The Human Upgrade: Biohacking for Longevity & Performance

Latest Episodes:

Hacking Dopamine Naturally: Pain, Focus, and Performance : 1320 Aug 28, 2025

Show notes

Your dopamine system is being hijacked every day, and the way to reclaim it might surprise you. This episode reveals how pain, pleasure, and addiction are wired in your brain, and how to use that knowledge for real brain optimization, resilience, and longevity. You’ll discover why your dopamine levels control motivation, focus, mood, and even cravings—and the science-backed strategies that reset your neuroplasticity, metabolism, and reward system.

Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR

Host Dave Asprey sits down with Dr. Anna Lembke, Stanford psychiatrist and bestselling author of Dopamine Nation. She is one of the world’s leading experts on addiction, compulsive behavior, and the neuroscience of reward pathways. With decades of clinical work and groundbreaking research, she explains why dopamine has become the modern lens for understanding desire, distraction, and dysfunction—and how we can hack it to upgrade human performance.

They break down how dopamine drives addiction, why pain can reset your reward system, and how simple practices like fasting, cold therapy, and supplements affect your brain chemistry. You’ll learn how nicotine, GLP-1 drugs, and even nootropics alter dopamine sensitivity, and why overstimulation from social media, pornography, and ultra-processed food is creating an epidemic of anhedonia. The conversation also covers how functional medicine and biohacking can protect your mitochondria, restore your natural dopamine balance, and make your brain more resilient.

You’ll Learn:

• Why dopamine itself is not addictive—and what really drives addiction

• How pain, hormesis, and “dopamine fasting” can reset your reward system

• Why social media and digital overstimulation create chronic dopamine deficit states

• The role of GLP-1 drugs, nicotine, psychedelics, and other substances in rewiring dopamine

• How functional medicine and supplements help restore dopamine balance

• The connection between dopamine, mitochondria, fasting, cold therapy, and longevity

• Why radical honesty and self-binding are powerful anti-addiction hacks

This is essential listening for anyone serious about hacking dopamine for better focus, sleep optimization, metabolism, and long-term brain health. Whether you’re curious about the link between dopamine and neuroplasticity, looking to upgrade human performance with smarter not harder tools, or just want to know how to stop dopamine hijacks from ruling your life, this episode gives you the science and strategies you need.

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.

Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.

Keywords: dopamine fasting, pleasure-pain balance, dopamine deficit state, addiction neurobiology, anhedonia treatment, dopamine receptors, neuroadaptation gremlins, endogenous opioids, cold plunge dopamine, hormesis neuroscience, nucleus accumbens dopamine, L-Dopa addiction, GLP-1 and dopamine, social media addiction neuroscience, dopamine reward pathway, compulsive behavior psychiatry, dopamine and neuroplasticity, anhedonia supplements, functional medicine addiction, dopamine repair party

Thank you to our sponsors!

Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order.
ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order.

Resources:

• Anna’s Website: https://www.annalembke.com/

• Danger Coffee: https://dangercoffee.com/DAVE15

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

0:00 — Trailer

1:10 — Introduction

5:47 — Pleasure–Pain Balance

6:45 — Homeostasis & Adaptation

8:22 — Addiction & Dopamine Deficit

10:14 — BICEP: Conscious Pain Exposure

14:26 — Adapting to Pleasure & Pain

20:20 — GLP-1s and Joy

21:39 — Modern Anhedonia

34:32 — Resilience in Young People

42:00 — Social Media & Mental Health

44:46 — Control & Addiction

55:14 — Dopamine Fasting

1:03:18 — Self-Binding Tools

1:07:56 — Psychedelics & Addiction

1:12:25 — Parenting in the Digital Age

1:14:39 — Progress & Outlook

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You Have A 25% Chance to Lose All Your Memory (Longevity Secrets) : 1319 Aug 26, 2025

Show notes

Alzheimer’s is not inevitable—and it may even be optional. In this groundbreaking episode, you’ll learn how to prevent, slow, and in some cases reverse cognitive decline using strategies that also enhance brain optimization, metabolism, and longevity.

Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR

Host Dave Asprey is joined by Dr. Dale Bredesen, a world-renowned neurologist and leading Alzheimer’s researcher who has published over 240 peer-reviewed papers. Dr. Bredesen has spent decades proving that Alzheimer’s is not a one-pathway disease but a network failure driven by inflammation, toxins, and mitochondrial dysfunction. His protocol has helped thousands of patients regain memory, extend healthspan, and reclaim brain performance.

Together, they unpack how biohacking tools like fasting, ketosis, supplements, sleep optimization, cold therapy, and functional medicine can rewire neuroplasticity, protect mitochondria, and keep the brain in “connection mode” instead of decline. You’ll hear why the pharmaceutical industry resists these solutions, how toxins like Paraquat and mold fuel cognitive decline, and what young people can do right now to bulletproof their brains for life.

This episode is essential listening if you care about hacking human performance, upgrading metabolism, or extending longevity. You’ll walk away with practical strategies you can use today—whether that means optimizing your mitochondria with nootropics, strengthening resilience with smarter not harder recovery, or fueling your brain with Danger Coffee.

You’ll Learn:

• Why Alzheimer’s can begin as early as your 20s and what biomarkers to track

• The seven major drivers of Alzheimer’s and how to reverse them with biohacking strategies

• How APOE4 genetics, toxins, and inflammation accelerate brain aging—and what to do about it

• The role of mitochondria, ketosis, and fasting in restoring brain optimization and neuroplasticity

• Why prevention is exponentially easier than reversal and the top three actions you should start in your 20s

• How to avoid “learned helplessness” in medicine and reclaim control over your brain span and longevity

Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.

Keywords: Alzheimer’s prevention biohacking, APOE4 genetics risk, mitochondrial dysfunction brain, network insufficiency model, cognitive decline reversal protocol, neuroplasticity longevity strategies, mild cognitive impairment treatment, subjective cognitive impairment biomarkers, ketoflex 12/3 diet, mycotoxins and Alzheimer’s, Paraquat Parkinson’s risk, mitochondrial transfusion therapy, fasting neuroprotection, ketosis brain optimization, natokinase soft plaque removal, sleep apnea cognitive decline, functional medicine Alzheimer’s, hippocampal volume preservation, nootropics cognitive resilience, learned helplessness medicine

Thank you to our sponsors!

EMR-Tek | Go to https://www.emr-tek.com/DAVE and use code DAVE for 40% off.
fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE.
OneSkin | Get 15% off your first purchase at https://oneskin.co/ASPREY with code ASPREY.

Resources:

• Dale’s Website: https://www.apollohealthco.com/dr-bredesen/

• Danger Coffee: https://dangercoffee.com/DAVE15

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

0:00 — Trailer

1:10 — Introduction

2:43 — Personal Story

7:52 — APOE4, Genetics, and Drug Development

11:37 — Pharma, Media, and Pushback

17:13 — Prevention, Stages, and Biomarkers

23:34 — Causes and Mechanisms

30:24 — Parkinson’s, Toxins, and Mitochondria

37:17 — Longevity, Biohacking, and Protocols

44:11 — AI, Data, and Future Treatments

54:11 — Case Studies and Success Stories

1:03:00 — Detox, Mold, and Environmental Triggers

1:12:00 — Neuroplasticity and Brain Regeneration

1:20:00 — Hormones, Supplements, and Personalized Hacks

1:29:00 — Cortisol, Addison’s, and AI Protocols

1:38:00 — Large-Scale Trials and Global Impact

1:45:00 — Final Takeaways

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The Hormone War Dividing Female and Male Longevity : 1318 Aug 22, 2025

Show notes

Your hormones may be waging a hidden war that determines how long you live and how well you perform. This episode reveals how male and female biology diverge—and what those differences mean for your longevity, metabolism, and brain optimization.

Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR

Revisit this episode where Dave Asprey sits down with Teal Swan, a bestselling author and international speaker known for her work on human behavior, healing, and consciousness. Her insights bridge biology and psychology, uncovering how hormones, trauma, and environment shape both performance and resilience. Her ability to decode patterns of narcissism, victimhood, and trust through the lens of functional medicine and human performance makes her one of the most provocative voices in personal transformation.

