The Human Upgrade: Biohacking for Longevity & Performance

Latest Episodes:

Your Penis Is a Longevity Organ (Here's How to Hack It) : 1430 Mar 12, 2026

Show notes

Testosterone levels in 40-year-old men are 30 percent lower than their fathers, and most doctors still have no idea what to do about it.

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR

Host Dave Asprey sits down with Dr. Justin Houman, a nationally recognized urologist and Assistant Professor of Urology at Cedars-Sinai Medical Center. Fellowship-trained and specializing in men's health, male fertility, and sexual medicine, Dr. Houman combines cutting-edge medical advancements with holistic lifestyle strategies to help men optimize testosterone, sexual health, and reproductive performance at every age.

Together, Dave and Dr. Houman tear through the myths, the bad science, and the outdated medical dogma around testosterone, erectile function, fertility, and male sexual health. They cover everything from why testosterone levels have collapsed in a single generation, to the real story behind the FDA black box warning, to practical protocols for men who want to optimize without sacrificing fertility. This is the masterclass on men's health that no one else is having on record.

This is essential listening for anyone serious about biohacking, longevity, human performance, hormone optimization, brain optimization, anti-aging, functional medicine, mitochondria, and Smarter Not Harder approaches to male health.

You'll Learn:

Why testosterone levels in 40-year-old men are 30 percent lower than their fathers and what is driving the collapse
How low testosterone connects to anxiety, depression, high cholesterol, blood sugar dysregulation, and all-cause mortality risk
The truth about the original testosterone and heart attack study and why it still has not been retracted
How to preserve fertility while on TRT using Clomid, enclomiphene, and HCG
Why daily low-dose Cialis is one of the cheapest and most effective longevity drugs available
What shockwave therapy, PRP, exosomes, and Botox injections actually do for erectile function
How red light therapy at 660 and 850 nanometers supports testosterone production and nocturnal erections
The supplement stack including ashwagandha, tongkat ali, fadogia agrestis, and creatine that supports healthy hormone levels
Why porn-induced ED is epidemic in young men and how to reverse it
How PT-141 and peptides fit into a complete male optimization protocol

Thank you to our sponsors!

Pre-order Arthur Brook's new book today at themeaningofyourlife.com. You can also see Arthur speak live at the 2026 Beyond Biohacking Conference
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Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: testosterone, low testosterone, TRT, testosterone replacement therapy, male fertility, erectile dysfunction, ED, men's health, sexual health, hormone optimization, Dave Asprey, biohacking, longevity, anti-aging, human performance, Dr. Justin Houman, Cedars-Sinai, urologist, shockwave therapy, PRP, exosomes, Botox penis, red light therapy, nitric oxide, Cialis, tadalafil, Viagra, sildenafil, PT-141, Melanotan, peptides, ashwagandha, tongkat ali, fadogia agrestis, creatine, Danger Coffee, Smarter Not Harder, Kyzatrex, clomid, enclomiphene, HCG, prolactin, cabergoline, porn-induced ED, refractory period, fertility, sperm health, spermatogenesis, FSH, LH, estrogen, aromatization, functional medicine, supplements, mitochondria, circadian rhythm, sleep optimization, cortisol, microplastics, inflammation, cardiovascular health, dementia, all-cause mortality, nocturnal erections, penile health, male optimization

Resources:

• Learn More About Dr. Houman’s Work At: https://houmanmd.com/

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.

• Danger Coffee: https://dangercoffee.com/discount/dave15

• My Daily Supplements: SuppGrade Labs (15% Off)

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/

• Upgrade Labs: https://upgradelabs.com

Timestamps:

00:00 – Introduction

01:15 – Low Testosterone Epidemic

04:23 – Ejaculation & Testosterone

07:30 – Refractory Period & Aging

09:58 – Porn-Induced ED

11:09 – Cabergoline & Prolactin Management

12:42 – Oral Testosterone

13:24 – Testosterone Target Levels

16:46 – Supplements for Testosterone

18:46 – Anxiety-Based ED

26:23 – Penis Enhancement Options

27:37 – Shockwave Therapy

28:57 – Cialis for Longevity

29:56 – Fat & Filler Injections

34:50 – Pre-Sex Optimization

40:13 – Red Light Therapy

42:18 – Heat & Cold for Testosterone

43:35 – Underwear & Microplastics

44:58 – Testosterone & Fertility

49:15 – HCG & Preserving Fertility

52:00 – Testosterone Dosing Timing

53:22 – Creatine & Mitochondrial Health

55:20 – Overtraining Effects

56:24 – Peptides (PT-141)

59:08 – Optimal Diet for Fertility

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AI Expert Says: Humans Are Just Mystical Meat Robots : 1429 Mar 10, 2026

Show notes

What if understanding how AI thinks could reveal uncomfortable truths about how your own brain works, and give you powerful tools to make smarter decisions, resist manipulation, and upgrade your cognition at the root level?

