This Week in Virology

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TWiV 389: Alphabet hepatitis with Stan Lemon May 15, 2016

Show notes

Vincent speaks with Stan Lemon about his career in virology, from early work on Epstein Barr virus, through making essential discoveries about hepatitis A virus, hepatitis C virus, and rhinoviruses.

Links for this episode

Live in Edmonton, Eh? (TWiV 235)
Replication of EBV in epithelial cells (Nature)
Returning to Carolina after 14 years
Evolutionary origins of hepatitis A virus (TWiV 265)
cre in rhinovirus genome (RNA)
Naked viruses that aren't always naked (Ann Rev Virol)
miR-122 and hepatitis C virus RNA (Cell Host Micr)

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Send your virology questions and comments to twiv@microbe.tv

TWiV 388: What could possibly go wrong? May 08, 2016

Show notes

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler

Preprint servers, the structure of an antibody bound to Zika virus, blocking Zika virus replication in mosquitoes with Wolbachia, and killing carp in Australia with a herpesvirus are topics of this episode hosted by Vincent, Dickson, Alan, and Kathy.

Links for this episode

biorXiv preprint server
Please review Vaccines and Your Child
Structure of antibody bound to Zika virus E protein (Cell Host Microbe)
Wolbachia blocks Zika virus in mosquitoes (Cell Host Microbe)
Zimmer on Wolbachia and Zika virus (NY Times)
Fauci on Zika virus vaccine (Science)
Carpageddon (The Conversation)
Letters read on TWiV 388

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Also brought to you by ASV 2016

Weekly Science Picks

Dickson - EarthEnv Alan - Research funding by lottery Kathy - Eugenia Cheng Math and Baking Vincent - Zika Diaries

Listener Picks

Stephen - Virus trading cards William - Virus trading cards Norma+Maurice - Virus trading cards Tom - Virus trading cards

Send your virology questions and comments to twiv@microbe.tv

TWiV 387: Quaxxed May 01, 2016

Show notes

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler

Guest: Nina Martin

Nina Martin joins the TWiV team to talk about the movie Vaxxed, her bout with dengue fever, and the latest research on Zika virus.

Links for this episode

Public Health United
Fifty Shades of Science (TEDx)
Parents convicted in death of toddler (Science Based Medicine)
CDC: Zika virus causes microcephaly (NEJM)
Dengue virus antibodies enhance Zika virus infection (biorXiv)
Zika virus in Brazilian nonhuman primates (biorXiv)
Zika virus IgM in CSF of microcephalic babies (Lancet)
Brain organoids for modeling Zika virus infection (Cell)
Letters read on TWiV 387

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Also brought to you by ASV 2016

Weekly Science Picks

Nina - Vaccines and Your Child by Paul Offit and Charlotte MoserDickson - The animals of Chernobyl Alan - Five rules of lab safety Kathy - 20 best science images of the year?Vincent - Massive undersea crab swarm

Listener Picks

JP - Global map of wind Todd - Doc Martin

Send your virology questions and comments to twiv@microbe.tv

TWiV 386: The dolphins did it Apr 24, 2016

Show notes

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

Guests: Ted Diehl and Welkin Johnson

Ted and Welkin inform the TWiV team how the evolution of ancient retroviruses can be inferred by studying their sequences in the genomes of modern mammals, and join in a discussion of virus dispersal during different methods for drying hands.

Links for this episode

More fun than a monkey full of viruses (TWiV 122)
Tracking ancient retrovirus evolution in mammals (eLife)
Virus dispersal during hand drying (J Appl Micro)
More than you wanted to know about hand drying (one, two, three, four, five, six)

This episode is sponsored by ASM Agar Art Contest, ASM Grant Writing Course, and ASV 2016

Weekly Science Picks 1:30:20

Welkin - Lab Girl by Hope Jahren (essay)Ted - Accidental brilliance in scienceRich - Perpetual motion?Kathy - R0 graphic and explanation Vincent - NWS ditches all caps forecasts

Listener Picks

Basel - Gimli Glider and Mars Climate OrbiterKen - Vaccination comic book

Send your virology questions and comments to twiv@microbe.tv

TWiV 385: Failure Apr 17, 2016

Show notes

Hosts: Vincent Racaniello and Dickson Despommier

Guest: Stuart Firestein

Stuart joins Vincent and Dickson to talk about his sequel to Ignorance, a book called Failure, which seeks to make science more appealing by revealing its faults.

Links for this episode

Stuart Firestein's site
Ignorance with Stuart Firestein (TWiV Special)
The pursuit of ignorance (TED)
Ignorance by Stuart Firestein
Failure by Stuart Firestein

This episode is sponsored by ASM Agar Art Contest and ASV 2016

Send your virology questions and comments to twiv@microbe.tv

TWiV 384: Agent 003, a view to a fish kill Apr 10, 2016

Show notes

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove and Rich Condit

Guests: Nischay Mishra and Ian Lipkin

Nischay and Ian join the TWiVions to discuss mass die-offs of tilapia by a novel orthomyxo-like virus, Ian's editorial on the movie Vaxxed, and new vaccines to prevent dengue virus infections, including a human challenge model.

