The Human Upgrade: Biohacking for Longevity & Performance

Latest Episodes:

Biohacking Your Voice? Here's How to Do It : 1330 Sep 18, 2025

Show notes

If you’ve ever cringed at the sound of your own voice or struggled to hold attention in a room, this episode will change the way you speak and how others respond to you. You’ll discover how vocal tone, breath, and emotion act as biological levers you can train to improve your health, extend your longevity, and build magnetic charisma.

Watch the condensed video highlight version of this episode (and much more!) on YouTube:

https://www.youtube.com/@DaveAspreyBPR

Host Dave Asprey sits down with Roger Love, the celebrity voice coach who trained Bradley Cooper, Tony Robbins, Selena Gomez, and Brendon Burchard. Roger has spent decades teaching actors, executives, and performers how to master their voice to create influence and impact. In this conversation, he shares the science behind vocal tone and the emotional cues hidden in your breath.

You’ll hear why most people speak from the wrong part of the body and how that drains power from every interaction. You’ll learn how digital habits dull your voice, which techniques make you sound more confident and trustworthy, and why sound can heal the nervous system. Dave and Roger also explore how voice training supports your biology, boosts emotional control, and protects your performance as you age.

This episode gives you tools to speak with more authority, connect on a deeper level, and improve your health through one of your most underused systems: your voice. If you want to lead, perform, persuade, or simply feel heard, this conversation shows you how to upgrade the way you sound—and how you feel when you speak.

You’ll learn:

• Why most people speak from the wrong part of their body

• How your voice shapes the way others feel about you

• The link between vocal tone, breathing, and nervous system health

• How to sound more confident, persuasive, and emotionally resonant

• Why digital habits are weakening your communication

• How to train your voice as a powerful analog biohack for longevity

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes release every Tuesday, Thursday, Friday (audio-only), and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: Roger Love, voice coach, Bradley Cooper, vocal tone training, voice confidence, charisma training, sound healing, biohacking voice, emotional resonance, public speaking, vocal mastery, breathwork, mitochondria and voice, analog biohacking, vocal optimization, high performance communication, voice training for health, Tony Robbins voice, Human Upgrade podcast

Thank you to our sponsors!

BodyGuardz | Visit https://www.bodyguardz.com/ and use code DAVE for 25% off.
STEMREGEN | Go to https://stemregen.co/dave25 and use code DAVE25 for 25% off your order.
Caldera + Lab | Go to https://calderalab.com/DAVE and use code DAVE at checkout for 20% off your first order.

**If you're interested in Voice Training, go to www.rogerlove.com/dave and use code DAVE for $50 off**

Resources:

• Roger’s Website:www.rogerlove.com/dave

• Danger Coffee: https://dangercoffee.com/DAVE15

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

• 0:00 – Trailer

• 1:30 – Intro

• 1:48 – Meet Roger Love

• 3:22 – Nature vs. Nurture

• 5:46 – Speaking vs. Singing

• 7:02 – Breathing & Voice Health

• 13:35 – Voice & Attractiveness

• 19:13 – Stuttering & Vocal Disorders

• 24:51 – Emotional Speaking

• 29:04 – Mastery & Finding Your Voice

• 39:55 – Voice & Technology

• 49:20 – Becoming AI-Proof

• 56:29 – Emotion & Sound

• 1:04:30 – Stage Fright & Tone Deafness

• 1:08:00 – Voice Training Tips

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Tom Cruise’s Secret FEAR Hack (+ Stress Biohacks for Longevity) : 1329 Sep 16, 2025

Show notes

If you’ve ever felt crushed by stress or trapped by fear, this episode gives you the science and strategies to break free. You’ll learn how Olympic-level coaching can rewire your brain for resilience, unlock peak human performance, and extend your longevity through proven biohacking tools.

Watch the video highlight version of this episode (and much more!) on YouTube:

https://www.youtube.com/@DaveAspreyBPR

Host Dave Asprey sits down with Jim Murphy, a former professional baseball player turned Olympic coach and now bestselling author of Inner Excellence. Jim has spent decades training world-class athletes and high performers to master their mindset, expand neuroplasticity, and build the courage to thrive under pressure. His work blends psychology, functional medicine, and elite coaching to help people overcome fear, reframe failure, and step into their highest potential.