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR

Host Dave Asprey sits down with Tom Griffiths, the Henry R. Luce Professor of Information Technology, Consciousness, and Culture in the Departments of Psychology and Computer Science at Princeton University. Griffiths directs Princeton's Computational Cognitive Science Lab, a research group focused on understanding the mathematical foundations of human cognition, and the Princeton Laboratory for Artificial Intelligence. He is the coauthor of Algorithms to Live By and the author of the new book The Laws of Thought, and his award-winning research has appeared in Science, Nature, and the Proceedings of the National Academy of Sciences.

Together, Dave and Tom go deep on the cognitive science behind human performance, brain optimization, and the surprising overlap between biohacking and artificial intelligence. They explore why your body filters reality before your conscious brain ever sees it, how your mitochondria function as a distributed cognitive network, and what that means for longevity, decision-making, and neuroplasticity.

You'll Learn:

Why AI models reveal that humans may be more "stochastic parrots" than we'd like to admit
How your mitochondria pre-process sensory reality before your auditory cortex even fires
Why emotions like anger, love, and remorse are computational tools evolution built into your reward function
How low energy and blood sugar directly degrade your decision-making at a hardware level
What "resource rationality" means and how to use it to make better decisions under constraint
Why AI systems have measurable psychological personalities, and which ones are least likely to mess with your head
How neuroplasticity can eliminate the inner critic and reshape your mental operating system
Why two-process cognition (fast and slow thinking) is a feature, not a bug, of human intelligence

Thank you to our sponsors!

-BEYOND Biohacking Conference 2026 | Register with code DAVE300 for $300 off https://beyondconference.com

-Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade.

-Quantum Upgrade | Try it free for 15 days — no credit card required — at QuantumUpgrade.io/DAVE. Simple. Powerful. Backed by data.

-Go to timeline.com/dave and save 20% with code DAVE20

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: AI, cognitive science, Tom Griffiths, The Laws of Thought, Princeton, brain optimization, neuroplasticity, mitochondria, decision-making, biohacking, Dave Asprey, human performance, longevity, anti-aging, consciousness, large language models, dopamine, reward function, resource rationality, emotions, game theory, altered states, chronic fatigue, dual process theory, Danger Coffee, Smarter Not Harder, cognitive biases, memory, AI bias, neurofeedback, Algorithms to Live By

Resources:

• Get Tom's new book: https://www.amazon.com/Laws-Thought-Quest-Mathematical-Theory/dp/1250358353

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.

• Danger Coffee: https://dangercoffee.com/discount/dave15

• My Daily Supplements: SuppGrade Labs (15% Off)

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/

• Upgrade Labs: https://upgradelabs.com

Timestamps:

00:00 – Intro

00:50 - Tom's Background & Chronic Fatigue

10:22 – Mathematics of Mind

12:43 – Memory and Emotion

15:29 – Decision Making Under Constraints

21:10 – Computational Problems of Consciousness

24:18 – Reality Pre-Processing

26:14 – Meat Robots vs Stochastic Parrots

29:21 – Emotions: Game Theory

35:39 – Dual Systems: Model-Based vs Model-Free

39:22 – Mitochondria and Consciousness

50:00 – Testing AI Like Humans

52:11 – Choosing AI Models

57:14 – AI Research Questions

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How I Finally FIXED My Terrible Sleep After 18 Years : 1428 Mar 08, 2026

Show notes

Block toxic light with these glasses: https://truedark.com/discount/DAVETUBE

Think 8 hours of sleep is enough? Think again. I used to think I had a sleep issue—turns out, it was a light issue. In this video, I break down why light exposure, not just sleep duration, controls your circadian rhythm, energy, and recovery. From morning sunlight to blocking blue light at night, I’ll show you how to biohack your environment for deeper sleep, better performance, and real recovery. Your biology is programmable—let’s upgrade it.

Thank you to our sponsors!

-Dave Asprey's 2026 Clean Nicotine Roadmap | Enroll for free at: daveasprey.com/2026-clean-nicotine-roadmap

-Generation Lab | Go to http://generationlab.com/, use code Dave20 for $20 off, and see what your body’s really doing behind the surface.

Resources:

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.

• Danger Coffee: https://dangercoffee.com/discount/dave15

• My Daily Supplements: SuppGrade Labs (15% Off)

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/

• Upgrade Labs: https://upgradelabs.com

Chapters:

0:00 – Introduction

0:38 – The Real Reason You're Still Tired

0:59 – How Light Controls Your Sleep Quality

1:36 – Circadian Rhythm Explained (NASA-Approved)

2:51 – The Secret Sleep Trigger

5:29 – Blue Light: The Silent Sleep Killer

6:12 – How to Hack Your Evening Light

7:52 – Screen Time vs. Sleep Time

8:12 – Social Jet Lag: The Weekend Mistake

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WW3 Doomscrolling, 5 Minute Sleep Hack, Diet Wars, Dopamine Supplements : 1427 Mar 06, 2026

Show notes

This week’s stories:

Healthy Diets That Offset "Bad Genes"

A major UK Biobank study of over 100,000 people found that following any one of five healthy dietary patterns was associated with up to 3 extra years of life — and the benefit held regardless of genetic predisposition to longevity. Your DNA is not an excuse. The macro pattern matters more than the perfect protocol.

