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    Health & Fitness

    The Body of Evidence

    Dr. Christopher Labos and guests use the body of evidence to go beyond science and medicine headlines and hype. All to help you develop your critical thinking skills so that when you google your symptoms, you won’t believe you’re going to die tomorrow.

    The Body of Evidence is your weekly dose of clarity on complex health topics and the often-sketchy medical information found online. Hosted by cardiologist Dr. Christopher Labos and featuring a rotating cast of co-hosts and guests, this podcast brings you engaging interviews, original reporting, and humour-filled commentaries to help you navigate the world of medicine. Episodes tackle everything from debunking misinformation to exploring the reality of certain conditions to the effectiveness of social media medical trends. With an extensive archive dating back to 2015,The Body of Evidence is your go-to source for understanding science and medicine and developing critical thinking about your health.

    Advertise

    Copyright: © Copyright 2015 Christopher Labos & Jonathan Jarry . All rights reserved.

    • Apple Podcasts
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    Latest Episodes:
    Bounty Hunting for Science (with Ian Hussey) Jun 18, 2024
    Show notes

    Chris and Jonathan speak to Dr. Ian Hussey, the Chief Recommender for the ERROR project. It turns out that scientific papers are not flawless: they can contain mistakes. What happens when people are paid to go and find these mistakes? You’re about to find out!

    * Theme music: “Fall of the Ocean Queen“ by Joseph Hackl.

    To contribute to The Body of Evidence, go to our Patreon page at: http://www.patreon.com/thebodyofevidence/.

    Patrons get a bonus show on Patreon called “Digressions”! Check it out!

    1) The ERROR project website: https://error.reviews/


    104 – LASIK / HIV PrEP and STIs / Krill Oil for Knee Osteoarthritis Jun 04, 2024
    Show notes

    What does the body of evidence say on LASIK, the use of lasers to correct vision? Plus: many men on PreP are abandoning condoms as STIs are becoming more common, and Chris tells us if krill oil can cure arthritis of the knee. Also, Jonathan briefly imitates Alex Jones.

    A Block: LASIK

    (0:59) How lasers are used in medicine; LASIK and its cousins; how to choose; effectiveness, satisfaction, and side effects.

    B Block: HIV PrEP and STIs

    (28:18) How does pre-exposure prophylaxis against HIV works, and what is simultaneously happening with condom use (going down) and rates of STIs (going up). Also, what is Doxy-PEP?

    C Block: Krill Oil for Knee Osteoarthritis

    (44:45) An Australian trial of krill oil for arthritis of the knee came to the conclusion that… well, what do you think?

    * Theme music: “Fall of the Ocean Queen“ by Joseph Hackl

    * Assistant researcher: Aigul Zaripova

    To contribute to The Body of Evidence, go to our Patreon page at: http://www.patreon.com/thebodyofevidence/.

    To make a one-time donation to our show, you can now use PayPal! https://www.paypal.com/donate?hosted_button_id=9QZET78JZWCZE

    Patrons get a bonus show on Patreon called “Digressions”! Check it out!

    References:

    Comparisons of LASIK and its related techniques:

    1) DOI: 10.1371/journal.pone.0174810

    2) DOI: 10.1016/j.jcrs.2007.07.026

    3) DOI: 10.1136/bjo.2007.131748

    4) DOI: 10.1016/j.ajo.2017.03.013

    5) DOI: 10.1002/14651858.CD012687.pub2

    Outcomes from LASIK:

    6) DOI: 10.1016/s0161-6420(99)00148-7

    7) DOI: 10.1016/s0161-6420(00)00528-5

    8) doi:10.1001/jamaophthalmol.2016.4587

    UpToDate entries pertaining to HIV, PrEP, and Doxy-PEP:

    9) https://www.uptodate.com/contents/hiv-pre-exposure-prophylaxis

    10) https://www.uptodate.com/contents/primary-care-of-gay-men-and-men-who-have-sex-with-men

    11) https://www.uptodate.com/contents/prevention-of-sexually-transmitted-infections

    12) https://www.uptodate.com/contents/hiv-infection-risk-factors-and-prevention-strategies

