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    Natural Sciences

    The Immunology Podcast

    A podcast featuring conversations with immunologists from around the globe. Brought to by STEMCELL Technologies.

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    Latest Episodes:
    IUIS 2025: Day 1 Aug 19, 2025
    Show notes

    In 2025, we attended the 19th International Congress of Immunology, hosted by the International Union of Immunological Societies, in Vienna, Austria, and recorded daily episodes discussing highlights of the conference. Here is the first of five special episodes from the meeting. Brenda and Jason discuss sessions on colon cancer organoids and stable induced regulatory T cells. They also cover presentations from the IUIS Rising Star Awardees and Dr. Yasmine Belkaid’s talk on maternal physiology.

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    • With no columns, minimal steps, and high-purity results, EasySep™ is the easy choice for simplified cell isolation.

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    Ep. 111: “Synthetic Immunology” Featuring Dr. Daniel Goodman Aug 12, 2025
    Show notes

    Guest:

    Dr. Daniel Goodman is an Assistant Professor at the University of Pennsylvania, where his lab researches high-throughput approaches to engineer the immune system. He talks about new technologies for immune cell engineering, and methods for screening and developing CAR T therapies. (47:30)

    Featured Products and Resources:

    • Share your feedback on the podcast and enter to win a Bluetooth speaker!
    • Register now for IUIS 2025!

    The Immunology Science Round Up

    Respiratory Infections and Breast Cancer – A study in mice shows that respiratory viruses can cause the proliferation of dormant disseminated cancer cells. (5:00)

    Early-Life HIV Antibodies – AAV-vectored delivery of HIV-1 broadly neutralizing antibodies led to long-term protection in infant rhesus macaques. (11:55)

    Obesity and Immunity – Researchers compared the effects of high-fat diets derived from animal and plant fat sources on tumor growth in obese mice. (22:25)

    Lithium Deficiency in Alzheimer’s Disease – Scientists showed that endogenous lithium contributes to cognitive preservation during aging. (32:37)

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    Ep. 110: “Placental Tolerance and Immunity” Featuring Dr. Tamara Tilburgs Jul 29, 2025
    Show notes

    Guest:

    Dr. Tamara Tilburgs is an Assistant Professor in the University of Cincinnati Department of Pediatrics, where her research focuses on immune tolerance during pregnancy. She talks about the immune paradox in trophoblast cells and how placental inflammation can lead to pregnancy complications. She also discusses CD8+ T cell responses at the maternal-fetal interface. (43:03)

    Featured Products and Resources:

    • Plan your transportation for the IUIS 2025 Congress in Vienna!
    • EasySep™ 8-Minute Human Cell Isolation Kits

    The Immunology Round Up

    Non-Antibiotics and Enteropathogens – Non-antibiotic drugs from a wide range of therapeutic classes can alter the ability of gut commensals to resist invasion by enteropathogens. (1:38)

    Medications and the Gut Microbiome – An analysis of prescription medications shows that several non-antibiotic drugs, such as the heart medication digoxin, can increase the risk of gastrointestinal infections. (7:20)

    Sex Dimorphism in Immune Responses – Fine-tuning of type 2 immune responses may explain why females are more susceptible to allergies. (15:00)

    Transposable Elements in Tregs – Researchers identified DNA methylation, chromatin accessibility, and gene expression programs that govern the tissue adaptation of human skin Treg cells. (28:10)

    Image courtesy of Dr. Tamara Tilburgs

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    Ep. 109: “Phagocyte Cell Biology” Featuring Dr. Johnathan Canton Jul 15, 2025
    Show notes

    Guest:

    Dr. Johnathan Canton is an Assistant Professor at the University of Calgary, where his lab uses advanced microscopy techniques to study dendritic cells, macrophages, and innate immunity. He talks about his career journey from studying tropical parasites to investigating phagocytes. He also discusses using advanced microscopy techniques, studying the mechanisms of dendritic cell cross-presentation, and running a farm in Belize. (35:55)

    Featured Products and Resources:

    • Check out the program for IUIS 2025!
    • The STEMdiff™ Monocyte Kit generates millions of monocytes that are ready for downstream assays, or further development into macrophages or dendritic cells.

    The Immunology Round Up

    Armored CAR T Cells – A CRISPR knock-in strategy can engineer CAR T cells that secrete proinflammatory cytokines directly within a tumor without causing toxicity. (2:15)

    Immune Invasion in Lung Cancer – Organoid immune co-cultures enable identifying immune evasion at subclonal resolution. (7:55)

    Chromatin Remodeling in Chronic Inflammation – Researchers identified a mechanism that separates the chronic and acute inflammation responses. (19:00)

    Reversing CD8⁺ T Cell Dysfunction – Scientists identified IL-27 as a tractable immunotherapeutic target in chronic hepatitis B virus infection. (25:40)

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    Ep. 108: “The Intestinal Epithelium” Featuring Dr. Mahima Swamy Jul 01, 2025
    Show notes

    Guest:

    Dr. Mahima Swamy is a Program Leader at the University of Dundee, where her lab studies immune homeostasis in the intestinal epithelium. She talks about intestinal intraepithelial lymphocytes and the role of LRRK2 in Parkinson’s and Crohn’s disease.