• Sources:

-https://www.science.org/doi/10.1126/sciadv.ads7559

-https://pmc.ncbi.nlm.nih.gov/articles/PMC12904179

-https://www.medicalnewstoday.com/articles/eat-well-live-longer-study-5-healthy-diet-plans-longevity

Micro-Habits in Sleep, Activity, and Diet That Extend Life

Researchers built a composite "SPAN" score combining sleep, movement, sedentary time, and diet quality and found that small improvements across all four — we're talking minutes per day — cut mortality risk by up to 64% when stacked together. The gains only showed up when behaviors improved in combination, not in isolation.

• Sources:

-https://pmc.ncbi.nlm.nih.gov/articles/PMC11863424

-https://theconversation.com/small-improvements-in-sleep-physical-activity-and-diet-are-linked-with-a-longer-life-273502

-https://www.lboro.ac.uk/news-events/news/2026/january/small-improvements-in-health-linked-to-longer-life

Methionine and Cysteine Restriction: The Diet That Mimics Cold Exposure

New research shows that reducing sulfur amino acids — methionine and cysteine, found heavily in certain animal proteins — triggers fat browning and thermogenesis in mice, mimicking the metabolic effects of cold exposure without the cold. Supporting human data from Nature Metabolism suggests this lever works in people too

• Sources:

-https://elifesciences.org/reviewed-preprints/108825v2

-https://www.nature.com/articles/s42255-025-01297-8

-https://topics.consensus.app/news/research-finds-low-methionine-and-cysteine-diet-increases-caloric-burn-in-mice-evidence-review

Tyrosine and Lifespan: What the Data Says for Men

A Mendelian randomization analysis of over 270,000 UK Biobank participants found that genetically higher tyrosine levels were associated with nearly one year shorter lifespan in men — with no significant effect in women. This reflects lifelong endogenous levels, not short-term supplementation, but it's a signal worth understanding if you're using tyrosine strategically

• Sources:

-https://www.news-medical.net/news/20260301/Higher-tyrosine-levels-linked-to-shorter-lifespan-in-major-UK-Biobank-analysis.aspx

-https://www.eurekalert.org/news-releases/1105915

-https://www.aging-us.com/news-room/high-tyrosine-levels-linked-to-shorter-lifespan-in-men

War Doomscrolling and WW3 Anxiety as a Stealth Aging Accelerator

Compulsive consumption of conflict and war news is linked to PTSD-like symptoms, existential anxiety, and chronic stress — even in civilians far from any battlefield. Layered on top of cardiology data connecting chronic stress to heart disease and stroke, your news diet is now a legitimate healthspan variable. Subtractive biohacking is still biohacking.

• Sources:

-https://www.sciencedaily.com/releases/2024/07/240718124709.htm

-https://www.theguardian.com/technology/article/2024/jul/19/doomscrolling-linked-to-existential-anxiety-distrust-suspicion-and-despair-study-finds

-https://www.health.harvard.edu/mind-and-mood/doomscrolling-dangers

-https://pmc.ncbi.nlm.nih.gov/articles/PMC9517387

All source links are provided for direct access to the original reporting and research.

This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on circadian biology, neurodegeneration signals, cognitive training, caffeine strategy, and supplement regulation. Host Dave Asprey connects emerging science, behavioral data, and policy shifts into practical frameworks you can use to build a resilient, adaptable health stack.

New episodes every Tuesday, Thursday, Friday, and Sunday.

Keywords: healthy diet longevity genes, UK Biobank diet study, Mediterranean diet lifespan, DASH diet mortality, SPAN score sleep activity diet, micro habits longevity, mortality risk reduction, methionine restriction thermogenesis, cysteine restriction fat loss, sulfur amino acids metabolism, FGF21 fat browning, tyrosine lifespan men, Mendelian randomization amino acids, tyrosine supplement risk, doomscrolling aging, war news anxiety stress, chronic stress heart disease, psychosocial stress healthspan, biohacking news, longevity research 2026

Thank you to our sponsors!

-AquaTru | Go to https://aquatruwater.com/daveasprey and save $100 on all AquaTru water purifiers.

-BEYOND Biohacking Conference 2026 | Register with code DAVE300 for $300 off https://beyondconference.com

Resources:

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/

• Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.