Together, they explore the science behind the hormonal divide between men and women—why birth control alters not just fertility but also male testosterone, why perception and neurodivergence impact neuroplasticity, and how early trauma imprints mitochondria and metabolism. You’ll learn how fasting, ketosis, cold therapy, sleep optimization, and smarter not harder strategies can shift your biology toward higher resilience and greater longevity.

They also break down the biohacking tools and supplements that can help balance hormones, upgrade mitochondria, and fuel nootropics-level brain performance. From the hidden biological costs of hormonal birth control to how carnivore and targeted nutrition affect both male and female healthspan, this episode gives you a framework for hacking your biology at the deepest level.

This is essential listening for anyone serious about biohacking, hacking human performance, brain optimization, functional medicine, or understanding how masculine and feminine biology directly influence lifespan and resilience.

You’ll Learn:

• How hormonal birth control impacts both women’s fertility and men’s testosterone

• Why victim mentality rewires the brain and reduces neuroplasticity

• How narcissism functions as a biological stress adaptation

• The role of mitochondria, metabolism, and trauma in shaping healthspan

• How fasting, ketosis, supplements, and cold therapy affect hormone balance

• Why balancing male and female energetics may be a key to longevity

Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.

Keywords: hormone war, male vs female longevity, hormonal birth control effects, testosterone collapse, estrogen disruption, masculine vs feminine biology, victim mindset neuroscience, narcissism as adaptation, betrayal and biology, neuroplasticity and trauma, perception and neurodivergence, fractal vision, birth trauma programming, mitochondria and stress, species-level hormone imbalance, industrial hormone disruption, male fertility decline, female hormone resilience, functional medicine hormones

Resources:

• Teals Website: https://tealswan.com/

• Teal’s YouTube: https://www.youtube.com/@TealSwanOfficial

• Danger Coffee: https://dangercoffee.com/DAVE15

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

0:00 — Cold Open

0:33 — Intro

2:49 — Defining Narcissism

5:48 — Gender Differences in Narcissism

7:47 — AI, Humanity, and the Future

10:25 — Extrasensory Perception & Childhood Experiences

14:04 — Birth Memories and Early Trauma

17:57 — Spiritual Abilities and Neurodivergence

22:48 — Functioning in the World with Unique Perceptions

23:45 — Trust, Support, and Creation

30:07 — Ego, Consciousness, and Spiritual Guides

33:46 — Dimensions and Multiverse Concepts

36:52 — Divine Masculine & Feminine

40:25 — Societal Imbalances and Gender Energies

46:20 — Hope for Humanity & Utopia

48:36 — Synchronization Workshops & Group Healing

51:30 — Science, Energy, and Invisible Communication

53:29 — Conclusion & Final Thoughts

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The 10-Second At-Home Walk Test for Longevity (Easy Biohack) : 1317 Aug 21, 2025

Show notes

Walking speed predicts your risk of death better than cholesterol—and this episode reveals why. You’ll learn how to test your biological age at home in just 10 seconds, and how to use that information to upgrade your human performance, extend your longevity, and tailor your biohacking strategy for maximum results. Discover the overlooked role of pelvic floor strength, glute activation, and neuromuscular training in brain optimization, metabolism, and injury prevention.

Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR

Host Dave Asprey speaks with Dr. Vonda Wright, a double board-certified orthopedic surgeon, hormone optimization expert, and elite sports medicine pioneer who’s worked with Olympic athletes, military special forces, and high-performing women through every phase of life. With decades of experience in functional medicine, movement science, and hormone therapy, Dr. Wright shares the essential strategies to prevent frailty, rebuild strength, and thrive through perimenopause and beyond.

You’ll learn:

• How walking speed reveals aging and longevity better than traditional blood tests

• The biomechanics behind muscle “shutdown” and how to turn muscles back on

• The truth about C-sections, pelvic floor rehab, and functional motion assessments

• Which supplements, nootropics, and hormone therapies restore metabolism and vitality

• Why perimenopause is a turning point for brain, bone, and cardiovascular health

• Testing tools and training methods to upgrade strength, prevent falls, and age powerfully

Whether you want to feel stronger, think sharper, or stay youthful into your 90s, this is your roadmap for smarter not harder biohacking with real-world impact.

Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.

