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    Health & Fitness

    Physionic

    I translate health studies for the public – from ‘the macro to the micro’.

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    Copyright: © Nicolas Verhoeven

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    Latest Episodes:
    Berberine: A Powerful New Metabolic Mechanism Discovered! Sep 07, 2026
    Show notes

    *JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - Introduction0:15 - The Classics1:57 - What’s the News?6:04 - BerberineReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][1] Dong H, Wang N, Zhao L, Lu F. Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis. Evid Based Complement Alternat Med. 2012;2012:591654. doi:10.1155/2012/591654[Study 985] Sebo ZL, Chakrabarty RP, Grant RA, D’Alessandro KB, Koss AR, Blum JLE, et al. Metformin inhibits mitochondrial complex I in intestinal epithelium to promote glycaemic control. Nat Metab. 2026;8:1291-1304. doi:10.1038/s42255-026-01530-y[Study 986] Koffert JP, Mikkola K, Virtanen KA, Andersson AMD, Faxius L, Hällsten K, et al. Metformin treatment significantly enhances intestinal glucose uptake in patients with type 2 diabetes: results from a randomized clinical trial. Diabetes Res Clin Pract. 2017;131:208-216. doi:10.1016/j.diabres.2017.07.015[Study 987] Yin J, Xing H, Ye J. Efficacy of berberine in patients with type 2 diabetes. Metabolism. 2008;57(5):712-717. doi:10.1016/j.metabol.2008.01.013Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

    ‘They Lied about High LDL!’ - The Corrupt Science behind Heart Disease Sep 05, 2026
    Show notes

    *JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Original Podcast: https://youtu.be/q57CNySsYxs?si=PIwVEVGj_-cYkDCU0:00 - Introduction1:54 - Genetics that cause High Cholesterol5:29 - The American Heart Association is lying to you8:05 - Extremely High Cholesterol doesn't Kill17:48 - High Cholesterol at 60? Protection from Death25:20 - Other ways of testing this?27:12 - Main PointsReferences[1] Mundal L, Sarancic M, Ose L, et al. Mortality among patients with familial hypercholesterolemia: a registry-based study in Norway, 1992–2010. *J Am Heart Assoc*. 2014;3(6):e001236. doi:10.1161/JAHA.114.001236[2] Brown MS, Goldstein JL. Familial hypercholesterolemia: defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity. *Proc Natl Acad Sci U S A*. 1974;71(3):788-792. doi:10.1073/pnas.71.3.788[3] Shishikura D, Harada-Shiba M, Michikura M, et al. Comparison of clinical characterization and therapeutic strategies between homozygous familial hypercholesterolemia and heterozygous familial hypercholesterolemia. *J Atheroscler Thromb*. 2026;33. Advance publication online March 27, 2026. doi:10.5551/jat.65959[4] Wiegman A, de Groot E, Hutten BA, et al. Arterial intima-media thickness in children heterozygous for familial hypercholesterolaemia. *Lancet*. 2004;363(9406):369-370. doi:10.1016/S0140-6736(04)15467-6[5] EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC). Global perspective of familial hypercholesterolaemia: a cross-sectional study from the EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC). *Lancet*. 2021;398(10312):1713-1725. doi:10.1016/S0140-6736(21)01122-3[6] Clarke R, Emberson JR, Parish S, et al. Cholesterol fractions and apolipoproteins as risk factors for heart disease mortality in older men. *Arch Intern Med.* 2007;167(13):1373-1378.[7] Ding M, Wennberg A, Ek S, et al. The association of apolipoproteins with later-life all-cause and cardiovascular mortality: a population-based study stratified by age. *Sci Rep.* 2021;11(1):24440. doi:10.1038/s41598-021-03959-5.[8] Mortensen MB, Nordestgaard BG. Elevated LDL cholesterol and increased risk of myocardial infarction and atherosclerotic cardiovascular disease in individuals aged 70-100 years: a contemporary primary prevention cohort. *Lancet*. 2020;396(10263):1644-1652. doi:10.1016/S0140-6736(20)32233-9Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

    Peptides with HUGE Cardiovascular Impact: New Mechanism Discovered! Sep 01, 2026
    Show notes

