Peptide of The Week

Hosted by JD Denham and Will Haas, The Peptide of The Week Podcastis your no-BS guide to peptides, performance, and total body optimization. Whether you’re an athlete, a high performer, or just hungry to feel better, move better, and live stronger this show’s for you. JD and Will dive deep into real-world protocols, hard-earned lessons, and the science behind what actually works. With expert guests and raw conversations, you’ll get everything from cutting-edge peptide talk to diet, training, recovery, and mindset. No fluff. No filters. Just the tools to rebuild your body and upgrade your life.

Latest Episodes:

Peptide of the Week: SLU-PP-332 & GW-501516 (Cardarine) – Fat Loss, Endurance & VO2 Max Boost Nov 17, 2025

Show notes

Welcome back, warriors! In this episode of Peptide of the Week, JD Denham and William T. Haas compare two of the most effective compounds for fat loss, endurance, and stamina: SLU-PP-332 (aka SLU or Sloop) and GW-501516 (commonly known as Cardarine). These two exercise-enhancing agents share many similar benefits but differ in safety, delivery method, and stacking potential.

Whether you’re a weekend warrior, a fat-loss focused athlete, or someone trying to improve conditioning without sacrificing muscle, this episode is your full breakdown.

We cover:

💥 What Cardarine (GW-501516) is, and how it boosts muscular and cardiovascular endurance

🔥 Why Cardarine helps your body shift into fat-burning mode even while lifting or doing cardio

⚠️ The truth behind the infamous rat cancer study and why dosage matters

💊 Why Cardarine is not technically a SARM or a peptide and who should avoid it

🧬 What SLU-PP-332 is and why it’s a next-gen exercise mimetic

🥇 How SLU tricks the body into acting like it's already exercised increasing fat burn, VO2 max, and nutrient partitioning

💉 Oral vs injectable vs sublingual: Which SLU delivery method works best and why

📆 How long to run each protocol (8–12 weeks for Cardarine, 90 days for SLU)

⚡ The ideal dosing strategy for SLU and how advanced users are increasing it for serious results

🏃‍♂️ Why both work better with nutrient-dense meals and proper hormone optimization

💣 The ultimate fat-burning stacks: Retatrutide, AOD-9604, 5-Amino-1MQ, L-Carnitine

🧪 How to compound these for better energy, faster recovery, and clean body recomposition

🔬 Tips for preserving potency (AOD prep, NAD handling, injection technique)

💡 Whether you’re looking to torch body fat, boost endurance, or simply perform better with less effort SLU and Cardarine are two of the most powerful tools available for athletes and everyday people alike.

⚠️ Peptides are amino acid chains. Not steroids. Not shortcuts. Just science that works when paired with discipline.

👉 Got a peptide or topic you want us to dive into next? Drop it in the comments.

📌 Subscribe for weekly no-fluff deep dives into the most powerful healing and performance tools on the planet.

Peptide Q&A #15 – Healing Injuries, Teen Peptide Use, GLP-3 Dosing, and Real-World TRT Balance Nov 13, 2025

Show notes

Welcome back, warriors! In this week’s Peptide Q&A, JD Denham and William T. Haas dive into some of the most personal, practical, and powerful questions from the community. From injury recovery to parenting challenges, cellular rejuvenation to testosterone optimization this one’s packed.

We cover:

💥 Joint & Back Pain: Why BPC + TB + GHK blends help inflammation but can’t fix structure and how to handle long-term pain

⚡ Mom Burnout & Energy Loss: The NAD + MOTS-C + SS-31 combo for restoring cellular power (and when to add RETA)

🔥 MIC + B12 vs. Fat-Burner Stacks: What actually works and what’s just clinic marketing

👩‍👦 Teen Peptide Safety: JD and Will discuss GLP-3 use in teens with eating disorders — what’s ethical, what’s risky, and what might actually help

🧠 Creatine & Protein Myths: Why HCL Monohydrate for women and why most protein “types” aren’t created equal