Keywords: 10-second walk test longevity, pelvic floor dysfunction and aging, glute activation for brain health, perimenopause hormone replacement therapy, VO2 max biohacking, estrogen for bone density, neuromuscular reactivation exercises, functional movement assessment AI, post-C-section core recovery, velocity training for longevity, strength vs muscle mass aging, menopause testosterone therapy, mitochondrial health for women, sleep optimization progesterone, cold therapy for muscle recovery, fascia training for anti-aging, diastasis recti long-term effects, smart exercise hacks for aging, hormone optimization for libido and brain, smarter not harder fitness protocols

Thank you to our sponsors!

Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order.
BodyHealth | Go to https://bodyhealth.com/ and use code DAVE20 for 20% off your first order of PerfectAmino.

Resources:

• Vonda's Website: https://www.drvondawright.com/

• Vonda's Instagram: https://www.instagram.com/drvondawright/?hl=en

• Danger Coffee: https://dangercoffee.com/DAVE15

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

0:00 — Trailer

1:23 — Intro

2:55 — Muscle Atrophy and Reactivation

6:10 — Pelvic Floor Health and Rehab

8:47 — Joint Mobility and Movement

10:02 — Science of Muscle Function

18:23 — Perimenopause and Menolescence

27:58 — Four Essential Female Hormones

42:50 — VO2 Max and Longevity

49:24 — Velocity Training and Bone Health

62:30 — Turning Menopause into Power

65:58 — Closing Thoughts and Book Rec

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

PhD at MIT: The Longevity Molecule That Reverses Aging (250 Studies) : 1316 Aug 19, 2025

Show notes

Learn how to slow, and even reverse, your biological age with cutting-edge science on the molecule that controls your longevity. Host Dave Asprey sits down with Dr. Leonard Guarente, an MIT PhD and one of the most respected longevity researchers in the world, to reveal how NAD+, sirtuins, and DNA methylation clocks can help you hack aging, upgrade your mitochondria, and extend your healthspan. This episode gives you the real science, proven by over 250 studies, behind supplements, nutrition, and biohacking tools that actually work for brain optimization, metabolism, and human performance.

Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR

You’ll learn why NAD+ is a master regulator of mitochondrial health, how DNA methylation clocks accurately measure biological age, and why boosting sirtuin activity improves resilience, neuroplasticity, and recovery. Dr. Guarente shares insider strategies from decades of functional medicine research, including nootropics, targeted supplements, fasting protocols, and diet adjustments from carnivore to Mediterranean that can shift your metabolism toward longevity. Dave and Dr. Guarente explore advanced biohacks like cold therapy, sleep optimization, and ketosis, plus how to balance these interventions with your genetics, lifestyle, and health goals. You’ll also hear about the surprising role of homocysteine in brain aging, how to use lab testing to guide your longevity plan, and why resilience is the ultimate measure of health.

You’ll learn:

• How emotional repression affects brain function, metabolism, and decision-making

• Tools for nervous system regulation and emotional healing that drive high performance

• Why most people fail without emotional intelligence and internal safety

• How somatic awareness can optimize your energy, focus, and relationships

• The science of fear, trauma release, and how to turn discomfort into growth

• How to coach yourself out of stress, shame, and negative self-talk

Whether you want to sharpen your brain, protect your heart, or upgrade your energy systems, this is a masterclass in smarter not harder biohacking for a longer, higher-performing life.

Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.

Keywords: NAD+ supplementation, Sirtuin activation, DNA methylation clocks, Biological age testing, Mitochondrial biogenesis, Epigenetic reprogramming, Pterostilbene benefits, Nicotinamide riboside (NR), Nicotinamide mononucleotide (NMN), Homocysteine reduction, Oxidative stress repair, Superoxide dismutase (SOD) activation, Functional medicine longevity, Healthspan optimization, Resveratrol bioavailability, Menopause mitochondrial support, Phenylbutyrate and protein folding, High-fat diet longevity studies, Neurodegenerative disease biohacking, INCHIANTI aging study

Thank you to our sponsors!

Screenfit | Get your at-home eye training program for 40% off using code DAVE https://www.screenfit.com/dave.
Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.
Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order.