• Danger Coffee: https://dangercoffee.com/discount/dave15

• My Daily Supplements: SuppGrade Labs (15% Off)

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/

• Upgrade Labs: https://upgradelabs.com

Timestamps:

0:00 - Introduction

0:18 - Story #1: Diet vs. Genetics

2:14 - Story #2: 1% Better Every Day

4:26 - Story #3: Sulfur Amino Acids & Fat Loss

5:55 - Story #4: Tyrosine & Longevity

7:58 - Story #5: Doomscrolling & Aging

10:00 - Weekly Roundup

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Your Brain Is 0.5% Plastic (Here’s How to Flush It) : 1426 Mar 05, 2026

Show notes

Microplastics are invading your brain, blood, hormones, and fat tissue, and most people have no idea how deep the damage goes. In this episode, Host Dave Asprey and microplastics expert Josephine Musco break down exactly what these particles are doing inside your body and give you a practical, science-backed action plan to detox, protect yourself, and take back control of your biology.

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR

-Get a discount on Olyxir Tea by going to https://www.olyxir.com/ and using code ‘Dave10’ at checkout

Josephine Musco is a multidisciplinary entrepreneur, Demeter-certified biodynamic farmer, and winemaker at Chateau Bellevue 1881 in Livermore, California. She is the founder of Olyxir Tea Strips and holds two scientific patents rooted in her deep expertise in botanical medicine and regenerative health. She is best known for translating complex research on aging, nutrition, environmental toxins, and functional medicine into practical daily habits, and for her work exposing microplastics and PFAs as one of the most underestimated drivers of accelerated biological aging.

Dave Asprey and Josephine cover the full picture: how nanoplastics cross the blood-brain barrier and accumulate in postmortem brain tissue, how endocrine disruption from plastics tanks testosterone and drives fat storage, and why your teabag, canned soup, and yoga pants may be among your biggest sources of daily exposure. They also go deep on real solutions, from lymphatic drainage protocols and infrared sauna to supplements like chlorella, lactobacillus, and olive leaf polyphenols that actively help the body clear microplastics and support longevity and brain optimization.

This is essential listening for anyone serious about biohacking, anti-aging, metabolism, brain optimization, supplements, human performance, and smarter not harder approaches to living clean in a toxic world. If you drink tea, cook with plastic utensils, or wear synthetic workout clothes, this episode will change how you make decisions every single day.

You'll Learn:

Why 0.5 percent of postmortem brain tissue is now made of microplastics and what that means for neuroplasticity and cognitive decline
How microplastics mimic estrogen, disrupt metabolism, and make it nearly impossible to lose fat
The link between microplastic plaque in carotid arteries and a 4.5x increased risk of cardiac events
Which everyday sources, including teabags, canned soup, cookware, and plastic cutting boards, are silently loading your body with nanoplastics
How lactobacillus reduced microplastics in the blood by 82 percent in studies, and which other supplements support detox
Why Dave Asprey drinks Danger Coffee from a metal container and what his full microplastic reduction protocol looks like
How olive leaf polyphenols, with 26,215 micrograms per gram, act as powerful free radical scavengers to support brain optimization and anti-aging
The morning lymphatic activation routine that combines rebounding, herbal strips, and whole body vibration for deep cellular detox
Why AI and citizen science are accelerating our understanding of microplastic damage faster than traditional medicine

Thank you to our sponsors!

The One Device | Use code DAVE for $10 off at http://theonedevice.com/dave
HeartMath | Go to https://www.heartmath.com/dave to save 15% off.
Igniton | Go to Igniton.com and use code DAVE to save 15% off.
Puori | Go to http://Puori.com/DAVE or use code DAVE at checkout to get 32% off your Puori Fish Oil subscription. You save more than $18.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: microplastics, nanoplastics, teabags, detoxification, BPA, endocrine disruptors, brain health, fertility, reproductive health, Josephine Musco, Elixir Tea Strips, sauna detox, infrared sauna, lymphatic system, probiotics, polyphenols, olive leaf, toxins, heavy metals, pesticides, plastic contamination, water bottles, non-stick cookware, synthetic fabrics, inflammation, Alzheimer's, dementia, cognitive decline, testosterone, preconception health, pregnancy, longevity, anti-aging, biohacking, functional medicine, Dave Asprey, environmental toxins, detox protocols, gut health, acacia gum, chlorella, spirulina, whole-body vibration, rebounding

Resources:

• Get a discount on Olyxir Tea by going to https://www.olyxir.com/ and using code ‘Dave10’ at checkout

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.