🩸 Diabetic Safety & Healing: Peptides that are safe for Type 1 diabetics (GLP-3, NAD, MOTS-C, SS-31) — and those to avoid

💪 Cellular Rejuvenation Protocol: The exact MOTS-C + SS-31 + NAD + FOX-04 + Epitalon stack, timing, and seasonal cycle

💉 Switching to RETA: How to move from Tirzepatide to Retatrutide safely and what to expect when appetite comes back

🏋️ Fat Loss + Muscle Gain: RETA + Tessa-Ipam + MK-677 stacking explained (and why eating more can mean burning more)

🧬 NAD Injection Strategy: The truth about “NAD burn,” sub-Q vs IM, dosing ramp-up, and cycling vs year-round use

🤲 Transdermal Peptides: Why gels underperform and when injections still win

⚖️ TRT Sweet Spot: Finding balance, adjusting anastrozole correctly, and reading free vs total testosterone the right way

💥 IGF-1 Timing: When to pin pre-workout for performance, post-workout for recovery

🦵 Ankle Reconstruction Recovery: JD’s exact BPC + TB dosing triangle method for surgical repair and regaining mobility

💡 Peptides aren’t shortcuts they’re tools. Stack them with nutrition, sleep, and training, and they’ll amplify everything you’re already earning.

👉 Drop your peptide questions below for next week’s Q&A.

📌 Subscribe for weekly deep dives, dosing breakdowns, and real-world results.

You’re a warrior. Act like one.

Peptide of the Week: Retatrutide – Fat Loss, Insulin Sensitivity & Metabolic Health Nov 10, 2025

Show notes

Welcome back, warriors! In this episode of Peptide of the Week, JD Denham and William T. Haas are joined by special guest Dr. Scott Collie to break down Retatrutide (GLP-3) one of the most advanced, fat-burning, insulin-sensitizing peptides on the market and how it’s changing the game for weight loss, fatty liver reversal, energy, and metabolic health.

This isn’t just another version of Semaglutide or Tirzepatide it’s the next evolution. Whether you’re an athlete, a mom trying to get healthier, or someone struggling with cravings and energy crashes, Retatrutide might be the powerful catalyst you’ve been waiting for.

We cover:

🔥 How GLP-3 works vs Semaglutide and Tirzepatide

🧬 Why Retatrutide boosts insulin sensitivity, fat oxidation, and brain glucose
🍽️ How it enforces portion control without extreme appetite suppression
🩺 Dr. Collie’s real-world patient bloodwork results: A1C drops, triglyceride improvement, and fatty liver reversal
🏋️‍♂️ JD’s personal experience: leaner, tighter skin in 7 days
💡 Why it’s not just for the overweight bodybuilders, gym rats, and everyday people are stacking it too
📉 Common concerns debunked: skin rash, gut side effects, hair loss, and detox symptoms
🛑 Cautions for those with slow digestion or severe gut issues
🥦 How to pair it with high-nutrient meals for better outcomes
🧪 How to prep bloodwork while using Retatrutide, HGH, or TRT
📊 When to test free vs total testosterone, and why most doctors do it wrong
🧠 Why holistic blood panels matter (inflammation, gut health, oxidative stress, and more)

💡 Whether you’re trying to reverse pre-diabetes, boost your energy, or finally change your lifestyle Retatrutide is a proven catalyst with life-changing potential.

⚠️ Peptides are amino acid chains. Not steroids. Not shortcuts. Just science that works when paired with discipline.

👉 Got a peptide or topic you want us to dive into next? Drop it in the comments.

📌 Subscribe for weekly no-fluff deep dives into the most powerful healing and performance tools on the planet.

Peptide Q&A #14 – Women’s Fat-Loss Roadblocks, RETA Dosing, MK-677 for Growth & Healing for Teens Nov 06, 2025

Show notes

Welcome back, warriors! In this episode of Peptide Q&A, JD Denham and William T. Haas tackle another round of your most pressing questions about hormones, peptides, and real-world use. No fluff. No scripts. Just straight talk from experience.