Together, they explore the inner game of stress mastery: why fear lives in your mitochondria, how shame and guilt sabotage performance, and how to turn setbacks into resilience. They also discuss supplements that improve metabolism, why childlike wonder fuels longevity, and how to use practical biohacking to cultivate courage.

This is essential listening for anyone serious about hacking fear, upgrading resilience, and living the smarter not harder way. Whether you’re chasing athletic greatness, leading at the highest level, or just seeking more freedom in daily life, these strategies show you how to unlock love over fear and achieve lasting longevity.

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.

Episodes are released every Tuesday, Thursday, Friday (audio-only), and Sunday (BONUS) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.

Keywords: inner excellence, Jim Murphy, Olympic coach, fear hacking, stress mastery, resilience training, courage mindset, shame vs guilt, brain optimization, neuroplasticity, mitochondria stress, childlike wonder, longevity habits, emotional resilience, high performance, mindset coaching, presence training, love over fear, functional medicine, stress recovery, AJ Brown, AJ Brown book, Eagles football player book, NFL sidelines book

Thank you to our sponsors!

LYMA | Go to https://lyma.sjv.io/gOQ545 and use code DAVE10 for 10% off the LYMA Laser.
BON CHARGE | Go to https://boncharge.com and use code DAVE for 15% off.
ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order

Resources:

• Jim’s Website:https://innerexcellence.com/

• Danger Coffee: https://dangercoffee.com/DAVE15

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

0:00 — Trailer

1:30 — Intro

3:10 — Subconscious Mind and Fear

4:36 — Purpose Beyond Results

6:38 — Writing Inner Excellence

10:16 — Redefining Mental Toughness

14:11 — Guilt and Shame

18:24 — Embracing Fear and Challenge

23:50 — Teaching Kids and Modeling Behavior

31:44 — Childhood Programming and Performance

45:59 — Living Fully, Ready to Die

??:?? — Maintaining Childlike Wonder

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BONUS: How To Reverse Testosterone Decline After 40 (Biohacking Tips) : 1328 Sep 14, 2025

Show notes

Most men think declining testosterone is just “part of aging”, but that’s a lie Big Pharma sold you. In this video, I break down exactly how I raised my testosterone in my 50s without injections, drugs, or TRT. These are the same biohacks I used to turn my energy, drive, and strength around, naturally. I’ll walk you through how your diet, your sleep, and even the light in your bedroom could be sabotaging your hormones. Want results? Start here.

Chapters:

0:00 – Introduction

1:40 – The Lie About Aging and Testosterone

2:49 – What’s Desatroying Your Testosterone Daily

3:42 – How Your Cells Actually Make Testosterone

4:58 – Why Diet is Step One (and What to Eat)

7:08 – The Most Underrated T Booster

8:38 – The Truth About Light and Hormones

14:40 – How to Fix It

Get Your Oral Testosterone Here: http://www.LiveThrive.co/asprey

Connect with Dave Asprey!

Website: https://daveasprey.com

TikTok: https://www.tiktok.com/@daveaspreyofficial

Instagram: https://www.instagram.com/dave.asprey/

Facebook: https://www.facebook.com/Daveaspreyofficial/

X: https://x.com/daveasprey

YouTube: https://www.youtube.com/c/daveaspreybpr

The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ and https://m.facebook.com/Thehumanupgrade/

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Eat THESE Anti-Aging Mushrooms to Live Longer (Paul Stamets) : 1327 Sep 12, 2025

Show notes

Want to biohack your biology with nature’s most powerful anti-aging compounds? In this episode, you’ll discover how medicinal mushrooms fuel neurogenesis, protect mitochondria, supercharge immunity, and even help save the planet’s pollinators. From sharper focus and deeper REM sleep to protecting DNA from oxidative stress, fungi are the ultimate biohacking tools for performance, resilience, and longevity.

Watch episodes on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR

(Re-run) Host Dave Asprey sits down with legendary mycologist and author Paul Stamets and mushroom entrepreneur Julian Mitchell. Together, they uncover the science of fungi as medicine — how mushrooms repair nerves, fight viruses, act as prebiotics for your microbiome, and provide the ultimate anti-aging biohacks. You’ll also hear how fungi hold the key to saving pollinators, regenerating soil, and extending human longevity.