    13) Statistics Canada survey of sexually active 15-to-24-year-olds: https://www150.statcan.gc.ca/n1/pub/82-003-x/2020009/article/00001-eng.htm

    14) Increased rates of STIs according to Public Health Agency of Canada: https://www.canada.ca/en/public-health/services/publications/diseases-conditions/report-sexually-transmitted-infection-surveillance-canada-2019.html

    15) Systematic review and meta-analysis on sexual risk behaviour in men who use PrEP: https://doi.org/10.1093/cid/ciy182

    16) Australian trial on krill oil for knee osteoarthritis: https://doi.org/10.1001/jama.2024.6063

    It’s Not Twitter But It’ll Do:

    1) Jonathan’s article about Lumina to avoid dental cavities: https://www.mcgill.ca/oss/article/medical-critical-thinking-technology/reports-death-dental-cavities-are-greatly-exaggerated

    2) The Skeptics’ Dictionary: https://www.skepdic.com/


    Hours of Boredom, Minutes of Terror (with Anesthesiologist Matthew Cameron) May 21, 2024
    Show notes

    Jonathan and Chris speak to Dr. Matthew Cameron, a local anesthesiologist who does a lot more than local anesthesias! They discuss the ins and outs of putting people to sleep; how safe epidurals really are; and whether or not you need to worry about waking up paralyzed in the middle of an operation (spoiler alert: no). Also, Jonathan is told about “blood patches” for the first time and can’t believe this is a real thing.

    * Theme music: “Fall of the Ocean Queen“ by Joseph Hackl.

    To contribute to The Body of Evidence, go to our Patreon page at: http://www.patreon.com/thebodyofevidence/.

    Patrons get a bonus show on Patreon called “Digressions”! Check it out!


    103 – Lupus / Tylenol in Pregnancy / Red Meat May 07, 2024
    Show notes

    What does the body of evidence say on lupus, the autoimmune disease that famously imitates so many other illnesses? Plus: a new study shows that Tylenol in pregnancy is not associated with neurodevelopmental problems, and Chris revisits the topic of red meat following a listener’s question.

    A Block: Lupus

    (0:57) How common lupus is; what may be causing it; what lupus looks like; how complicated its diagnosis is; what treatment options exist

    B Block: Tylenol in Pregnancy

    (34:27) Is Tylenol use in pregnancy really responsible for autism, ADHD, and intellectual disability? A new study says no.

    C Block: Red Meat

    (50:13) Are the harms of eating red meat regularly nowhere near as bad as we were told?

    * Theme music: “Fall of the Ocean Queen“ by Joseph Hackl

    * Assistant researcher: Aigul Zaripova

    To contribute to The Body of Evidence, go to our Patreon page at: http://www.patreon.com/thebodyofevidence/.

    To make a one-time donation to our show, you can now use PayPal! https://www.paypal.com/donate?hosted_button_id=9QZET78JZWCZE

    Patrons get a bonus show on Patreon called “Digressions”! Check it out!

    References:

    Lupus epidemiology:

    1) https://www.lupuscanada.org/living-with-lupus/what-is-lupus/

    2) https://doi.org/10.1177/096120339500400303

    3) https://doi.org/10.1038/s41584-021-00668-1

    Causes of lupus:

    4) DOI: 10.1002/art.22510

    5) DOI: 10.7326/0003-4819-142-12_part_1-200506210-00004

    6) https://doi.org/10.1097/bor.0b013e32833c6297

    7) https://doi.org/10.1016/0190-9622(90)70020-i

    8) https://doi.org/10.1136/ard.2007.084582

    9) DOI: 10.1177/0961203306069346

    What lupus looks like in a patient:

    10) https://dermnetnz.org/topics/cutaneous-lupus-erythematosus

    11) https://dermnetnz.org/topics/discoid-lupus-erythematosus

    12) doi: 10.2147/CCID.S269288

    13) https://dermnetnz.org/topics/raynaud-phenomenon

    14) DOI: 10.1097/01.md.0000091181.93122.55

    15) DOI: 10.1002/art.39070

    How to manage lupus:

