This Week in Virology

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TWiV 379: A mouse divided Mar 06, 2016

Show notes

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

Scott Tibbetts joins the TWiVists to describe his work on the role of a herpesviral nocoding RNA in establishment of peripheral latency, and then we visit two last minute additions to the Zika virus literature.

Links for this episode

Noncoding RNA required for establishment of latency (mSphere) 17:20
Lessons learned from in vivo studies of a viral noncoding RNA (mSphere) 1:05:05
Zika virus in pregnant women in Rio de Janeiro (NEJM) 1:06:10
Zika virus infects cortical neural progenitors (Cell Stem Cell) 1:12:00
Image credit
Letters read on TWiV 379 1:15:10

This episode is sponsored by 32nd Clinical Virology Symposium and Microbe Magazine Podcast 4:15, 1:05:25

Weekly Science Picks 1:42:45

Alan - Okeanos ExplorerDickson - Rome Reborn Vincent - Twitter Missing ManualScott - Best Science Images of 2015Kathy - Space Travel Posters Rich - GoISSWatch

Listener Pick

Peter - Antibiotics and the Problem of the Broken Market

Send your virology questions and comments to twiv@microbe.tv

TWiV 378: Herpes plays DUBstep Feb 28, 2016

Show notes

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler

Guests: Greg Smith and Mark Fuccio

Greg Smith joins the TWiVirate to reveal how his lab discovered a switch that controls herpesvirus neuroinvasion, and then we visit the week's news about Zika virus.

Links for this episode

Dynamic ubiquitination drives herpesvirus neuroinvasion (PNAS)
Releasing Zika virus data in real time (Nature)
Zika virus infection and stillbirths (PLoS NTD)
Zika virus infection, imported, Italy (Eurosurveillance)
Letters read on TWiV 378

This episode is sponsored by 32nd Clinical Virology Symposium and Microbe Magazine Podcast

Weekly Science Picks

Alan - Science byline counting projectDickson - Bill Nye on climate change Vincent - Zdziarski's blog of things (Apple's motion to vacate)Greg - Atlas, the next generationKathy - Sources of Chaco woodMark - How Dogs Love Us by Gregory Berns

Listener Pick

Bohdan - The real reason for brains

Send your virology questions and comments to twiv@microbe.tv

TWiV 377: Chicken with a side of Zika Feb 21, 2016

Show notes

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

The TWiVniks review the past week's findings on Zika virus and microcephaly, and reveal a chicken protein that provides insight on the restriction of transmission of avian influenza viruses to humans.

Links for this episode

Larvicide not involved in microcephaly (CBS News)
Obama seeks $1.8b for Zika virus (Guardian)
Zika virus in Puerto Rico (MMWR)
Zika virus in semen (EID)
Zika virus in Indonesia (EID)
Phylogeny of Zika virus (EID)
Zika virus may cause mental disease (NYTimes)
Zika virus from amniotic fluid (Lancet)
Host protein underlies avian influenza host restriction (Nature)
Wendy Barclay on TWiV 177
Home to roost (Cell)
Image credit
Letters read on TWiV 377

This episode is sponsored by 32nd Clinical Virology Symposium and Microbe Magazine Podcast

Weekly Science Picks

Alan - CDC vaccine quizDickson - A telescope so powerful Vincent - Virology Lectures 2016 (virology blog, iTunes U)Rich - Ion propulsion (Wiki)Kathy - Spurious Correlations

Listener Pick

Johnye - Magellan telescope and van Egmond photograpy at Kids Should See This

Send your virology questions and comments to twiv@microbe.tv

TWiV 376: The flavi of the month is Zika Feb 14, 2016

Show notes

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

Guest: Jeremy Luban

The TWiV team discusses the latest data on Zika virus, including ocular defects in infants with microcephaly, and isolation of the entire viral genome from fetal brain tissue.

Links for this episode

Ocular findings in infants with microcephaly (JAMA and Arq Bras Oft)
Evidence of Zika virus infection in brain and placenta (MMWR)
Zika virus associated with microcephaly (NEJM)
Hard-core sequencing (Science)
Zika virus and microcephaly (virology blog)
Zika virus in the Americas (NEJM)
JEV and WNV transplacental infections
Rubella virus facts (WHO)
Share your Zika virus reagents (virology blog)
No link between anencephaly and Cache Valley Virus (EID)
Image credit
Letters read on TWiV 376

This episode is sponsored by 32nd Clinical Virology Symposium and ASM Microbe 2016

Weekly Science Picks

Alan - PhD Comics on gravitational wavesDickson - 25 years of Hubble Vincent - Amazon AWS TOS and Confirming EinsteinRich - Mosquito mass productionKathy - TileApp Jeremy - IL17A and autism and The Perfect Theory by Pedro Ferreira

Send your virology questions and comments to twiv@microbe.tv

TWiV 375: Zika and you will find Feb 07, 2016

Show notes

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

Guests: Carolyn Coyne, Helen Lazear, and Jeremy Luban

The TWiVziks present everything you want to know about Zika virus, including association of infection with microcephaly and Guillain-Barré syndrome, transmission, epidemiology, and much more.

