TopPodcast.com
Menu
  • Home
  • Top Charts
  • Top Networks
  • Top Apps
  • Top Independents
  • Top Podfluencers
  • Top Picks
    • Top Business Podcasts
    • Top True Crime Podcasts
    • Top Finance Podcasts
    • Top Comedy Podcasts
    • Top Music Podcasts
    • Top Womens Podcasts
    • Top Kids Podcasts
    • Top Sports Podcasts
    • Top News Podcasts
    • Top Tech Podcasts
    • Top Crypto Podcasts
    • Top Entrepreneurial Podcasts
    • Top Fantasy Sports Podcasts
    • Top Political Podcasts
    • Top Science Podcasts
    • Top Self Help Podcasts
    • Top Sports Betting Podcasts
    • Top Stocks Podcasts
  • Podcast News
  • About Us
  • Podcast Advertising
  • Contact
Not in our directory?
Add Show Here
Podcast Equipment
Center

toppodcastlogoOur TOPPODCAST Picks

  • Comedy
  • Crypto
  • Sports
  • News
  • Politics
  • True Crime
  • Business
  • Finance

Follow Us

toppodcastlogoStay Connected

    View Top 200 Chart
    Back to Rankings Page
    Science

    Mind & Matter

    Whether food, drugs or ideas, what you consume influences who you become. Learn directly from the best scientists & thinkers alive today about how your mind-body reacts to what you feed it.

    The weekly M&M podcast features conversations with the most interesting scientists, thinkers, and technology entrepreneurs alive today.

    Not medical advice.

    At M&M, we are interested in trying to figure out how things work, not affirming our existing beliefs. We prefer consulting primary rather than secondary sources and independent rather than institutional voices. If we encounter uncomfortable truths or the evidence suggests unfashionable ideas may be valid, so be it.

    As the host, my aim is to help you better understand how the body & mind work by curating & synthesizing information in a way that yields science-based insights that you can choose to use or disregard in your own life. Taking ownership of your health starts with taking ownership of your information diet.

    I am motivated to connect the dots and distill general principles from what I learn, preferring to ask questions and play devil’s advocate to debating or incessantly pushing my own viewpoint.

    My beliefs:

    • Taking ownership of your health starts with taking ownership of your information diet.
    • All knowledge is provisional and we must work hard to prevent ourselves from becoming attached to our favorite ideas & preferred conclusions.
    • Wisdom comes from an iterative, trial-and-error process of learning and unlearning. Letting go of pre-conceived notions can be painful, but pain is information.

    Sometimes modern discoveries teach us we must unlearn received wisdom. Other times, modern information overload & historical chauvinism cause us to forget ancient wisdom which stills applies. The framework for learning that I embody is inspired by three Ancient Greek maxims inscribed in the Temple of Apollo at Delphi:

    • “Γνῶθι σεαυτόν” (Know thyself)
    • “Μηδὲν ἄγαν” (Nothing in excess)
    • “Ἐγγύα πάρα δ Ἄτα” (Certainty brings insanity)
    Advertise

    Copyright: © 2025 Nick Jikomes

    • Apple Podcasts
    • Google Play
    • Spotify

    Latest Episodes:
    Neural Basis of Pain, Placebo Effects, Opioid Pain Relief & Addiction | Gregory Scherrer | Episode 177 Sep 15, 2024
    Show notes

    Send us Fan Mail

    About the guest: Gregory Scherrer, PharmD, PhD is a neuroscientist whose lab at the University of North Carolina studies the neural basis of pain, including its sensory, emotional, and cognitive components.

    Episode summary: Nick and Dr. Scherrer discuss: the neural basis of pain sensation & pain perception; opioids & the opioid system; cognitive modulation of painful experiences; neural basis of placebo effects; endogenous opioid system; and more.

    *This content is never meant to serve as medical advice.

    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    Ancestral vs. Modern Human Diets, Seed Oils & Influence of Industry on Food Science | Steven Rofrano | Episode 194 Sep 11, 2024
    Show notes

    Send us Fan Mail

    Episode summary: Nick and Steven discuss ancestral vs. modern foods; seed oils & polyunsaturated fatty acids (PUFAs); inflammation, allergies, and immunity; PUFAs, free radicals, and oxidative stress; the corrupting influence of private industry on food science; the history of seed oils; animal vs. plant fats; Steven’s food startup; and more.