    Featured Products and Resources:

    • Register now for IUIS 2025!
    • Enter to win a personalized lab coat!

    The Immunology Science Round Up

    Fungal Meningitis in Mammals – Researchers examined Cryptococcus neoformans phenotypes and identified factors that drive mammalian virulence.

    γδ T cell Receptor Activation – Using cryoelectron microscopy, researchers identified an MHC-independent antigen presentation mechanism distinct from αβ T cells.

    Fungal Pulmonary Fibrosis – The Dectin-1-Raf1 axis is a key regulator of pulmonary fibrosis and a promising therapeutic target for fibrotic diseases.

    Early-Life Fructose Exposure – High-fructose treatment of mouse and human microglia suppresses phagocytosis capacity.

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    Ep. 107: “Immune Cell Manipulation” Featuring Dr. Rizwan Romee Jun 17, 2025
    Show notes

    Guest:

    Dr. Rizwan Romee is a Oncologist at the Dana-Farber Cancer Institute and Associate Professor at Harvard Medical School, where his research focuses on genetically manipulating NK cells to enhance their anti-tumor function. He talks about advances and challenges in engineering NK cells for cancer therapy. He also discusses using E. coli to deliver immune-activating cytokines to tumors. (37:31)

    Featured Products and Resources:

    • Register now for IUIS 2025!
    • Enter to win a personalized lab coat!

    The Immunology Science Round Up

    The Y Chromosome in Cancer – Loss of the Y chromosome in tumor and T cells worsens survival. (5:00)

    Boosting CD8 T Cell Responses – Cytokine-adjuvanted mRNA-lipid nanoparticles can enhance immune response to vaccination. (11:40)

    Bacterial Antitumor Immunotherapy – Intratumoral Listeria monocytogenes can either enhance or inhibit tumor progression. (21:30)

    NK Cell Signaling – CAR activation and IL-15 signaling rapidly induce CREM upregulation in NK cells. (28:20)

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    Ep. 106: “Innate Lymphocytes” Featuring Dr. Arthur Mortha Jun 03, 2025
    Show notes

    Guest:

    Dr. Arthur Mortha is an Associate Professor at the University of Toronto. His research focuses on innate lymphoid cells and their interactions with microbes. He talks about ILCs and how the gut microbiome can affect respiratory disease. (37:44)

    Featured Products and Resources:

    • Register now for IUIS 2025!
    • Enter to win a personalized lab coat!

    The Immunology Round Up

    Serotonin and Antitumor Immunity – Serotonin transporter acts as an immune checkpoint restricting CD8 T cell antitumor immunity. (3:35)

    T Cells in the Brain – CD4 T cells reside in the brain at steady state and are concentrated in the subfornical organ. (8:40)

    Bat Antiviral Immunity – A new organoid platform reveals key features of bat epithelial antiviral immunity that may inform therapeutic strategies. (22:30)

    Acetylcholine in the Thymus – Cholinergic signaling regulates immune cell development through thymic negative selection. (27:00)

    Image courtesy of Dr. Arthur Mortha

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    Ep. 105: IMMUNOLOGY2025™: On the Ground May 20, 2025
    Show notes

    In May 2025, we attended IMMUNOLOGY2025™, the annual meeting of the American Association of Immunologists, in Honolulu. We chat with delegates about their research and impressions of the meeting. They discuss their reasons for attending, the most memorable research, and their experiences in Hawaiʻi.

    Featured Products and Resources:

    • IUIS 2025 is taking place August 17-22 in Vienna!
    • Prepare for your next conference.

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    Ep. 104: Live from IMMUNOLOGY2025™: Insights from 100 Conversations with Immunologists May 13, 2025
    Show notes

    This special episode was recorded in front of a live audience at IMMUNOLOGY2025™ in Honolulu. In this conversation, hosted by Dr. Nicole Quinn, Brenda and Jason share what they’ve learned from recording over 100 episodes of the Immunology Podcast. They talk about how the field has evolved during the past four years, the importance of making science and scientists accessible, and predictions for emerging areas of research.

    Featured Products and Resources:

      • Register now for IUIS 2025!
      • Enter to win a custom lab coat, personalized with your name!

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    IMMUNOLOGY2025™: Day 5 May 08, 2025
    Show notes

    In May 2025, we attended IMMUNOLOGY2025™, the annual meeting of the American Association of Immunologists in Honolulu, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the final of five special episodes from the meeting, in which Brenda and Jason discuss sessions on lymphatic immunophysiology and how opioids drive immunosuppression in cancer.

    Featured Products and Resources:

    • Download a free conference toolkit!

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