Links for this episode

Zika outbreak in Brazil (EID) 13:40
Zika summary (ProMedMail) 19:30
Zika and microcephaly (MMWR) 27:30
Facts about microcephaly (CDC)
Brazil Ministry of Health microcephaly numbers
Zika spread in Americas (MMWR)
Deu Zica 42:30
Microcephaly in Brazil (Lancet) 46:10
GM mosquitoes did not start Zika outbreak (Discover) 1:31:30
Debunking myths around Zika (Mad Virologist)
Sexual transmission vs sexually transmissible (virology blog) 1:22:10
CDC Zika travel guidance 1:15:45
CDC on Zika and sex 1:17:10
Image credit: Esper Kallas, University of Sao Paulo
Letters read on TWiV 375

This episode is sponsored by 32nd Clinical Virology Symposium and ASM Grant Writing Webinar

Weekly Science Picks 1:50:45

Alan - Jetstream Online School for Weather Vincent - New virus watercolors from Michele Banks (one, two)Rich - The Mad Virologist (Facebook, blog)Kathy - Orcas in Antarctica Jeremy - Pardis Sabeti on TEDHelen - Science ValentinesCarolyn - Three letter word missing from Zika warnings

Send your virology questions and comments to twiv@microbe.tv

TWiV 374: Discordance in B Jan 31, 2016

Show notes

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

The TWiVniks consider the role of a cell enzyme that removes a protein linked to the 5'-end of the picornavirus genome, and the connection between malaria, Epstein-Barr virus, and endemic Burkitt's lymphoma.

Links for this episode

Divergent requirements for removing VPg (mBio)
Bond, covalent bond (TWiV 210)
Link between malaria and endemic Burkitt's lymphoma (PLoS Path)
Multifactorial role of malaria in Burkitt's lymphoma (PLoS Path)
Plasmodium infection promotes AID-dependent B cell lymphoma (Cell)
Children's cancer dependent on climatic factors (Nature)
Denis Burkitt (Wikipedia)
Request for PACE trial data (virology blog)
Letters read on TWiV 374

This episode is sponsored by 32nd Clinical Virology Symposium and ASM Grant Writing Webinar

Weekly Science Picks

Alan - Indoor skydiving Vincent - Cancer Virus by Crawford, Johannessen, and RickinsonRich - WitKathy - The Only Woman in the Room by Eileen PollackDickson - Show everyone your clinical data

Send your virology questions and comments to twiv@microbe.tv

TWiV 373: The distinguished virology career of Julius S. Youngner Jan 24, 2016

Show notes

Host: Vincent Racaniello

Guest: Julius S. Youngner

Vincent speaks with Julius about his long career in virology, including his crucial work as part of the team at the University of Pittsburgh that developed the Salk inactivated poliovirus vaccine.

Links for this episode

Trypsin for cell cultures (Proc Soc Exp Biol Med)
Interferon induction by nonviral stimuli (J Gen Physiol)
Interferons of different molecular weight (Proc Soc Exp Biol Med)
Poliovirus thermal mutants (J Bacteriol)
Combination of different cells in culture (Science)
Equine influenza vaccine (Eq Vet J)
Younger role in Salk vaccine (interview, amednews)
Cutter Incident (JRSM)
Video of this episode - coming as soon as I can get home!

Send your virology questions and comments to twiv@microbe.tv

TWiV 372: Latent viral tendencies Jan 17, 2016

Show notes

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

The TWiV-osphere introduces influenza D virus, virus-like particles encoded in the wasp genome which protect its eggs from caterpillar immunity, and a cytomegalovirus protein counters a host restriction protein that prevents establishment of latency.

Links for this episode

Ebolavirus update (ProMedMail)
Influenza D virus (mBio)
Vincent's influenza C virus paper (J Virol)
Virus-like particles protect wasp eggs (Sci Adv)
CMV protein foils cell defense against latency (Sci Adv)
Image credit: Mark
Letters read on TWiV 372

This episode is sponsored by ASM Grant Writing Webinar and ASM Biodefense

Weekly Science Picks

Alan - Go viral Vincent - 3D virus popsicles (3ders, dangerous popsicles)Rich - Galileo thermometerKathy - Thing Explainer by Randall Munroe

Listener Picks

Christiane - Using PowerPoint to shine

Send your virology questions and comments to twiv@microbe.tv

TWiV 371: Sympathy for the devil Jan 10, 2016

Show notes

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

The TWiVologists discuss the finding of a second transmissible cancer in Tasmanian devils, and development of new poliovirus strains for the production of inactivated vaccine in the post-eradication era.

Links for this episode