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    Science

    Mind & Matter

    Whether food, drugs or ideas, what you consume influences who you become. Learn directly from the best scientists & thinkers alive today about how your mind-body reacts to what you feed it.

    The weekly M&M podcast features conversations with the most interesting scientists, thinkers, and technology entrepreneurs alive today.

    Not medical advice.

    At M&M, we are interested in trying to figure out how things work, not affirming our existing beliefs. We prefer consulting primary rather than secondary sources and independent rather than institutional voices. If we encounter uncomfortable truths or the evidence suggests unfashionable ideas may be valid, so be it.

    As the host, my aim is to help you better understand how the body & mind work by curating & synthesizing information in a way that yields science-based insights that you can choose to use or disregard in your own life. Taking ownership of your health starts with taking ownership of your information diet.

    I am motivated to connect the dots and distill general principles from what I learn, preferring to ask questions and play devil’s advocate to debating or incessantly pushing my own viewpoint.

    My beliefs:

    • Taking ownership of your health starts with taking ownership of your information diet.
    • All knowledge is provisional and we must work hard to prevent ourselves from becoming attached to our favorite ideas & preferred conclusions.
    • Wisdom comes from an iterative, trial-and-error process of learning and unlearning. Letting go of pre-conceived notions can be painful, but pain is information.

    Sometimes modern discoveries teach us we must unlearn received wisdom. Other times, modern information overload & historical chauvinism cause us to forget ancient wisdom which stills applies. The framework for learning that I embody is inspired by three Ancient Greek maxims inscribed in the Temple of Apollo at Delphi:

    • “Γνῶθι σεαυτόν” (Know thyself)
    • “Μηδὲν ἄγαν” (Nothing in excess)
    • “Ἐγγύα πάρα δ Ἄτα” (Certainty brings insanity)
    Advertise

    Copyright: © 2025 Nick Jikomes

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    Latest Episodes:
    Ancient Diets, Human Carnivory, Mammoth Hunting, Clovis Culture & Origin of Native Americans | Ben Potter & Jim Chatters | Episode 199 Dec 12, 2024
    Show notes

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    Podcast episodes are fully available to paid subscribers on the M&M Substack and freely on YouTube. Partial versions are available elsewhere.

    About the guest: Ben Potter, PhD is an archaeologist & Professor of Anthropology at the University of Alaska-Fairbanks. James Chatters, PhD is a retired archaeologist and paleontologist. They recently published a paper on the diet of the Clovis people of North America at the end of the last Ice Age.

    Episode summary: Nick talks to Dr. Potter & Dr. Chatters about: the Clovis culture and initial human colonization of the Americas; human diet since the last Ice Age; ancient human diets; hunting of Mammoths and other large herbivores; Clovis technology & culture, including projectile weapons; and more.

    *This content is never meant to serve as medical advice


    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    Vaccine Adverse Events & mRNA Biotechnology | Jessica Rose | Episode 198 Dec 07, 2024
    Show notes

    Send us Fan Mail

    Podcast episodes are fully available to paid subscribers on the M&M Substack and full video versions are free on YouTube. This episode will not be posted on YouTube due to the controversial nature of the content.

    About the guest: Jessica Rose, PhD is a computational biologist who has been studying and analyzing data from the Vaccine Adverse Event Responding System (VAERS) related to COVID.

    Episode summary: Nick and Dr. Rose discuss: Vaccine Adverse Event Responding System (VAERS); analysis of VAERS data for COVID; mRNA technology; spike protein persistence & lipid nanoparticles; common adverse events reported for the Pfizer & Moderna shots; myocarditis & menstrual irregularities; IgG4 antibodies, molecular mimicry & autoimmunity; and more.

