients with severe COVID-19, providing an explanation for short-lived humoral immunity and limited somatic hypermutation of antibodies to SARS-CoV-2.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guest: Alexander Dent

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Loss of germinal centers in severe COVID-19 patients (Cell)
Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Immune 35: SARS-CoV-2 antibodies Sep 23, 2020

Show notes

Immune examines antibodies to SARS-CoV-2, including the relationship between severe COVID-19 and anti-spike antibodies, kinetics of production, and correlates of protection among coronaviruses.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

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Links for this episode