This Week in Virology

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TWiV 399: Zika la femme Jul 24, 2016

Show notes

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit

The latest Zika virus news from the ConTWiVstadors, including a case of female to male transmission, risk of infection at the 2016 summer Olympics, a DNA vaccine, antibody-dependent enhancement by dengue antibodies, and sites of replication in the placenta.

Links for this episode

Zika virus disease in the US (CDC)
Female to male Zika virus transmission (CDC)
Zika virus in female genital tract (Lancet)
Zika virus transmission in Utah (CDC and NYTimes)
Olympic Zika virus risk (CDC)
15 companies on Zika virus vaccines (WSJ)
Zika virus DNA vaccine in mice (Nature)
Zika virus disease in Colombia (NEJM)
Dengue virus antibody dependent enhancement of Zika virus (PNAS)
Zika virus antibodies enhance dengue virus disease (Science)
Zika virus in human placenta and developing brain (bioRxiv)
Zika virus targets different human placenta cells (Cell Host Microbe)
Letters read on TWiV 399

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

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Weekly Science Picks

Alan - CDC postmortem on Ebolavirus outbreakRich - Refutations to anti-vaccine memes (Twitter, Facebook) Dickson - History of urbanization Vincent - How to cut subject from background in Photoshop

Listener Picks

Marion - Skeptics Guide to the Universe podcastJennie - Leatherback turtles in Costa Rica

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TWiV 398: Permission to be intuitive Jul 17, 2016

Show notes

Host: Vincent Racaniello

Guest: Sandy Weller

Vincent speaks with Sandy Weller about her career and her work on the mechanisms of synthesis, maturation and cleavage and packaging of viral DNA genomes.

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Links for this episode

Cell killing by avian leukosis virus (Sandy's first paper, J Virol)
ND10 protein and herpes simplex virus replication (J Virol)
Recombination promoted by DNA viruses (Ann Rev Micro)
HSV-1 and DNA damage response (Fut Virol)
Video of this episode at YouTube

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Send your virology questions and comments to twiv@microbe.tv

TWiV 397: Trial by Error Jul 10, 2016

Show notes

Host: Vincent Racaniello

Guest: David Tuller

Vincent speaks with David Tuller about flaws in the U.K's $8 million PACE trial for chronic fatigue syndrome, and efforts to have the trial data released.

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Links for this episode

Science and journalism (TWiV 111)
Chronic fatigue syndrome and the CDC (virology blog)
PACE trial (Lancet)
Trial by error part one, two, three (virology blog)
PACE economics analysis (PLoS One)
All articles by David Tuller at virology blog
Valerie Eliot Smith's blog
Karina Hansen, prisioner of Denmark

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Send your virology questions and comments to twiv@microbe.tv

TWiV 396: Influenza viruses with Peter Palese Jul 03, 2016

Show notes

Host: Vincent Racaniello

Guest: Peter Palese

Vincent speaks with Peter Palese about his illustrious career in virology, from early work on neuraminidases to universal influenza virus vaccines.

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Links for this episode

Palese Laboratory
Pig kidney neuraminidase (Hoppe Seylers Z Physiol Chem)
DNAse in cytoplasmic DNA virus (Virology)
Inhibitor of influenza virus neuraminidase (Virology)
Influenza neuraminidase defective mutants (Virology)
Swine influenza virus of 1976 RNA pattern (Nature)
1977 influenza H1N1 similar to 1950s strains (Nature)
H5N1 influenza: Facts, not fear (PNAS)
Influenza HA stalk immunity in ferrets (J Virol)

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Send your virology questions and comments to twiv@microbe.tv

TWiV 395: The cancer thief Jun 26, 2016

Show notes

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

Guest: Stephen J. Russell

From ASV 2016 at Virginia Tech, Vincent, Rich and Kathy speak with Stephen Russell about his career and his work on oncolytic virotherapy - using viruses to treat cancers.

