This Week in Virology

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TWiV 407: Tar Heels go viral, part two Sep 21, 2016

Show notes

Guests: Ralph Baric, Kristina De Paris, Tal Kafri, Helen Lazear, Mark Heise, and David Margolis

In the second of two shows recorded at the University of North Carolina in Chapel Hill, Vincent meets up with faculty members to talk about how they got into science, their research on RNA viruses, and what they would be doing if they were not scientists.

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TWiV 407: Tar Heels go viral, part one Sep 18, 2016

Show notes

Host: Vincent Racaniello

Guests: Dirk Dittmer, Cary Moody, Nat Moorman, Nancy Raab-Traub, Lishan Su, and Jennifer Webster-Cyriaque

In the first of two shows recorded at the University of North Carolina in Chapel Hill, Vincent meets up with faculty members to talk about how they got into science, their research on DNA viruses, and what they would be doing if they were not scientists.

View video of this episode at YouTube

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Send your virology questions and comments to twiv@microbe.tv

TWiV 406: Pow, right in the enteroids! Sep 11, 2016

Show notes

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

The TWiV team discussed eye infections caused by Zika virus, failure of Culex mosquitoes to transmit the virus, and replication of norovirus in stem cell derived enteroids.

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Links for this episode

Florida DOH daily Zika update
Congress fails again on Zika (NY Times)
Culex pipiens does not support Zika virus replication (EID)
Zika virus in the eye (Cell Rep)
Norovirus replication in enteroids (Science)
Norovirus replication in B cells (TWiV 312)
Baylor press release
Norovirus replication in B cells confirmed (Antiviral Res)
Letters read on TWiV 406

Weekly Science Picks

Alan - Infective PerspectiveDickson - The Living RiverRich - Freddy Mercury around the Sun Kathy - A Day in Pompeii Vincent - Spraying Pesticides

Listener Picks

Ricardo - Why the metric system matters Eric - The Giving Plague by David Brin

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TWiV 405: All the world's a phage Sep 04, 2016

Show notes

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler

The TWiXers discuss a study on vertical transmission of Zika virus by Aedes mosquitoes, and uncovering Earth's virome by mining existing metagenomic sequence data.

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Links for this episode

Roger Tsien, 64 (UC San Diego Health)
CDC running out of Zika money (NYTimes)
Zika virus in Miami mosquitoes (NYTimes)
No Zika virus in Rio Olympics (NYTimes)
Vertical transmission of Zika virus in Aedes aegypti (AJTMH)
Uncovering Earth's virome (Nature)
Image credit (Global water volume)
Letters read on TWiV 405

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. 0:25, 58:55

Weekly Science Picks

Alan - The VizziesDickson - NASA Spinoff Kathy - Maps.me Vincent - Zika: The Emerging Epidemic by Donald McNeil

Listener Picks

Tarwin - Darwin's Radio by Greg Bear (paper or Kindle)Bodham - The start of scientific publishing, 1665

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TWiV 404: Not found Aug 28, 2016

Show notes

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit

From the twiVivants, follow up on FluMist and Zoster vaccines, Zika virus update, and isolation of a multicomponent animal virus from mosquitoes.

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Links for this episode

FluMist problem (FDA)
DA Henderson obituary (NY Times)
DA Henderson, smallpox eradicator (TWiV Special)
Efficacy of VZV vaccine (Ther Adv Vaccines)
Zika virus burden, Puerto Rico (JAMA)
Zika virus in Miami Beach (STAT)
Congenital brain anomalies and Zika virus (Radiology)
Congenital Zika syndrome with arthrogryposis (BMJ)
Multicomponent animal virus from mosquitoes (Cell Host Microbe)
Breaking rules of infection (NPR)
Image credit
Letters read on TWiV 404

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Weekly Science Picks

Alan - Sally Le PageDickson - Comfortably Numb by Jamie Dupuis Rich - Learned Helplessness Vincent - Virus by Marilyn Roossinck

Listener Picks

OneTime - The Stranglers - Old Codger Steve - A Poem About Pronunciation

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TWiV Special: DA Henderson, smallpox eradicator Aug 23, 2016

Show notes

Donald "D.A." Henderson, a physician, educator, and epidemiologist who led the World Health Organization's campaign to eradicate smallpox, died at 87 years of age on Aug. 19, 2016. Vincent was fortunate to have the opportunity to speak with DA Henderson in 2014 about his career, the smallpox eradication effort, and what it means for the eradication of polio.

Become a patron of TWiV!

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

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TWiV 403: It's not easy being vaccine Aug 21, 2016

Show notes

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

The TWiV team takes on an experimental plant-based poliovirus vaccine, contradictory findings on the efficacy of Flumist, waning protection conferred by Zostavax, a new adjuvanted subunit zoster vaccine.