You’ll Learn:

• Which anti-aging compounds in mushrooms protect your mitochondria and DNA

• How lion’s mane stimulates nerve growth factor and improves memory, focus, and REM sleep

• Why oyster mushrooms may help fight flu viruses and reduce chronic inflammation

• How mushroom tinctures unlock more bioactive compounds than powders or capsules

• The surprising role fungi play in saving bees and restoring environmental balance

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.

Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.

Keywords: anti-aging mushrooms, Paul Stamets fungi, lion’s mane memory, mushroom tincture benefits, ergothionine mitochondrial protection, oyster mushroom flu prevention, reishi immune system, cordyceps endurance, turkey tail microbiome, medicinal mushroom research, fungi save the bees, chaga antioxidants, mushroom longevity biohack, mycelium networks, functional mushrooms anti-inflammatory, mushroom brain health, neurogenesis fungi, adaptogenic mushrooms, mushroom cooking bioavailability

• Lifecykel Mushroom Products - use code ‘DAVE20’ for 20% off:https://www.lifecykel.com/?rfsn=4497217.61b030&utm_source=refersion&utm_medium=affiliate&am…

• Paul Stamets’ Website: https://hostdefense.com/

Thank you to our sponsors!

• ECHO Water | Go to http://echowater.com/dave and use code DAVE10 for 10% off your ECHO Flask.

Resources:

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

• 0:00 — Trailer

• 0:47 — Intro

• 6:15 — Mushrooms vs. Algae

• 10:21 — Mushroom Safety & Microbiome

• 12:24 — Mushrooms as Medicine

• 14:43 — Psychedelics & Microdosing

• 16:26 — Kakadu Plum & Prebiotics

• 18:07 — Oyster Mushrooms & Cooking

• 21:35 — Mushrooms & Bees

• 25:59 — Lion’s Mane & Chaga

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MIT Neuroscientist: The Ultimate Nootropic For Memory : 1326 Sep 11, 2025

Show notes

Want to improve memory, unlock neuroplasticity, and achieve sharper brain optimization? This episode reveals how Transcendental Meditation (TM) functions as one of the most powerful nootropics for human performance, longevity, and resilience.

Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR

Host Dave Asprey sits down with neuroscientist and physician Dr. Tony Nader, the global leader of the Transcendental Meditation movement. With an MD and PhD from MIT and Harvard, Dr. Nader bridges hard science with ancient wisdom, showing how TM measurably changes brainwaves, boosts mitochondria, and even slows biological aging. His research connects meditation to reduced stress, faster reaction time, and improved memory, giving listeners cutting-edge tools for smarter not harder living.

You’ll Learn:

• How Transcendental Meditation induces high-coherence alpha brain states that improve clarity, focus, and resilience

• Why TM increases blood flow to the prefrontal cortex and supports memory, decision-making, and creativity

• How meditation measurably reduces biological age by 5–10 years through stress reduction and physiological balance

• Why reaction time and situational awareness improve immediately after meditation — even used by fighter pilots

• How TM differs from mindfulness or concentration practices at the brainwave level (alpha vs. theta vs. gamma)

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.

Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.

Keywords: Transcendental Meditation benefits, Tony Nader MIT neuroscientist, TM brainwaves alpha coherence, Meditation and neuroplasticity, Default mode network meditation, Meditation and mitochondria, TM and biological age, Consciousness and quantum field theory, Meditation vs psychedelics, Meditation and intuition training, Meditation and dopamine, TM reaction time studies, Hippocampus meditation memory, TM and functional medicine, Meditation and metabolism, Meditation and PTSD recovery, TM for sleep optimization, Meditation and fasting stack, TM and human performance, Meditation and longevity research

Thank you to our sponsors!

Business of Biohacking Summit | Apply to The Business of Biohacking Summit https://businessofbiohacking.com/.
fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE.
Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order.