We cover:

🍑 Stubborn Thighs & Glutes in Women: Why Tessa + AOD sometimes falls flat and why RETA is a game-changer

🤢 Semaglutide Myths: The real reason people lose hair, muscle, and curves and how RETA avoids it

💉 RETA Dosing Strategy: 1mg M/W/F to start, slow increases, and why keeping appetite intact matters

🔥 SLU-PP-332 vs 5-Amino: Sublingual fat-burning options for women who want to avoid injectables

💪 Muscle Gain Stacks: Why MK-677 pairs perfectly with TRT + RETA for building without losing calories

🥩 Eating Enough While Fasting: How to train at 5AM and still fuel growth (feeding windows done right)

💧 Reconstituting Peptides: When bacteriostatic water is enough and when AA water is a red flag

🧬 Using RETA to Get Shredded: Dose pacing, protein targets, and avoiding metabolic slowdown

🌍 Peptides Overseas: What to know if you're sourcing internationally (Malaysia listener shout-out!)

🦴 13-Year-Old Injury Healing: When BPC-157 + TB-500 is appropriate and when to avoid secretagogues

👩‍🦳 Mom’s Cognitive + Longevity Stack: NAD, MOTS-C, SS-31, Glow, and micro-dosing PT-141 for quality of life

⏱️ CJC/IPA Timing: Splitting doses AM/PM to match natural growth hormone pulses

⚠️ Peptides & Cancer Concerns: When to skip HGH secretagogues and use AOD + creatine instead

🧠 HGH vs HGH Frag: The difference between full 191aa somatropin and fat-burner fragments

🛠️ Private Coaching Forum: Why it’s being built and how it will allow real, uncensored conversation

💡 Whether you’re dialing in fat loss, healing from injury, or optimizing TRT, this Q&A is packed with straight answers to help you make informed decisions.

⚠️ Reminder: Peptides are amino acid chains. Not steroids. Not shortcuts. Just science that works when paired with discipline.

👉 Got a peptide question for JD and Will? Drop it in the comments for next week’s Q&A.

📌 Subscribe now for weekly deep dives, protocols, and no-fluff education.

You’re a warrior. Act like one.

Peptide of the Week: Kisspeptin + Oxytocin – Hormone Balance, Libido & Love Drug Effects Nov 03, 2025

Show notes

Welcome back, warriors! In this episode of Peptide of the Week, JD Denham and William T. Haas break down two powerful compounds Kisspeptin-54 and Oxytocin that tackle low testosterone, hormone imbalance, emotional connection, and libido from two unique angles.

Whether you're a man looking to naturally support testosterone, or a woman dealing with cycle irregularity or low libido, these peptides offer science-backed benefits. From reproductive health to emotional bonding and even lactation support, this episode dives deep into the science of hormone optimization and connection.

We cover:

🧬 What Kisspeptin-54 is and how it naturally kickstarts LH production

🧠 Why it's a safer, more holistic alternative to HCG and Clomid

🩸 JD’s real-world experience and the unexpected return of gyno symptoms

👶 Boosting fertility in men and women even regulating menstrual cycles

⚖️ How Kisspeptin helps balance estrogen and progesterone in women

🔥 Libido boosters — Kisspeptin vs PT-141 vs Oxytocin: what stacks best

😬 Estrogenic side effects explained (water retention, acne, sensitive nipples)

💊 Aromatase inhibitors 101: Arimidex vs Aromasin vs Letrozole

❤️ Oxytocin: the “Love Drug” that increases bonding, orgasm intensity, and trust

🧘 How oxytocin reduces cortisol, improves mood, and supports sleep

🍼 Lactation support, emotional calm, PTSD reduction & addiction cravings

💡 Whether you're struggling with hormone imbalance, intimacy, emotional stress, or fertility — these two compounds offer a powerful, natural path forward for both men and women.