    Related episodes:

    • M&M #196: Vaccine Contamination & Fiat Science | Kevin McKernan
    • M&M #100: Infectious Disease, Epidemiology, Pandemics, Health Policy, COVID, Politicization of Science | Jay Bhattacharya

    *This content is never meant to serve as medical advice

    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    Creation Myths, Stoned Apes & the Eve Theory of Consciousness | Andrew Cutler | Episode 197 Dec 04, 2024
    Show notes

    Send us Fan Mail

    Full episodes are available to paid subscribers on the M&M Substack and free on YouTube. This is a free, partial version.
    About the guest: Andrew Cutler, PhD is a machine learning engineer who has studied natural language processing, psychometrics & personality using quantitative methods. He writes about the origins of consciousness on his Substack, "Vectors of Mind"

    Episode summary: Nick and Dr. Cutler discuss: language & recursion; human evolution & the origins of "higher" consciousness; symbolic cognition, social intelligence & metacognition; creation myths & ritual cults throughout history; snake cults in human history; the intentional ingestion of snake venom in the present-day; the "Stone Ape Theory" of consciousness; the origins of civilization; and more.

    Related episodes:

    • M&M #141: Evolution, Language, Domestication, Symbolic Cognition, AI & Large Language Models | Terrence Deacon
    • M&M #1: Psychedelics, Civilization, Religion, Death & Plant Medicine | Brian Muraresku

    *This content is never meant to serve as medical advice

    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    Neurobiology of Stress: Resilience, HPA Axis, Stress Hormones, Sex Differences, Early Life | Rosemary Bagot | Episode 191 Nov 30, 2024
    Show notes

    Send us Fan Mail

    Full episodes are available to paid subscribers on the M&M Substack and free on YouTube. This is a free, partial version.
    About the guest: Rosemary Bagot, PhD is an Associate Professor in the Department of Psychology at McGill University and the Canada Research Chair in Behavioural Neurogenomics. Her lab studies the neurobiology of stress at the molecular, circuit, and behavioral levels.

    Episode summary: Nick and Dr. Bagot discuss the hypothalamic-pituitary-adrenal (HPA) Axis, cortisol and hormonal responses to stress; neural circuits related to the perception of threats & stressors; resilience & early life stress; sex differences & individual variability in stress response; epigenetics & transgenerational effects of stress; and more.

    Related episodes:

    • M&M #183: Calorie Restriction & Fasting: Aging, Immunity, Health Biomarkers, Stress, Genetics | Gary Churchill

    *This content is never meant to serve as medical advice

    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    Mental Illness & Substance Abuse: Genetics, Psychosis, THC, Dopamine & the Brain | Jibran Khokhar | Episode 190 Nov 26, 2024
    Show notes

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    About the guest: Jibran Khokhar, PhD is Associate Professor of Anatomy & Cell Biology at Western University in Ontario. His lab studies the neurobiology of the co-occurrence of psychiatric illnesses like schizophrenia with substance use disorders.

    Episode summary: Nick and Kevin discuss high comorbidity among mental illness, the dopamine reward system, antipsychotics & other psychiatric drugs; the relationship between THC (marijuana) and psychosis; sex differences in the brain; nicotine e-cigarettes (vaping) compared to smoking; and more.

    *This content is never meant to serve as medical advice.

    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    Vaccine Contamination & Fiat Science | Kevin McKernan | Episode 196 Nov 21, 2024
    Show notes

    Send us Fan Mail

    Full episodes are available to paid subscribers on the M&M Substack and free on YouTube. This is a free, partial version.
    About the guest: Kevin McKernan is the founder and Chief Science Officer of Medicinal Genomics. He has worked in biotechnology since the early 1990s, when he was involved in the Human Genome Project.

    Episode summary: Nick and Kevin discuss: components of the COVID vaccines, including modified mRNA & lipid nanoparticles; DNA contamination in COVID vaccines; vaccine adverse events & IgG4 immune modulation; concerns with COVID PCR testing; origins of the SARS-CoV-2 virus; Fiat Science from the AIDS epidemic to today; how Big Pharma works with government regulators; decentralized medicine; and more.

