This Week in Virology

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TWiV 530: Quiet please! Jan 13, 2019

Show notes

Steve Goff returns to TWiV to discuss the work of his laboratory on how retroviral genomes are silenced in infected cells.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler

Guest: Steve Goff

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🎼 They'll histone you when you start to transcribe, And they'll histone you just for tryin' to get by, So be careful when you uncoat your genome, 'Cause everybody must histone.

Links for this episode

Please take the TWiV listener survey
ASV 2019
European Congress of Virology 2019
Histones loaded onto incoming retroviral DNA (Cell Host Micr)
NP220 and silencing of incoming retroviral DNA (Nature)
HIV-1 and HUSH (TWiV 516)
TWiV World Tour 2018 t-shirt
Timestamps by Jolene. Thanks!

Weekly Science Picks

Alan - The Tangled Tree by David Quammen Dickson- Ammonia could power the globe Kathy- Portmanteaux and A.Word.A.Day Vincent - Curioscity Steve- Alice and Bob Meet the Wall of Fire

Listener Pick

Chaim- Tony Fauci on getting your flu vaccine (mp3)

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 529: Rueckert Road Jan 08, 2019

Show notes

At the University of Wisconsin-Madison, Vincent meets up with one of his virology heroes, Roland R. Rueckert, to talk about his research and his second career as a forest manager.

Host: Vincent Racaniello

Guest: Roland R. Rueckert

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Links for this episode

Video of this episode (YouTube)
Roland's first paper (Anesthesiol)
Purification of phiX174 (Virology)
Studies on viral structure (Virology)
Automated gel fractionator (Anal Bioch)
Picornaviral gene order (J Virol)
Picornavirus protease discovery (J Virol)
Poliovirus processing map (J Virol)
Nomenclature of picornavirus proteins (J Virol)
Black beetle virus (J Virol)
Rhinovirus crystallization (PNAS)
Mapping mAb binding sites (J Virol)
Replication of animal virus in yeast (PNAS)
Roland's last paper (J Virol)
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 528: Our annual recapsidation Jan 06, 2019

Show notes

In the first episode for 2019, the TWiV team reviews the amazing virology stories of the past year.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

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Links for this episode

Please take the TWiV listener survey
ASV 2019 Satellite Symposia
Crowdfunding for EV-D68 research
TWiV World Tour 2018 t-shirt (Amazon)
Cool virology from 2018
- Viruses behind AD? TWiV 505, TWiV 519, clinical trial one and two
- Wolbachia-mosquito release halts dengue (TWiV 506); World Mosquito Program
- Evolutionary history of RNA viruses: TWiV 491 and TWiV 526
- Horsepox as ancestral smallpox vaccine, including synthesis: TWiV 478
- Ebola continues: TWiV 494, TWiV 495, TWiV 505, TWiV 507, TWiV 515, TWiV 482
- Clues to many mysteries: TWiV 481, TWiV 484, TWiV 493, TWiV 515, TWiV 522
- Pro-vaccination: TWiV 500, TWiV 496, TWiV Special; measles in Ukraineand Europe
- Outbreak influence: TWiV 501, TWiV 527, TWiV 520, TWiV 507, TWiV 504
- Insect viruses and immunity: TWiV 525, TWiV 524, TWiV 522, TWiV 495, TWiV 485, TWiV 482, TWiV 479
- Big RNA virus genomes (TWiV 509) and Giant viruses: TWiV 490, TWiV 506, TWiV 521, TWiV 484
Letters read on TWiV 528
Timestamps by Jolene. Thanks!

Weekly Science Picks

Alan - Pandemic Trail game Rich- On a Bat's Wing and a Prayer Dickson- Decoding Watson Kathy- Phenotypic variation in outbred and inbred mice Vincent - Trump County Confronts the Administration Amid Rash of Child Cancers

Listener Pick

Anne- Peter Hotez interview Islam- Letter from Crick to Watson (pdf)

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 527: City mouse, country mouse Dec 30, 2018

Show notes

The TWiV team summarizes the discovery of Sin Nombre virus, and presents evidence that neurotropic flaviviruses can cause intestinal dysmotility syndromes after systemic infection of mice.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

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Links for this episode

Please take the TWiV listener survey
ASV 2019 Satellite Symposia
Crowdfunding for EV-D68 research
Outbreak (exhibit, TWiV 501)
Four Corners hantavirus outbreak (Wikipedia)
Death at the Corner (Atlantic)
Hantavirus infection by US state (CDC)
Hantavirus US cases and mortality (CDC)
Hantavirus international cases (CDC)
Belmont hantavirus death (NYTimes)
Intestinal dysmotility following flavivirus infection of mice (Cell)
Image credit
Letters read on TWiV 527
Timestamps by Jolene. Thanks!