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Links for this episode

Tribunal orders release of PACE trial data (Valerie Eliot Smith)
Our request for PACE trial data (virology blog)
GM mosquito release on ballot (NPR)
Florida Keys Mosquito Control District on TWiV #111
Cold chain and virus free plant based polio vaccine (Plant Biotechnol J)
Disappointing flu vaccine effectiveness (CBC)
ACIP votes down use of LAIV (CDC)
LAIV as effective as inactivated flu vaccine (Ann Int Med)
Flumist does work (NPR)
Declining effectiveness of zoster vaccine (J Inf Dis)
Efficacy of adjuvanted subunit zoster vaccine (NEJM)
Risk of zoster from vaccine (J Inf Dis)
Image credit: ViralZone
Letters read on TWiV 403

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Weekly Science Picks

Alan - To Scale: The Solar SystemRich - Route 66 Goes Solar Vincent - Race for a Zika Vaccine by Siddhartha Mukherjee

Listener Picks

Bohdan - Penn and Teller on Vaccinations Bill - Connections, Episode 1

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TWiV 402: The plight of the bumblebee Aug 14, 2016

Show notes

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit

Polio returns to Nigeria, Zika virus spreads in Miami, and virus infection of plants attracts bumblebees for pollination, from the virus gentlepeople at TWiV.

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Links for this episode

Marian Horzinek, 80 (ProMedMail)
Polio in Nigeria (Atlantic, Stat, ProMedMail)
Zika virus spreads in Miami (NYTimes)
More Zika virus vaccines (Science)
Back to work on Zika, Congress ! (Asbury Park Press)
Lack of funding will stymie Zika vaccines (Wash Examiner)
FDA OK on genetically modified mosquitoes (FDA)
CMV attracts aphid vectors (TWiV #70)
CMV attracts pollinating bumblebees (PLoS Path)
Earth dwarfed by solar flare (jpg)
Letters read on TWiV 402

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Weekly Science Picks

Alan - Solar storm that launched US space weather scienceRich - Data storage on DNA Dickson - Perseid meteor show live Vincent - In the Company of Microbes by Elio Schaechter

Listener Picks

Neva - I Contain Multitudes by Ed YongAmanda - American Gut

Send your virology questions and comments to twiv@microbe.tv

TWiV 401: Vector victorious Aug 07, 2016

Show notes

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler

Zika virus spreads in the USA, a Zika virus DNA vaccine goes into phase I trials, and how mosquito bites enhance virus replication and disease, from the friendly TWiFolk Vincent, Dickson, Alan, and Kathy.

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Links for this episode

Beverly Griffin, 86 (1 2 3)
Zika virus in the US (CDC)
Zika virus spreading in Miami (CDC)
Zika virus in Florida (NY Times)
NIH begins phase I trial of Zika virus DNA vaccine (NIAID)
Mosquito salive enhances West Nile replication in mice (J Virol)
Mosquito bites enhance virus infection (Immunity)
Photo of A. aegyptii and mouse ears from Marieke Pingen
Letters read on TWiV 401

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Weekly Science Picks

Alan - The DoubleclicksKathy - WHO ZIKV app and ZIKV Giant Microbe Dickson - Photographer Rosamond Purcell Vincent - Spillover: Zika, Ebola, and Beyond

Listener Picks

Ricardo - Portugal Four Days on Renewable Energy Fatma - DeNovo: Predicting virus-host protein interactionsStephen - How mosquitoes use six needles to suck your blood

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TWiV 400: Harold '400' Varmus, a scientist for all seasons Jul 31, 2016

Show notes

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

Guest: Harold Varmus

The TWiV team is together in New York City for a conversation with Nobel Laureate Harold Varmus about his remarkable career in science.

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Links for this episode

Varmus Laboratory
Varmus and Kandel on Charlie Rose (transcript)
Rescuing biomedical research
Letters read on TWiV 400
Video of this episode at YouTube

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

This episode was made possible by PLoS Pathogens - the leading Open Access journal to publish breakthroughs in understanding pathogens and their interactions with host organisms and each other. PLOS Pathogens fosters the open exchange of ideas across fields, publishing original research on viruses, bacteria, fungi, parasites, and prions. For more information, check out www.plospathogens.org

Weekly Science Picks

Alan - A year on EarthRich - TWiV #1: West Nile Virus Dickson - Chasing storms, chasing beautyKathy - Bioartography and FASEB image and video competition Vincent - The Art and Politics of Science by Harold Varmus (free download)

Listener Picks

Trudy - Scientific Studies on Last Week Tonight with John Oliver

Send your virology questions and comments to twiv@microbe.tv

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