⚠️ Peptides are amino acid chains. Not steroids. Not shortcuts. Just science that works when paired with discipline.

👉 Got a peptide or topic you want us to dive into next? Drop it in the comments.

📌 Subscribe for weekly no-fluff deep dives into the most powerful healing and performance tools on the planet.

Peptide Q&A #13 – RETA + Tessa Microdosing, Gear Replacements, Anxiety Fat-Burners & Fasting Fixes Oct 30, 2025

Show notes

We cover:

🔥 RETA + Tessa Microdosing: Monday/Wednesday/Friday vs. single-dose debate, JD’s personal dosing plan, and why microdosing wins for steady results

💉 CJC/IPA vs. Tessa/IPA: Which combo builds muscle, which burns fat faster, and when to swap protocols

⚡ AOD Timing: Morning vs. night injections and why fat burn continues while you sleep

💪 Gear Replacements: Safely transitioning from Anavar + Clen to peptides using RETA, MK-677, and SLOOP for sustainable results

👩‍🔬 Women’s Stacks: Peptides that tone, heal, and preserve muscle without water retention or hormonal crashes

🧠 Anxiety-Safe Fat Burners: 5-Amino-1-MQ, AOD, and SLU dosing for clean energy without stimulant side effects

🩸 TRZ + RETA Combo Myths: Why running them together is wasteful and how to taper off correctly

🧬 MK-677 + RAD140 Stacking: JD and Will’s honest take on SARMs, muscle gain, and why quality peptides outperform “freebies”

⚙️ L-Carnitine Injection Method: Why intramuscular wins every time and the proper daily dose range

🌙 Fasting & Cortisol Fix: Why women shouldn’t overfast, how to heal with food, and JD’s 12-hour eating window solution

💤 High Cortisol & Stress: C-Lonk + DSIP + grounding methods for recovery, hormone balance, and better sleep

💡 Peptide Blood Testing: The best panels for checking mitochondrial health, NAD levels, and peptide effectiveness

🧴 Skin & Eczema Protocols: Real-world results with BPC/TB, KPV, Thymosin Alpha-1, and Melanotan-1

💋 Next Week’s Focus: Deep dive into Oxytocin & Kisspeptin the connection between hormones, libido, and emotional health

💡 Whether you’re replacing gear, reducing stress, or optimizing recovery, this Q&A is packed with straight answers to help you make informed decisions.

⚠️ Reminder: Peptides are amino acid chains. Not steroids. Not shortcuts. Just science that works when paired with discipline.

👉 Got a peptide question for JD and Will? Drop it in the comments for next week’s Q&A.

📌 Subscribe now for weekly deep dives, protocols, and no-fluff education.

You’re a warrior. Act like one.

Peptide of the Week: L-Carnitine – Fat Burning, Mitochondrial Energy & Performance Boost Oct 27, 2025

Show notes

Peptide of the Week: L-Carnitine – Fat Burning, Mitochondrial Energy & Performance Boost

Welcome back, warriors! In this episode of Peptide of the Week, JD Denham and William T. Haas break down the powerhouse fat-burner L-Carnitine a staple compound for anyone looking to use stored fat as energy, improve endurance, and enhance performance.

If you’re already grinding in the gym but want more from your stack this is your next step. L-Carnitine acts like “ketosis in a bottle,” helping your body tap into fat stores without needing to be fully keto. It shuttles fatty acids directly into the mitochondria to be burned as clean energy, without draining muscle or spiking your nervous system.

We cover:

🔥 How L-Carnitine works to prioritize fat as fuel even if you're not in ketosis

🏋️ Why it's a game-changer for endurance, performance, and fat loss

💉 Oral vs. injectable and why liquid L-Carnitine is mostly a gimmick

⚠️ Who should NOT take it (especially anyone on T3 or thyroid meds)

💪 Stacking suggestions: pair with 5-Amino-1MQ and Retatrutide for amplified results

⚙️ JD’s personal protocol and pinning experience why daily injections can be worth it

📦 Mixing with TRT or intramuscular injections: what works, what doesn’t

🧬 Why injectable L-Carnitine is bioavailable and superior to over-the-counter versions

💊 HCL vs Monohydrate Creatine bonus breakdown performance insight that stacks well with Carnitine

💡 Whether you’re deep into a fat loss phase or just want clean, efficient energy L-Carnitine is a simple yet potent addition to your peptide arsenal.