    16) DOI: 10.1136/annrheumdis-2015-207726

    17) https://pubmed.ncbi.nlm.nih.gov/12784392/

    18) DOI: 10.1016/j.jaad.2014.12.025

    19) https://doi.org/10.1016/j.autrev.2017.02.005

    20) DOI: 10.1191/096120398678919778

    21) https://doi.org/10.1136/ard.2008.101766

    22) DOI: 10.1056/NEJMoa035471

    23) https://doi.org/10.1191/0961203305lu2039oa

    24) DOI: 10.1002/14651858.CD010668.pub2

    25) DOI: 10.1002/art.27233

    26) DOI: 10.1002/art.34359

    27) DOI: 10.1136/lupus-2018-000284

    28) DOI: 10.1056/NEJMoa1912196

    29) https://ash.confex.com/ash/2023/webprogram/Paper180547.html

    30) https://doi.org/10.1016/C2009-0-02062-5

    31) Study on Tylenol in pregnancy: https://doi.org/10.1001/jama.2024.3172


    102 – Too Tired to Party / Avian Flu / Earwax Apr 23, 2024
    Show notes

    It’s the case of the woman who was too tired to “par-tay!” What is afflicting her? It’s something that we don’t about enough. Plus: what is happening with avian flu and should you keep using Q-tips in your ears to remove earwax?

    A Block: The Case of the Woman Who Was Too Tired to Party

    (0:58) A woman falls asleep at work and has a constant headache. It also took her much longer than four years to complete her undergrad. What could be causing this?

    B Block: Avian Flu

    (25:36) An update on the avian flu situation

    C Block: Earwax

    (36:03) What should you do about your earwax? Use it as lip balm? Actually….

    * Theme music: “Fall of the Ocean Queen“ by Joseph Hackl

    * Assistant researcher: Aigul Zaripova

    To contribute to The Body of Evidence, go to our Patreon page at: http://www.patreon.com/thebodyofevidence/.

    To make a one-time donation to our show, you can now use PayPal! https://www.paypal.com/donate?hosted_button_id=9QZET78JZWCZE

    Patrons get a bonus show on Patreon called “Digressions”! Check it out!

    References:

    1) Inspection Canada webpages on avian flu: https://inspection.canada.ca/animal-health/terrestrial-animals/diseases/reportable/avian-influenza/facts-about-avian-influenza/eng/1356193731667/1356193918453 & https://inspection.canada.ca/animal-health/terrestrial-animals/diseases/reportable/avian-influenza/latest-bird-flu-situation/hpai-in-livestock/eng/1711895796746/1711895797730

    2) Nature News Explainer on avian flu: https://www.nature.com/articles/d41586-024-01036-1

    3) WHO surveillance page on avian flu: https://www.who.int/westernpacific/wpro-emergencies/surveillance/avian-influenza

    4) Case report on the man who caught H5N1: https://www.cdc.gov/ncird/whats-new/human-infection-H5N1-bird-flu.html


    101 - Measles / AG1 / A Day in the Life of a Doctor Apr 09, 2024
    Show notes

    What does the body of evidence say on measles, that scourge we thought we’d gotten rid of? Plus: do you need to drink AG1 every day for the rest of your life, and Chris explains what doctors do and don’t control when you see them at the clinic.

    A Block: Measles

    (0:57) How many people have measles; how measles is transmitted; how the disease progresses; complications; vaccination; treatments

    B Block: AG1

    (34:27) AG1 by Athletic Greens: what it contains and whether or not there’s good evidence that you need it

    C Block: A Day in the Life of a Doctor

    (50:13) Do doctors decide how many patients they see in a day? The answer may surprise you!

    * Theme music: “Fall of the Ocean Queen“ by Joseph Hackl

    * Assistant researcher: Aigul Zaripova

    To contribute to The Body of Evidence, go to our Patreon page at: http://www.patreon.com/thebodyofevidence/.

    To make a one-time donation to our show, you can now use PayPal! https://www.paypal.com/donate?hosted_button_id=9QZET78JZWCZE

    Patrons get a bonus show on Patreon called “Digressions”! Check it out!

