This Week in Virology

Latest Episodes:

TWiV 359: A Blossom by any other name Oct 17, 2015

Show notes

Vincent speaks with Blossom about her laboratory's research on Kaposi's sarcoma-associated herpesvirus, including how it transforms cells, the switch between lytic and latent replication, and its interaction with the innate immune system of the host.

Links for this episode

Damania Laboratory
Modulation of cGAS-STING by KSHV (PNAS)
KSHV vIRF1 interacts with ISG15 pathway member (J Virol)
KSHV NLR homolog inhibits inflammasome (Science)
KSHV inhibition of PI3K and mTOR (Blood)
KSHV confers survival advantage to endothelial cells (Cancer Res)
UNC Global Oncology Program
Blossom on Twitter
Video of this episode - view at YouTube

Send your virology questions and comments to twiv@twiv.tv

TWiV 358: Virology and proteomics with Ileana Cristea Oct 11, 2015

Show notes

Host: Vincent Racaniello

Guest: Ileana Cristea

Vincent meets up with Ileana at Princeton University to talk about how her laboratory integrates molecular virology, mass spectrometry-based proteomics, and bioinformatics to unravel the interplay between virus and host.

Links for this episode

Cristea Laboratory
Ileana's work previously on TWiV 269
Blowing off steam (Cell Host Micr)
Nuclear viral DNA sensors (J Biol Chem)
mSystems
Video of this episode - view at YouTube (coming soon!)

Send your virology questions and comments to twiv@twiv.tv

TWiV 357: Mistletoe on the Tree of Life Oct 04, 2015

Show notes

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

Guest: Jens Kuhn

Jens joins the TWiVomics to discuss the strengths and weaknesses of viral taxonomy, including its history and evolution, how viruses are ordered, and why T. rex was classified without having a living isolate.

Links for this episode

Jens' previous TWiV (283) 5:15
International Committee on the Taxonomy of Viruses (ICTV) 27:50
ICTV 9th Report 32:55
Classifying viruses by capsid architecture (Curr Opin Virol) 1:43:00
Image credit
Letters read on TWiV 357 10:55, 1:55:40

Timestamps by Jennifer. Thanks!

Weekly Science Picks 56:30, 2:07:15

Alan - The Jefferson Grid Rich - Summer of ScienceKathy - Bill Nye dances The ClickDickson - The Martian Jens - How I Killed Pluto, Life in Our Phage World, Why the Seahorse Tail is SquareVincent - Does the public trust science? (videos, summaries)

Send your virology questions and comments to twiv@twiv.tv

TWiV 356: Got viruses? Sep 27, 2015

Show notes

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

Guest: Stephanie Neal

Stephanie joins the super professors to discuss the gut virome of children with serious malnutrition, caterpillar genes acquired from parasitic wasps, and the effect of adding chemokines to a simian immunodeficiency virus DNA vaccine.

Links for this episode

Invitrogen Science Hero Awards 15:05
Gut DNA viromes of twins with severe malnutrition (PNAS) 34:30
Random forests 48:00
Wasps engineer caterpillars (PLoS Genetics) 50:20
Chemokine-adjuvanted SIV DNA vaccine (Mucos Immunol) 1:02:20
Guide to chemokines (pdf)
Role for CCR10 in IgA secreting cell accumulation (J Immunol)
CCL28 controls IgA plasma cell accumulation (J Exp Med)
In vivo electroporation 1:07:25, 1:09:50
Kathy's groan (jpg)
Image credit
Letters read on TWiV 356 14:55

Weekly Science Picks 1:18:35, 1:45:30

Alan - Plates from Hooke's Micrographia Rich - The Wright Brothers by David McCulloughKathy - Spore evaporation-driven engines (video and article)Dickson - Color variations of Pluto and Lunar total eclipse Stephanie - The science of moldy cheese by Carl ZimmerVincent - But Why?

Listener Pick of the Week

Reed - The Bench Warmers Podcast

Send your virology questions and comments to twiv@twiv.tv

TWiV 355: Baby's first virome Sep 20, 2015

Show notes

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

The TWiV team considers the effect of a Leishmaniavirus on the efficacy of drug treatment, and the human fecal virome and microbiome in twins during early infancy.

Links for this episode

Announcing mSphere 5:50
Leishmania virus influences drug outcome (paper 1, paper 2) 25:15
Human gut virome and microbiome in infants (Nat Med) 46:00
Multiple displacement amplification (Wiki) 46:00
Virome of adult twins (Nature) 49:15
Illumination by Kevin Folta 1:31:00
Folta story at RetractionWatch 1:41:40
Image credit
Letters read on TWiV 355 9:40, 1:20:30

This episode is sponsored by ASMGAP 5:00

Timestamps by Jennifer. Thanks!

Weekly Science Picks 1:42:20

Alan - Vexed Muddler store Rich - Ivanpah Solar Power FacilityKathy - The real KermitDickson - Animal Portraits Vincent - Adventures of the Regatjes, Vaccines by Susan Nasif

Listener Pick of the Week

Jacob - Great Wall of China keeps rabbits out

Send your virology questions and comments to twiv@twiv.tv

TWiV 354: The cat in the HAART Sep 13, 2015

Show notes

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

The esteemed doctors of TWiV review a new giant virus recovered from the Siberian permafrost, why influenza virus gain of function experiments are valuable, and feline immunodeficiency virus.

