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    Natural Sciences

    The Immunology Podcast

    A podcast featuring conversations with immunologists from around the globe. Brought to by STEMCELL Technologies.

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    Latest Episodes:
    Ep. 132: “Tumor-Infiltrating B Cells” Featuring Dr. Tullia Bruno May 13, 2026
    Show notes

    Guest:

    Dr. Tullia Bruno is an Assistant Professor at the University of Pittsburgh. She discusses how B cells and tertiary lymphoid structures shape anti-tumor immunity within solid tumors, challenging the traditional T cell–centric view of cancer immunology. She highlights how these immune niches influence responses to immunotherapy, the importance of spatial organization within the tumor microenvironment, and emerging strategies to therapeutically induce tertiary lymphoid structures to improve cancer treatment.

    Featured Products and Resources:

    • Subscribe for a chance to win a pair of STEMCELL science socks.
    • Request a free EasySep EV isolation kit sample to try in your own lab.

    The Immunology Science Round Up

    Feeding Boosts T Cell Immunity – Postprandial metabolism enhances T cell fitness and improves effector and CAR-T cell function through chylomicron-driven metabolic reprogramming.

    Chemokines Control T Cell Priming – CCR7 signaling limits CD8+ T cell interactions with dendritic cells to preserve effective effector and memory responses.

    Helminths Boost Offspring Immunity – Maternal helminth-driven microbiome changes protect offspring from respiratory viruses through the metabolite indole-3-propionic acid.

    Enhancing CAR T Persistence – CAR-modified stem-cell memory T cells show improved persistence, expansion, and anti-tumor responses compared to standard CAR T cells.

    Image courtesy of Dr. Tullia Bruno.

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    Ep. 131: “Lymphocyte Development” Featuring Dr. Alfred Singer May 05, 2026
    Show notes

    Guest:

    Dr. Alfred Singer is a Senior Investigator at the National Cancer Institute Center for Cancer Research. He discusses his pioneering work on thymus development and T cell differentiation, including how T cells are selected to become CD4 helper or CD8 cytotoxic cells through MHC-restricted signaling. He shares the evolution of key concepts in the field, such as the “kinetic signaling” model of lineage commitment, and offers insights into T cell receptor signaling, regulatory T cell development, and the complexities of immune cell fate decisions.

    Featured Products and Resources:

    • Receive a free 250 mL bottle of Lymphoprep plus a free SepMate tube to try in your own lab.
    • Achieve simple, reliable EV isolation with EasySep kits from STEMCELL Technologies.

    The Immunology Science Round Up

    CEACAM6 Enables Viral Entry – Bat alphacoronavirus enters human cells via CEACAM6, revealing potential for zoonotic transmission.

    Cross-Dressing Drives T Cell Priming – mRNA vaccines activate CD8+ T cells through redundant dendritic cell pathways and cross-dressing mechanisms.

    Unlocking NK Antitumor Responses – Removing tumor Tregs unleashes NK cell responses to control cancers, including MHC I–deficient tumors.

    RUNX1 Controls Immune Aging – A single-cell immune aging clock identifies RUNX1 as a key regulator of T cell senescence and rejuvenation.

    Image courtesy of Dr. Alfred Singer

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    IMMUNOLOGY2026™: On the Ground Apr 28, 2026
    Show notes

    On the Ground

    In April 2026, we attended IMMUNOLOGY2026™, the annual meeting of the American Association of Immunologists, in Boston. We spoke with delegates about their research and impressions of the meeting, including why they attended, the most memorable science they encountered, and their experiences in Boston.

    Featured Products and Resources:

    • Stay up-to-date with the latest in cell therapy news.
    • Access a collection of checklists and guides to ensure you’re prepared for your next conference.

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    Ep. 129: Live from IMMUNOLOGY2026TM: Emerging Immunotherapies for Solid Tumors Apr 21, 2026
    Show notes

    Guest:

    This special episode was recorded in front of a live audience at IMMUNOLOGY2026™ in Boston. Brenda and Jason sit down with Dr. Charles Sentman, Director of the Center for Synthetic Immunity at Dartmouth College, and Dr. Giulia Escobar, Director of Pre-Clinical Research at Massachusetts General Hospital, to explore new strategies aimed at overcoming the unique challenges of treating solid tumors. They focus on real-world challenges in CAR T and NK cell therapies, including barriers to treating solid tumors, manufacturing and accessibility hurdles, and emerging applications beyond oncology, such as autoimmunity and neurodegenerative disease.