Resources:

• Elysium Website. Use code ‘UPGRADE25’ for 25% off the first month of a monthly subscription to any Elysium supplement: https://www.elysiumhealth.com/

• Dave Asprey’s Website: https://daveasprey.com

• Danger Coffee: https://dangercoffee.com/DAVE15

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

0:00 — Introduction to NAD & Sirtuins

0:59 — Intro

7:04 — Animal vs Human Aging Studies

10:07 — Discovery of Sirtuins

14:43 — NAD’s Role in Aging

15:34 — Resveratrol vs Pterostilbene

23:13 — Timing NAD Supplementation

36:34 — Diet & Lifestyle Factors

50:05 — Elysium’s Basis & Signal

1:00:03 — Future Clinical Trials

1:05:14 — Psychology of Aging & Wrap-Up

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Still Fasting in 2025? Here’s How to Make It Work Better : 1315 Aug 15, 2025

Show notes

How do you activate your body’s natural repair system? How can you hack stem cells for faster recovery, brain optimization, and peak human performance? This episode reveals how to trigger stem cell release, direct them to the right tissues, and stack biohacking tools for maximum regeneration. You’ll learn science-backed strategies for boosting mitochondria, enhancing neuroplasticity, and extending longevity through targeted supplements, fasting, and functional medicine techniques.

Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR

Host Dave Asprey talks with Christian Drapeau, a leading stem cell scientist and founder of STEMREGEN. Christian’s decades of research have transformed our understanding of how stem cells repair the body, reverse damage, and amplify performance. He shares practical protocols to mobilize stem cells, improve microcirculation, and reduce inflammation so your body heals faster, functions better, and stays younger for longer.

You’ll learn:

• How stem cells rebuild muscle, brain, and organ tissue for optimal human performance

• Why fasting rejuvenates bone marrow and increases stem cell effectiveness

• The synergy between PEMF, vibration therapy, cold therapy, and stem cell activation

• How microcirculation and inflammation control improve longevity and recovery

• The best supplements and nutrients to support mitochondria and stem cell health

• How to stack nootropics, ketosis, and brain optimization tools for lasting energy and focus

This is essential listening for anyone serious about biohacking, longevity, human performance, mitochondria health, neuroplasticity, functional medicine, fasting protocols, supplements for recovery, brain optimization, smarter not harder healing, metabolism upgrades, cold therapy stacks, and next-level physical and cognitive resilience

Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.

Keywords: STEMREGEN, biohacking, natural stem cell activation, human performance, longevity, mitochondria, neuroplasticity, fasting, bone marrow rejuvenation, functional medicine, supplements, brain optimization, metabolism, cold therapy, microcirculation, nootropics, ketosis, smarter not harder, recovery hacks

Resources:

• STEMREGEN Website: https://www.stemregen.co/dave for 20% off your first order.

• Dave Asprey’s Website: https://daveasprey.com

• Danger Coffee: https://dangercoffee.com/DAVE15

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

0:00 — Trailer

1:00 — Why Some People Regenerate Better

1:52 — Testing Stem Cell Levels

2:58 — Natural Stem Cell Function

3:59 — Exercise & Stem Cell Response

5:13 — Tissue Turnover & Regeneration

7:03 — Bone Marrow Production

8:16 — Fasting & Bone Marrow

9:33 — Nutrition for Bone Marrow

11:14 — Traditional Meets Modern Science

12:58 — Training Bone Marrow

13:57 — Stem Cells as Repair System

34:20 — Stem Cells & Brain Injury

47:01 — Inside STEMREGEN Products

55:41 — Stress, Cortisol & Stem Cells

58:12 — Final Recommendations

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

How to Make Life-Changing Decisions Without Fear – Joe Hudson : 1314 Aug 14, 2025

Show notes

How do you make tough decisions? How do you make them without fear or lying? This episode shows you how unresolved emotions disrupt decision-making, relationships, and functioning in peak brain performance. You’ll learn tips to rewire your nervous system for decision making, optimizing emotional intelligence, and regulating your body for high-level clarity, energy, and resilience. Discover biohacking techniques that use emotional release and somatic awareness to boost mitochondria, activate neuroplasticity, and achieve lasting personal transformation.

Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR

Host Dave Asprey talks with Joe Hudson, a world-renowned executive coach to unicorn founders and billion-dollar leaders. Joe works with a select group of top performers to unlock emotional clarity, leadership mastery, and deep personal change. His methods combine neuroscience, trauma healing, somatic therapy, and conscious coaching to help people perform at their highest level while becoming more authentic, fulfilled, and connected.