    References:

    Origin of the measles virus:

    1) https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-7-52

    Measles epidemiology:

    2) https://www.cdc.gov/measles/hcp/index.html

    3) https://www.cdc.gov/measles/downloads/measlesdataandstatsslideset.pdf

    4) https://www.cdc.gov/measles/downloads/IntroToMeaslesSlideSet.pdf

    5) https://doi.org/10.1086/368114

    6) https://doi.org/10.1136/bmj.o2844

    7) https://www.cdc.gov/globalhealth/measles/news/covid-impact-on-measles-vaccination.html

    8) https://www.cdc.gov/mmwr/volumes/66/wr/mm6642a6.htm

    Clinical progression of the disease:

    9) https://dermnetnz.org/topics/measles

    10) https://jidc.org/index.php/journal/article/view/22421609

    11) https://dermnetnz.org/topics/measles-images

    12) https://doi.org/10.1016/S0140-6736(21)02004-3

    Atypical measles:

    13) https://www.nature.com/articles/nm918

    Complications from measles:

    14) https://www.science.org/doi/10.1126/science.aay6485

    State of measles in Canada:

    15) https://www.canada.ca/en/public-health/services/diseases/measles/surveillance-measles/measles-rubella-weekly-monitoring-reports.html

    State of measles in the United States:

    16) https://www.cdc.gov/measles/cases-outbreaks.html

    17) Jonathan’s article on AG1: https://www.mcgill.ca/oss/article/critical-thinking-health-and-nutrition/you-probably-dont-need-green-ag1-smoothie

    It’s Not Twitter, But It’ll Do:

    1) Jonathan’s article on leaky gut syndrome: https://www.mcgill.ca/oss/article/medical-critical-thinking/you-probably-dont-have-leaky-gut

    2) Appearances on CTV Montreal News: https://montreal.ctvnews.ca/video?binId=1.1332485

    3) Chris will be in Ottawa on April 13: https://allevents.in/ottawa/dr-labos-live-in-person/200026332496559?ref=eventlist-cat

    4) Jonathan will be at WeCanReason on May 4: https://wecanreason.com/


    100 - Ask Us Anything Mar 19, 2024
    Show notes

    It’s episode 100! For this very special episode, Jonathan and Chris do the Wired autocomplete interview; they answer listeners’ personal and health-related questions; and they make an announcement that will forever change the face of the podcast.

    A Block: The Wired Interview

    (1:14) What happens when you google “Jonathan Jarry” and “Christopher Labos,” and why do so many people want to know if Chris is married (and is he? Is he, though? Can we know, please?)

    B Block: Listeners’ Questions

    (22:42) Health-related questions

    (47:55) Personal questions

    C Block: The Future Is Here

    (1:26:15) Chris has no idea what he’s about to hear.

    * Theme music: “Fall of the Ocean Queen“ by Joseph Hackl

    * Assistant researcher: Aigul Zaripova

    To contribute to The Body of Evidence, go to our Patreon page at: http://www.patreon.com/thebodyofevidence/.

    To make a one-time donation to our show, you can now use PayPal! https://www.paypal.com/donate?hosted_button_id=9QZET78JZWCZE

    Patrons get a bonus show on Patreon called “Digressions”! Check it out!


    099 - Acne / New Food Allergy Drug / Answering Emails Mar 05, 2024
    Show notes

    What does the body of evidence say on acne and how to treat it? Plus: you’re going to want to pay attention to this latest study if you have food allergies, and Chris answers listeners’ questions about when to exercise, whether spinal cord stimulators work, and why some older adults are told that surgery would mess with their brain.

    A Block: Acne

    (0:59) Who gets acne; what causes acne; what are the risk factors for acne; how to treat both mild and moderate-to-severe acne.

    B Block: New Food Allergy Drug

    (34:16) A drug already approved to treat asthma, omalizumab (Xolair), can work against food allergies, including peanut allergy.

    C Block: Answering Emails

    (47:32) Questions about when is the best time to exercise (and whether or not you should be fasting); the benefits of spinal cord stimulators for people dealing with chronic pain; and why some older adults are being denied surgery.

    * Theme music: “Fall of the Ocean Queen“ by Joseph Hackl

    * Assistant researcher: Aigul Zaripova

    To contribute to The Body of Evidence, go to our Patreon page at: http://www.patreon.com/thebodyofevidence/.