Weekly Science Picks

Alan - Zooming into Sagittarius A, ESO video Rich- Orbits and Ice Ages: A History of Climate Dickson- National Geographic Best Photos 2018 Kathy- HealthMap Vaccine Finder Vincent - Taylor Custom

Listener Pick

Neal- The Yoda of Silicon Valley

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 526: In the beginning there was pol Dec 23, 2018

Show notes

The TWiV hosts discuss the distribution of prions in the eyes of patients with sporadic Creutzfeldt-Jacob disease, and the origins and evolution of RNA viruses.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler

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Links for this episode

Please take the TWiV listener survey
ASV 2019 Satellite Symposia
Crowdfunding for EV-D68 research
Aaron Klug, 1926-2018 (Nature)
Prions in sCJD eyes (mBio)
Evolution of RNA viruses (mBio)
Walter Gilbert's The RNA World (Nature)
Image credit
Letters read on TWiV 526
Timestamps by Jolene. Thanks!

Weekly Science Picks

Alan - Population mountains to visualize cities Rich- A Neanderthal Perspective on Human Origins with Svante Pääbo Kathy- NASA Space Mission posters Vincent - Package Thief vs Glitter Bomb Trap

Listener Pick

Neal- Was a Scientist Jailed?

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV Special: Vaccines Did Not Cause Rachel's Autism Dec 19, 2018

Show notes

Vaccine scientist, pediatrician, and autism dad Peter Hotez talks about his new book, Vaccines Did Not Cause Rachel's Autism.

Host: Vincent Racaniello

Guest: Peter Hotez

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Links for this episode

Peter Hotez at Baylor College of Medicine
Peter Hotez on Twitter
Vaccines Did Not Cause Rachel's Autism (Amazon)
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 525: The A Bee Cs of bee viruses Dec 16, 2018

Show notes

Michelle Flenniken joins TWiV to talk about honeybees and the work of her laboratory on honeybee viruses.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Michelle Flenniken

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Links for this episode

MSU Pollinator Health Center
Honeybee antiviral defenses (Sci Rep)
The buzz about honeybee viruses (PLoS Path)
Recently identified bee viruses (Curr Op Insect Sci)
Videos on honey bee researchat MSU, honey bee pathogens, honey bee pathogen detection (YouTube)
Timestamps by Jolene. Thanks!

Weekly Science Picks

Michelle - First 21 days of a bee's life; NPR's Hidden Brain; Varroa destructor triggers deformed wing virus in bees Brianne - Flu Near You Alan - Skype a Scientist program Rich- NASA's Voyager 2 Probe Enters Interstellar Space Kathy- Which ones are bees? And What it feels like to be a bee Vincent - Fecal sequencing and Vaccines did not cause Rachel's autism by Peter Hotez

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 524: Slicing and dicing with Raul Dec 12, 2018

Show notes

Raul Andino joins Vincent and Amy to talk about the finding that a cricket paralysis virus protein restricts RNA-based immunity in insects by regulating the activity and stability of the Argonaute protein.

Hosts: Vincent Racaniello and Amy Rosenfeld

Guest: Raul Andino

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Links for this episode

TWiV 138: RISCy business with Raul Andino
TWiV 33: Live in Philly
Viral protein restricts insect immunity (Cell Host Micr)
Timestamps by Jolene. Thanks!

Weekly Science Picks

Amy - Insectropolis Vincent- Genome-edited baby

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 523: Virology in Zürich Dec 09, 2018

Show notes

At the University of Zürich, Vincent speaks with virologists Cornel Fraefel, Urs Greber, and Silke Stertz about their careers and their work on AAV2, adenovirus entry, and influenza virus.

Hosts: Vincent Racaniello

Guests: Cornel Fraefel, Urs Greber, and Silke Stertz

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Links for this episode

AAV2 and HSV1 co-infections (J Virol)
Movies of HeLa Fucci cells (J Virol)
Cathepsin W and influenza virus entry (mBio)
Plaque 2.0 (PLoS One)
Video of this episode (YouTube)
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 522: Readers of the lost ORF Dec 02, 2018

Show notes

The TWiVsters review isolation of a naturally occurring DNA virus from fruit flies, and the cell-type specific function of a small transmembrane protein encoded in an open reading frame upstream of the enterovirus polyprotein.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler

Subscribe (free): iTunes, Google Podcasts, RSS, email

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Links for this episode