Links for this episode

Non-viral proteins in vaccinia virus particles (Arch Virol) 8:15
Thing a week (Jonathan Coulton, downloads) 23:20
Immortal Life pornographic? Not! (HuffPost) 25:25
Mollivirus sibericum (PNAS) 27:00
Don't worry about Frankenvirus (WashPost) 27:10
We need flu GOF research (article, Wisc State J, Science) 40:35
Isolation of FIV (Science) 50:20
FIV at Cornell Vet 1:06:25
FIV latency (Retrovirol) 1:08:00
FIV-receptor interactions (Curr Op Virol) 1:08:45
Clin aspects FIV infection (Viruses)
FIV antivirals (Viruses) 1:10:05
How to treat FIV 1:10:45
Bud's FIV therapy 1;10;50
FIV vectors (CSH Prot) 1:13:50
Lion FIV (Proc Biol Sci)
FIV in cat species (J Virol) 1;01;45
ACIP HVP vaccine recommendations (MMWR) 1:28:45
HPV and cancer (CDC) 1:33:45
Cervical cancer screening (pdf, CDC)
Letters read on TWiV 354 7:45, 1:17:10

This episode is sponsored by ASMGAP

Timestamps by Jennifer. Thanks!

Weekly Science Picks 1:40:40

Alan - Experience CuriosityRich - Primrose SchoolKathy - Egg drop solutionsDickson - Dragonflies by Pieter van DokkumVincent - NASA guide to air-filtering houseplants

Listener Pick of the Week

Amir - Publons (Nature article)

Send your virology questions and comments to twiv@twiv.tv

TWiV 353: STING and the antiviral police Sep 06, 2015

Show notes

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler

The TWiVniacs discuss twenty-eight years of poliovirus shedding by an immunodeficient patient, and packaging of the innate cytoplasmic signaling molecule cyclic GMP-AMP in virus particles.

Links for this episode

28 years of poliovirus shedding (PLoS Path) 36:50
NOT a rare poliovirus (Wash Post) 44:35
Ukraine polio outbreak (ProMedMail) 41:00
Virus particle transfer of cGAMP (Science one, two) 47:50
cGAS on TWiV 222 47:05
Image credit
Letters read on TWiV 353 6:30, 1:10:25

This episode is sponsored by ASMGAP 3:10

Timestamps by Jennifer. Thanks!

Weekly Science Picks 1:27:50

Alan - Miniature calendarKathy - Dr. Brainlove (prologue, v. 2.0, IndieGoGo)Dickson - The Ph.D. Movie Vincent - Ghostery

Listener Pick of the Week

Ramon - Children dieChris - ASMLive at ICAAC/ICC

Send your virology questions and comments to twiv@twiv.tv

TWiV 352: Science art with Michele Banks Aug 30, 2015

Show notes

Host: Vincent Racaniello

Guest: Michele Banks

Vincent meets up with Michele Banks in Washington, DC to discuss her career as a creator of science-themed art.

Links for this episode

Michele Banks on Twitter
Artologica
Michele's blog
The Finch and the Pea
Joseph Cornell
Not Exactly Rocket Science (Ed Yong)
Tree of Life (Jonathan Eisen)
Home Microbiome Study
Kitten Microbiome Project
Science Online
The Vexed Muddler
Luke Jerram
A Daily Dish (Klari Reis)
Neuroscience art (Greg Dunn)
Ai Weiwei
Video of this episode - coming soon
Video of Michele working in her studio - view at YouTube

Send your virology questions and comments to twiv@twiv.tv

TWiV 351: The dengue code Aug 23, 2015

Show notes

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

The Masters of the ScienTWIVic Universe discuss a novel poxvirus isolate from an immunosuppressed patient, H1N1 and the gain-of-function debate, and attenuation of dengue virus by recoding the genome.

Links for this episode

Paula Pitha-Rowe (Balt Sun)
Novel poxvirus (CID)
H1N1 and gain-of-function debate (mBio)
Recoding dengue virus genome (PNAS)
Attenuation by dinucleotide frequency change (PNAS)
Codon pair and dinucleotide bias not distinguished (PNAS)
Codon pair deoptimization artefact of CG/UA change (eLife)
Can engineering subdue viral vaccine reversion? (Virus Evol)
Attenuation by a thousand cuts (NEJM)
Image credit
Letters read on TWiV 351

Weekly Science Picks

Alan - Genetic roulette Rich - The Huntington Kathy - Simulated vomiting machine (video) Dickson - Last Cassini Saturn flybyVincent - Decaying Still Life (YouTube)

Listener Pick of the Week

Ken - Cave meterology (Times, Nature)

Send your virology questions and comments to twiv@twiv.tv

TWiV 350: Viral gene therapy with Katherine High Aug 16, 2015

Show notes

Host: Vincent Racaniello

Guest: Katherine A. High

Vincent speaks with Katherine High about her career and her work on using viral gene therapy to treat inherited disorders.

This episode is drawn from one of twenty-six video interviews with leading scientists who have made significant contributions to the field of virology, part of the new edition of the textbook Principles of Virology.

Links for this episode

Katherine A. High, MD
AAV gene therapy for congenital blindness (Sci Trans Med)
Gene therapy for hemophilia (Hematol)
AAV capsid decoys (Sci Trans Med)
Video of this episode - view at YouTube

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Our TOPPODCAST Picks

Follow Us

Stay Connected

Related Podcasts

Links

Stay Connected