This Week in Virology

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TWiV 511: Accessory found guilty in DC Sep 16, 2018

Show notes

Ned Landau joins the TWiV team to discuss restriction of HIV replication by SAMHD1, and a viral antagonist that can be used to produce a dendritic cell vaccine.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guest: Ned Landau

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Links for this episode

Support Viruses Gordon Conference
TWiV #124 September 2008
SAMHD1 restricts HIV-1 replication (Nature)
SAMHD1 restricts diverse retroviruses (Retrovirology)
Vpx degradation of SAMHD1 independent of uncoating (J Virol)
Transduction of myeloid cells with Vpx vector (Gene Ther)
Letters read on TWiV 511
Timestamps by Jolene. Thanks!

Weekly Science Picks

Brianne- Online Immunology Course Alan- Bacteria Builder Rich- 2018 Ig Nobel Prizes Dickson- Between Fear and Hope Ned - HUSH silencing of transposons Vincent - Paywall publishing ban (Schlitz statement); Curry on DORA

Listener Pick

Steve- Paywall: Business of Scholarship and Biohazard Islam- Peer review Twitter post

Intro music is by Ronald Jenkees.

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TWiV 510: Retroviruses at Cold Spring Harbor Sep 09, 2018

Show notes

Vincent and Dickson travel to the 44th Retrovirus meeting at Cold Spring Harbor Laboratories, where they speak with John Coffin, Stephen Hughes, Ya-Chi Ho, and Matt Takata about the meeting and their work on HIV-1.

Hosts: Vincent Racaniello and Dickson Despommier

Guests: John Coffin, Stephen Hughes, Ya-Chi Ho, and Matt Takata

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Links for this episode

Cold Spring Harbor Retrovirus Meeting 2018
Retroviruses and cranberries (TWiV 320)
Identical proviruses in HIV-1 reservoir (PLoS Path)
Measuring HIV-1 latency (PNAS)
CG dinucleotide suppression is host defense (Nature)
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 509: 41,103 bases under the sea Sep 02, 2018

Show notes

The TWiV team considers whether those who can do, can't teach, and newly discovered viruses of planarians and Aplysia with the largest RNA genomes.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler and Brianne Barker

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Links for this episode

Support Viruses Gordon Conference
KNAW Beijerinck Prize
Bioterrorism and Biocrimes by Seth Carus (free pdf)
History of Biological Warfare by Seth Carus (free)
Those Who Can Do, Can't Teach (NYTimes)
Planarian nidovirus (bioRxiv)
Aplysia nidovirus (bioRxiv)
Image credit
Letters readon TWiV 509

Weekly Science Picks

Brianne- Climate change visualization Alan- Anova sous vide cooker Dickson- Fire season in western US Kathy- Sunscreen in UV and The Projector Illusion Vincent - The Usefulness of Useless Knowledge

Listener Pick

River- The Conscience of the Present

Intro music is by Ronald Jenkees.

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TWiV 508: Bioweapon Aug 26, 2018

Show notes

Jens returns to present a brief history of bioweapons, with a focus on the program in the Soviet Union, the largest ever undertaken, and his experience working in the decommissioned Soviet bioweapons laboratory known as Vector.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler

Guest: Jens Kuhn

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Links for this episode

Russia's Bioweapons Labs (Nature)
Medical Aspects of Biological Warfare
The Soviet Biological Weapons Program by Leitenberg, Zilinskas, Kuhn
Biological Threats in the 21st Century by Lentzos
Bioterrorism and Biocrimes by W. Seth Carus
Russia's Secret Weapons (Nature)
Image credit

Weekly Science Picks

Jens - Nudibranchs, Beastly Garden, large nidovirus (one, two) Rich - Living inside a canister Dickson - Global rivers and streamsKathy - TWiM 181 Dr. Warhol's Periodic Table of Microbes Vincent - Twitter Bots and Russian Trolls Amplify Vaccine Debate

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 507: The fusion of form and function Aug 19, 2018

Show notes

The TWiV team discuss the biology of Ebola viruses, and how localization of the membrane proteins of vaccinia virus drive function: the fusion machinery sits at the tips of virions, and binding proteins are at the sides.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

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Links for this episode

Support Viruses & Cells Gordon Conference
Outbreak at the Smithsonian
Outbreak (TWiV 501)
Latest Ebola virus outbreak, DRC (WHO)
Summary of Ebola virus outbreaks (CDC)
Ebola virus nomenclature (ICTV)
Ebola virus distribution map (CDC)
Polarization of vaccinia virus membrane proteins (bioRxiv)
Image credit
Letters read on TWiV 507

Weekly Science Picks

Alan - Puzzled Escape Games Rich - An Extremely Detailed Map of the 2016 Election Dickson - Parker Solar ProbeKathy - Ancient earth globe and connected Dinosaur database Brianne - STEMM education should get HACD Vincent - Free tuition for all NYU medical students

Listener Pick

Heather- GoFarm blog

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV Special: David Tuller is PACEman Aug 17, 2018

Show notes

David Tuller returns to provide an update of his investigative work to expose the methodological and ethical problems with the PACE trial for ME/CFS.