    About the guest: Steven Rofrano became interested in human health & food, including ancestral vs. modern diets, from personal experiences in diet & allergies during college. He is co-founder and CEO at Ancient Crunch, Inc., which provides alternatives to widely consumed ultra-processed snack foods. Before becoming an entrepreneur Steven studied mathematics at Yale University and worked as a software engineer.

    Related episodes:

    • M&M #136: Seed Oils, Omega-6 PUFAs, Inflammation, Obesity, Diabetes, Chronic Disease & Metabolic Dysfunction | Chris Knobbe

    *This content is never meant to serve as medical advice.

    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    Bad Science, Nutrition Epidemiology, History of Obesity Research, Diet & Metabolic Health | Gary Taubes | Episode 176 Sep 06, 2024
    Show notes

    Send us Fan Mail

    About the guest: Gary Taubes is a researcher, science historian, and science journalist. He has written several books, including “Rethinking Diabetes.”

    Episode summary: Nick and Gary Taubes discuss: the field of nutrition epidemiology and why it’s filled with so much junk science; social factors influencing scientific research; the history of obesity & diabetes research; the energy balance vs. carbohydrate-insulin models of obesity; fats, carbs & insulin resistance; and more.

    Related episodes:

    • M&M 140: Obesogens, Oxidative Stress, Dietary Sugars & Fats, Statins, Diabetes & the True Causes of Metabolic Dysfunction & Chronic Disease | Robert Lustig

    *This content is never meant to serve as medical advice.

    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    Aging, Biological Clocks, Proteomics, Longevity & Healthspan | Austin Argentieri | Episode 175 Sep 03, 2024
    Show notes

    Send us Fan Mail

    About the guest: Austin Argentieri, PhD is a researcher in the Analytic & Translational Genetics Unit at the Massachusetts General Hospital with academic appointments at Harvard & the Broad Institute. His research focuses on large-scale analyses to to understand human aging.

    Episode summary: Nick and Dr. Argentieri discuss: chronological vs. biological age; DNA methylation and aging clocks; proteomics and protein measurements in aging research; health, longevity, and human healthspan; and more.

    Related episodes:

    • Aging, mTOR, Sirtuins, Rapamycin, Metformin, the Truth of Resveratrol & Longevity Supplements, David Sinclair & Anti-Aging Myths | Matt Kaeberlein | 151

    *This content is never meant to serve as medical advice.

    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    Adipose Tissue & Body Fat: Obesity, Insulin, Leptin, Fertility, Weight Loss & GLP-1 Drugs | Sean Hartig | Episode 174 Aug 29, 2024
    Show notes

    Send us Fan Mail

    About the guest: Sean Hartig, PhD is an associate professor at the Baylor College of Medicine, where is lab studies adipose (fat) tissue, metabolic regulation, and obesity & energy balance disorders.

    Episode summary: Nick and Dr. Hartig discuss: visceral vs. subcutaneous fat; white, brown, and beige adipose tissue; physiology of fat cells; obesity, insulin resistance, and leptin resistance; hormones & fertility; GLP-1 drugs for weight loss; and more.

    Related episodes:

    • Obesogens, Oxidative Stress, Dietary Sugars & Fats, Statins, Diabetes & the True Causes of Metabolic Dysfunction & Chronic Disease | Robert Lustig | #140
    • GLP-1, Weight Loss Drugs, Ozempic, Obesity, NMDA Receptors, Metabolism & Brain Health | Christoffer Clemmensen | #161

    *This content is never meant to serve as medical advice.

    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    Psychedelics, Consciousness, Mental Health & the Entropic Brain | Robin Carhart-Harris | Episode 173 Aug 24, 2024
    Show notes

    Send us Fan Mail

    About the guest: Robin Carhart-Harris, PhD is a neuroscientist & psychopharmacologist. His lab at the University of California-San Francisco studies the effects of psychedelics and other drugs on the human brain, using neuroimaging and other approaches.

    Episode summary: Nick and Dr. Carhart-Harris discuss: psychedelics & the human brain; functional connectivity & entropy in brain patterns; the “entropic brain” hypothesis of psychedelic drug action; psychiatry & depression; psychology, Carl Jung & Sigmund Freud; the FDA’s rejection of MDMA-assisted psychotherapy for PTSD; latest research on psychedelics; and more.

    Related episode:

    • Anesthesia, Placebo Effects, Consciousness, Subjectivity, MDMA, Ketamine, Opioids, Psychedelics | Boris Heifets | 163

    *This content is never meant to serve as medical advice.