Resources:

• Tony’s Website:https://drtonynader.com/

• Danger Coffee: https://dangercoffee.com/DAVE15

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

0:00 — Trailer

1:47 — Intro

2:57 — Transcendental Meditation

3:56 — States of Consciousness

10:16 — Brainwaves & Practice

18:35 — Science Bias

38:07 — Mind & Reality

50:32 — Psychedelics & TM

54:29 — Brain & Body Effects

59:31 — Daily Practice

1:02:43 — Closing Thoughts

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How To Deal With The Fear Of Death (Ethics Of Longevity) : 1325 Sep 09, 2025

Show notes

Most people spend their lives trying to outrun death instead of learning from it. This episode shows you why facing mortality directly can unlock resilience, forgiveness, gratitude, and peace while upgrading longevity, human performance, and even brain optimization.

Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR

Host Dave Asprey sits down with Suzanne O’Brien, RN—an end-of-life expert, hospice nurse, and founder of Doulagivers who has guided over 1,000 people through their final moments. She shares what the dying can teach the living about biohacking fear, letting go of unresolved trauma, and finding clarity before it’s too late.

Together they explore how hacking your mindset around death transforms not only emotional well-being but also physical health, neuroplasticity, and metabolism. You’ll hear stories of people who discovered forgiveness and gratitude at the end of life, and how those practices directly influence mitochondria, sleep optimization, and longevity. They dive into the link between fear, stress chemistry, and chronic illness—and why tools like fasting, ketosis, cold therapy, supplements, nootropics, and functional medicine create the inner and outer resilience needed to face life fully.

You’ll Learn:

• Why fear of death silently undermines health, performance, and human potential

• How forgiveness and gratitude rewire neuroplasticity and boost brain optimization

• What hospice nurses know about consciousness and near-death experiences that science is only starting to confirm

• How unresolved trauma shows up as physical pain and disease at the end of life

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.

Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.

Keywords: fear of death, hospice nurse, doulagivers, end of life planning, good death, forgiveness practice, gratitude science, near death experience, hospice care stories, emotional trauma release, spiritual awakening, conscious dying, home funeral, palliative care, death doula training, legacy planning, end of life rituals, soul agreements, dying process stages, compassionate care

Thank you to our sponsors!

ECHO Water | Go to http://echowater.com/dave and use code DAVE10 for 10% off your ECHO Flask.
Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial.
BodyHealth | Go to https://bodyhealth.com/ and use code DAVE20 to save 20% off your first order of PerfectAmino.

Resources:

• Suzanne’s Website: https://suzannebobrien.com/

• Get Suzanne's Book 'The Good Death': https://thegooddeathbook.com

• Danger Coffee: https://dangercoffee.com/DAVE15

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

00:00 — Trailer

01:05 — Introduction

03:13 — End-of-Life Choices

09:50 — Forgiveness & Suffering

15:46 — Advice to Younger Self

20:00 — What Makes a Good Death

23:00 — Hospice Stories & Mystical Experiences

33:05 — The Good Death Defined

41:01 — Meaning & Purpose

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The Hidden Traps of “Healthy” Eating (Biohacking Daily Nutrition) : 1324 Sep 05, 2025

Show notes

What if the foods you think are healthy are actually disrupting your biology? From sugar marketed as a performance tool to “whole grains” that drive cravings, this episode uncovers how hidden traps in modern nutrition can hijack your brain, wreck your metabolism, and accelerate aging. You’ll learn how to rethink daily eating so it fuels energy, resilience, and long-term health instead of quietly sabotaging it.

Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR

Host Dave Asprey sits down with Max Lugavere, health journalist, filmmaker, and bestselling author of Genius Foodsand The Genius Kitchen. Max is one of the most trusted voices in nutrition and functional medicine, translating complex science into practical tools you can use right now. His work has been featured on The Today Show, PBS, and across global media for helping people reclaim health through smarter food and lifestyle choices.

In this re-run, Dave and Max break down the real impact of sugar, salt, and food processing on your brain and body. They explore how cooking methods change health outcomes, when fasting and ketosis become powerful tools, and why supplements, nootropics, and trace minerals fill gaps in the modern diet. They also tackle controversial topics like carnivore diets, cold therapy, and whether “healthy” plant-based foods are truly supporting resilience—or quietly eroding it.

