This Week in Virology

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TWiV 550: Covering up the shiny parts Jun 02, 2019

Show notes

TWiV explains the use of a neuronal cell line to study herpes simplex virus latency and reactivation, and a strategy for creating vaccines that induce antibodies against specific epitopes.

Hosts: Vincent Racaniello, Dickson Despommier,Alan Dove, Rich Condit, and Brianne Barker

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Links for this episode

Neuronal cell line supports herpes simplex virus latency (J Virol)
Protect, modify, deprotect (PNAS)
Timestamps by Jolene. Thanks!

Weekly Science Picks

Alan - Quabbin Reservoir Rich - Katherine Swan Ginsburg Humanism in Medicine Program; The Arnold P. Gold Foundation Brianne- UPitt Measles Simulator Dickson- James Webb Space Telescope Vincent- Nobel Prizes and Life Sciences by Erling Norrby

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 549: The church of protocadherin May 26, 2019

Show notes

Kartik and Rohit join the TWiV team to present their identification of protocadherin-1 as a cell receptor for New World hantaviruses.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

Guests: Kartik Chandran and Rohit Jangra

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Links for this episode

Einstein goes viral (TWiV 314)
Michael Rossmann, 88 (virology blog)
Protocadherin-1 essential for New World hantavirus entry (Nature)
Image credit
Timestamps by Jolene. Thanks!

This episode is sponsored by the 2019 Chem/Bio Defense Science and Technology Conference. Are you working on innovative research that can shape the future of chemical or biological defense? Submit your abstract and present your work to more than 1,500 leaders from government, academia and industry. Visit www.cbdstconference.comfor more details.

Weekly Science Picks

Alan - Temi and Trint Rich - Using Jupiter's moons to determine where on Earth you are Kathy- Best architecture in every state Vincent - Cyberwire Podcast: The Ghost and the Mole Kartik- Slack Rohit- Antibody responses to viral infections

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 548: Mice, shrews, and caterpillars May 19, 2019

Show notes

Vincent travels to the European Congress of Virology in Rotterdam and with local co-host Marion Koopmans speak with Martin Beer, Stephan Gunther, and Vera Ross about their careers and their work on Lassa virus, Borna virus, and insect viruses.

Hosts: Vincent Racanielloand Marion Koopmans

Guests: Martin Beer, Stephan Gunther, and Vera Ros

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Links for this episode

ECV2019
Partnerships not parachutes (TWiV 413)
Fatal Borna disease virus infection in transplant recipients (NEJM)
Sequencing of 2018 Lassa virus outbreak (Science)
Zombie caterpillar behavior (Parasitol)
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 547: Upstate virology May 12, 2019

Show notes

Vincent travels to the University at Albany to speak with Cara, Rachel, and Alex about their careers and their work on stress granules, epitranscriptomics, and arboviruses.

Host: Vincent Racaniello

Guests: Cara Pager, Rachel Netzband, and Alex Ciota

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Links for this episode

Five postdocs in North America (TWiV 194)
Zika virus subverts stress granules (J Virol)
DDX68 modulates miR-122 interaction with HCV RNA (Virol)
(+) RNA virus epitranscriptome (Nucl Acids Res)
Adaptation of Rabensburg virus to vertebrate hosts (Virol)
Effects of Zika virus strain and Aedes species on vector competence (Emerg Inf Dis)
Inter- and intra-host genetic variation of West Nile virus and fine-scale evolutionary pressures (Infect Genet Evol)
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 546: Delta blues and chitlins May 05, 2019

Show notes

The un-encapsidated TWiV Humans discuss finding hepatitis D virus-related sequences in birds and snakes, and fatal swine acute diarrhoea syndrome caused by a coronavirus of bat origin.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

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Links for this episode

European Virus Archive
ASV early bird registrationends 15 May
FDA approves Dengvaxia
Divergent hepatitis D-like agentin birds(Viruses)
Novel deltavirus in snakes(mBio)
SADS-coronavirusin piglets (Nature)
Hosts and sources of endemic human coronaviruses(Adv Virus Res)
Image credit
Letters readon TWiV 546
Timestamps by Jolene. Thanks!

Weekly Science Picks

Alan - Plots of Data visualization tool Rich - How to control the brain; Meet UF Physician Kelly Foote, MD Dickson- Oceanix Kathy- Iceproofing large structures Vincent - Neanderthal Man: In Search of Lost Genomes by Svante Paabo

Listener Pick

Johyne- NYTimes Mag Lab (sorry, no link) Sheena - History of Vaccines by NPR

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 545: Biocrimes and misdemeanors Apr 28, 2019

Show notes

Jens Kuhn returns to TWiV to explain Select Agents, Priority Pathogens, Australia List Pathogens, Risk Group Agents, biosafety, biosecurity, and biosurety.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker

Guest: Jens Kuhn

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Links for this episode

Bioweapon (TWiV 508)
Bioterrorism and Biocrimes by W. Seth Carus
Select Agents (selectagents.gov)
BMBL Manual 5th Edition (pdf)
Threading the NEIDL video (YouTube)
Timestamps by Jolene. Thanks!

Weekly Science Picks

Jens - Forvo pronunciation guide Brianne -How long do vaccines last? Alan- How much hotter is your home town than when you were born? Dickson- 50 Stunning Photos of Earth Vincent - Madness and Memory by Stanley Prusiner

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 544: Immunogaga Apr 21, 2019

Show notes

The TWiV team reveals the repertoire of anti-viral antibodies in newborn humans, and a complement protein that binds the adenovirus capsid and prevents release of the viral DNA.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Links for this episode

Maternal anti-viral antibodies in newborns (Nat Med)
Complement protein blocks adenovirus uncoating (Cell Host Micr)
Antibodies neutralize virus inside cells (virology blog)
Image credit
Letters read on TWiV 544
Timestamps by Jolene. Thanks!

Weekly Science Picks

Brianne - Doctors use HIV in gene therapy to fix 'bubble boy' disease Rich - I Want What My Male Colleague Has Kathy- Preventing airborne disease (video and primary article) Vincent - The Mueller Report

Listener Pick

Steve- Vaccine Mythbusting Cyprian- Ten simple rules towards healthier research labs

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 543: Stoned and senile Apr 14, 2019

Show notes

The TWiV team discusses Medusavirus, isolated from a hot spring in Japan, and induction of neurodegeneration by recurrent herpes simplex virus 1 infection of mice.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

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Links for this episode

Medusavirus (J Virol)
Recurrent herpes simplex virus-1 and Alzheimer's (PLoS Path)
Image credit
Letters read on TWiV 543
Timestamps by Jolene. Thanks!

Weekly Science Picks

Brianne - How to Take a Picture of a Black Hole Alan- Jupiter Marbleimage Rich - NASA Commercial Crew Program; How SpaceX and Boeing will get Astronauts to the ISS; Everyday Astronaut Dickson- Sky-High Stunners Kathy- Arts at Michigan photo winnersand UM Microscopy Core image contest winners Vincent - NYC declares emergency over measles outbreak, mandates vaccinations and EMDataResource

Listener Pick

Martin- Sydney Brenner passes

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 542: Inside Microbiotix Apr 07, 2019

Show notes

Vincent travels to Microbiotix, Inc, a biopharmaceutical company in Worcester, MA to speak with four members of the company about their discovery and development of small molecule drugs that target serious infectious diseases.

Host: Vincent Racaniello

Guests: Terry Bowlin, Zach Aron, Grace Lui, and Islam Hussein

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Links for this episode