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Dr. Rhonda Patrick: ‘Scientists discovered a Supplement that Repairs Aging Mitochondria!’ Oct 24, 2026

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*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with BiorenderDr. Patrick's Video: https://www.youtube.com/shorts/1Du-MKJOjk80:00 - Introduction1:05 - It Clears out Old Mitochondria!4:30 - It Rejuvenates the Immune System!6:54 - VO2 Boost, Anti-Aging Benefits11:52 - A Huge Caveat!13:22 - Main PointsReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][1] Singh A, D'Amico D, Andreux PA, et al. Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population. Eur J Clin Nutr. 2022;76(2):297-308. doi:10.1038/s41430-021-00950-1 [2] Alpert A, Pickman Y, Leipold M, et al. A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring. Nat Med. 2019;25(3):487-495. doi:10.1038/s41591-019-0381-y [3] Imboden MT, Harber MP, Whaley MH, Finch WH, Bishop DL, Kaminsky LA. Cardiorespiratory fitness and mortality in healthy men and women. J Am Coll Cardiol. 2018;72(19):2283-2292. doi:10.1016/j.jacc.2018.08.2166. [6] Bailey SJ, Winyard P, Vanhatalo A, et al. Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans. J Appl Physiol (1985). 2009;107(4):1144-1155. doi:10.1152/japplphysiol.00722.2009[7] Lansley KE, Winyard PG, Bailey SJ, et al. Acute dietary nitrate supplementation improves cycling time trial performance. Med Sci Sports Exerc. 2011;43(6):1125-1131. doi:10.1249/MSS.0b013e31821597b4[8] Cuenca E, Jodra P, Pérez-López A, et al. Effects of Beetroot Juice Supplementation on Performance and Fatigue in a 30-s All-Out Sprint Exercise: A Randomized, Double-Blind Cross-Over Study. Nutrients. 2018;10(9):1222. Published 2018 Sep 4. doi:10.3390/nu10091222[Study 230] D'Amico D, Olmer M, Fouassier AM, et al. Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis. Aging Cell. 2022;21(8):e13662. doi:10.1111/acel.13662[Study 232] Singh A, D'Amico D, Andreux PA, et al. Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. Cell Rep Med. 2022;3(5):100633. doi:10.1016/j.xcrm.2022.100633[Study 549] Denk D, Singh A, Kasler HG, et al. Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial. Nat Aging. 2025;5(11):2309-2322. doi:10.1038/s43587-025-00996-xPlease use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

Why is Cheese immune to raising Cardiovascular Disease risk? Oct 22, 2026

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TUDCA: A New Way of Addressing Insulin Resistance Oct 19, 2026

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*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - Introduction1:50 - TUDCA2:59 - Mechanisms of Intrigue4:18 - TUDCA Results7:50 - Dosing & ConsiderationsReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][1] She J, Tuerhongjiang G, Guo M, et al. Statins aggravate insulin resistance through reduced blood glucagon-like peptide-1 levels in a microbiota-dependent manner. Cell Metab. 2024;36(2):408–421.e5. doi:10.1016/j.cmet.2023.12.027.[2] Crosignani A, Battezzati PM, Cestari C, et al. Tauroursodeoxycholic acid for the treatment of chronic hepatitis: a multicentre dose-response study. Hepatol Res. 1998;13:10–19.[3] Ma H, Zeng M, Han Y, et al. A multicenter, randomized, double-blind trial comparing the efficacy and safety of TUDCA and UDCA in Chinese patients with primary biliary cholangitis. Medicine (Baltimore). 2016;95(47). doi:10.1097/MD.0000000000005391.[4] Pan XL, Zhao L, Li L, et al. Efficacy and safety of tauroursodeoxycholic acid in the treatment of liver cirrhosis: a double-blind randomized controlled trial. J Huazhong Univ Sci Technolog Med Sci. 2013;33(2):189–194. doi:10.1007/s11596-013-1095-x.[5] Poupon RE, Poupon R, Balkau B; UDCA-PBC Study Group. Ursodiol for the long-term treatment of primary biliary cirrhosis. N Engl J Med. 1994;330(19):1342–1347.[Study 1078] Kars M, Yang L, Gregor MF, et al. Tauroursodeoxycholic acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women. Diabetes. 2010;59(8):1899–1905. doi:10.2337/db10-0308.[Study 1079] Walsh LK, Restaino RM, Neuringer M, Manrique C, Padilla J. Administration of tauroursodeoxycholic acid prevents endothelial dysfunction caused by an oral glucose load. Clin Sci (Lond). 2016;130(21):1881–1888. doi:10.1042/CS20160501.[Study 1080] Panzhinskiy E, Hua Y, Culver B, Ren J, Nair S. Endoplasmic reticulum stress upregulates protein tyrosine phosphatase 1B and impairs glucose uptake in cultured myotubes. Diabetologia. 2013;56(3):598–607. doi:10.1007/s00125-012-2782-z.Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