• Danger Coffee: https://dangercoffee.com/discount/dave15

• My Daily Supplements: SuppGrade Labs (15% Off)

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/

• Upgrade Labs: https://upgradelabs.com

Timestamps:

00:00 – Introduction

03:00 – Microplastics in the Brain

08:40 – Olyxir Tea Strip Solution

10:10 – Health Impacts & Weight Gain

11:05 – Environmental Solutions

14:29 – The Teabag Problem

18:57 – How to Remove Microplastics

22:04 – Olive Leaf Benefits

28:26 – Josephine's Scientific Background

33:00 – Guarana & Lymphatic Support

34:22 – Skincare & Microplastics

36:38 – Sauna Protocol

44:19 – Household Exposure Sources

47:18 – Workout Clothing Risk

48:59 – Leather vs Synthetic Fashion

50:54 – Pregnancy & Fertility

54:20 – Closing & Discount Code

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Why Are Hackers Microdosing “Sex Drugs” Now? : 1425 Mar 03, 2026

Show notes

Most doctors treat the average patient. But you are not average, and this episode gives you the precision medicine blueprint to treat yourself like the individual you are, using multi-omic testing, biohacking technology, and longevity science to optimize every layer of your biology.

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR

Host Dave Asprey sits down with Dr. Anil Bajnath, a Board-Certified Family Physician, author of The Longevity Equation, and President and Founder of the American Board of Precision Medicine. He serves as Adjunct Professor at the George Washington University School of Medicine and CEO of the Institute for Human Optimization. Dr. Bajnath is certified through the Institute for Functional Medicine, board certified in anti-aging and regenerative medicine, and is one of the few clinicians actively applying genomics, transcriptomics, proteomics, and epigenetics together in a real clinical practice.

Together, Dave and Dr. Bajnath break down why population-based medicine fails individuals, how functional medicine and precision science combine to unlock real human performance, and why your mitochondria sit at the foundation of every longevity strategy worth pursuing. They dig into how AI can help you decode your own inflammasome biology, why biohackers are using “sex drugs” to extend longevity, why vagal nerve stimulation directly suppresses the NLRP3 inflammasome, and which biomarkers like MMP9 and homocysteine mainstream medicine keeps ignoring. They also cover peptides, supplements, the dark side of metformin, microdosing for anti-aging, and why biohacking works best when it's personalized and precise.

This is essential listening for anyone serious about longevity, smarter not harder health strategies, metabolism, sleep optimization, brain optimization, functional medicine, and taking full control of their biology.

You'll Learn:

Why precision medicine outperforms population-based health strategies for human performance
How to layer genomics, transcriptomics, and proteomics into one complete biological picture
Which longevity biomarkers your doctor is likely ignoring, including MMP9 and homocysteine
How vagal nerve stimulation suppresses the NLRP3 inflammasome and drives anti-aging benefits
The real story on metformin, peptides, and which supplements actually move the needle
How AI can help you understand your own biology and act on it faster
Why biohacking precision beats random stacking every time

Thank you to our sponsors!

• Igniton | Head over to Igniton.com and use code DAVE for an exclusive 15% off your first order.

• BEYOND Biohacking Conference 2026 | Register with code DAVE300 for $300 off https://beyondconference.com

• Caldera + Lab | Go to https://calderalab.com/DAVE and use code DAVE at checkout for 20% off your first order.

• Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: precision medicine, biohacking, Dave Asprey Cialis, Anil Bajnath, American Board of Precision Medicine, multi-omics, genomics, transcriptomics, proteomics, epigenetics, NLRP3 inflammasome, vagal nerve stimulation, MMP9, homocysteine, mitochondria, longevity, anti-aging, peptides, BPC-157, metformin, rapamycin, functional medicine, human performance, supplements, EGCG, exposome, nitric oxide, vascular health, metabolism, brain optimization, AI health, biohacking technology, Dave Asprey Sex Drugs

Resources:

• Learn More About Anil’s Work And the Institute For Human Optimization At: https://ifho.org/

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.

• Danger Coffee: https://dangercoffee.com/discount/dave15

• My Daily Supplements: SuppGrade Labs (15% Off)

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/

• Upgrade Labs: https://upgradelabs.com

Timestamps:

00:00 – Trailer

00:53 – Intro to Precision Medicine

01:58 – Dr. Bajnath's Holistic Health Journey

05:03 – Pharmaceuticals vs. Supplements

07:58 – Peptides and Longevity Molecules

10:34 – Sexual Health and Vitality

13:56 – Vascular Health and Blood Flow

15:14 – Multi-Omics Approach

19:03 – DNA and Genomics

22:17 – Transcriptomics and RNA

24:24 – Proteomics and Inflammation Markers

32:00 – The Human Exposome

34:55 – Key Health Biomarkers

36:58 – Cell Membrane Dynamics

40:28 – Biological Investment Strategy

41:53 – Life Extension Possibilities

48:52 – Bioenergetics and Mitochondria

49:47 – Quantum Medicine and the Future

51:33 – Vagal Nerve Stimulation

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

A-List Celebrities' Anti-Aging Hack to Look 30 At 50 (Drug-free) : 1424 Mar 01, 2026

Show notes

What if the secret to living longer wasn't locked in a lab, but hiding in plain sight? And what could lobsters possibly teach us about staying young?

Scientists have discovered a remarkable connection between an ancient practice and our cellular aging process - one that celebrities and longevity researchers are quietly using to their advantage. It involves an enzyme in your body that most people don't even know exists, yet it plays a crucial role in how fast (or slow) you age.

