The Human Upgrade: Biohacking for Longevity & Performance

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Mini-Episode: Cool Facts Friday #11 May 28, 2021

Show notes

Cool Facts are quick hits of new human and world science curated into short bursts of information just for you. This fun compilation publishes one Friday a month. Enjoy!

Here’s the current lineup for episode #11:

Hyperbaric oxygen treatments could make your blood cells grow younger.
Infection-fighting immune cells in your brain get their training in your gut.
Reprogramming T-cells to act like stem cells helps your immune system.
What happens in the womb changes genes through mom's epigenetics.
Self-watering soil could expand farmable land and reduce water used in agriculture.

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Stop NAD+ Decline and Slow Down Your Aging – Dr. Nichola Conlon with Dave Asprey : 826 May 27, 2021

Show notes

In this episode of Bulletproof Radio, molecular biologist Dr. Nichola Conlon joins me to talk about the role of a little molecule found in every cell in your body that has a huge impact on aging. She specializes in the study of aging as a biologically complex disorder, specifically the role of NAD+ (Nicotinamide Adenine Dinucleotide).

You’re going to learn about how NAD+ works in the body from this scientist who was named one of 2021’s Coolest Female Founders of UK Tech Making Huge Impacts.

Dr. Conlon says a key thing for people to understand is to go back to why NAD+ actually declines. “You really need to understand actually how NAD+ is produced by the cells when they're young.”

NAD+ is a natural molecule found in every cell in our bodies. It’s involved in energy production, helping convert the food you eat into the energy your cells need to stay alive. It is an activator of longevity proteins that are associated with cellular health and good aging, DNA repair and more. But as you get older, those NAD+ levels rapidly decline. Dr. Conlon explored why.

“It's become a lot more apparent recently that it's not just energy production that NAD+ is involved with,” Dr. Conlon says. “It's also involved in cellular maintenance and repair. It's almost like the fuel which switches on different enzymes and different processes. NAD+ is critical and actually driving DNA repair and making sure that DNA repair enzymes get to the damage site and do the job that is required.”

She says she got frustrated with the lag time between scientific discovery and actually getting new supplements and drugs to consumers—often a process of 10 to 15 years. “It's like all of science is encapsulated in this bubble, where it never actually gets out to real people in the outside world,” Dr. Conlon says.

So, she took her years of expertise focused on early stage drug discovery with a leading biotech firm and founded Nuchido. She uses a “systems pharmacology” approach to look at the complexity of our individual biology because there’s no single magic bullet for any ailment. Systems pharmacology has three main principles that differ from conventional pharmaceutical discovery, Dr. Conlon says.

“Biology is really complex and there is a lot going on and it is very robust. It's built to withstand impact generally and it doesn't ignore that. It actually looks at every single gene, every single pathway, every single protein, every single feedback, feedforward, inhibition, everything that is going on and almost looks at it as a big network.”
“It’s never, ever scientifically plausible to take a single target approach. Try to put your finger on one tiny little piece of that massive complex puzzle, it's just never going to work,”
“You've got to take a multi targeted approach and look at the best combinations of targets within all of that complexity and understand how you can target them.”

Nuchido looked at NAD+ through that lens and wanted to repair the ways our bodies lose that NAD. Dr. Conlon and her team of scientists and scientific advisors– several who are giants in the field of biogerontology–identified the right combination of targets to restore cellular NAD+ production back to youthful levels, leading to the development of a breakthrough NAD+ booster called Nuchido TIME+.

The TIME+ booster restores and improves the cell’s ability to make and recycle its own NAD+, makes cells more efficient at making NAD+ again, stops cells from wasting NAD+, and reboots the efficiency of your salvage pathway recycling. Your cell function improves and you get your energy back. Pretty cool!

Dr. Conlon says, “I think people don't realize how their energy is actually really pretty bad and the brain fog is pretty bad, and then all of a sudden when it's gone, they're like, ‘Wow! I feel like I can breathe again. I've been living under a cloud.’”

Enjoy! And get more resources at Dave.Asprey/podcasts.

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How to Find Your Own Winning Lane – Danica Patrick with Dave Asprey : 825 May 25, 2021

Show notes

On this episode of Bulletproof Radio, pretty intense professional race car driver Danica Patrick joins the show to talk about her winding journey doing all the things that excite and scare her the most.

She lets her curiosity drive her, including doing what she fears. Could be bungee jumping, diving out of airplanes or eating scorpions and running wild with Bear Grylls. “It's not like I'm over the fear,” Danica admits. “I just like to know that if I have to overcome it, I can. I just like to know I can do it.”