⚠️ Peptides are amino acid chains. Not steroids. Not shortcuts. Just science that works when paired with discipline.

👉 Got a peptide or topic you want us to dive into next? Drop it in the comments.

📌 Subscribe for weekly no-fluff deep dives into the most powerful healing and performance tools on the planet.

Peptide Q&A #12 – AOD Timing, Surgery Recovery, Peptide Math, Glow Cycling & Stack Order Oct 23, 2025

Show notes

We cover:

🔥 AOD + RETA Stack: How to combine AOD morning/night with RETA for max fat burn and why it’s JD’s favorite duo

🌙 Nighttime Fat Loss: Why you burn more fat while sleeping than you think, and how timing changes everything

💪 Bicep Surgery Repair: JD’s personal recovery stack, high-dose Wolverine protocol, and real-world healing results

🧬 Glow vs Wolverine: When to use each, why GHK-Cu matters, and how to avoid copper overload

📈 Peptide Math Simplified: Reconstitution explained vials, units, MLs, and the easy way to calculate doses

👩‍🔬 Female Users & Math: Why confusion is common, and how to make peptide dosing less intimidating

🧫 Cycling Glow: Whether to take breaks, what to swap during downtime (Thymosin Alpha-1, Cartalax, BPC/TB), and how to maintain results

⚙️ Stack Order Strategy: How to sequence mitochondrial, immunity, and fat-loss cycles for long-term optimization

💉 TRT Gel vs Injections: Why creams fall short, why injections outperform, and when to ditch the gel

🧴 Eczema & Skin Health: Real-world healing stories using BPC/TB, KPV, Thymosin Alpha-1, and Melanotan for pigment repair

⚡ Methylene Blue vs MOTS-C: Why they’re not the same, how they complement each other, and dosing for athletic performance

🔥 SLOOP + BAM-15 Debate: Do they cancel each other out? JD and Will settle it once and for all

👩 Women’s Anti-Aging Stack: RETA + CJC/IPA + NAD + HGH for muscle, mood, and longevity

⚠️ Birth Control & Cysts: Peptides that reduce inflammation and support hormonal balance naturally

💡 Whether you’re troubleshooting recovery, cycling smart, or fine-tuning performance, this Q&A is packed with straight answers to help you make informed decisions.

⚠️ Reminder: Peptides are amino acid chains. Not steroids. Not shortcuts. Just science that works when paired with discipline.

👉 Got a peptide question for JD and Will? Drop it in the comments for next week’s Q&A.

📌 Subscribe now for weekly deep dives, protocols, and no-fluff education.

You’re a warrior. Act like one.

Peptide of the Week: PE-22-28, pinealon & Cerebrolysin – Mood, Memory & Brain Repair Oct 20, 2025

Show notes

Peptide of the Week: PE-22-28, pinealon & Cerebrolysin – Mood, Memory & Brain Repair

Welcome back, warriors! In this episode of Peptide of the Week, JD Denham and William T. Haas break down three cutting-edge nootropics designed to target different aspects of brain health: PE-22-28, pinealon, and Cerebrolysin. Whether you're fighting brain fog, mood dips, memory decline, or want to get ahead of neurodegeneration this episode maps it all out.

Each peptide serves a distinct function one boosts mood, another protects cognition, and the third actively repairs damaged brain cells. It’s the perfect stack for anyone over 40, battling stress, or with Alzheimer’s in the family.