You’ll learn:

• How emotional repression affects brain function, metabolism, and decision-making

• Tools for nervous system regulation and emotional healing that drive high performance

• Why most people fail without emotional intelligence and internal safety

• How somatic awareness can optimize your energy, focus, and relationships

• The science of fear, trauma release, and how to turn discomfort into growth

• How to coach yourself out of stress, shame, and negative self-talk

This is essential listening for anyone serious about emotional intelligence, high-performance coaching, biohacking, somatic healing, trauma work, executive leadership, nervous system regulation, brain optimization, functional medicine, and building unstoppable inner resilience.

Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.

Keywords: Joe Hudson, Dave Asprey, emotional intelligence, nervous system regulation, somatic therapy, trauma healing, executive coaching, biohacking emotions, brain optimization, emotional mastery, making tough decisions, fear or failure, leadership development, negative self talk, childhood trauma, personal transformation, smarter not harder, stress relief tools, leadership listening

Thank you to our sponsors!

Puori | Head to http://puori.com/dave for 20% off, including subscriptions.
Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial.
Active Skin Repair | Visit http://activeskinrepair.com/ to learn more and use code DAVE to get 20% off your order.

Resources:

• Sign up for a complimentary transformation guide from Joe: https://www.artofaccomplishment.com/

• Joe’s Art of Accomplishment Podcast: https://open.spotify.com/show/6MjoHFfLmNgo0Msais7IJ2

• Daily Insights on Twitter: https://tinyurl.com/4kazb783

• Dave Asprey’s Website: https://daveasprey.com

• Danger Coffee: https://dangercoffee.com/DAVE15

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

0:00 — Introduction

2:42 — Why We Struggle with Fasting

6:28 — Identity and Control Patterns

11:56 — The Nervous System and Decision-Making

23:33 — Letting Go vs. Forcing Change

28:09 — Rebuilding Every Organ with Anti-Aging Work

33:51 — How to Actually Feel Emotions (Without Getting Stuck)

39:18 — Upgrading the Subconscious

45:02 — Final Thoughts and Takeaways

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The New Poisons Lurking Around You – Save Your Longevity : 1313 Aug 12, 2025

Show notes

Toxins you cannot see are damaging your health, wrecking your metabolism, and quietly accelerating aging. This episode reveals how to detect the new poisons lurking in your home, how they sabotage mitochondria and brain optimization, and the biohacking fixes that restore longevity, energy, and human performance. You’ll learn actionable strategies you can implement right away, from functional medicine detox protocols to supplements that protect your nervous system and upgrade neuroplasticity.

Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR

Host Dave Asprey sits down with Alan Bell, an environmental health attorney and author of POISONED. Alan’s landmark legal work and decades of investigative experience have exposed some of the most dangerous everyday chemicals in modern life. After surviving his own severe toxic exposure, he’s dedicated his career to helping others identify hidden threats, fight back against corporate negligence, and restore their health through targeted biohacking and functional medicine.

You’ll learn:

• The most common invisible poisons in homes and how they impact metabolism, mitochondria, and brain optimization

• Biohacking techniques for detox, from supplements to fasting and cold therapy

• How to protect longevity and human performance with targeted functional medicine strategies

• Why your sleep optimization, ketosis, and nootropics stack may fail without toxin removal

• The connection between environmental toxins, neuroplasticity, and emotional resilience

• How to use smarter not harder thinking to upgrade your biology for the long term

This is essential listening for anyone serious about biohacking, brain optimization, hormone hacking, nootropics, functional medicine, emotional resilience, and building a state of unstoppable energy.

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.

Episodes are released every Tuesday, Thursday, and Friday where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.

Keywords: Alan Bell, Dave Asprey, environmental illness, toxic building syndrome, VOC exposure, multiple chemical sensitivity, U.S. chemical safety laws, environmental toxins, mast cell activation, mitochondrial health, ten most dangerous chemicals, biohacking detox, air filtration, flame retardant-free bedding, non-toxic cookware, chronic illness

Thank you to our sponsors!

