This Week in Virology

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TWiV 492: CRISPR diagnostics May 06, 2018

Show notes

The Masters of the TWiXome review the development of sensitive, portable, and field-based viral diagnostics using the CRISPR-Cas system.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

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Links for this episode

ASM Microbe 2018
Support Viruses & Cells Gordon Conference
Faculty positions at Icahn School of Medicine
Norovirus outbreaks from nori(Emerging Inf Dis)
SHERLOCK(Science)
HUDSON(Science)
DETECTR(Science)
Letters readon TWiV 492

Weekly Science Picks

Alan - Decline of local newspapers leaves epidemiologists blind Kathy- Journal oversight, mental health research Rich- The Big Sort: An Insider's Tour of a Recycling Plant Dickson- When Science Meets Art Vincent - A Crack in Creationby Doudna and Sternberg

Listener Pick

Tom- Trillions Upon Trillions of Viruses Fall From the Sky Each Day

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 491: The Ileum and the Odyssey Apr 29, 2018

Show notes

The TWiVome deconstructs the evolutionary history of RNA viruses, and immune promortion of murine norovirus pathogenesis by replication in intestinal tuft cells.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

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Links for this episode

ASM Microbe 2018
Support Viruses & Cells Gordon Conference
Faculty positions at Icahn School of Medicine
Evolutionary historyof RNA viruses (Nature)
The amphioxus song
Norovirus tropism for tuft cells(Science)
Letters readon TWiV 491

Weekly Science Picks

Alan - Oligodendroglioma in song Kathy- Everything-repellent coating to grime proof phone screens & more Rich- Gaia star map Dickson- Clouds are complicated Vincent - Eradicating polio with a vaccine we must stop using

Listener Pick

Stephen- Forget the Avengers, it took real heroes to make India polio-free

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 490: Shave ice and giant viruses Apr 22, 2018

Show notes

From the TWiV team, human cowpox infection possibly acquired from a pet cat, and a new giant mimivirus of green algae with genes encoding enzymes of fermentation.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler

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Links for this episode

ASM Microbe 2018
ASV Job Site revamped
Support Viruses & Cells Gordon Conference
Faculty positions at Icahn School of Medicine
Dick Courtney obit
Human cowpox infection(NEJM)
Mimivirus encodes fermentation genes(Virology)
Letters readon TWiV 490

Weekly Science Picks

Kathy- Landscapes that look like another world (but they are from Spain) Rich - Brighton Collaboration; Viral Vector Vaccines Safety Working Group (V3SWG)(Chen & DeStefano: Vaccine adverse events: causal or coincidental?) Dickson- Clouds of Jupiter and EBNA2 and autoimmunity Vincent - More than one-third of graduate students report being depressed (original article)

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 489: CD4 Hunter Apr 15, 2018

Show notes

Vincent visits Sandra Urdaneta-Hartmann at Drexel University College of Medicine in Philadelphia to talk about the development of the mobile video game 'CD4 Hunter'.

Host: Vincent Racaniello

Guest: Sandra Urdaneta-Hartmann

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Links for this episode

CD4 Hunter iOS Android
Sandra on Twitter
Carla Brown on Twitter
Inactivation of HIV in breast milk(Retrovirology)
Nipple shieldto inactivate HIV (Int J Pharm)

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 488: Who nose if it will work in humans Apr 08, 2018

Show notes

The TWiV team reveals that recent mumps virus outbreaks in the US are due to waning vaccine efficacy, and an intranasally delivered small interfering RNA that controls West Nile infection in the brain.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler

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Links for this episode

ASM Microbe 2018
ASV 2018
Microbiology Student Symposium at UC Berkeley
Support Viruses & Cells Gordon Conference
Waning mumps vaccinein US (Sci Trans Med)
siRNA controlof West Nile virus brain infection (Cell Host Microbe)
Image credit
Letters readon TWiV 488

Weekly Science Picks

Kathy- Peak bloom and photographing cherry blossoms Dickson- Origins of vertebrate RNA viruses Alan- Rare footage of anglerfishin the deep ocean Vincent - NIH must reduce disparities in funding

Listener Picks

Mariann - Eden Project and Bellyvision Apparatus and the Like Amir- Winners of ICR Science Photography and Photography Contest

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 487: Milwaukee viral Apr 01, 2018

Show notes

At the Medical College of Wisconsin, Vincent talks with current and former members of the Department of Microbiology and Immunology about their work and their careers.

Host: Vincent Racaniello

Guests: Dominique Carter, Sid Grossberg, John Kirby, Scott Terhune, and Vera Terakanova

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Intro music by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV 486: Sean Whelan on being haploid Mar 25, 2018

Show notes

Sean Whelan returns to TWiV to speak with Vincent about using haploid cell lines to identify genes encoding cell receptors for viruses, including Ebolavirus, Lassa virus, and more.

Host: Vincent Racaniello

Guest: Sean Whelan

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Links for this episode

Ebola virus entry requires the cholesterol transporter Niemann-Pick C1 (Nature)
Lassa virus entry requires a trigger-induced receptor switch (Science)
Infectious Entry Pathway Mediated by the Human ERV K Envelope Protein (J Virol)
Novel Broad-Spectrum Virus Entry Inhibitor (J Virol)
Mechanism of membrane fusion induced by VSV G protein (PNAS)
NRP2 and CD63 Are Host Factors for Lujo Virus Cell Entry (Cell Host Micr)
Image credit

Intro music by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV 485: Fishing with defective flies Mar 18, 2018

Show notes

The TWiV posse considers viral insulin-like peptides encoded in fish genomes, and insect antiviral immunity by production of viral DNA from defective genomes of RNA viruses.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker

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Links for this episode

ASM Microbe 2018
Insulin-like peptides in Iridovirus genomes (PNAS)
Dicer-2 dependent generation of cvDNA from defective genomes (Cell Host Micr)
Carla Saleh on insect antiviral immunity (TWiV 301)
RNAseIII ancient antiviral RNA platform (TWiV 450)
cvDNA precursor to EVEs (TWiV 482)
Image credit: Paul Young
Letters read on TWiV 485

Weekly Science Picks

Kathy - Vegas casinos lost money on physicists Brianne - Astronaut twin's DNA is not 7% different! Dickson - Parasitic Diseases lecture videos Alan - In Season blog by Donna Long Vincent - Buckyball viruses

Listener Picks

Paul - Wine labels (front, back)

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 484: Float like a mimivirus STING like a bat Mar 11, 2018

Show notes

The TWiVumvirate discuss the giant Tupanvirus, with the longest tail in the known virosphere, and dampened STING dependent interferon activation in bats.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker

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Links for this episode

ASM Microbe 2018
Tailed giant Tupanvirus (Nat Commun)
Soda Lakes (Wikipedia)
Dampened STING in bats (Cell Host Microbe)
Image credit
Letters read on TWiV 484

Weekly Science Picks

Kathy - How to read a phylogenetic tree Brianne - No immune overload for vaccines Dickson - Flowchart of viral families Alan - Letters to a Pre-Scientist Vincent - True believers, entrepreneurs, and scammers in alternative medicine and Simply Put: Vaccines Save Lives

Listener Picks

Vinayaka - Code of Ethics for Young Scientists Matt - TWiV 443

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 483: Every infection is unhappy in its own way Mar 04, 2018

Show notes

Vincent and the Virals review undermining of antiviral effectiveness by genital inflammation, and heterogeneity of influenza virus infection in single cells.

Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler

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Links for this episode