The twist? You can activate it in just 10 minutes a day, no prescription required.

Curious about the biological "switch" that might help you turn back your cellular clock? The answer might surprise you...

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0:00 – Introduction

0:46 – Lobsters and Human Longevity Connection

1:14 – Understanding Telomeres and Aging

2:26 – How Lobsters Defy Aging

3:32 – Rethinking Aging Biology

4:53 – The Telomerase Challenge

6:43 – Natural Ways to Protect Telomeres

9:33 – Meditation's Role in Anti-Aging

11:04 – Different Meditation Techniques

13:19 – Benefits and Long-Term Effects

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Mexican Cartel Biohacking, Google Anti-Aging Breakthrough, Measles Is Back, Age Reversal In 2026 : 1423 Feb 27, 2026

Show notes

This week’s stories:

Sinclair’s This Is the Test: Are we about to see age reversal in humans?

At the World Governments Summit 2026 in Dubai, Harvard geneticist David Sinclair told world leaders that ageing could soon be reversible and said the first human clinical trials of epigenetic reprogramming therapies are moving forward. The core idea is that ageing is partly an information problem, how cells read DNA, not just cumulative damage, and that partial reprogramming could restore youthful function without turning tissues into tumors. Dave frames this as a rare binary moment for longevity: either early, localized human trials (starting with tightly controlled tissue targets like the eye) show meaningful functional rejuvenation with acceptable safety, or the field has to recalibrate fast. Either way, the next couple of years will heavily influence where money, regulators, and serious researchers place their bets.

• Sources:

– World Governments Summit: https://www.worldgovernmentssummit.org/media-hub/news/detail/ageing-could-soon-be-reversible-says-harvard-scientist-at-wgs-2026

– NAD / Life Biosciences coverage: https://www.nad.com/news/fda-greenlights-life-biosciences-human-study-setting-up-pivotal-test-for-aging-theory-from-harvards-david-sinclair

AlphaFold 4 in a locked box: DeepMind’s private AI drug design engine

Isomorphic Labs, DeepMind’s drug discovery company, unveiled a proprietary drug design engine that outside scientists are comparing to an AlphaFold 4 moment, but for designing drugs, not just predicting structures. The big shift is that this system is closed: no public weights, no open database, and access appears to flow through partnerships with pharma companies. Dave breaks down why that matters for the longevity world: if AI makes early discovery cheaper and faster, we might see more serious shots on ageing targets over the next decade, but a closed model can also mean less transparency, bigger IP moats, and no guarantee that faster discovery leads to cheaper drugs.

• Sources:

– Nature: https://www.nature.com/articles/d41586-026-00365-7

– Isomorphic Labs: https://www.isomorphiclabs.com/articles/the-isomorphic-labs-drug-design-engine-unlocks-a-new-frontier

Peptides in the freezer: El Mencho’s anti aging stash and the dark side of wellness

After reports and images from the final hideout linked to Jalisco New Generation Cartel leader Nemesio Oseguera Cervantes (El Mencho), coverage highlighted a detail that feels uncomfortably familiar to anyone in the modern wellness internet: injectable vials stored in a freezer with a schedule attached, including Tationil Plus, a glutathione based injectable marketed in some places for “cellular health,” cosmetic effects, and anti ageing. Dave uses the absurdity as a narrative wedge, not cartel gossip, to talk about how normalized gray market injectables have become, and how marketing (“detox,” “cellular reset”) often outruns evidence and safety. The segment pivots into a practical filter: which compounds are real therapeutics under medical supervision, and which are expensive folklore with sourcing risk and unknown long term downsides.

• Sources:

– New York Post: https://nypost.com/2026/02/25/world-news/inside-the-luxurious-love-nest-where-mexican-drug-lord-el-mencho-spent-his-final-days/

– Sky News (Reuters photos referenced): https://news.sky.com/story/inside-the-mexican-villa-where-feared-drug-lord-el-mencho-spent-final-hours-13511954

– Reuters photo gallery: https://www.reuters.com/pictures/el-menchos-last-hideout-inside-villa-where-cartel-leader-spent-final-hours-2026-02-25/W7DK5WEXS5IMLLZQO2P3CXGXFM

The disease we thought was dead: measles comes roaring back

Measles cases have surged in early 2026, with reporting citing at least 588 cases in the U.S. by late January, already more than many full year totals, and additional updates showing continued acceleration into February. Dave reframes this as a healthspan floor issue: you can argue about peptides and mitochondria all day, but measles is so contagious that once community immunity drops, outbreaks move fast and hit the most vulnerable first, especially infants and immunocompromised people. He also flags the systems problem: many clinicians have never seen measles, which increases the odds of delayed recognition and wider exposure in waiting rooms. The actionable move is boring and high ROI: verify MMR status for you and your family and close gaps before outbreaks get closer to home.

