This Week in Virology

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TWiV 521: Spitting in the Allee Nov 25, 2018

Show notes

Team TWiV cover the discovery of another giant virus from 30,000 year old Siberian permafrost, and how viral aggregation accelerates the production of new infectious viruses and increases fitness, demonstrating an Allee effect.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker

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Links for this episode

PhD and postdoctoral programs at Dept of Microbiology, Icahn School of Medicine at Mount Sinai
30,000 year old Mollivirus sibericum (PNAS)
Aggregating viruses promotes early replication (Curr Biol)
Letters read on TWiV 521
Timestamps by Jolene. Thanks!

Weekly Science Picks

Brianne - Why don't we have vaccines against everything? Rich- Golden Globe Race Dickson- The Anatomy of Figure Drawingby Robert Demarest and Warder Clyde Allee Kathy- Orientation of the moon's appearance, Southern Hemisphere Vincent - Paul has Measles in English and Spanish

Intro music is by Ronald Jenkees.

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TWiV 520: This old mouse Nov 18, 2018

Show notes

The TWiVidae review universal influenza vaccines that are in clinical trials, and discovery of an atypical parvovirus that causes chronic kidney disease in middle aged, immunocompromised laboratory mice.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

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Links for this episode

PhD and postdoctoral programs at Dept of Microbiology, Icahn School of Medicine at Mount Sinai
MSc program Molecular Biology and Pathology of Viruses, Univ College London
Virology Comics on sale (Amazon)
Outbreak at the Smithsonian
NIAID strategic plan for universal influenza vaccine
Fauci article on universal influenza vaccine (J Inf Dis)
Severe 2017-18 flu season (CDC)
Progress on universal influenza vaccine (The Scientist)
Influenza vaccine is safe for those with egg allergies
Atypical parvovirusdrives mouse kidney disease (Cell)
Contagious Thinking: Visible Viruses AR app
Letters read on TWiV 520
Timestamps by Jolene. Thanks!

Weekly Science Picks 1:17:24

Brianne - Nebula Genomics: a new start-up offering free genome sequencing (with a catch) Alan- GRE scores are poor predictorof degree completion Rich- The Science Mill(video) Dickson- The 12 cranial nerves (mnemonic) Kathy- NAS report on Sexual Harassment of Women (free pdf) Iceberg figure Vincent - The Tangled Tree by David Quammen and TWiEVO #37

Listener Pick

Mark- Weekly US Map: Influenza Summary

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 519: Fishing for viruses in senile Nov 11, 2018

Show notes

The TWiVomers review a potential role for herpes simplex virus type 1 as a cause of Alzheimer's Disease, including the finding that amyloid-beta acts as an antiviral by enveloping virus particles.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

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Links for this episode

Virology Comics on sale (Amazon)
Clinical Trial: antiviral for AD
HHV6 and HHV7 transcripts in AD brain (TWiV 505)
HSV1 in AD (Front Ag Neuro)
Taiwan cohort study on antivirals and AD (Neurother)
HSV1 antibodies in CSF (J Med Virol)
HSV1 induces amyloid-beta fibrillization (Neuron)
Image credit
Letters read on TWiV 519
Timestamps by Jolene. Thanks!

Weekly Science Picks

Brianne - Pandemic (board game) Alan- The Shortwave Radio Audio Archive (siteand blog) Rich- James Cook's First Pacific Voyage, 1768-1771 (interactive map) Dickson- The Scientist on Instagram Vincent - State of the World's Fungi

Listener Pick

David- Bruno LaTour

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 518: Hershey's viruses Nov 04, 2018

Show notes

Vincent travels to Penn State College of Medicine in Hershey, PA to speak with Nick and Leslie about their careers and their work on human cytomegalovirus and retroviruses.

Host: Vincent Racaniello

Guests: Nicholas Buchkovich and Leslie Parent

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Links for this episode

HIV-1 gag membrane binding domain (J Virol)
Nuclear experience for gag (PNAS)
Gag in nucleolus (J Virol)
YB-1 for retrovirus assembly (J Virol)
HCMV controls BiP levels (J Virol)
HCMV regulates La (J Virol)
Inhibition of HCMV by modulating syntaxin 5 (J Virol)
Non-envelopment role for ESCRT-III during HCMV infection (J Virol)
Late retroviral budding function (J Virol)
Grit by Angela Duckworth
The Scientists by John Gribbin
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 517: Just in time for Halloween Oct 28, 2018

Show notes

Brianne and Vincent tackle two studies that utilize infectious viruses to examine zoonotic potential of Bombali virus, a new ebolavirus from an insectivorous species in Sierra Leone, and a human mumps-like virus from an African flying fox in DRC.

Hosts: Vincent Racaniello and Brianne Barker

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Links for this episode

Pan American Society for Clinical Virology San Diego and Houston Regional Meetings
It's not SARS 2.0 (TWiV 364)
Bats out of hell (TWiV 183)
Bombali virus, a new Ebolavirus (Nat Micro)
Asymptomatic Ebolavirus infections (virology blog)
Bat-borne mumps virus (Cell Rep)
Image credit
Letters read on TWiV 517
Timestamps by Jolene. Thanks!