You’ll Learn:

• The biggest nutrition myths that silently damage health and performance

• How sugar can act as both poison and fuel depending on context

• Why cooking methods make the difference between nourishment and toxicity

• The overlooked role of minerals, supplements, and culinary literacy

• How nootropics, cold therapy, and sleep optimization reset your brain

• Why some “health foods” accelerate aging instead of protecting you

• The truth about carnivore diets, industrial farming, and sustainability

• When fasting, ketosis, and carb cycling create optimal results

This episode gives you a science-backed blueprint to hack your nutrition, sharpen your brain, and extend your longevity with foods that truly support your biology.

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.

Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.

Keywords: uric acid longevity, uric acid metabolism, fructose uric acid pathway, xanthine oxidase inhibition, quercetin uric acid, luteolin supplements, AMP kinase uric acid, AMP deaminase metabolism, uric acid and mitochondria, uric acid and neuroplasticity, uric acid Alzheimer’s risk, uric acid dementia prevention, uric acid and nitric oxide, fructose metabolism hibernation biology, evolutionary mismatch uricase mutation, fructokinase inhibition, uric acid and insulin resistance, gout biohacking, uric acid and obesity, uric acid functional medicine

Resources:

• Max’s Website: https://www.maxlugavere.com/

• Screenfit | Get your at-home eye training program for 40% off using code DAVE https://www.screenfit.com/dave

• Danger Coffee: https://dangercoffee.com/DAVE15

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

0:00 — Trailer

0:30 — Introduction

1:51 — Resilience & Stress

2:41 — Food Philosophy

6:20 — Sugar & Metabolism

11:21 — Fructose & Flexibility

21:57 — Big Food & Morality

24:51 — Meat & Sustainability

26:30 — Cooking at Home

28:34 — Salt & Minerals

30:07 — Dietitians & Industry

32:45 — Intuitive Eating

41:13 — Cooking Risks

45:26 — Fish & Contaminants

49:16 — Lectins & Sensitivities

52:22 — Herbs & Spices

54:59 — Recipes & Highlights

58:17 — Closing

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Sulforaphane, Curcumin, and NEW GLP-1 Drugs (Biohacking for Longevity) : 1323 Sep 04, 2025

Show notes

Most people think broccoli is a superfood, but the reality is more nuanced. In this episode of The Human Upgrade, Host Dave Asprey explores the good and bad of broccoli—why adult broccoli can block thyroid function and cause gut issues, while broccoli seeds deliver sulforaphane, the powerful compound that activates all three of your body’s detox pathways. You’ll learn how sulforaphane protects against glyphosate, repairs leaky gut, and upgrades mitochondria, metabolism, and longevity.

Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR

Dave is joined by two Johns Hopkins–trained researchers whose expertise in biohacking, biochemistry, and functional medicine makes them trusted leaders in the field. Together they reveal how sulforaphane, berberine, curcumin, and alpha-lipoic acid outperform bulk vegetables and even rival GLP-1 weight loss drugs—delivering natural ways to improve metabolism, regulate dopamine, and protect the brain. Their research shows how targeted supplements can boost neuroplasticity, brain optimization, and human performance without the side effects of pharmaceuticals.

Dave and his guests break down why bulk vegetables don’t deliver enough beneficial compounds, how to hack plant toxins for maximum benefit, and why supplement stacks often outperform carnivore, vegan, or high-vegetable diets for long-term health. You’ll discover how biohacking tools like fasting, ketosis, nootropics, cold therapy, and sleep optimization amplify these compounds for smarter not harder living.

You’ll Learn:

• Why adult broccoli can disrupt thyroid function while broccoli seeds fuel detox and longevity

• How sulforaphane, berberine, curcumin, and alpha-lipoic acid support metabolism and mitochondria

• Why natural compounds can rival GLP-1 drugs for weight loss and energy regulation

• The connection between glyphosate, leaky gut, inflammation, and brain fog

• How to stack supplements with fasting, ketosis, and cold therapy for brain optimization

• Why functional medicine and biohacking provide better long-term solutions than fad diets

• The smarter not harder way to extract benefits from plants without the toxic load

This episode is essential for anyone serious about biohacking, upgrading metabolism, extending longevity, and achieving high performance with resilience and clarity.

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.

Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.