Danica started racing go-karts when she was just 10 years old. She left high school and moved to England to race when she was a teen and worked her way up to driving an IndyCar going 240 mph at age 23. She’s had gigs as a sports announcer, starred in 14 Super Bowl commercials, hosted the ESPY sports awards, created a clothing line and written a book. She’s currently a vineyard owner, hosts her own podcast, and a whole more.

“I just like challenging myself,” Danica says. “I've realized that that's where I thrive, whether it was pushing a car to the very limit or interviewing someone that I'm intimidated by or hosting the ESPYs and not being funny at all. I'm like, how am I going to do this? Or even in a workout. I like to challenge myself.”

This episode offers a great conversation on how we can get past the internal obstacles we tend to set up for ourselves and find our own kind of flow state. Danica’s approach to life is grounding, and we talk about how it frames everything from her foray into biohacking to her racing career.

“I think that that's what's being asked of us, as humans, is that we learn how to get back into that emotional body and let that be the ultimate lie detector test for situations,” she says.

Be sure to check out her podcast, “Pretty Intense™️.” She interviews fascinating people from vastly different backgrounds–again, letting her curiosity lead her. She even has some great tips for all you other podcaster out there on how to write questions and give a fruitful interview.

Enjoy! And get more resources at Dave.Asprey/podcasts.

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Get Your Mojo On With All Things Keto – Dorian Greenow with Dave Asprey : 824 May 20, 2021

Show notes

You’ve told me you want to hear about ketosis, ketones, glucose, monitoring your ketones, what happens when you want to go into ketosis and what happens when you want to go out of it. So, I've got a guest for you who’s definitely geeky, who has gone really, really deep on this to the point that they call him. Mr. Mojo. Dorian Greenow, founder of Keto-Mojo, shares his expertise in ketogenic research and ketone testing.

This episode of Bulletproof Radio is filled with information, tips and takeaways for integrating keto into your life.

Our ketone levels tell us if we’re actually burning fat to make energy, and keto test strips tell us what those ketone levels are. Different people, depending on their lifestyle and bio-individuality, will have different ranges of ideal ketone levels.

“So there are different types of keto,” Dorian says. “Having it data-driven helps you refine it into the bio-individuality. And that to me is the key. I'm agnostic on whatever somebody is keto, and I'm not going to play the keto police saying, "That's not keto." The data should guide people. And once you have that, you get data-driven outcomes because the blood doesn't lie.”

Keto-Mojo has developed cost-effective keto measuring devices so your own data is within reach. Keto-Mojo keeps its focus on funding ketogenic therapies and finding ways to support people in a healthy lifestyle that suits them.

“I'm not about selling a meter,” Dorian says. “You'll view our website, you'll see recipes. There's over 182 hours of the leading clinicians and researchers that were once CME credits, so you can do a deep dive into the medical research that is there.”

“Don't go chasing ketones, chase the results that you've got,” Dorian says. “Learn how to interpret the data.”

Dorian and his wife, Gemma, also founded The Ketogenic Foundation, a 501(c)(3)non-profit Public Charity which fosters ketogenic education, medical research, and information sharing.

Maybe you’re looking for ways to cope with type 2 diabetes, maybe you want to home in on your athletic performance, or maybe you’re just curious. In this episode, you’ll learn why your ketone levels change throughout the day and what your levels may mean for your overall lifestyle and more. No matter how you’ve incorporated keto (or are just thinking about it), you’ll feel like you can really make keto work for you and learn some new tips.

Enjoy! And get more resources at Dave.Asprey/podcasts.

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Saunas Use Infrared to Power Detox, Immunity & Renewal – Connie Zack with Dave Asprey : 823 May 18, 2021

Show notes

In this episode of Bulletproof Radio, Connie Zack, founder of infrared sauna company, Sunlighten, joins the show to talk about the many benefits of infrared light. This technology has incredible impacts on your longevity and recovery, and I want to make sure you learn as much as possible about it.

Traditional steam and heat-based saunas warm you by heating the air and in turn, heating your body. Infrared saunas work by delivering heat directly to your body through wavelengths that are curated to easily access and transform the body. Even the sweat produced between the two is different!

Different parts of the infrared light spectrum have unique benefits in serving our bodies. Near, mid and far-Infrared each offer different benefits, such as improving cell health, quickening muscle recovery, reducing inflammation, lowering blood pressure and more.

“There's been studies showing that infrared can help reduce colds, flus,” Connie says. “The increase in core temperature helps with the antiviral effect as far as activating heat shock proteins and kind of helping to prepare the body to be stronger.”

Other studies have shown a connection between core temperature and reduction of depression or major depression symptoms.

“So with infrared, if you can get the maximum heat and you've mastered the wavelength, then you can get it all into your body to change and transform your body,” Connie says.