Get 15% off your first purchase at https://oneskin.co/ASPREY with code ASPREY.
BON CHARGE | Go to https://boncharge.com and use code DAVE for 15% off.
Calroy | Head to https://calroy.com/dave for an exclusive discount.

Resources:

• Alan’s Website: https://alanbell.me/

• Dave Asprey’s Website: https://daveasprey.com

• Danger Coffee: https://dangercoffee.com/DAVE15

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

0:00 — Trailer

1:07 — Intro

3:45 — Life in a Bubble

5:40 — Building Syndrome Impact

7:04 — Legal Gaps

11:55 — Medical Blind Spots

13:04 — Chemicals + Mold

14:00 — Legal Barriers

17:15 — Environmental Disease Links

18:54 — Toxic Burden

20:53 — Media Awareness

21:55 — Hollywood Hazards

24:00 — MCS & Fibromyalgia

26:04 — Recovery Strategies

27:22 — Mast Cell Science

38:15 — Biohacking & AI

40:17 — Top 10 Chemicals

44:00 — Reduce Exposure

48:45 — Detox & Travel

50:20 — Legal + Media Power

52:33 — Chemical Industry Truth

56:19 — Policy & Advocacy

58:12 — Closing

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Jim Kwik: What I Take to Biohack Brain Speed and Focus : 1312 Aug 08, 2025

Show notes

Want to think faster, remember more, and rewire your brain for high performance? This special archived episode breaks down the real nootropic stack, neuroplasticity tools, and brain optimization protocols Jim Kwik uses daily, plus the biohacking routines that rebuilt his cognition after traumatic brain injury.

Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR

Host Dave Asprey sits down with world-renowned brain coach Jim Kwik, bestselling author of Limitless and advisor to billionaires, athletes, and Hollywood performers. After being labeled “the boy with the broken brain” as a child, Jim transformed his life through functional medicine, nootropics, cold therapy, neurorehab, and smart supplementation. He’s now the go-to expert on learning how to learn, with cutting-edge insights on memory, speed reading, focus, and cognitive recovery.

Together, they reveal the most effective supplements for brain optimization, how to stack smart drugs with sleep optimization, the surprising downside of alpha GPC, and why things like ketosis, mitochondrial support, and even Danger Coffee are essential for modern cognition. You’ll also hear why your brain speed depends on your metabolism, the forgotten science of post-traumatic growth, and how to combine breathing, fasting, and cold therapy for massive neuroplasticity gains.

Jim also shares his Brain Animal system, a new way to personalize your learning, decision-making, and communication based on your unique cognitive style. From performance to parenting, he shows how your “brain type” influences every part of life and how to hack it for focus, clarity, and flow.

This episode is packed with high-impact strategies for biohacking your brain, improving human performance, upgrading memory, and building real resilience using smarter not harder protocols.

You’ll Learn:

• What Jim Kwik takes daily for brain speed, cognition, and mental stamina

• The exact nootropics Dave Asprey uses (and the ones he avoids)

• How sleep apnea nearly destroyed Jim’s performance and how he hacked it

• The connection between mitochondria, memory, and metabolism

• Why brain inflammation blocks focus and cognitive clarity

• When to use cold therapy, hyperbaric oxygen, and stem cells for brain repair

• How to know if your brain needs more acetylcholine and what happens if you overdo it

• The best biohacking tools for focus, speed reading, learning, and flow state

• Why your brain animal determines how you learn, lead, and connect

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.

Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.

Keyword Index:

Acetylcholine supplements, Alpha GPC vs CDP choline, Post-traumatic growth brain, Stem cells for brain repair, Hyperbaric oxygen therapy for TBI, Brain inflammation supplements, Learning disabilities recovery, Best supplements for neurogenesis, Brain fog biohacks, Brainwave training programs, Smart drug protocols, Cognitive stack routines, Mitochondrial support for cognition, Electrolytes for brain performance, Danger Coffee brain benefits, ADHD nootropics protocol, Sleep apnea and cognition, High dopamine supplements, Brain types and learning styles, Upgrade Labs review

Thank you to our sponsors!

Generation Lab | Go to http://generationlab.com/, use code Dave20 for $20 off, and see what your body’s really doing behind the surface.
GOT MOLD? | Go to http://gotmold.com/shop and use DAVE10 to save 10% and see what’s in your air.
BodyHealth | Go to https://bodyhealth.com/ and use code DAVE20 to save 20% off your first order of PerfectAmino.