Keywords: sulforaphane supplements, broccoli seed extract, detox pathways phase 1 2 3, NRF2 activation, glyphosate gut health, leaky gut repair biohacking, thyroid blockers broccoli, DIM I3C compounds, functional medicine detox, Johns Hopkins biohacking research, berberine metabolism, alpha lipoic acid mitochondria, curcumin weight loss, GLP-1 natural alternatives, dopamine metabolism regulation, neuroplasticity supplements, fasting and sulforaphane, ketosis and detox synergy, smarter not harder supplements, Dave Asprey broccoli

Mara Labs Website: https://mara-labs.com/Dave for 28% off!

Resources:

-Mara Labs Website: https://mara-labs.com/Dave

for 28% off!

-BrocElite link: https://partnerships.mara-labs.com/4H6KD28/TZW7X/?&sub4=biohack&uid=123

-GLPerfect link: https://partnerships.mara-labs.com/4H6KD28/TZW7X/?&sub4=biohack&uid=123

Thank you to our sponsors!

EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off.
Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.
Calroy | Head to https://calroy.com/dave for an exclusive discount.

Resources:

• Mara Labs Website: NEED TO INSERT CODE

• Danger Coffee: https://dangercoffee.com/DAVE15

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

00:00 — Trailer

01:10 — Introduction

01:49 — Broccoli Benefits & Risks

09:24 — Plant Toxins & Modern Diet

12:56 — Mold Detox Experiences

18:30 — Mycotoxins, Glyphosate & Gut Health

26:20 — Metabolic Syndrome & Endotoxins

35:44 — Timing Sulforaphane for Glyphosate Protection

39:35 — Weight Loss & GL Perfect

49:19 — Personalization & Supplement Stacking

55:10 — Sleep, Ketosis & Berberine

58:30 — Alpha Lipoic Acid + Berberine Synergy

1:01:00 — Natural Alternatives to GLP-1 Drugs

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Mast Cells Explained: Biohacking Inflammation, Allergies, and Brain Fog : 1322 Sep 02, 2025

Show notes

Millions of people are living with unexplained symptoms like allergies, brain fog, anxiety, and chronic fatigue without realizing the hidden cause: mast cells gone rogue. In this episode of The Human Upgrade, Host Dave Asprey sits down with leading functional medicine physician Dr. Tania Dempsey to uncover how Mast Cell Activation Syndrome (MCAS) drives inflammation, disrupts mitochondria, and sabotages metabolism—and what you can do to switch it off.

Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR

Dr. Dempsey is internationally recognized for her work in functional medicine, biohacking, and chronic illness. She co-founded the AIM Center for Personalized Medicine, has published groundbreaking research on MCAS with Dr. Lawrence Afrin, and treats some of the most complex cases of immune dysregulation, autoimmune disease, and environmental illness. Her expertise helps you understand why mast cells are the missing link in allergies, long COVID, Lyme, mold toxicity, and even hormone disruption—and how to reclaim control of your biology.

Dave and Dr. Dempsey break down how mast cells interact with mitochondria, hormones, and the nervous system, showing how chronic inflammation accelerates aging and blocks human performance. You’ll discover why biohacking tools like fasting, ketosis, supplements, red light, cold therapy, sleep optimization, and smarter not harder lifestyle strategies all influence mast cell stability. They also explore why brain optimization, neuroplasticity, and nootropics are essential for calming inflammatory cascades, and how functional medicine provides practical solutions beyond conventional treatment.

You’ll Learn:

• Why mast cells are the hidden switch behind allergies, chronic inflammation, and brain fog

• How mitochondria and mast cells work together to drive human performance—or disease

• The connection between toxic mold, Lyme, long COVID, hormone imbalance, and MCAS

• How supplements, fasting, ketosis, and cold therapy stabilize mast cells and boost longevity

• Why functional medicine and biohacking are essential for complex chronic illness

• How mast cells impact metabolism, sleep optimization, and neuroplasticity

• The surprising link between mast cells, anxiety, and mental health symptoms

This episode is essential for anyone serious about hacking inflammation, protecting longevity, upgrading metabolism, and achieving high performance with resilience and clarity.

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.

Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.