    To make a one-time donation to our show, you can now use PayPal! https://www.paypal.com/donate?hosted_button_id=9QZET78JZWCZE

    Patrons get a bonus show on Patreon called “Digressions”! Check it out!

    References:

    Prevalence of acne

    1) https://doi.org/10.1016/j.jaad.2007.06.045

    2) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788264/

    Genetics as a cause of acne

    3) https://doi.org/10.1046/j.1523-1747.2002.19621.x

    Psychological toll of acne

    4) https://doi.org/10.1016/j.jaad.2008.07.013

    5) https://doi.org/10.1046/j.1365-2133.1997.18131897.x

    Diet and acne: the impact of milk

    6) https://doi-org/10.1016/j.jaad.2004.08.007

    7) https://doi.org/10.1016/j.jaad.2007.08.049

    8) https://pubmed.ncbi.nlm.nih.gov/17083856/

    9) https://doi.org/10.1016/j.jaad.2016.04.030

    10) https://doi.org/10.1111/jdv.13835

    Diet and acne: the role of carbohydrates (or glycemic load)

    11) https://doi.org/10.1016/j.jaad.2007.01.046

    12) https://doi.org/10.1111/ced.12673

    13) https://doi.org/10.1111/j.1365-4632.2009.04002.x

    14) https://doi.org/10.1016/j.jaad.2009.07.043

    15) https://doi.org/10.1016/j.jaad.2009.07.043

    Stress and acne

    16) https://doi.org/10.1001/archderm.139.7.897

    Overview of acne treatments

    17) https://doi.org/10.1067/mjd.2003.618

    18) The clinical trial of Xolair for food allergies: https://www.nejm.org/doi/10.1056/NEJMoa2312382

    19) The Nature News Explainer on Xolair and food allergies: https://www.nature.com/articles/d41586-024-00586-8

    It’s Not Twitter, But It’ll Do:

    1) Jonathan on The Current to talk about wellness and skepticism: https://www.cbc.ca/listen/live-radio/1-63-the-current/clip/16040098-how-tell-wellness-trends-wrong


    098 - The Case of the Injured Water-Skiier / Cancer Update Feb 27, 2024
    Show notes

    It’s the case of the injured water-skier, which gets Chris to talk about painkillers (NSAIDs, opioids, and Tylenol) and how quickly you lose muscle mass when you’re injured. Plus: a cancer update! Should you pay thousands of dollars for a full-body scan to make sure you don’t have cancer? Can you legally send poop through the mail? And how can we make Pap smears obsolete?

    Jonathan couldn’t speak much, so Aigul stepped up as co-host!

    A Block: The Case of the Injured Water-Skier

    (0:58) A man survives a water-skiing accident with two fractures, but he’s still in pain two months later. Is this normal or is he malingering?

    B Block: Cancer Update

    (28:24) Full-body MRIs promoted by Kim Kardashian: should you pay for one?

    (36:29) Colorectal cancer screening test available for free in Quebec

    (41:22) Is cervical cancer coming to an end?

    * Theme music: “Fall of the Ocean Queen“ by Joseph Hackl

    * Assistant researcher: Aigul Zaripova

    To contribute to The Body of Evidence, go to our Patreon page at: http://www.patreon.com/thebodyofevidence/.

    To make a one-time donation to our show, you can now use PayPal! https://www.paypal.com/donate?hosted_button_id=9QZET78JZWCZE

    Patrons get a bonus show on Patreon called “Digressions”! Check it out!

    Episode 100 will be an “Ask Us Anything” special. Email us your questions at: thebodyofevidence@gmail.com.

    References:

    1) La Presse’s report on full-body MRIs (in French): https://www.lapresse.ca/actualites/sante/un-examen-a-2500-qui-seme-le-doute/2024-02-10/vante-par-des-influenceurs-critique-par-le-corps-medical.php

    2) Montreal Gazette coverage of free colorectal screening tests in Quebec: https://montrealgazette.com/news/local-news/quebec-to-make-free-home-based-test-available-for-colorectal-screening

    3) Chris’ article about cervical cancer: https://montrealgazette.com/opinion/columnists/christopher-labos-we-can-now-envision-the-end-of-cervical-cancer


    097 – Microplastics / Long COVID Update / CRISPR Therapy Approved Feb 06, 2024
    Show notes

    What does the body of evidence say on microplastics and their impact on our health? Plus: we talk about what we have learned about long COVID since 2020, and we discuss the very first approval for a clinical application of the gene-editing technology known as CRISPR.