Resources:

• Jim's Website: https://www.jimkwik.com/

• Dave Asprey’s Website: https://daveasprey.com

• Danger Coffee: https://dangercoffee.com/DAVE15

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

• 0:00 — Introduction & Brain Health

• 0:47 — Childhood Injury & Struggles

• 2:53 — Adversity & Purpose

• 6:31 — Nootropics & Optimization

• 18:49 — Daily Biohacking Habits

• 32:14 — Exercise & Brain Function

• 34:21 — Learning & Cognition

• 38:06 — Sleep & Resilience

• 41:41 — Brain Types Explained

• 52:16 — Parenting & Neuroplasticity

• 57:19 — Limitless Update & Wrap-Up

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Why I Inject a “Female Hormone” 3x a Week (Nootropic Hacking) : 1311 Aug 07, 2025

Show notes

What if the most powerful upgrades for brain energy, metabolism, and drive aren’t in mainstream medicine, but in rare peptides and misunderstood hormones? In this episode, you’ll discover the cutting-edge compounds, nootropics, and hormonal strategies that elite biohackers are using right now to optimize every part of their biology.

Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR

Host Dave Asprey sits down with Jay Campbell and Hunter Williams, co-founders of BioLongevity Labs—a performance biotech company creating oral peptide-based products like BioMind and BioGutPro. Jay is a globally recognized expert in testosterone optimization, author of The TOT Bible, and a leading voice in hormone and peptide therapeutics. Hunter is a high-performance coach and podcast host focused on metabolism, mindset, and men’s health through functional medicine and advanced supplementation.

In this high-energy, high-clarity conversation, the trio explore what’s working right now in advanced human performance, spanning hormone synergy, mitochondrial enhancement, libido compounds, nootropics, and muscle-preserving stacks. You’ll hear why Dave injects estradiol three times per week, how Jay and Hunter use oral bioregulators to improve gut-brain signaling, and what peptides are quietly reshaping the future of health.

You’ll Learn:

• Who should use estradiol—and how it can protect brain performance in men

• The real role of testosterone and estradiol synergy in male health and longevity

• How BioLongevity Labs is innovating with oral peptide delivery for cognitive and gut health

• Why peptides like BPC‑157, TB‑500, PT‑141, and SS‑31 are changing mitochondrial care

• The truth about Melanotan‑1, SLU, AOD‑9604, GW‑501516, and BAM‑15

• What makes BioMind and BioGutPro different from standard nootropic or probiotic stacks

• Why libido and metabolic health are deeply connected

• The dangers of unvetted peptide sources—and what to look for in quality and bioavailability

This is essential listening for anyone serious about biohacking, hormone optimization, mitochondrial support, brain energy, nootropics, neuroplasticity, functional medicine, sleep optimization, metabolism, and smarter-not-harder living.

Keyword Index:

estradiol for men, Dave Asprey hormone therapy, Jay Campbell BioLongevity Labs, Hunter Williams performance coaching, BPC‑157 recovery peptide, TB‑500 tissue regeneration, PT‑141 libido peptide, SS‑31 mitochondria peptide, Melanotan‑1 for skin and mitochondria, SLU stack, AOD‑9604 fat loss peptide, GW‑501516 Cardarine, BAM‑15 mitochondrial uncoupler, oral peptide delivery, BioMind brain supplement, BioGutPro gut-brain axis, testosterone estradiol synergy, mitochondrial uncoupling, nootropic peptide stacks, performance biohacking supplements

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.

Episodes are released every Tuesday, Thursday, and Friday where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.

Thank you to our sponsors!

Puori | Head to http://puori.com/dave for 20% off, including subscriptions.
Leela Quantum Tech | Head to https://leelaq.com/DAVE for 10% off.
ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order.

Resources:

• BioLongevity Labs Website: https://biolongevitylabs.com/?ref=DAVE#

• Dave Asprey’s Website: https://daveasprey.com

• Danger Coffee: https://dangercoffee.com/DAVE15

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

00:00 – Trailer

01:00 – Introduction & Early Days of Biohacking