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    Science

    Mind & Matter

    Whether food, drugs or ideas, what you consume influences who you become. Learn directly from the best scientists & thinkers alive today about how your mind-body reacts to what you feed it.

    The weekly M&M podcast features conversations with the most interesting scientists, thinkers, and technology entrepreneurs alive today.

    Not medical advice.

    At M&M, we are interested in trying to figure out how things work, not affirming our existing beliefs. We prefer consulting primary rather than secondary sources and independent rather than institutional voices. If we encounter uncomfortable truths or the evidence suggests unfashionable ideas may be valid, so be it.

    As the host, my aim is to help you better understand how the body & mind work by curating & synthesizing information in a way that yields science-based insights that you can choose to use or disregard in your own life. Taking ownership of your health starts with taking ownership of your information diet.

    I am motivated to connect the dots and distill general principles from what I learn, preferring to ask questions and play devil’s advocate to debating or incessantly pushing my own viewpoint.

    My beliefs:

    • Taking ownership of your health starts with taking ownership of your information diet.
    • All knowledge is provisional and we must work hard to prevent ourselves from becoming attached to our favorite ideas & preferred conclusions.
    • Wisdom comes from an iterative, trial-and-error process of learning and unlearning. Letting go of pre-conceived notions can be painful, but pain is information.

    Sometimes modern discoveries teach us we must unlearn received wisdom. Other times, modern information overload & historical chauvinism cause us to forget ancient wisdom which stills applies. The framework for learning that I embody is inspired by three Ancient Greek maxims inscribed in the Temple of Apollo at Delphi:

    • “Γνῶθι σεαυτόν” (Know thyself)
    • “Μηδὲν ἄγαν” (Nothing in excess)
    • “Ἐγγύα πάρα δ Ἄτα” (Certainty brings insanity)
    Advertise

    Copyright: © 2025 Nick Jikomes

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    Latest Episodes:
    Sleep: Neural Circuits, Orexin/Hypocretin, Hypothalamus, Neuromodulators, Stress & Cortisol, Sleep Drugs & Ultrasound Technology | Luis de Lecea | Episode 168 Aug 05, 2024
    Show notes

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    About the guest: Luis de Lecea, PhD is a neurobiologist whose lab at Stanford University studies the neural basis of sleep & wakefulness in animals.

    Episode summary: Nick and Dr. de Lecea discuss: the neural basis of sleep; sleep architecture & sleep phases (NREM vs. REM sleep); orexin/hypocretin neurons & the lateral hypothalamus; cortisol & stress; circadian rhythms; neuromodulators (norepinephrine, dopamine, etc); sleep across animal species; sleep drugs; ultrasound technology; and more.
    Related episodes:

    • Sleep, Dreaming, Deep Neural Networks, Machine Learning & Artificial Intelligence, Overfitted Brain Hypothesis, Evolution of Fiction & Art | Erik Hoel | #43
    • Consciousness, Anesthesia, Coma, Vegetative States, Sleep Pills (Ambien), Ketamine, AI & ChatGPT | Alex Proekt | #101

    *This content is never meant to serve as medical advice.

    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    Plant Chemistry & the Chemical Basis of Marijuana Aroma | Iain Oswald | 167 Jul 26, 2024
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    About the guest: Iain Oswald, PhD is an organic chemist and Director of Research & Development at Abstrax Tech.

    Episode summary: Nick and Dr. Oswald discuss: plant chemistry; marijuana strains and their aroma; the chemical basis of cannabis aroma; terpenes vs. non-terpene volatile organic compounds; and more.
    Related episodes:

    • Marijuana, Plant Chemistry, Terpenes, Volatile Sulfur Compounds, Cannabis Industry, What Pungent Weed Smells Like & Why | Iain Oswald | #114
    • Endocannabinoids, Stress, Exercise, Cortisol, Anxiety, Cannabis & Effects of Marijuana on Brain Development | Matthew Hill | #123

    *This content is never meant to serve as medical advice.

    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    History of Diet & Food, Population Size & Social Stability, Psychological Pandemics, Civilization Cycles | Rudyard Lynch | Episode 193 Jul 19, 2024
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    About the guest: Rudyard Lynch is a history and anthropology scholar and host of the popular YouTube channel, whatifalthist.

    Episode summary: Nick and Rudyard discuss: history of agriculture, diet & food; population density, social structure, and social behavior; the rise and fall of civilizations; history and future of religion & spirituality; and more.
    Episodes in this podcast sub-series are available on Substack, YouTube, and elsewhere.
    Related episodes:

    • Organisms, Cities, Companies & the Science of Scale | Geoffrey West
    • Psychedelics, Civilization, Religion, Death & Plant Medicine | Brian Muraresku

    *This content is never meant to serve as medical advice.

    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    Evolution: Natural Selection, Genetic Drift, Origin of Life, Cellular Complexity, Epigenetics | Michael Lynch | Episode 166 Jul 14, 2024
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    About the guest: Michael Lynch, PhD is an evolutionary biologist at Arizona State University who studies the origins of genomic and cellular complexity.

    Episode summary: Nick and Dr. Lynch discuss: natural selection vs. genetic drift; genetic mutations & the speed of evolution; origin of life; the evolution of cellular complexity; epigenetics & the inheritance of acquired characteristics; and more.
    Related episodes:

    • Evolution & Animal Development: How Nature Builds & Changes Bodies | Sean B. Carroll | #138
    • Evolution, Language, Domestication, Symbolic Cognition, AI & Large Language Models | Terrence Deacon | #141

    *This content is never meant to serve as medical advice.