Links for this episode

Novel orthomyxo-like virus in Tilapia die-offs (mBio)
Fish flu (TWiV 41)
Anti-vaccination lunacy won't stop (WSJ)
Single-dose dengue vaccine effective (J Inf Dis)
Dengue vaccine needs (J Inf Dis)
Composition of TV003 (J Inf Dis)
Dengue vaccine mutagenesis (Curr Top Micr Imm)
Dengue human challenge model (Sci Transl Med)
Yellow fever alarm (STAT)
Experiment: Zika virus
UC Berkeley Microbiology Student Symposium
Image credit
Letters read on TWiV 384

This episode is sponsored by ASM Agar Art Contest, ASM Grant Writing Course, and ASV 2016

Weekly Science Picks

Rich - Dune by Frank HerbertAlan - Adult vaccination video contestDickson - Ski town greenhouse Vincent - Preprint servers: Force awakens or revenge of undead?

Listener Picks

Ken - Golden Mole Awards for Accidental Brilliance (list, video)Jim - Linear algebra course

Send your virology questions and comments to twiv@microbe.tv

TWiV 383: A zillion Zika papers and a Brazilian Apr 03, 2016

Show notes

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove and Kathy Spindler

Guest: Esper Kallas

Esper and the Merry TWiXters analyze the latest data on Zika virus and microcephaly in Brazil, and discuss publications on a mouse model for disease, infection of a fetus, mosquito vector competence, and the cryo-EM structure of the virus particle.

Links for this episode

Zika virus in the Americas (Science)
Co-circulation of dengue, Zika, chik in Brazil (Medicine)
Murine model for Zika virus infection (Am J Trop Med Hyg)
Zika virus susceptibility of A. aegypti and A. albopictus (PLoS NTD)
Infectious Zika virus from saliva (EuroSurveill)
Zika virus spread through saliva? (Braz Oral Res)
Five Zika virus reviews (one, two, three, four, five)
Zika virus and microcephaly, Brazil (MMWR)
Zika virus in urine (EuroSurveill)
Zika virus infection of fetus (NEJM)
Real-time sharing of Zika virus data (JAMA)
Image credit: Richard Kuhn
Letters read on TWiV 383

This episode is sponsored by ASM Agar Art Contest and ASV 2016

Weekly Science Picks

Esper - The Chaos by Gérard Nolst Trenité and HIV pathogenesis courseAlan - Science KombatDickson - Four steps to wiping out a mosquito Vincent - Public lacks information on Zika virusKathy - Zika virus cryo-EM structure video

Listener Picks

Justin - Culture-independent discovery of Archaeal virusMelinda - Zika virus open research portal and Your body battles series

Send your virology questions and comments to twiv@microbe.tv

TWiV 382: Everyone's a little bit viral Mar 27, 2016

Show notes

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove and Kathy Spindler

Guests: Nels Elde and Edward Chuong

Nels and Ed join the TWiV team to talk about their observation that regulation of the human interferon response depends on regulatory sequences that were co-opted millions of years ago from endogenous retroviruses.

Links for this episode

Endogenous retroviruses and regulation of innate immunity (Science)
Placenta is viral (Nature)
An ERV that maintains pluripotency of human embryonic stem cells (TWiV 279)
Letters read on TWiV 382

This episode is sponsored by ASM Agar Art Contest and ASV 2016

Weekly Science Picks

Nels - Don't Get Me Started - Matt GiorgianniAlan - Sun's magnetic field (paper)Dickson - Most realistic dinosaur terrifies Vincent - Top secret!Kathy - Zika virus risk for US 50 cities (paper)Ed - Watching comb jellies poop

Listener Picks

Asal - Lost paper of Gregor MendelDennis - PhysicsGirlJacob - Second (XKCD) and ACI blogger interview

Send your virology questions and comments to twiv@microbe.tv

TWiV 381: Add viruses and Zimmer Mar 20, 2016

Show notes

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

Guest: Carl Zimmer

Carl Zimmer joins the TWiV team to talk about his career in science writing, the real meaning of copy-paste, science publishing, the value of Twitter, preprint servers, his thoughts on science outreach, and much more.

Links for this episode

Carlzimmer.com
All Carl's articles at NYTimes
Carl at Stat
The Loom
Staying afloat in the rising tide of science (Cell)
Parasite Rex
Planet of Viruses
Handful of biologists went rogue (NYTimes)

This episode is sponsored by ASV 2016 and ASM Agar Art Contest

Weekly Science Picks

Carl - Surprising benefit of viral DNAAlan - Global ship trafficDickson - Music with 2000 marbles Vincent - The whiteboard revolutionKathy - How to interpret UK and American advisors Rich - Carina Storrs, science writer

Send your virology questions and comments to twiv@microbe.tv

TWiV 380: Viruses visible in le microscope photonique Mar 13, 2016

Show notes

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

The TWiVeroos deliver the weekly Zika Report, then talk about a cryoEM structure of a plant virus that reveals how the RNA genome is packaged in the capsid, and MIMIVIRE, a CRISPR-like defense system in giant eukaryotic viruses.

Links for this episode