    Featured Products and Resources:

    • Stay up-to-date with the latest in human immunology news.
    • Download a free wallchart on the production of CAR T cells.

    Image courtesy of [Drs. Charles Sentman and Giulia Escobar]

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    IMMUNOLOGY2026™: Day 5 Apr 20, 2026
    Show notes

    Day 5

    Guest:

    In April 2026, we attended IMMUNOLOGY2026™, the annual meeting of the American Association of Immunologists in Boston, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the last of five special episodes from the meeting. Jason and Brenda discuss highlights from sessions on advances in translational immunology, including immune-targeting strategies for autoimmune disease, as well as new insights into emerging technologies to map T cell receptor specificity.

    Featured Products and Resources:

    • Make the most of your experience by downloading STEMCELL’s collection of tools to help you prepare for your next conference.

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    IMMUNOLOGY2026™: Day 4 Apr 19, 2026
    Show notes

    Day 4

    Guest:

    In April 2026, we attended IMMUNOLOGY2026™, the annual meeting of the American Association of Immunologists in Boston, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the fourth of five special episodes from the meeting. Jason and Brenda discuss highlights from talks about immunometabolic dysfunction in disease and neuroimmune interactions in inflammation and allergy.

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    • Learn how to isolate highly pure immune cells and efficiently process human samples with a free, on-demand course.

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    IMMUNOLOGY2026™: Day 3 Apr 18, 2026
    Show notes

    Day 3

    Guest:

    In April 2026, we attended IMMUNOLOGY2026™, the annual meeting of the American Association of Immunologists in Boston, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the third of five special episodes from the meeting. Brenda and Jason discuss highlights from sessions on obesity, immunometabolism, microbiome-driven immunity, antigen presentation, and new immunotherapy strategies.

    Featured Products and Resources:

    • Explore the production of therapeutic CAR T cells with a a Nature Protocols wallchart.

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    IMMUNOLOGY2026™: Day 2 Apr 17, 2026
    Show notes

    Day 2

    Guest:

    In April 2026, we attended IMMUNOLOGY2026™, the annual meeting of the American Association of Immunologists in Boston, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the second of five special episodes from the meeting. Jason and Brenda cover new insights into microbiome–immune interactions, including bacterial influences on cancer and inflammatory disease, as well as advances in mucosal and early-life immunity.

    Featured Products and Resources:

    • Improve your skills in T cell culture with a free, on-demand course on human T cell expansion.

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    IMMUNOLOGY2026™: Day 1 Apr 16, 2026
    Show notes

    Day 1

    Guest:

    In April 2026, we attended IMMUNOLOGY2026™, the annual meeting of the American Association of Immunologists in Boston, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the first of five special episodes from the meeting. Brenda and Jason discuss highlights including advances in high-throughput proteomics and multi-omics integration for understanding immune regulation, as well as new insights into respiratory and mucosal immunology.

    Featured Products and Resources:

    • Get a free wallchart summarizing the processes involved in producing CAR T cells for therapy.

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    Ep. 128: “Lymphatic Immunobiology” Featuring Dr. Amanda Lund Apr 07, 2026
    Show notes

    Guest:

    Dr. Amanda Lund is an Associate Professor at the NYU Grossman School of Medicine. She discusses how the lymphatic vasculature serves as a critical and dynamic interface between tissues and the immune system, challenging the traditional view of lymphatics as passive conduits. She highlights how lymphatic vessels actively regulate immune responses by controlling fluid flow, antigen transport, and cell migration during infection and cancer, and explores their emerging roles in shaping immunity and tissue biology.

    Featured Products and Resources:

    • Download the free cell separation e-book from STEMCELL Technologies.
    • Learn how to isolate highly pure immune cells and efficiently process human samples.

    The Immunology Science Round Up

    MHC I Shapes CD4 Immunity– MHC class I unexpectedly regulates CD4+ T cell cytotoxicity by protecting target cells from ferroptosis.

    Re-Emergence of Oropouche Virus – Scientists have mapped the resurgence and long-term burden of Oropouche virus, revealing widespread infection across Latin America.

    Scalable In Vivo T Cell Engineering – A new in vivo CRISPR-based system enables precise, stable generation of CAR T cells.

    Gut–Brain Axis in Autoimmunity – Intestinal epithelial cells initiate autoimmune neuroinflammation via TH17 cell responses that migrate to the central nervous system.

    Image courtesy of Dr. Amanda Lund.

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