    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    PUFAs in Brain Health & Disease, Dietary Fats, Brain Lipids, Nutrition | Richard Bazinet | Episode 165 Jul 10, 2024
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    About the guest: Richard Bazinet, PhD is neurochemist and nutritional scientist at the University of Toronto. His lab studies brain lipid metabolism in health and disease.

    Episode summary: Nick and Dr. Bazinet discuss: lipid metabolism in the liver and brain; dietary fatty acids (saturated, monounsaturated, polyunsaturated); fatty acids in brain health & disease; endocannabinoids; omega-3 PUFAs, seed oils & diet; and more.

    *This content is never meant to serve as medical advice.

    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    Seed Oils, Chronic Disease, Diet & Religious Cults, Mainstream Medicine vs. Independent Research | Tucker Goodrich | Episode 192 Jun 30, 2024
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    About the guest: Tucker Goodrich is an independent researcher and self-described “seed oil zealot” who credits many of his own health improvements with minimizing his consumption of industrial seed oils. He runs a Substack page, and provides interesting commentary about scientific research on seed oils, metabolic health, and related topics.

    Episode summary: Nick and Tucker discuss: what seed oils are and their history; differences between omega-6 and omega-3 polyunsaturated fatty acids (PUFAs); seed oils, sunburn, and oxidative stress; Seventh Day Adventism and the relationship between religion, ideology, and diet; paleobiology of human diet; and more.
    *This content is never meant to serve as medical advice.

    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    Dopamine, Reward, Motivation, Lateral Hypothalamus, Feeding Behavior & Eating Disorders | Melissa Sharpe | Episode 164 Jun 26, 2024
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    About the guest: Melissa Sharpe, PhD is a neuroscientist. Her lab at the University of Sydney studies reinforcement and reward learning in rodents.

    Episode summary: Nick and Dr. Sharpe discuss: dopamine and its association with reward learning and motivation; reinforcement learning & the brain; the lateral hypothalamus and feeding behavior; and more.
    Related episodes:

    • Drugs, Addiction & Neuroplasticity: Psychedelics, MDMA, Opioids, Cocaine, Amphetamine (Adderall), Nicotine, Marijuana & Alcohol | Robert Malenka | #162
    • Neuroscience of Pleasure, Reward, Liking vs. Wanting, Motivation, Food vs. Drug Addiction & Emotion | Kent Berridge | #94

    *This content is never meant to serve as medical advice.

    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    Anesthesia, Placebo Effects, Consciousness, Subjectivity, MDMA, Ketamine, Opioids, Psychedelics | Boris Heifets | Episode 163 Jun 21, 2024
    Show notes

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    About the guest: Boris Heifets, MD, PhD is an anesthesiologist and researcher at Stanford University. His lab studies non-ordinary states of consciousness and psychoactive drugs like MDMA, ketamine, and psychedelics.

    Episode summary: Nick and Dr. Heifets discuss: anesthesia and how anesthetics work; placebo effects & expectations in clinical research; ketamine as an antidepressant, anesthetic, and recreational drug; the subjective effects of psychedelics and other drugs; MDMA and Lykos Therapeutics’ attempts to gain FDA approval for MDMA-assisted psychotherapy; opioids & placebo effects; and more.
    Related episodes:

    • How Does Ketamine Work & Is It Addictive? | Christian Lüscher | #90

    *This content is never meant to serve as medical advice.

    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    Addiction & Neuroplasticity: Psychedelics, MDMA, Opioids, Cocaine, Adderall, Nicotine, Marijuana & Alcohol | Robert Malenka | Episode 162 Jun 16, 2024
    Show notes

    Send us Fan Mail

    About the guest: Robert Malenka, MD, PhD is psychiatrist & neuroscientist. He has spent most of his career at Stanford University, where his lab studies synaptic plasticity, mechanisms of drug action in the brain, and the neural basis of behavior.

    Episode summary: Nick and Dr. Malenka discuss: mechanisms of synaptic plasticity in the brain, such as LTP & LTD; addiction & the dopamine reward circuitry of the brain; psychoactive drugs ranging from stimulants (cocaine, nicotine, amphetamines) to opioids (fentanyl), psychedelics, MDMA, THC, and alcohol; and more.
    Related episodes:

    • How Does Ketamine Work & Is It Addictive? | Christian Lüscher | #90
    • Neuroscience of Social Behavior, Pain, Empathy, Emotion, Brain Mechanisms of MDMA | Monique Smith | #159


    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    GLP-1, Weight Loss Drugs, Ozempic, Obesity, NMDA Receptors, Metabolism & Brain Health | Christoffer Clemmensen | Episode 161 Jun 12, 2024
    Show notes

    Send us Fan Mail

    About the guest: Christoffer Clemmensen, PhD is scientist running the Metabolism & Molecular Pharmacology group at the University of Copenhagen in Denmark. His lab studies the biological basis of obesity & other metabolic disorders.

    Episode summary: Nick and Dr. Clemmensen discuss: GLP-1 & gut hormones; obesity & metabolic disease; GLP-1 agonists and weight loss drugs (e.g. Ozempic); novel, dual-action weight loss drugs his lab has created; and more.
    Previous discussion: Metabolism, Obesity & Psychedelics for Metabolic Disease | Christoffer Clemmensen | #105
    *This content is never meant to serve as medical advice.

    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


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