The ‘Berberine Signature’: A New Heart Disease Protection Uncovered! Oct 15, 2026

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15 Studies Later: Investigating Omega-3 Fats promoting Cancer Oct 12, 2026

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Bombshell Study Upends Low Carb Nutrition Science! Oct 08, 2026

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*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with BiorenderOriginal Prediction on Ketone Mechanism: https://www.youtube.com/watch?v=q-uG5lMwHlU&t=228s0:00 - Introduction1:20 - Finally!2:59 - Agreement across Studies?4:50 - The Carbohydrate Twist5:15 - Protein Inequality6:06 - Time Matters?7:18 - Revisiting my PredictionReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][Study 518] Queathem ED, Stagg DB, Nelson AB, et al. Ketogenesis mitigates metabolic dysfunction–associated steatotic liver disease through mechanisms that extend beyond fat oxidation. J Clin Invest. 2025;135(12). doi:10.1172/JCI191021.[Study 1056] Petersen MC, Smith GI, Farabi SS, et al. Effect of diet macronutrient content on the cardiometabolic response to weight loss: a randomized clinical trial. Cell Metab. 2026;38:1–12. doi:10.1016/j.cmet.2026.07.020.[Study 1057] Qadri SF, Porthan K, Dufour S, et al. Distinct effects of ketogenic and non-ketogenic weight-loss diets on hepatic steatosis and mitochondrial metabolism in MASLD. J Hepatol. 2026;85:26–36. doi:10.1016/j.jhep.2026.02.001.[Study 1058] London A, Richter MM, Sjøberg KA, et al. The impact of short-term eucaloric low- and high-carbohydrate diets on liver triacylglycerol content in males with overweight and obesity: a randomized crossover study. Am J Clin Nutr. 2024;120:283–293. doi:10.1016/j.ajcnut.2024.06.006.[Study 1059] Kirk E, Reeds DN, Finck BN, et al. Dietary fat and carbohydrates differentially alter insulin sensitivity during caloric restriction. Gastroenterology. 2009;136(5):1552–1560. doi:10.1053/j.gastro.2009.01.048.[Study 1060] Haufe S, Engeli S, Kast P, et al. Randomized comparison of reduced fat and reduced carbohydrate hypocaloric diets on intrahepatic fat in overweight and obese human subjects. Hepatology. 2011;53(5):1504–1514. doi:10.1002/hep.24242.Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