    A Block: Microplastics

    (0:58) What are micro- and nanoplastics; microplastics in the environment and in our bodies; how they get into humans and animals; the infamous study that was retracted; occupational exposure to microplastics versus casual exposure; eating microplastics by consuming seafood; can they cause infertility; BPA and BPS; the latest study on microplastics; are plastic water filters bad; should you avoid bottled water; alternatives to single-use plastic bottles.

    B Block: Long COVID Update

    (37:55) The problems with diagnosing it; how to treat it; the involvement of the mitochondria; probiotics for long COVID; should people with long COVID exercise; the COVID vaccine protects against long COVID; direct-to-participant digitized clinical trials.

    C Block: CRISPR Therapy Approved

    (56:22) CRISPR therapy approved in the UK and US for sickle cell disease and transfusion-dependent beta thalassemia. Jonathan initially mischaracterizes the therapy as repairing the mutation. Chris corrects him. Don’t email us, thank you!

    * Theme music: “Fall of the Ocean Queen“ by Joseph Hackl

    * Assistant researcher: Aigul Zaripova

    To contribute to The Body of Evidence, go to our Patreon page at: http://www.patreon.com/thebodyofevidence/.

    To make a one-time donation to our show, you can now use PayPal! https://www.paypal.com/donate?hosted_button_id=9QZET78JZWCZE

    Patrons get a bonus show on Patreon called “Digressions”! Check it out!

    References:

    1) Background on micro- and nanoplastics: https://montrealgazette.com/opinion/columnists/christopher-labos-is-bottled-water-bad-for-your-health

    2) The recent study published in PNAS: https://doi.org/10.1073/pnas.2300582121

    3) The retracted study: https://www.nature.com/articles/nature.2017.21929

    4) The WHO 2022 report on microplastics: https://www.who.int/publications/i/item/9789240054608

    5) What kind of reusable bottle is best: https://wapo.st/3O1yy3R

    6) Review article on long COVID from a Chinese team: https://www.nature.com/articles/s41392-023-01640-z

    7) Mitochondria are involved in long COVID: https://doi.org/10.1126/scitranslmed.abq1533

    8) Dr. Eric Topol’s commentary on the mitochondria paper: https://erictopol.substack.com/p/long-covid-mitochondria-the-big-miss

    9) The positive clinical trial on probiotics for long COVID: https://doi.org/10.1016/S1473-3099(23)00685-0

    10) Exercising can be bad for long COVID: https://www.nature.com/articles/s41467-023-44432-3

    11) At least 3 doses of the COVID vaccine seem to provide a 70% reduction in the risk of getting long COVID: https://erictopol.substack.com/p/sotp-state-of-the-pandemic

    12) What happened to the NIH RECOVER Long COVID initiative funds: https://erictopol.substack.com/p/long-covid-mitochondria-the-big-miss

    13) Direct-to-participant digitized clinical trials: https://erictopol.substack.com/p/long-covid-mitochondria-the-big-miss

    14) Information on CASGEVY: https://pi.vrtx.com/files/patientpackageinsert_exagamglogene_autotemcel.pdf

    It’s Not Twitter, But It’ll Do:

    1) Jonathan’s article on mindfulness meditation: https://www.mcgill.ca/oss/article/critical-thinking-health-and-nutrition/mindfulness-meditation-often-fails-scientific-test

    2) Jonathan’s article on the graveyard of skeptical projects: https://www.skeptic.org.uk/2024/01/the-graveyard-of-skeptical-projects-suggests-its-funding-not-talent-that-were-lacking/

    3) Chris featured at Darwin Day on February 10th for the Humanist Association of Toronto: https://www.humanisttoronto.ca/events-1/hat-forum-240127-g3ja3-3g8g9

    4) Chris being interviewed at Indigo Pointe-Claire by Ken Connors on February 17: https://www.facebook.com/drlabos/posts/926877516110207


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