Keywords: mast cell activation syndrome, MCAS, chronic inflammation, mitochondria dysfunction, histamine intolerance, functional medicine, biohacking, allergies, brain fog, long covid, mold toxicity, Bartonella, Lyme co-infections, oxalates, salicylates, mast cell stabilizers, immune dysregulation, neuroinflammation, chronic fatigue syndrome, autoimmune triggers, personalized medicine, longevity supplements

Thank you to our sponsors!

Leela Quantum Tech | Head to https://leelaq.com/DAVE for 10% off.

LMNT | Free LMNT Sample Pack with any drink mix purchase by going to https://drinklmnt.com/DAVE.

Resources:

• Tania’s Website: https://drtaniadempsey.com/

• Danger Coffee: https://dangercoffee.com/DAVE15

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

00:00 — Trailer

01:10 — Introduction

03:27 — Why So Sick Today?

05:57 — MCAS Explained

08:33 — Mold & Environment

11:36 — Spotting MCAS

13:43 — Personal Stories

15:15 — Research & Biohacking

16:35 — Managing Triggers

20:15 — Gut & Stomach Acid

22:42 — Reaction Timing

25:30 — Hormones & MCAS

28:39 — Thyroid & Mitochondria

32:28 — Chronic Illness Navigation

40:06 — Insurance Battles

44:44 — Cholesterol & Ethics

49:11 — Personalized Care

53:24 — Circadian & Stress

58:24 — Testing Approaches

01:01:35 — Collagen & Joints

01:04:34 — MMPs & Aging

01:09:12 — Access & Experimentation

01:13:14 — MCAS & Mental Health

01:17:46 — Benzos & Stigma

01:20:23 — Vaccines & Spike Protein

01:25:18 — Research & Treatments

01:26:12 — Nicotine & Focus

01:29:24 — Closing

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What Is Uric Acid and How Does It Predict Your Longevity : 1321 Aug 29, 2025

Show notes

Most people track glucose or ketones, but almost no one is measuring the hidden signal that could be silently wrecking your metabolism, brain function, and longevity: uric acid. This episode reveals why this overlooked biomarker drives obesity, diabetes, cardiovascular disease, Alzheimer’s, and even accelerated aging—and how you can hack it to unlock resilience, human performance, and smarter not harder health upgrades.

Watch the podcast on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR

We revisit host Dave Asprey sitting down with Dr. David Perlmutter, one of the world’s leading functional medicine neurologists and the #1 New York Times bestselling author of Grain Brain and Drop Acid. Dr. Perlmutter has spent decades connecting gut health, brain optimization, and neuroplasticity with lifestyle interventions that truly change the trajectory of disease. In this conversation, he explains how uric acid acts as a metabolic switch that determines whether you burn fat or store it, whether your mitochondria power you up or slow you down, and whether your brain stays sharp or declines with age.

They break down how fructose, purines, alcohol, and even dehydration spike uric acid, why Japan is decades ahead in using this as a health marker, and how supplements like quercetin and luteolin rival pharmaceuticals in keeping it under control. You’ll also learn how ketosis, fasting, cold therapy, carnivore and plant-based approaches, and sleep optimization all interact with uric acid to shape your healthspan. This is biohacking at its most actionable—because once you measure this signal, you can control it, and once you control it, you radically upgrade your metabolism, your brain, and your longevity.

This is essential listening for anyone serious about hacking their biology, building neuroplasticity, powering up mitochondria, exploring nootropics, and discovering smarter not harder ways to live longer and perform better.

You’ll Learn:

• Why uric acid may be the most important overlooked biomarker for longevity

• How it connects obesity, diabetes, cardiovascular disease, and Alzheimer’s

• The evolutionary reason your body uses uric acid as a survival signal

• How fructose and hidden sugars sabotage metabolism and brain optimization

• The role of quercetin, luteolin, and targeted supplements in lowering uric acid

• Why measuring at home with a simple device can change your health trajectory

• How functional medicine uses uric acid as a predictive tool for chronic disease

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.

Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.

Resources:

• David’s Website: https://drperlmutter.com/

• Danger Coffee: https://dangercoffee.com/DAVE15

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

0:00 — Trailer

0:35 — Introduction

2:26 — Why Uric Acid Matters