Oats, Heart Disease, and the Molecules within Oats Oct 05, 2026

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*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with BiorenderMain Analysis: https://www.youtube.com/watch?v=c0Hm9tQ9zuc&t=1s0:00 - Introduction0:43 - Oats: Eat ‘em or Leave ‘em?1:52 - The Traditional3:10 - Something Suspicious about Oats…References[Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][1] Zhang J, Li L, Song P, et al. Randomized controlled trial of oatmeal consumption versus noodle consumption on blood lipids of urban Chinese adults with hypercholesterolemia. Nutrition Journal. 2012;11:54. doi:10.1186/1475-2891-11-54.[2] Thongoun P, Pavadhgul P, Bumrungpert A, Satitvipawee P, Harjani Y, Kurilich A. Effect of oat consumption on lipid profiles in hypercholesterolemic adults. Journal of the Medical Association of Thailand. 2013;96 Suppl 5–S32.[Study 1002] Klümpen L, Mantri A, Philipps M, et al. Cholesterol-lowering effects of oats induced by microbially produced phenolic metabolites in metabolic syndrome: a randomized controlled trial. Nature Communications. 2026;17:598. doi:10.1038/s41467-026-68303-9.[Study 1003] Xu D, Feng M, Chu Y, et al. The prebiotic effects of oats on blood lipids, gut microbiota, and short-chain fatty acids in mildly hypercholesterolemic subjects compared with rice: a randomized, controlled trial. Frontiers in Immunology. 2021;12:787797. doi:10.3389/fimmu.2021.787797.[Study 1004] Hu Y, Willett WC, Manson JE, et al. Intake of whole grain foods and risk of coronary heart disease in US men and women. BMC Medicine. 2022;20:192. doi:10.1186/s12916-022-02396-z.[Study 1005] Helnæs A, Kyrø C, Andersen I, et al. Intake of whole grains is associated with lower risk of myocardial infarction: the Danish Diet, Cancer and Health Cohort. American Journal of Clinical Nutrition. 2016;103:999–1007. doi:10.3945/ajcn.115.124271.Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

4 Ways to Melt Visceral Fat! Sep 28, 2026

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Created with Biorender

0:00 - Introduction1:22 - Option 12:20 - Option 23:55 - Option 35:55 - Option 4

References[1] Kadowaki T, et al. Obes Res Clin Pract. 2025;19(2):146-153. doi:10.1016/j.orcp.2025.03.003.

[2] Wilding JPH, et al. J Endocr Soc. 2021;5(Suppl 1):A16-A17. doi:10.1210/jendso/bvab048.030.

[3] Arciero PJ, et al. Obesity. 2023;31(Suppl 1):139-149. doi:10.1002/oby.23660.

[4] Zuo L, et al. Front Physiol. 2016;7:350. doi:10.3389/fphys.2016.00350.

[Study 396] Zelicha H, et al. BMC Med. 2022;20:327. doi:10.1186/s12916-022-02525-8.

[Study 427] Kaplan A, et al. Am J Clin Nutr. 2022;115(5):1270-1281. doi:10.1093/ajcn/nqac001.

[Study 780] Look M, et al. Diabetes Obes Metab. 2025;27(5):2720-2729. doi:10.1111/dom.16275.

[Study 790] Falutz J, et al. J Clin Endocrinol Metab. 2010;95(9):4291-4304. doi:10.1210/jc.2010-0490.

[Study 793] Makimura H, et al. J Clin Endocrinol Metab. 2012;97(12):4769-4779. doi:10.1210/jc.2012-2794.

[Study 509] Di Tano M, et al. Nat Commun. 2020;11:2332. doi:10.1038/s41467-020-16243-3.

[Study 510] Vernieri C, et al. Cancer Discov. 2022;12(1):90-107. doi:10.1158/2159-8290.CD-21-0030.

[Study 511] Ligorio F, et al. Int J Cancer. 2024;154(1):114-123. doi:10.1002/ijc.34701.

[Study 512] Vernieri C, et al. Cell Metab. 2024;36(8):1644-1667. doi:10.1016/j.cmet.2024.06.014.

[Study 606] Ni Y, et al. Cell Metab. 2023;35(9):1530-1547. doi:10.1016/j.cmet.2023.08.002.

[Study 607] Long X, et al. Cell Metab. 2025;37:2342-2361. doi:10.1016/j.cmet.2025.10.017.

[Study 608] Li H, et al. Nat Metab. 2024;6(3):578-597. doi:10.1038/s42255-024-00988-y.