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Links for this episode

Hokies go viral (TWiV 285)
MV NIS de Myelo (TWiV 298)
Remission of disseminated myeloma after MV treatment (Mayo Clin Proc)
miRNA detargeting (J Virol)
Video of this episode at YouTube

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Weekly Science Picks

Kathy - Can you explain your science in 30 seconds? and How Far Can We Go?Rich - Small asteroid Earth's companion Vincent - The Gene by Siddhartha Mukherjee

Listener Picks

Dylan - Microsculpture by Levon Biss (website)

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TWiV 394: Cards in a hand Jun 19, 2016

Show notes

Hosts: Vincent Racaniello and Alan Dove

Guest: Erica Ollmann Saphire

Vincent and Alan speak with Erica about her career and her work on understanding the functions of proteins of Ebolaviruses, Marburg virus, and other hemorrhagic fever viruses, at ASM Microbe 2016 in Boston, MA.

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Links for this episode

Structure of antibodies bound to Ebola virus glycoprotein (PNAS)
Structure of cross-reactive filovirus antibody (Cell)
Multiple functions of Ebola virus VP40 protein (Cell)
View video of this episode on YouTube
Letters read on TWiV 394

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Weekly Science Picks

Alan - Slime Lapse Vincent - Virus Watch

Listener Picks

Patricia - NECSS, People Behind the Science, The Life Scientific Peter - Iron Lung on eBay

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TWiV 393: Lovers and livers Jun 12, 2016

Show notes

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

The TWiVerati revisit possible sexual transmission of Zika virus, and reveal how a cell protein that allows hepatitis C virus replication in cell culture enhances vitamin E mediated protection against lipid peroxidation.

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Links for this episode

Late sexual transmission of Zika virus (Lancet)
Zika virus disease in US (CDC)
Zika virus lab accident (ABC News)
Mosquito eradication (virology blog)
Florida mosquito control (TWiV 111)
How tequila mosquito (TWiV 178)
SEC14L2 allows HCV replication in cell culture (Nature)
Lipid peroxidation (Wikipedia)
HCV replicase regulated by lipid peroxidation (Nat Med)
Letters read on TWiV 393

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Also brought to you by ASV 2016

Weekly Science Picks

Alan - All About That SpaceRich - The Expanse by James S.A. Corey (SyFy) Kathy - Five Pivotal Paragraphs in a Paper Vincent - Agar Art Contest Winners

Listener Picks

Ted - Marshall Niremberg charts

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TWiV 392: Zika virus! Jun 05, 2016

Show notes

Host: Vincent Racaniello

Guests: Michael Diamond, Michaela Gack, Laura Kramer, and Charles Rice

Four virologists discuss our current understanding of Zika virus biology, pathogenesis, transmission, and prevention, in this special live episode recorded at the American Society for Microbiology in Washington, DC.

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Video of this episode at YouTube

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Send your virology questions and comments to twiv@microbe.tv

TWiV 391: Whiter reefs, fresh breath May 29, 2016

Show notes

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

Guests: David Pride and Forest Rohwer

If you have always wanted to know what coral reefs and the human oral cavity have in common, listen as guests David Pride and Forest Rohwer talk about their work on the microbiomes and viromes of these two environments, and you'll also understand why mucus is cool.

Links for this episode

Lytic to temperate switching of viral communities (Nature)
Viromes in ancestral holobiont Hydra (PLoS One)
Phage in human oral cavity (J Oral Micro)
Human oral viruses are personal, consistent, gender specific (ISME)
Video of this episode at YouTube

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Weekly Science Picks

Alan - Vax Pack HeroRich - Helicopter autorotation Vincent - Live in Our Phage World by Forest Rohwer, Merry Youle, Heather Maughan, Nao Hisakawa

Listener Picks

Matt - Experiment.com

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TWiV 390: Building a better mosquito trap May 22, 2016

Show notes

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

Guests: Ethan Jackson and Jonathan Carlson

Project Premonition, a Microsoft Research project that uses drones to capture mosquitoes and analyze them for pathogens, preprint servers, and three mouse models for Zika virus induced birth defects are the topics of this episode hosted by the TWiumvirate and theirs guests Ethan and Jonathan.

Links for this episode