Show notes
Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.
Welcome back, warriors! In this powerhouse episode of Peptide of the Week, JD Denham and William T. Haas break down two of the most talked-about compounds in the game: AOD-9604, the fat-blasting fragment of HGH, and IGF-1 LR3, the muscle-building giant.
From deep dives into dosing and cycling to real-world protocols, stacks, and who should be taking what—this episode is packed with expert insight, personal anecdotes, and no-BS education for anyone trying to lose fat or build lean mass.
We cover:
🔥 AOD-9604 Breakdown
– A synthetic fragment of HGH (amino acids 177–191) that’s purely fat-burning
– No effect on IGF-1, insulin sensitivity, or muscle mass = ultra-targeted shredder
– Great for men and women, especially those coming off GLP-1s like Retatrutide
– Best stacked with: Retatrutide, SLU, 5-Amino-1MQ, or L-Carnitine
– Typical dose: 250–500mcg, 1–2x/day
– Cycle: 12–16 weeks, then rotate to another fat burner
💪 IGF-1 LR3 Deep Dive
– Long-acting form of IGF-1 (stays active for 20–30 hours)
– Directly signals lean muscle growth, nutrient partitioning, and recovery
– Bypasses pituitary, HGH, and liver—delivers pure muscle-building power
– Works best when paired with heavy training volume and carbs (not for keto)
– Use post-workout, pre-big meals, or pre-workout for massive pumps
– Dose: Start at 20mcg/day, ramp to 60–80mcg max. Run for 4–6 weeks max
– Expect: Fuller muscles, faster recovery, and nutrient super-absorption
🧪 Stacking Strategies for Fat Loss & Muscle Growth
– Best Cutting Stack (Men/Women): Retatrutide + AOD + SLU + L-Carnitine
– Best Muscle Growth Stack: TRT + IGF-1 LR3 + Protein + Carbs + Volume Training
– Maintenance/Transition: Swap from GLP-1 to AOD for ongoing fat metabolism
– Advanced Users: Add Tesamorelin, MK-677, or GH Secretagogues depending on goals
– Cycle Recommendation: AOD (16 weeks), IGF-1 LR3 (4–6 weeks), then rotate
💡 Tips & Warnings
– IGF-1 LR3 requires high protein intake + carbs to be effective
– Not ideal on a strict keto or fasting protocol
– AOD is not stimulatory, very safe, and can be used long term
– Do not inject AOD if it gels—reconstitute with proper AOD water or acetic solution
– Avoid stacking GLP-1s together, but you can stack everything else
🧠 Big Takeaways
– Peptides are optimizers, not miracle workers
– Fat burners only shine when paired with workouts and clean eating
– IGF-1 LR3 = closest peptide to a steroid effect, but safer and leaner
– If you're looking to shred fat or pack on lean muscle, these two are top-tier
Chapters
00:00 Intro
00:18 Hat mix-up + sick talk
04:02 Episode topic: HGH family peptides overview
05:20 AOD-9604 explained (fat loss only)
11:06 HGH vs Secretagogues vs IGF-1 (key differences)
18:40 HGH timing + safety/cancer talk
25:19 AOD dosing + how long to run it
28:02 AOD mixing/gelling problem + fix
34:49 IGF-1 LR3 explained (muscle growth peptide)
38:10 Best ways to use IGF-1 (post-workout / carbs / cheat meal)
46:11 IGF-1 dosing basics + final recommendations
49:09 Outro
⚔️ Drop your questions in the comments. JD and Will read every DM.
🎥 Subscribe for more real-talk, no-hype breakdowns. Q&A episode drops later this week.
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