Every part of a Sunlighten sauna is intentional–from the type of wood they use (yes, wood can have a chemical reaction to heat) to the construction of the sauna itself.

“This is all about living the world a healthier place as a result of what we're doing every day,” Connie says. “And we want to do it to the maximum.”

Enjoy! And get more resources at Dave.Asprey/podcasts.

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How to Build Your Community and Grow Your Influence – Jon Levy with Dave Asprey : 822 May 13, 2021

Show notes

In this episode of Bulletproof Radio, my guest Jon Levy shares that the greatest predictors of longevity are close social ties and how much you feel like a part of a community.

Jon is a behavioral scientist who researches human connection, trust and influence. He can teach you how to build your own communities and in turn, grow your influence exponentially. He’s done it himself by creating a private community of more than 2,000 industry leaders including Nobel laureates, Olympians, celebrities, executives, royalty, and more.

“If I wanted to accomplish things like being healthy, happy and successful, the most important thing I could do is figure out how to connect with extraordinary people and also connect them with each other. So, I needed to figure out ‘how do I hack connection?’” says Jon. “How do I hack trust and how do we use that to create a positive impact?”

In order to create connections in a new relationship, you have to start by building trust. Jon’s research found that trust is made up of three pillars: competence, honesty/integrity and benevolence. There are ways to use these three pillars to build really meaningful relationships with people you’ve just met. Jon says these new relationships you build directly relate to your level of influence.

“Our influence is a by-product of who we're connected to, how much they trust us, and the sense of community that we share. So, if it starts with connecting with people, it starts with an invitation,” Jon says.

In his new book “You’re Invited: The Art and Science of Cultivating Influence,” you’ll learn how an invitation can be the beginning of a new relationship. Jon’s research also looks at topics like how to build relationships in families and the pandemic workplace to the trust-building ideas of door-to-door knives salesmen.

Enjoy! And get more resources at Dave.Asprey/podcasts.

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7 Ways to Influence People – Robert Cialdini, Ph.D., with Dave Asprey : 821 May 11, 2021

Show notes

The man who pioneered the science and psychology of Influence returns to Bulletproof Radio today.

Known as “The Godfather of Influence,” Robert Cialdini, Ph.D., is the foundational expert in the science of influence and how to apply it ethically in business.

After nearly 40 years of evidence-based, peer-reviewed scientific research, he’s earned a global reputation for his ability to translate his scientific studies into valuable and practical actions. This makes his principles of influence and persuasion accessible to everyone and a cornerstone for people and organizations serious about effectively increasing their influence.

In this episode, you’re going to learn about the psychology of why people say yes and the brand-new principle of influence Robert has added to the original six, which is unity.

“Unity is a standalone principle of influence,” Robert says. “ If we can, as communicators, simply arrange our language, arrange how we comport ourselves so that people see us as partners with them before we begin the process of trying to move them in our direction, their barriers to influence drop dramatically.”

His latest book, “Influence, New and Expanded: The Psychology of Persuasion,” includes new research so you can become an even more skilled persuader using all seven principles.

You’ll also learn how social influence improves personal relationships and governmental effectiveness and affects work relationships and political decisions.

Robert is president and CEO of Influence at Work and a prolific public speaker. His work and books have been featured in the New York Times, Forbes, Inc., Psychology Today Magazine, on the PBS Newshour, and on many podcasts and media outlets.

Enjoy! And get more resources at Dave.Asprey/podcasts.

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8 Reasons Why Obesity Isn’t the Problem, Metabolic Dysfunction Is – Dr. Robert Lustig with Dave Asprey : 820 May 06, 2021

Show notes

In this episode of Bulletproof Radio, Robert H. Lustig, M.D., M.S.L., the New York Times bestselling author of several books about the problems caused by sugar, processed food and the health conditions of obesity, shares his expertise and research about metabolic health.

He addresses nutrition, food science, and global health, and explains how by focusing on real food we can reverse chronic disease and promote longevity. He also challenges the current healthcare paradigm and the influence of Big Food, Big Pharma, and Big Government.

Dr. Lustig is a pediatric neuroendocrinologist who’s spent his 40-plus year career treating and finding ways to prevent obesity and diabetes. He’s emeritus professor of pediatrics in the Division of Endocrinology and member of the Institute for Health Policy Studies at the University of California, San Francisco.

He's authored 130 peer-reviewed articles, 80 academic chapters and reviews, and dozens of op-eds for the public. He now has a new bookto explain the eight pathologies that underlie all chronic disease and document how processed food has impacted our health, economy, and environment over the past 50 years.

“So all these medicines that we currently throw at these various chronic diseases, they are treating the symptoms of the disease but they are not treating the underlying pathology,” Dr. Lustig says. “The disease is still there.”

