Immune

Latest Episodes:

Immune 75: Ang Cui unveils the cytokine symphony Dec 28, 2023

Show notes

Ang Cui joins Immune to discuss her career and her work on establishing the Immune Dictionary, a compendium of single-cell transcriptomic profiles of more than 17 immune cell types in response to each of 86 cytokines (>1,400 cytokine-cell type combinations) in mouse lymph nodes in vivo.

Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker

Guest: Ang Cui

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Publishing is broken (Solving for Science)
Immune Dictionary (Nature)
Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Immune 74: Germinal center dynamics with Carla Nowosad Dec 11, 2023

Show notes

Carla Nowosad joins Immune to discuss her career and her work on germinal centers, the structure in secondary lymphoid tissues where B cells proliferate, differentiate, and diversify their immunoglobulin genes by somatic hypermutation.

Hosts: Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guest: Carla R. Nowosad

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B cells and the intestinal microbiome (Sem Immunol)
B cell selection in gut germinal centres (Nature)
B cell antigen internalization (Methods Mol Biol)
Immune synapse architecture (Nat Immunol)
Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Immune 73: Big macs Nov 08, 2023

Show notes

Immune reveals the total mass (1.2kg), number (1.8 trillion), and distribution of immune cells in the human body, with macrophages contributing nearly 50% of the total cellular mass.

Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker

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Immune cells in the human body (PNAS)
Letters read on Immune 73
Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Immune 72: After dark in the library with Ellen Rothenberg Sep 23, 2023

Show notes

From Cornell University in Ithaca New York, Vincent and Cindy meet with Ellen Rothenberg to review her career in science, starting with work on retroviruses to unraveling transcriptional networks underlying T-cell development and signaling.

Hosts: Vincent Racaniello and Cynthia Leifer

Guest: Ellen Rothenberg

Click arrow to play Download Immune 72 (53 MB .mp3, 73 min) Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune!

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Synthesis of infectious DNA of murine leukaemia virus (Nature)
Runx factors launch T cell and innate lymphoid programs (Nat Immunol)
Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Immune 71: Can parasitic worms prevent pandemics? Sep 08, 2023

Show notes

Immune explains how, in a mouse model of roundworm infection with Nippostrongylus brasiliensis, exposure to lung-migrating helminths protects mice against SARS-CoV-2 infection.

Hosts: Cynthia Leifer, Stephanie Langel, and Brianne Barker

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Helminth protects against murine SARS-CoV-2 infection (Sci Immunol)
Pandemic spared Africa (ScienceInsider)
Letters read on Immune 71
Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Immune 70: Immunology of picky eating Jul 26, 2023

Show notes

Immune explains how mast cells, IgE antibody, and the brain collaborate to promote avoidance of certain foods to evade allergic responses.

Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker

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Mast cells and immune avoidance behavior (Nature)
Immune sensing of food allergens promotes avoidance (Nature)
Immunology that underlies picky eating (Nature)
Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Immune 68: Sins and blessings of immunity May 18, 2023

Show notes

Immune discusses immunological imprinting, also called original antigenic sin, in the context of infection with SARS-CoV-2 and influenza virus.

Hosts: Vincent Racaniello, Cynthia Leifer, and Steph Langel

Download Immune 66 (45 MB .mp3, 76 min) Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune!

Links for this episode

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Immunological imprinting (Immunity)
COVID-19 vaccine imprinting (bioRxiv)
Original antigenic sin (J Inf Dis)
Are competition (LJII)
Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

Immune 67: Can T cells live forever? May 03, 2023

Show notes

Immune explains the results of a study which show that in mice, functional T cells respond to vaccination for over 10 years and 51 successive immunizations, exhibiting supernumerary cell division and longevity.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

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T cells capable of supernumerary division (Nature)
Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Immune 66: COVID-19 immune memory - what you need to know Apr 04, 2023

Show notes

Immune discusses the current understanding of immune memory to SARS-CoV-2 infection and COVID-19 vaccines, which supersedes that of any other acute infectious disease.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

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Links for this episode

MicrobeTV Discord Server
COVID-19 immune memory (Imm Rev)
Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Immune 65: Infection infidelities with Jonathan Kagan Feb 20, 2023

Show notes

Jon joins Immune to discuss the research of his laboratory on understanding how the innate immune system recognizes and responds to pathogens, and his hypothesis that infection infidelities drive innate immunity.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

Guest: Jonathan C. Kagan

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Links for this episode