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

Dr. Fung: ‘Cholesterol is barely relevant to Heart Disease’ Sep 26, 2026

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*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - Introduction2:13 - Blood Cholesterol is not Important13:08 - Something else matters WAY more than Blood Cholesterol16:45 - Main PointsReferences[Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][1] Khan SS, Matsushita K, Sang Y, et al. Development and validation of the American Heart Association’s PREVENT equations. Circulation. 2024;149:430–449. doi:10.1161/CIRCULATIONAHA.123.067626.[2] Dugani SB, Moorthy MV, Li C, et al. Association of lipid, inflammatory, and metabolic biomarkers with age at onset for incident coronary heart disease in women. JAMA Cardiol. 2021;6(4):437–447. doi:10.1001/jamacardio.2020.7073.[3] Magnussen C, Alegre-Diaz J, Al-Nasser LA, et al. Global effect of cardiovascular risk factors on lifetime estimates. N Engl J Med. 2025;393(2):125–138. doi:10.1056/NEJMoa2415879.[4] Blumenthal RS, Morris PB, Gaudino M, et al. 2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA guideline on the management of dyslipidemia: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2026;153:e1154–e1276. doi:10.1161/CIR.0000000000001423.[5] Cannon CP, Blazing MA, Giugliano RP, et al; IMPROVE-IT Investigators. Ezetimibe added to statin therapy after acute coronary syndromes. N Engl J Med. 2015;372(25):2387–2397. doi:10.1056/NEJMoa1410489.[6] Nordestgaard BG, Langlois MR, Langsted A, et al. Quantifying atherogenic lipoproteins for lipid-lowering strategies: Consensus-based recommendations from EAS and EFLM. Atherosclerosis. 2020;294:46–61. doi:10.1016/j.atherosclerosis.2019.12.005.[7] Prospective Studies Collaboration, Lewington S, Whitlock G, et al. Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths. Lancet. 2007;370(9602):1829–1839. doi:10.1016/S0140-6736(07)61778-4.[8] Johannesen CDL, Langsted A, Mortensen MB, Nordestgaard BG. Association between low density lipoprotein and all cause and cause specific mortality in Denmark: prospective cohort study. BMJ. 2020;371:m4266. doi:10.1136/bmj.m4266.Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

Manipulating Vitamin D to fight Cancer! [New Research] Sep 24, 2026

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[Study 1045] Perez KJ, et al. Gemcitabine and nab-paclitaxel ± paricalcitol for metastatic pancreatic cancer. Nat Cancer. 2026;7:928–943.

[Study 1046] Sherman MH, et al. Vitamin D receptor-mediated stromal reprogramming enhances pancreatic cancer therapy. Cell. 2014;159:80–93.

[Study 1047] Grierson PM, et al. Paricalcitol plus nanoliposomal irinotecan and 5-FU/LV in advanced pancreatic cancer. Clin Cancer Res. 2023;29:4733–4739.

[Study 1048] Chung V, et al. Pembrolizumab ± paricalcitol in metastatic pancreatic cancer. Oncologist. 2025;30.

[Study 1049] Easty D, et al. Paricalcitol with gemcitabine and nab-paclitaxel in advanced pancreatic cancer. BMC Cancer. 2026;26:255.

[Study 1050] Viniotis AF, et al. NABPLAGEM and paricalcitol as neoadjuvant therapy in pancreatic cancer. Oncologist. 2026;31.

[Study 1051] Rasmussen LS, et al. Vitamin D deficiency, inflammation, and survival in pancreatic cancer. Eur J Cancer. 2021;144:72–80.

[Study 1052] Yuan C, et al. Prediagnostic 25-hydroxyvitamin D and pancreatic cancer survival. J Clin Oncol. 2016;34:2899–2905.

[Study 1053] Cho M, et al. Vitamin D deficiency and prognosis in pancreatic adenocarcinoma. J Transl Med. 2013;11:206.

[Study 1054] Van Loon K, et al. 25-Hydroxyvitamin D and survival in advanced pancreatic cancer. J Natl Cancer Inst. 2014;106.

[Study 1055] Mukai Y, et al. Vitamin D supplementation with chemoradiation for pancreatic ductal adenocarcinoma. Ann Surg Oncol. 2018;25:1868–1879.

Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

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