    *JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with BiorenderMain Analysis: https://www.youtube.com/watch?v=e2_9mHtWwBQ0:00 - Introduction0:36 - Peptides on Cardiovascular Disease1:25 - Ceramides!3:44 - One Ceramide to instill Fear in All!6:16 - Returning to PeptidesReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][Study 1022] Lincoff AM, Brown-Frandsen K, Colhoun HM, et al; SELECT Trial Investigators. Semaglutide and cardiovascular outcomes in obesity without diabetes. N Engl J Med. 2023;389(24):2221-2232. doi:10.1056/NEJMoa2307563[Study 998] Lundgren JR, Janus C, Jensen SBK, et al. Healthy weight loss maintenance with exercise, liraglutide, or both combined. N Engl J Med. 2021;384(18):1719-1730. doi:10.1056/NEJMoa2028198[Study 999] Sandsdal RM, Holt J, Alkhefagie HGA, et al. Effects of exercise and liraglutide on vascular health and inflammation during weight loss maintenance: a prespecified secondary analysis of the S-LiTE trial. Nat Metab. 2026;8:1483-1488. doi:10.1038/s42255-026-01554-4[Study 1000] Mashayekhi M, Beckman JA, Nian H, et al. Comparative effects of weight loss and incretin-based therapies on vascular endothelial function, fibrinolysis, and inflammation in individuals with obesity and pre-diabetes: a randomized, controlled trial. Diabetes Obes Metab. 2023;25(2):570-580. doi:10.1111/dom.14903.[Study 1001] Akawi N, Checa A, Antonopoulos AS, et al. Fat-secreted ceramides regulate vascular redox state and influence outcomes in patients with cardiovascular disease. J Am Coll Cardiol. 2021;77(20):2494-2513. doi:10.1016/j.jacc.2021.03.314Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

    Glycine Restriction for Cancer, Berberine against Colorectal Cancer, and More Apr 20, 2026
    Show notes

    *JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*

    Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2


    *HEALTH AUTONOMY [COURSE]*

    Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy


    *JOIN THE COMMUNITY*

    Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2


    *EMAIL LIST*

    1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6


    *HIRE ME FOR CONSULTING:*

    Consulting: https://bit.ly/3dmUl2H

    0:00 - Introduction4:43 - Berberine on Colorectal Cancer21:36 - 5 Free Health Tests1:03:15 - Glycine Restriction and Cancer1:39:12 - Favorite Anti-Aging Hack2:06:00 - Lithium on Alzheimer's Disease2:29:20 - Vitamin K on Cardiovascular Disease3:14:00 - Housekeeping/Hanging Out

    Collagen for Skin 'Debunked, Non-Nutritive Sweeteners on Cognitive Decline, Seed Oils, and More Oct 25, 2025
    Show notes

    *JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*

    Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2


    *HEALTH AUTONOMY [COURSE]

    *Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy


    *JOIN THE COMMUNITY*

    Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2


    *EMAIL LIST*

    1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6


    *HIRE ME FOR CONSULTING:*

    Consulting: https://bit.ly/3dmUl2H

    0:00 - Introduction

    4:02 - Collagen for Skin 'Debunked'

    36:30 - Ketones track with Liver Disease

    52:15 - Butyrate and Cancer

    1:25:50 - Seed Oils - Harmful?

    1:59:55 - Ineffective Creatine

    2:17:17 - Non-Nutritive Sweeteners and Cognitive Decline

    2:42:39 - Housekeeping, Updates, Hangout

    Age Reversing Antibodies, Glycine and Longevity, Ergothioneine and Mitochondria, and More Sep 21, 2024
    Show notes

    *JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]* Join the Physionic Insiders [Standard Tier]: https://bit.ly/PhysionicInsiders2 Join the Physionic Insiders [Pro Tier]: https://bit.ly/PhysionicInsidersPro *Standard Tier:* Access to the Premium Video Library, Full Study Analyses (+ Summaries), Insider Podcast, , Research Reviews, and More *Pro Tier:* All benefits of the Standard Tier + Live Sessions with Me, Consulting Lite, and More *HEALTH AUTONOMY [COURSE]* Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy *JOIN THE COMMUNITY* Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2 *EMAIL LIST* One Weekly Email of Value: http://bit.ly/2AXIzK6 *HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H *DONATIONS FOR A SCIENCE BASED CAUSE* Patreon: https://bit.ly/PhysionicPatreon *OTHER SOCIAL MEDIA* Instagram: http://bit.ly/2OBFe7i

    Reversing Heart Disease, Creatine on Kidney Health, 5 Life Extending Habits, and More May 04, 2024
    Show notes

    *JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*

    Join the Physionic Insiders [Standard Tier]: https://bit.ly/PhysionicInsiders2

    Join the Physionic Insiders [Pro Tier]: https://bit.ly/PhysionicInsidersPro


    *Standard Tier:* Access to the Premium Video Library, Full Study Analyses (+ Summaries), Insider Podcast, , Research Reviews, and More

    *Pro Tier:* All benefits of the Standard Tier + Live Sessions with Me, Consulting Lite, and More


    *JOIN THE COMMUNITY

    *Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

    *EMAIL LIST*

    One Weekly Email of Value: http://bit.ly/2AXIzK6


    *HIRE ME FOR CONSULTING*

    Consulting: https://bit.ly/3dmUl2H


    *DONATIONS FOR A SCIENCE BASED CAUSE*

    Patreon: https://bit.ly/PhysionicPatreon


    *OTHER SOCIAL MEDIA*

    Instagram: http://bit.ly/2OBFe7i

    Oreos lowering Blood Cholesterol, Science Communication, Mechanisms of Heart Disease, Ft. Dr. Norwitz, Dave Feldman Mar 16, 2024
    Show notes