    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    Immune System, Gut Microbiome, Vitamin D, Cancer, Innate Immunity, Inflammation & Gut-Immune Interactions | Caetano Reis e Sousa | Episode 172 Aug 21, 2024
    Show notes

    Send us Fan Mail

    About the guest: Caetano Reis e Sousa, DPhil is an immunologist and Principal Group Leader at the Francis Crick Institute in London. His lab studies immune system function, including its ability to fight infection and cancer.

    Episode summary: Nick and Dr. Reis e Sousa discuss: dendritic cells & innate immunity; how the immune system recognizes pathogens, damaged cells, and cancer cells; gut microbiome & non-pathogenic bacteria; inflammation; vitamin D & gut-immune interactions; cancer; and more.

    Related episode:

    • Ketogenic Diet, Cancer, Microbiome, Nutrition & the Immune System | Maayan Levy | #72

    *This content is never meant to serve as medical advice.


    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    Comparative Brain Evolution: Mammals, Primates & Humans | Robert Barton | Episode 171 Aug 18, 2024
    Show notes

    Send us Fan Mail

    About the guest: Robert Barton, PhD is an evolutionary anthropologist and Professor at Durham University. He studies the evolution of the brain and behavior across species, including humans.

    Episode summary: Nick and Dr. Barton discuss: mammalian brain evolution; how brain and body size scale across mammals; how metabolism relates to brain size and function; the evolution of the neocortex & cerebellum in primates & humans; the concept of “intelligence” and whether it relates to brain size; and more.

    Related episodes:

    • Evolution of Complex Behavior, Perception, Cognition, Consciousness & the Brain | Paul Cisek | #107
    • Organisms, Cities, Companies & the Science of Scale | Geoffrey West | #12

    *This content is never meant to serve as medical advice.

    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    Sex Differences, Drugs & the Brain: Psychedelics, Psilocybin, Alcohol & Nicotine | Melissa Herman | Episode 170 Aug 14, 2024
    Show notes

    Send us Fan Mail

    About the guest: Melissa Herman, PhD is a neuroscientist and associate professor at the University of North Carolina. Her lab studies the effects of drugs on the brain and behavior in rodents.

    Episode summary: Nick and Dr. Herman discuss: sex differences in the brain between males and females; behavioral variability among individuals; the effects of psychedelics like psilocybin on the amygdala and hypothalamus; effects of alcohol and vaporized nicotine; and more.
    Related episode:

    • Sex Differences in the Brain, Endocannabinoid Biology, Purpose of Juvenile Play Behavior, Cannabis & Pregnancy | Margaret McCarthy | #81

    *This content is never meant to serve as medical advice.

    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    Epigenetics, Chromatin Plasticity & the Neural Basis of Memory | Giulia Santoni | Ep 169 Aug 09, 2024
    Show notes

    Send us Fan Mail

    About the guest: Giulia Santoni, PhD is a neuroscientist who obtained her PhD at the EPFL in Switzerland, where she studied epigenetic influences on memory formation.

    Episode summary: Nick and Dr. Santoni discuss: transcription & gene regulation; synaptic plasticity; learning & associative memory; epigenetics, histones, DNA methylation, and mechanisms of gene regulation; chromatin plasticity & the neural basis of memory formation; and more.
    Related episodes:

    • Emotion, Cognition, Consciousness, Behavior & Brain Evolution | Joseph LeDoux | #73
    • Cognitive Neuroscience, Cognitive Flexibility & Control, Attention, Working Memory, Multitasking & Behavior | Tobias Egner | #130

    *This content is never meant to serve as medical advice.

    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    Previous 1 12 13 14 15 16 32 Next

    Related Podcasts

    Invisibilia

    1

    Invisibilia Personal Journals
    Hidden Brain – Hidden Brain, Shankar Vedantam

    2

    Hidden Brain – Hidden Brain, Shankar Vedantam Science
    How To Do Everything

    3

    How To Do Everything Science
    Hidden Brain

    4

    Hidden Brain Games & Hobbies
    Something You Should Know

    5

    Something You Should Know Education
    Sword and Scale – Sword and Scale

    6

    Sword and Scale – Sword and Scale Alternative Health
    footer-logo

    Contact Us

    Toll Free: 844-670-7747

    Links

    • Home
    • Top Charts
    • Networks
    • Apps
    • Independents Podcasts
    • Podcast Advertising
    • Podcast News
    • Contact Us
    • About Us
    • Analytics & Insights

    Stay Connected

      Privacy, Terms of Use & Our Code of Ethics Protecting Content Creators Copyrights