• Sources:

– AMA Morning Rounds (Week of Feb. 2, 2026): https://www.ama-assn.org/about/publications-newsletters/top-news-stories-ama-morning-rounds-week-feb-2-2026

– ABC News (CDC case count coverage): https://abcnews.com/Health/588-us-measles-cases-reported-january-cdc/story?id=129699078

– CIDRAP (case tracking context): https://www.cidrap.umn.edu/measles/us-measles-cases-soar-588-so-far-year-south-carolina-confirms-58-new-infections

DC vs your health: Trump’s State of the Union health reset

President Donald Trump’s 2026 State of the Union included a cluster of healthcare themes that function as a directional signal for agencies and payers this year, including drug pricing rhetoric, price transparency, and broader coverage and affordability framing. Dave translates the politics into a practical heuristic for biohackers: federal posture quietly determines what becomes easy versus painful to access in the legitimate system, from GLP 1 coverage rules and prior auth behavior to how friendly the environment is for telehealth, at home diagnostics, and eventually whatever “real longevity medicine” looks like. You do not need every policy detail in a weekly rundown, just the weather report: reimbursement and enforcement trends shape what stays niche, what scales, and what gets friction.

• Sources:

– Advisory Board: https://www.advisory.com/daily-briefing/2026/02/25/health-policy-roundup

– Healthcare Dive: https://www.healthcaredive.com/news/trump-state-of-the-union-healthcare-2026/812962/

– This Week in Public Health analysis: https://thisweekinpublichealth.com/blog/2026/02/25/the-2026-state-of-the-union-what-it-means-for-health-and-public-health/

All source links are provided for direct access to the original reporting and research.

New episodes every Tuesday, Thursday, Friday, and Sunday.

Keywords: David Sinclair age reversal, epigenetic reprogramming therapy, Yamanaka factors OSK, Life Biosciences clinical trial, human rejuvenation trial 2026, biological age reset, longevity breakthrough news, DeepMind Isomorphic Labs, AlphaFold 4 drug design, AI drug discovery engine, geroprotective drug development, peptide gray market risks, injectable glutathathione Tationil Plus, GLP-1 regulation FDA warning, wellness industry regulation, measles outbreak 2026 US, MMR vaccine status adults, vaccine trust public health, health policy 2026 State of the Union, GLP-1 access and reimbursement, telehealth longevity care, biohacking news, anti-aging research update

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Resources:

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Timestamps:

0:00 - Introduction

0:30 - Story #1: David Sinclair 2026

2:13 - Story #2: Google Drug Discovery

3:48 - Story #3: El Mencho Biohacking

5:30 - Story #4: Measles Outbreak

6:51 - Story #5: Trump State of the Union

8:00 - Weekly Roundup

9:10 - Closing

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The Secret to Staying DANGEROUS After 50 : 1422 Feb 26, 2026

Show notes

Peptides can change how you heal, lean out, build muscle, and age, but only if you stop taking influencer advice and start thinking like a scientist.

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR

-Get a discount from BIOLONGEVITY LABS by using code ‘Dave’ at: https://biolongevitylabs.com/

Host Dave Asprey sits down with Josh Felber and Jay Campbell for a deep, practical conversation on what peptides actually are, how they work in the body, and how to use them without doing something dumb. Josh Felber and Jay Campbell are both cofounders of BioLongevity Labs and longtime leaders in the peptide and performance space. Josh is also the host of the Making Bank podcast and a serial entrepreneur in health. Jay has spent more than a decade researching and teaching advanced peptide protocols and performance strategies.

They break peptides down in plain English as chains of amino acids that act like signaling molecules, then get into what matters in the real world: delivery methods, dosing, and why pharmacokinetics and timing decide whether something works. You’ll hear why peptide pens feel like a huge upgrade over vials and syringes, why Dave wants patches and microneedle tech next, and how convenience can make the difference between consistency and quitting.

Dave and the guys also go deep on mitochondria and longevity. They talk about SS31, now called elamipretide, and why it focuses on mitochondrial membranes and cardiolipin. They cover MOTS-c as a “turbocharger” peptide that people often feel fast, especially if they feel metabolically sluggish. They get into growth hormone peptides like Tesamorelin, Ipamorelin, and CJC, plus why MK-677 sounds convenient but can come with tradeoffs like appetite and other downstream effects.

Then the conversation turns into what’s new. Jay shares what he claims is a new long-acting folistatin-style compound called FLGR 242, designed to stay active for weeks. He frames it as a potential solution for GLP users who worry about losing muscle. They also talk about Klotho, what it does in aging, why it is hard to stabilize, and why Jay believes small dosing matters because of kidney risk at higher levels. Dave ties Klotho back to endothelial function and kidney protection, and they swap stories about what people report noticing.