Weekly Science Picks

Brianne - Ed Yong on AFM Vincent - Goggles Optional podcast (especially #243)

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 516: HUSH little virus, don't you transcribe Oct 21, 2018

Show notes

Lonya and Jeremy take the TWiV team beTWIXt primate immunodeficiency virus proteins Vpx and Vpr and how they counteract transcriptional repression of proviruses by the HUSH complex.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker

Guests: Leonid Yorkovetskiy and Jeremy Luban

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Links for this episode

Pan American Society for Clinical Virology San Diego and Houston Regional Meetings
Vpr and Vpx counter HUSH (Nat Micro)
Vpr and Vpx counter HUSH (bioRxiv version)
Schematic of HUSH complex (Lehner lab)
Olive colobus monkey sound credit
Image credit: William (Ted) Diehl
Letters read on TWiV 516
Timestamps by Jolene. Thanks!

Weekly Science Picks

Brianne - The Chimp and the River by David Quammen Rich- James Cook's First Voyage Journal (20 sec Google Earth summary) Kathy- High resolution Antarctica map NYTimes 46MB Maps (more info and 43 tb maps) Dickson- Jellyfish Jeremy - Pictorial Guide to Living Primates; All The World's PrimatesLonya- Chougui et al. HIV-2/SIV Vpx counters HUSH Vincent - Research!America

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 515: When virus is in retrograde Oct 14, 2018

Show notes

The TWiV team notes the passing of Tom Steitz, an outbreak of acute flaccid myelitis in the US, a continuing Ebola virus outbreak in DRC, respiratory vaccinia due to inhalation of ground up rabbit skin, and how a human papillomavirus capsid protein directs virus-containing endosomes towards the nucleus.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker

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Links for this episode

Sea Phages program and application materials
Tom Steitz, 78 (NY Times)
AFM outbreak, US (CIDRAP)
AFM surveillance (CDC)
Acute Flaccid Paralysis and Enteroviral Infections (Curr Inf Dis Rep)
EV-D68 neurotropism (bioRxiv)
Ebola virus outbreakcontinues in DRC (CIDRAP)
Vaccinia virus respiratory infection (Int J Inf Dis)
HPV L2 penetrates endosome, brings virus retro (Cell)
Letters read on TWiV 515
Timestamps by Jolene. Thanks!

Weekly Science Picks

Brianne - Germ City-Microbes and the Metropolis Museum Exhibition Alan- Nikon 2018 Small World in Motion competition Kathy- Ion Torrent Sequencing (video) Dickson- 2018 Nobel Prizes Economics Kathy- Ocean-centric map Vincent - Intelligence Matters Podcast: Anthony Fauci on threats from epidemics

Listener Picks

Gonsalo - Cells at Work (Manga, Anime)

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 514: Staying below the ADAR Oct 07, 2018

Show notes

The TWiVumvirate reviews this years crop of Nobel Prizes, and how cells prevent leakage of mitochondrial double-stranded RNA into the cytoplasm, which would otherwise lead to the production of interferon.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler

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Links for this episode

Sea Phages program and application materials
Plant biologists penalized by CNRS (The Scientist)
2018 Nobel Prize in Medicine (pdf)
2018 Nobel Prize in Chemistry (pdf)
2018 Nobel Prize in Physics (pdf)
2018 Nobel Peace Prize (Nobel)
Mitochondrial dsRNA triggers IFN (Nature)
Letters read on TWiV 514
Timestamps by Jolene. Thanks!

Weekly Science Picks 1:28:33

Alan- Compound Interest chemistry graphics Kathy- Writing letters of recommendation Guidelines Trix & Psenka Schmader et al. Madera et al. Dickson- Japan Fireworks Vincent - The Game of T-Cells and Apple Park Lego

Listener Picks

Steve - Shomu's Biology

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 513: Double-stranded in Belgium Sep 30, 2018

Show notes

From the 13th International Symposium on dsRNA viruses in Belgium, Vincent speaks with Harry Greenberg about his career and his work on rotaviruses, noroviruses, hepatitis B virus, and influenza virus.

Host: Vincent Racaniello

Guest: Harry Greenberg

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Links for this episode

13th dsRNA Virus Symposium
Hepatitisin blood donors (Lancet)
Interferon treatmentof hepatitis B (NEJM)
Mycoplasmamutantsin volunteers (PNAS)
Norwalk virus infectionof chimpanzees (J Med Virol)
Rotavirus rescueby reassortment (PNAS)
Cold-adaptedinfluenza vaccine (Virol)
Rotavirus correlates of protection(Curr Opin Virol)
Rotavirus vaccine and intussusception(NEJM)
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 512: Flexuous SUMO wrestlers Sep 23, 2018

Show notes

Anne Simon joins the TWiV team to talk about plant viruses, including plum pox virus that devastates nut and stone fruit trees, and a geminivirus protein that regulates viral DNA synthesis.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Brianne Barker, and Anne Simon

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