The eight pathologies we discuss include glycation, oxidative stress, mitochondrial dysfunction, insulin resistance, membrane instability, inflammation, epigenetics, and autophagy.

“It’s not about obesity, it never was,” Dr. Lustig says. “The key to the kingdom is that it is not about obesity, it is about metabolic dysfunction and anyone can get it, and that’s what makes it a public health crisis, because obesity is a result of the problem, not the cause. I never want to hear any of you talk about the obesity epidemic ever again, because that is the food industry’s mantra, that is what they use to obfuscate the truth, and you play right into it when you talk about it.”

In his new book, “Metabolical: The Lure and the Lies of Processed Food, Nutrition, and Modern Medicine,” Dr. Lustig proposes a strategy to cure both us and the planet.

Enjoy! And get more resources at Dave.Asprey/podcasts.

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VIRTUAL BIOHACKING CONFERENCE MAY 8, 2021

Recharge Your Cells & Upgrade Your Life at this one-day event! Register at https://www.biohackingconference.com

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The Limited Edition Dave Asprey Upgraded Box is worth more than three times its price! Got to https://upgrade.biohackingconference.com to purchase and use code BOXPLUS to get a free ticket to the Virtual Biohacking Conference.

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Change Your Body Position To Get Better Sleep – Dr. Peter Martone with Dave Asprey : 819 May 04, 2021

Show notes

This episode of Bulletproof Radio kicks off Better Sleep Month. Sleep hacking is core to what I do, so I wanted to invite someone on who’s dedicated to that practice. I’m talking with Dr. Peter Martone who is a chiropractor, exercise physiologist and inventor of the Neck Nest, a pillow specifically designed to improve your sleeping postures.

Here's a challenge: try watching a two-hour movie in the position you normally sleep in. Peter bets you won’t last more than 30 minutes without needing to move. You spend eight hours a night (ideally) sleeping, and a third of your life in total, so the way you orient your body during sleep is incredibly important.

What position should we try to move to? Our backs! As Peter says, we were designed to sleep in a position that distributes our weight over the greatest surface area. When you sleep on your side, you lose the cervical curve in your spine and overtime develop scoliosis in your lower back.

“It’s no coincidence that your sleep center and your pain center are right next door to each other,” Peter says. You can't stay in an uncomfortable position during sleep, because your body will toss out of it. “Sleeping on your back, if you can do it without your back hurting, without snoring like a machine, that's ideal.”

I had always felt pain every time I slept on my back, but ever since I started using this pillow, I’m a back sleeper. This pillow, once broken in, uses traction to support and restore your spine to that cervical curve. You only need to use it two to three hours a night to restore that curve.

“Being on a computer all day, texting all day, our spines are getting destroyed,” Peter says. “Our sleep scores are getting destroyed because we're tossing and turning all night long. You can fix your spine while you sleep, get 30% better sleep scores by just changing your position, and you can virtually eliminate neck and back pain by doing it while you sleep. It's crazy to me that we're a side sleeping culture, and I am trying to do my part to create the happiest, healthiest, most well-rested people on earth by teaching them how to sleep in a different position.”

The conversation also goes into heart rate variability, vagus nerve stimulation, deep sleep, energy spikes, circadian rhythms and other tips for getting great sleep.

Enjoy! And get more resources at Dave.Asprey/podcasts.

Got a comment, idea or question for the podcast? Submit via this form.

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VIRTUAL BIOHACKING CONFERENCE MAY 8, 2021

Recharge Your Cells & Upgrade Your Life at this one-day event! Register at https://www.biohackingconference.com

DAVE ASPREY BOX

This quarterly subscription box gives you access to biohacking resources that can support you in achieving your health goals and unlocking your potential. Go to https://daveaspreybox.com/; NEW subscribers use code VBC21 to get $10 off.
The Limited Edition Dave Asprey Upgraded Box is worth more than three times its price! Got to https://upgrade.biohackingconference.com to purchase and use code BOXPLUS to get a free ticket to the Virtual Biohacking Conference.

UPGRADE YOURSELF EVEN MORE

Learn directly from Dave Asprey in his new membership group https://ourupgradecollective.com

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Mini-Episode: Cool Facts Friday #10 Apr 30, 2021

Show notes

Cool Facts are quick hits of new human and world science curated into short bursts of information just for you. This fun compilation publishes one Friday a month. Enjoy!

Here’s the current lineup for episode #10:

How a tiny brain-manipulating machine helps understand neurological disease and neurotrauma..
How to simplify your life.
Why you're struggling to maintain a healthy weight.
Why your body replaces cells at incredible speed.
How to identify "hot spots" of aging and disease in DNA.
How zombie genes come to life after you die.

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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