We cover:

🧠 PE-22-28 rapid-acting antidepressant peptide that boosts mood, lifts anxiety, and increases joy

💡 How PE-22-28 is fast, potent, and works better than many prescription options (with fewer side effects)

🧪 Dosing: 100–500 mcg subQ or 400 mcg nasal daily, and why less is more

🛡️ pinealon cognitive protector that supports memory, focus, and neurotransmitter performance

🧬 What makes pinealon a “bioregulator” and how it promotes cellular longevity

🕒 How to dose it: 600 mcg M/W/F, for 4–6 weeks with short breaks

⚒️ Cerebrolysin the most expensive but powerful neuro-repair agent, ideal for stroke, TBI, and Alzheimer’s risk

🐷 What it’s made from (yes, pig brain peptides) and why it’s multimodal and unique

📦 Dosing protocols: 30mg daily for 10 days, repeated 3–4x/year

💰 Cost breakdown and why it’s worth it if you're serious about prevention and repair

🔥 How to stack all 3 peptides together and add C-Max, Selank, NAD+, or BPC-157 for even more brain support

📊 Case study preview: upcoming results from real-world testing of these stacks in both men and women

💡 If you want to protect your brain, recover faster, and age with clarity this nootropic stack is your best friend. And yes, you can run all 3 together without redundancy.

⚠️ Peptides are amino acid chains. Not steroids. Not shortcuts. Just science that works when paired with discipline.

👉 Got a peptide or topic you want us to dive into next? Drop it in the comments.

📌 Subscribe for weekly no-fluff deep dives into the most powerful healing and performance tools on the planet.

Peptide Q&A #11 – Bulking Stacks, Women’s Fat-Loss Fixes Oct 16, 2025

Show notes

Peptide Q&A #11 – Bulking Stacks, Women’s Fat-Loss Fixes, HGH Cancer Risks & Peptide Mixing Rules

We cover:

💪 Bulking Stacks: RETA + Tessa + IPA + Glow for clean growth, diet adjustments, and why food still wins

🥩 Diet Deep Dive: High-fat vs high-protein eating, finding your personal macro groove, and why consistency beats perfection

⚙️ MK-677 & IGF-1 LR3: Boosting appetite, lean muscle gain, and how to use short cycles for better metabolism

🧬 TRT & Low T: Why hormone optimization is critical before any peptide protocol

👩 Women’s Fat-Loss Plan: Transitioning from Tirzepatide to RETA, triple stack with AOD + 5-Amino-1-MQ + SLOOP, and why the next 30 lbs are the hardest

🔥 GLP-2 vs GLP-3: When to combine, taper, and how to manage hunger correctly

🧠 Cancer & HGH: Real talk on genetic risk, family history, and why caution always beats regret

💉 Mixing Peptides in One Syringe: What’s safe, what clouds instantly, and the visual clarity test

🏋️ Wolverine Blend Healing: BPC-157 + TB-500 + KPV + GHK-Cu for torn shoulders and faster post-surgery recovery

⚡ SLU-PP-332 + BAM-15 Stack: Mitochondrial activation, fat-loss synergy, and why Methylene Blue isn’t always the answer

🧪 Colon Polyps & Caution: When to skip HGH, focus on BPC/TB only, and the truth about conservative doctors

🥇 100-lb Weight-Loss Success: How to transition from Tirzepatide to RETA, add Tessa/IPA, and fine-tune dosing for longevity

👩‍🦰 Female Transformation Plan: RETA + NAD + 5-Amino + MOTS-C + AOD + Tessa for lean, sculpted results and breaking stubborn plateaus

💡 Whether you’re dialing in fat loss, healing from injury, or chasing peak performance, this Q&A is packed with straight answers to help you make informed decisions.

⚠️ Reminder: Peptides are amino acid chains. Not steroids. Not shortcuts. Just science that works when paired with discipline.

👉 Got a peptide question for JD and Will? Drop it in the comments for next week’s Q&A.

📌 Subscribe now for weekly deep dives, protocols, and no-fluff education.

You’re a warrior. Act like one.

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