    Related episodes:

    • M&M #149: DNA & RNA Biology, mRNA Vaccines, Vax Contamination & Side Effects, Spike Protein, Ivermectin, Hop Latent Viroid | Kevin McKernan

    *This content is never meant to serve as medical advice


    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    Skin Biology: Hormones, Light, Vitamin D, Melatonin & Stress | Andrzej Slominski | Episode 189 Nov 18, 2024
    Show notes

    Send us Fan Mail

    About the guest: Andrzej Slominski, MD, PhD is a dermapathologist and skin biologist who has spent decades studying skin biology, especially regarding endocrinology (hormones), stress response, photobiology, and more.

    Episode summary: Nick and Dr. Slominski discuss: hormone production in the skin; vitamin D photobiology; risks and benefits of UVB light; skin cancer & sunscreen; protective effects of melatonin production in the skin; and more.

    Related episodes:

    • M&M #104: Benefits & Risks of UV Radiation & Sunlight, Skin Health, Vitamin D, Nitric Oxide, Evolution of Skin Color | Richard Weller

    *This content is never meant to serve as medical advice

    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    Psychedelics, Functional Neuroimaging & the Human Brain | Joshua Siegel | Episode 188 Nov 13, 2024
    Show notes

    Send us Fan Mail

    About the guest: Joshua Siegel, MD, PhD is a psychiatrist & systems neuroscience at New York University. He uses functional imaging to study the effects of psychedelics and other drugs on the human brain.

    Episode summary: Nick and Dr. Siegel discuss: fMRI and how it works; relationship between neural activity and blood flow; functional connectivity & the default mode network of the human brain; the functional effects of psilocybin on the brain; the role that subjective & expectancy effects in psychedelics medicine; and more.

    Related episodes:

    • M&M #173: Psychedelics, Consciousness, Psychiatry, Psychology, Mental Health & the Entropic Brain Hypothesis

    *This content is never meant to serve as medical advice

    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    Synesthesia & Effects of Digital Technology on Brain & Mental Health | Richard Cytowic | 187 Nov 10, 2024
    Show notes

    Send us Fan Mail

    About the guest: Richard Cytowic is a neurologist, poplar science writer and professor at the George Washington University.

    Episode summary: Nick and Dr. Cytowic discuss: the effects of smart phones and social media on the developing and adult brain; artificial blue light vs. broad spectrum natural light; attention & addiction to technology; sensory overstimulation & “virtual autism”; synesthesia and multimodal sensory perception; and more.

    Related episodes:

    • M&M 78: Nature vs. Nurture, Neurogenetics, Personality, Autism, Schizophrenia, Synesthesia, Perception, Agency & Free Will | Kevin Mitchell

    *This content is never meant to serve as medical advice

    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    Kidney Biology: Simple Diet & Lifestyle Practices for Kidney Health | Thomas Weimbs | Episode 186 Nov 06, 2024
    Show notes

    Send us Fan Mail

    About the guest: Thomas Weimbs, PhD is a biologist at UC-Santa Barbara whose lab studies kidney function in health and disease.

    Episode summary: Nick and Dr. Weimbs discuss: basic kidney biology; kidney stones and their causes, including dietary oxalates and fructose; the kidney damaging effects of common pharmaceuticals like Ibuprofen; the beneficial effects of BHB and ketosis for kidney health; the myth that high protein intake is bad for the kidney; kidney diseases and their causes; and more.
    Full version available on Substack and YouTube.

    Related episodes:

    • M&M 158: Ketosis & Ketogenic Diet: Brain & Mental Health, Metabolism, Diet & Exercise, Cancer, Diabetes | Dominic D'Agostino
    • M&M #139: Metabolic Switching, Fasting, Ketosis, Neuroplasticity, Diet & Neurodegenerative Disease | Mark Mattson

    *This content is never meant to serve as medical advice

    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


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