    *JOIN THE PHYSIONIC INSIDERS [PREMIUM

    CONTENT]*

    Join the Physionic Insiders

    [Standard Tier]: https://bit.ly/PhysionicInsiders2

    Join the Physionic Insiders [Pro Tier]: https://bit.ly/PhysionicInsidersPro


    *Standard Tier:* Access to the Premium Video Library, Full Study Analyses (+ Summaries), Insider Podcast, , Research Reviews, and More


    *Pro Tier:* All benefits of the Standard Tier + Live Sessions with Me, Consulting Lite, and More


    *JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

    *EMAIL LIST*One Weekly Email of Value: http://bit.ly/2AXIzK6

    *HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H

    *DONATIONS FOR A SCIENCE BASED CAUSE*Patreon: https://bit.ly/PhysionicPatreon

    *OTHER SOCIAL MEDIA*Instagram: http://bit.ly/2OBFe7i Nick's Channel: https://youtu.be/yiq67wpUhIs?si=AAercNmT4OX6fk_z

    Dave's Channel: https://youtu.be/RzG6N8WWufM?si=XNl6HTJ66vUpZ0QT 0:00 - Introduction of Study 3:47 - Introduction to Dr. Nick Norwitz and Dave Feldman 8:31 - Dr. Norwitz details the Oreo Study 31:52 - Problems with Science Communication 1:12:42 - Discussion with Dave Feldman

    1:15:20 - Lipid Heart Model of Heart Disease

    1:27:28 - Lean Mass Hyper-Responders

    1:35:10 - Mechanisms of Action Discussion



    Dr. Brad Stanfield: A Discussion of Supplements for Longevity and Health Dec 18, 2023
    Show notes

    *JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]

    *Join the Physionic Insiders [Standard Tier]: https://bit.ly/PhysionicInsiders2

    Join the Physionic Insiders [Pro Tier]: https://bit.ly/PhysionicInsidersPro


    *Standard Tier:* Access to the Premium Video Library, Full Study Analyses (+ Summaries), Insider Podcast, , Research Reviews, and More

    *Pro Tier:* All benefits of the Standard Tier + Live Sessions with Me, Consulting Lite, and More


    *JOIN THE COMMUNITY*

    Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2


    *EMAIL LIST*

    One Weekly Email of Value: http://bit.ly/2AXIzK6


    *HIRE ME FOR CONSULTING:*

    Consulting: https://bit.ly/3dmUl2H


    *DONATIONS FOR A SCIENCE BASED CAUSE*

    Patreon: https://bit.ly/PhysionicPatreon


    *OTHER SOCIAL MEDIA*

    Instagram: http://bit.ly/2OBFe7i


    Dr. Stanfield's Channel: https://www.youtube.com/@DrBradStanfield


    Timestamps

    0:00 – Introduction 1:05 – Nicotinamide Mononucleotide (NMN) 17:14 – Creatine 20:25 – Collagen Peptides 25:58 – Thoughts on Meta-Analyses 29:18 – Hyaluronic Acid 34:08 – Taurine 37:42 – Thoughts on Mouse Studies 39:55 – Do Blood Markers Matter for Longevity? 42:29 – Trusting Science/Experts 44:05 – Dr. Stanfield’s Motivations for Clinical Education 53:12 – Ending Remarks

    Reconsidering Aging, Muscle Growth, Niacin Supplementation, Your Questions, and More Nov 19, 2023
    Show notes

    *JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]* Join the Physionic Insiders [Standard Tier]: https://bit.ly/PhysionicInsiders2 Join the Physionic Insiders [Pro Tier]: https://bit.ly/PhysionicInsidersPro *Standard Tier:* Access to the Premium Video Library, Full Study Analyses (+ Summaries), Insider Podcast, , Research Reviews, and More *Pro Tier:* All benefits of the Standard Tier + Live Sessions with Me, Consulting Lite, and More *JOIN THE COMMUNITY* Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2 *EMAIL LIST* One Weekly Email of Value: http://bit.ly/2AXIzK6 *HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H *DONATIONS FOR A SCIENCE BASED CAUSE* Patreon: https://bit.ly/PhysionicPatreon *OTHER SOCIAL MEDIA* Instagram: http://bit.ly/2OBFe7i 0:00 - Introduction 5:11 - How to think about Aging 33:48 - Oxidized Blood Lipoproteins 58:34 - Study shows Age Reversal 1:15:28 - Oxalates 1:28:28 - Creatine as a Nootropic 1:35:48 - Niacin and Heart Disease 2:13:17 - Methylene Blue 2:25:25 - NMN on Health 2:38:46 - Inflammation contributing to Heart Disease 2:50:39 - Understanding Cellular Energy for Muscle Growth 3:07:08 - Subscriber Questions & Comments 3:42:05 - Housekeeping

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