Host: Vincent Racaniello

Guest: David Tuller

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Links for this episode

Articleby Lubet and Tuller (STAT)
David's Australian trip (virology blog)
Sir Simon scores own goal (virology blog)
Lightning process (virology blog)
Letter to Parliament (virology blog)
Crowdfunding is not conflict of interest (virology blog)
Open letter to Lancet 3.0 (virology blog)
Mayo still champions GET (virology blog)
Image Credit

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 506: A Cafeteria full of jelly rolls Aug 12, 2018

Show notes

The TWiVniks explain how the three-dimensional structure of the giant Cafeteria roenbergensis virus suggests a new mode of assembly, and the apparent elimination of dengue fever in an Australian city by release of mosquitoes harboring Wolbachia.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker

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Links for this episode

Support Viruses & Cells Gordon Conference
New DRC Ebola strains distinct (Outbreak News)
Immunizations for new DRC Ebola outbreak (The Scientist)
Structure of Cafeteria roenbergensis virus (Sci Rep)
Chuan (River) Xiao laboratory
CroV movies
Scaled deployment of Wolbachia(Gates Open Res)
In the wake of Wakefield (BBC)
Letters read on TWiV 506

Weekly Science Picks

Alan - Ebola research begins at the NEIDL Dickson - Science Photo Library Brianne - First liquid water (underground lake) found on Mars Vincent - Thirty years ago, we could have saved the planet

Listener Pick

Edmund- STEM talk

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 505: Rosebola Aug 05, 2018

Show notes

The TWiV hosts review persistence of Ebola virus after the end of the Liberian outbreak, and the potential role of two herpesviruses in the pathogenesis of Alzheimer's disease.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker

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Links for this episode

Support Viruses & Cells Gordon Conference
Trump picks science advisor (Scientist)
Hendra vaccine: no effect on horses racing (Aust Vet J)
Persistence of Ebola virus (Lancet Inf Dis)
New Ebolavirus outbreak (Telegraph)
Alzheimer's disease and herpesviruses (Neuron)
Herpesviruses, beta-amyloid and Alzheimer's disease (Neuron)
Letters read on TWiV 505

Weekly Science Picks

Alan - Impossible Burger Rich - SpaceX Just Sent Algae to the ISS, Here's How It'll Power Deep Space Missions Dickson - Art and Science Intersection (Art Science Museum) Brianne - Why it is not a 'failure' to leave academia Kathy- 2003 video history of nuclear explosions 1945 - 1998 Vincent - Revisionist History Episode 8 and Episode 9

Listener Pick

Mark- TWIV bingo (png)

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 504: Flying foxes and barking pigs Jul 29, 2018

Show notes

The TWiVerinos discuss Nipah virus and the recent outbreak in India, and the first cast of polio in Papua New Guinea in 18 years.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

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Links for this episode

Support Viruses & Cells Gordon Conference
TWiV 501: Outbreak
Nipah virus infection (JCM)
Anatomy of an outbreak (The Hindu)
Do we need to worry about Nipah virus? (Tufts Now)
Nipah virus infection of bats (EID)
Papua New Guinea no longer polio-free (virology blog)
WHO polio endgame (polioeradication)
Letters read on TWiV 504

Weekly Science Picks

Alan - Glaciers of the Rockies aerial photos Rich - SpaceX CRS-15 mission to the space station(wiki) Dickson - Test of Einstein's theory of relativity Brianne - biorender Vincent - True or False? with Michael Schmidt

Listener Pick

Jolene- Dogs cannot get autism

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 503: The greening of TWiV Jul 22, 2018

Show notes

Vincent, Rich and Kathy travel to ASV 2018 at the University of Maryland to speak with Svetlana Folimonova and Anne Simon about their work on viruses that infect plants.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

Guests: Svetlana Folimonova and Anne Simon

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Links for this episode