You’ll Learn:

• What peptides are, explained without jargon

• Why delivery matters and why pens beat mixing vials all day

• How PK curves change real results and dosing schedules

• What elamipretide means for mitochondria and longevity

• Why MOTS-c can feel like a fast energy shift for some people

• How Tesamorelin, Ipamorelin, and CJC fit into growth hormone support

• Why MK-677 sounds easy but can bring unwanted effects

• What Jay claims FLGR 242 does for myostatin, muscle, and fat loss

• Why Klotho shows up in longevity research and why dose matters

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Keywords: peptides, biohacking, Dave Asprey, Jay Campbell, Josh Felber, BioLongevity Labs, mitochondrial peptides, elamipretide SS31, MOTS-c, growth hormone peptides, Tesamorelin, Ipamorelin, CJC-1295, MK-677, folistatin, myostatin inhibitor, FLGR 242, Clotho peptide, longevity science, anti-aging, human performance, muscle growth, fat loss, GLP-1 muscle preservation, pharmacokinetics, peptide dosing, nootropics, functional medicine, metabolism, endothelial function, kidney protection

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Timestamps:

0:00 – Trailer

1:22 – Introduction to Peptides

7:52 – Peptide Delivery Systems & Pens

14:22 – Safety & Regulation of Peptides

19:22 – SS-31 & Mitochondrial Health

26:22 – Blending Peptides & Cross-Linking

38:22 – Growth Hormone Peptides

44:22 – FLGR-242: The New Myostatin Inhibitor

54:22 – Melanin & Consciousness

57:22 – Klotho: The Longevity Peptide

59:25 – Regulatory Landscape & Future of Peptides

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The Home Laser That Reverses Skin Age By 20 Years : 1421 Feb 24, 2026

Show notes

Your skin is not just a cosmetic surface. It’s a living organ that responds to signals, and the right light signal can flip your biology into repair mode.

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR

-Get a discount from LYMA by using code ‘DAVE-10’ at: https://lyma.life/

-Offer not valid on LYMA Laser PRO or LYMA Youth System

In this episode, Host Dave Asprey goes to London to meet Lucy Goff, founder of LYMA, at the LYMA headquarters. Lucy and her scientific team engineered a rare kind of at-home cold laser that delivers precise 808nm light with deep penetration, without burning, cutting, or “damaging to rebuild.” Their work is backed by published research in the Aesthetic Surgery Journal, and they’ve tested gene expression in human dermis, including a reported sixfold increase in SIRT1, a major longevity pathway. This is why you can trust this conversation. It’s not vibes, it’s engineering, biology, and data.

Most “red light” products are basically glorified LEDs. They can be fine for the surface, but they do not deliver the kind of coherent, polarized, monochromatic light that your cells actually respond to in deep tissue. That matters because your mitochondria run the whole show. When mitochondria get a clean signal and more usable energy, your body suddenly has budget for repair, collagen, circulation, and recovery. That is the real mechanism behind anti-aging that does not rely on controlled injury.

We get into how this kind of light hacking can change skin quality, muscle support under the skin, and even scars and fascia. We talk cartilage, knees, jowls, pigmentation, and the weird reality that you might not feel anything while it’s working. Dave also shares his early biohacking experiments using light for brain optimization, including the time he overdid it and temporarily scrambled his speech. That story will make you respect the power of light as a biological tool.

We also talk human performance and travel. Dave breaks down how he uses light management for sleep optimization and jet lag, and why controlling light is as important as controlling food, fasting, ketosis, and metabolism. There’s also a practical angle here that most people miss: with AI, you can now take dense PubMed research and translate it into usable decisions without needing a PhD, which changes how fast you can learn, test, and personalize.

If you care about longevity, neuroplasticity, recovery, and looking younger without trashing your tissue, this episode gives you a smarter way to think about lasers, supplements, nootropics, and the whole functional medicine stack. This is Smarter Not Harder biohacking, with a laser.

You’ll Learn:

• Why LED “red light therapy” is not the same as laser-based mitochondrial activation

• How coherent light influences mitochondria, collagen quality, and anti-aging repair

• What gene expression changes like SIRT1 suggest about longevity signaling

• How light may support brain optimization, circulation, and neuroplasticity

• Why scars and fascia can disrupt performance, and how light can support remodeling

• How Dave uses light and lifestyle hacking for sleep optimization, travel, and metabolism

• How AI makes research-driven biohacking more accessible and more personal

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New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: cold laser therapy, 808nm laser, LYMA laser, infrared light therapy, red light vs laser, mitochondrial activation, SIRT1 gene expression, longevity biohacking, anti aging skin tech, collagen regeneration, fascia repair, scar healing laser, pigmentation removal light, brain optimization light therapy, neuroplasticity support, circulation enhancement, human performance recovery, functional medicine tools, Dave Asprey biohacking

Resources:

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• My Daily Supplements: SuppGrade Labs (15% Off)

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/

• Upgrade Labs: https://upgradelabs.com

Timestamps: