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    Natural Sciences

    The Immunology Podcast

    A podcast featuring conversations with immunologists from around the globe. Brought to by STEMCELL Technologies.

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    Latest Episodes:
    Ep. 117: “The Pathogenesis of Viruses and Cancer” Featuring Dr. Matteo Iannacone Oct 21, 2025
    Show notes

    Matteo Iannacone

    Guest:

    Professor Matteo Iannacone is Director of the Division of Immunology, Transplantation and Infectious Diseases, Professor of Pathology, and Head of the Dynamics of Immune Responses laboratory at Vita-Salute San Raffaele University. His work centers on understanding the generation of dysfunctional adaptive immune cells in chronic hepatitis B virus infection and developing new strategies to reprogram them into functional cells endowed with potent antiviral activity.

    Featured Products and Resources:

    • Stay up-to-date with the latest in human immunology news
    • Isolate highly purified immune cells from virtually any sample source with EasySep

    The Immunology Science Round Up

    The Cells That Keep Immunity in Check – Brenda reviews Dr. Shimon Sakaguchi’s seminal study demonstrating that a population of T cells expressing the IL-2 receptor α chain acts to maintain self-tolerance by suppressing other T cells.

    The Gene That Controls Immune Balance – Brenda reviews Dr. Mary Brunkow and Dr. Fred Ramsdell’s work identifying FOXP3 as the gene disrupted in a fatal lymphoproliferation syndrome in the “scurfy” mouse, pointing to FOXP3 as a master regulator of regulatory T cells.

    Zap70 and the Treg Cell Repertoire – Age-dependent Zap70 expression regulates negative selection and thymic Treg cell development.

    T Cell Exhaustion Driven by Protein Stress – Researchers show that proteotoxic stress, induced by protein aggregation, is not merely a consequence, but a driver of the exhausted T cell state.

    Image courtesy of Professor Matteo Iannacone.

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    Ep. 116: “Allelic Variation” Featuring Dr. Robin Orozco Oct 07, 2025
    Show notes

    Guest:

    Dr. Robin Orozco is an Assistant Professor at the University of Kansas, where her lab studies how specific allelic variants affect immune responses. She talks about what we can learn from mouse models and the role of PTPN22 in antiviral immunity. (36:48)

    Featured Products and Resources:

    • Stay up-to-date with the latest in immune regulation news.
    • EasySep™ 8-Minute Human Cell Isolation Kits

    The Immunology Round Up

    Skin Infections and Food Allergy – Scientists unraveled mechanisms by which S. aureus skin colonization can aggravate food allergy in atopic dermatitis. (3:10)

    Cytotoxic T Cell Dynamics – Nuclear polarization represents a key step during cytotoxic T cell-mediated killing. (11:55)

    CRISPR-Boosted CAR T Therapies – Researchers discovered, validated, and biologically characterized CRISPR-boosted CAR T cells that outperform standard CAR T cells. (18:36)

    CAR T Cells in Myeloma – New findings reveal differing effects of gene perturbation on CAR T cells and highlight a promising target to generate highly effective CAR T cells for multiple myeloma. (26:40)

    Image courtesy of Dr. Robin Orozco

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    Ep. 115: “Intercellular Communication” Featuring Dr. Harikesh Wong Sep 23, 2025
    Show notes

    Guest:

    Dr. Harikesh Wong is an Assistant Professor at the Ragon Institute and MIT, where his lab studies the design principles of the immune system. He talks about how Tregs constrain conventional T cell responses during infection, and advanced fluorescence microscopy techniques to study immune responses. (38:11)

    Featured Products and Resources:

    • Stay up-to-date with the latest in immune regulation news.
    • Learn how to isolate highly pure immune cells and efficiently process human samples with a free, on-demand course on human immune cell isolation.

    The Immunology Science Round Up

    Immunometabolism in HIV – Immunometabolic defects in colon-resident CD8+ T cells in people with HIV lead to intestinal epithelial apoptosis and disruption of intestinal barrier integrity. (2:50)

    T Cell Dysfunction in Tumors – Mitochondria or telomeric reactive oxygen species induce DNA damage responses driving T cell dysfunction. (9:15)

    Microglia-Astrocyte Crosstalk – Microglia-derived Wnts drive astrocytes to reduce their association with synapses. (22:00)

    Monocyte-Derived Macrophages in Tumors – Researchers identified myeloid progenitor programs that fuel pro-tumorigenic monocyte-derived macrophages. (28:45)

    Image courtesy of Dr. Harikesh Wong

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    Ep. 114: “The Importance of Investing in Science” Featuring Dr. Eric Vivier Sep 09, 2025
    Show notes

    Eric Vivier

    Guest:

    Dr. Eric Vivier is a Professor of Immunology at Aix-Marseille Université and the Centre d’Immunologie de Marseille-Luminy. He is also an awardee of the European Research Council and a member of the French Society of Immunology. In this special episode recorded at the IUIS 2025 Congress in Vienna, Dr. Vivier highlights the critical importance of investing in science, explores the responsibility of governments and other organizations in funding research, and reflects on the role science plays in society.

    Featured Products and Resources:

    • Register for an on-demand course on human immune cell isolation
    • Download a free wallchart summarizing the development, phenotypes, and functions of regulatory T cells

    The Immunology Science Round Up

    Strengthening CAR NK Cell Therapies – Scientists have found that natural killer (NK) cells become better at killing cancer cells after removal of key gene targets. (3:00)

    Maternal Stress Triggers Infant Eczema – Offspring of stressed pregnant dams have dysregulated mast cells and skin-projecting neurons and quickly develop eczema in response to harmless mechanical friction. (8:55)

    Suppressing Necroptosis-Induced Colitis – Researchers show that XBP1 and caspase-8 synergize to prevent colon inflammation. (17:07)

    Reprograming T Cells through Cytokine Receptor Expansion – Scientists have leveraged synthetic cytokine receptor engineering to successfully rewire T cell fate decisions and amplify anti-cancer immunity. (24:25)

    Image courtesy of Eric Vivier

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    IUIS 2025: On the Ground Sep 02, 2025
    Show notes

    In August 2025, we attended the 19th International Congress of Immunology, hosted by the International Union of Immunological Societies, in Vienna, Austria. We chat with delegates about their research and impressions of the meeting. They discuss the most memorable research presented and their experiences in Austria.

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    • Prepare for your next conference.

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    Ep. 112: “The Evolution of mRNA-Based Dendritic Cell Cancer Vaccines” Featuring Dr. Zwi Berneman Aug 26, 2025
    Show notes

    Guest:

    Dr. Zwi Berneman is Emeritus Professor of Hematology at the University of Antwerp, and previously Head of the Division of Hematology at the Antwerp University Hospital. His basic and clinical research is focused on vaccination with immunogenic dendritic cells in cancer and with tolerogenic dendritic cells in multiple sclerosis. He talks about the history and development of dendritic cell vaccines and the work needed to make them more widely available to patients.

    Featured Products and Resources:

    • Share your feedback on the podcast.
    • The STEMdiff™ Monocyte Kit generates millions of monocytes that are ready for downstream assays, or further development into macrophages or dendritic cells.

    Image courtesy of Dr. Zwi Berneman

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    IUIS 2025: Day 5 Aug 23, 2025
    Show notes

    In 2025, we attended the 19th International Congress of Immunology, hosted by the International Union of Immunological Societies, in Vienna, Austria, and recorded daily episodes discussing highlights of the conference. Here is the final of five special episodes from the meeting, in which Brenda and Jason discuss sessions on AI applications and CAR T therapy progress.

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    • ImmunoCult™ Mouse T Cell Activator Kit

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    IUIS 2025: Day 4 Aug 22, 2025
    Show notes

    In 2025, we attended the 19th International Congress of Immunology, hosted by the International Union of Immunological Societies, in Vienna, Austria, and recorded daily episodes discussing highlights of the conference. Here is the fourth of five special episodes from the meeting, in which Jason and Brenda discuss sessions on cancer immunotherapy and neuroimmunology.

    Featured Products and Resources:

    • Say goodbye to manual labor and hello to efficiency with RoboSep™—your ultimate solution for automated cell isolation.

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    IUIS 2025: Day 3 Aug 21, 2025
    Show notes

    In 2025, we attended the 19th International Congress of Immunology, hosted by the International Union of Immunological Societies, in Vienna, Austria, and recorded daily episodes discussing highlights of the conference. Here is the third of five special episodes from the meeting. Brenda and Jason discuss sessions on CD4+ T cells in Hepatitis B infections and how amoebas make their way to the brain. They also cover research on the effects of antibiotics on immunotherapy, and what we can learn about allergies by comparing pet shop and lab mice.

    Featured Products and Resources:

      • Improve your T cell therapy development with ImmunoCult™-XF

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    IUIS 2025: Day 2 Aug 20, 2025
    Show notes

    In 2025, we attended the 19th International Congress of Immunology, hosted by the International Union of Immunological Societies, in Vienna, Austria, and recorded daily episodes discussing highlights of the conference. Here is the second of five special episodes from the meeting. Brenda and Jason cover research on Lynch syndrome, dendritic cells, and the epigenome of regulatory T cells.

    Featured Products and Resources:

    • Simply and efficiently isolate untouched, viable human NK cells from PBMCs or leukapheresis samples with EasySep™.

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