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    Science

    Mind & Matter

    Whether food, drugs or ideas, what you consume influences who you become. Learn directly from the best scientists & thinkers alive today about how your mind-body reacts to what you feed it.

    The weekly M&M podcast features conversations with the most interesting scientists, thinkers, and technology entrepreneurs alive today.

    Not medical advice.

    At M&M, we are interested in trying to figure out how things work, not affirming our existing beliefs. We prefer consulting primary rather than secondary sources and independent rather than institutional voices. If we encounter uncomfortable truths or the evidence suggests unfashionable ideas may be valid, so be it.

    As the host, my aim is to help you better understand how the body & mind work by curating & synthesizing information in a way that yields science-based insights that you can choose to use or disregard in your own life. Taking ownership of your health starts with taking ownership of your information diet.

    I am motivated to connect the dots and distill general principles from what I learn, preferring to ask questions and play devil’s advocate to debating or incessantly pushing my own viewpoint.

    My beliefs:

    • Taking ownership of your health starts with taking ownership of your information diet.
    • All knowledge is provisional and we must work hard to prevent ourselves from becoming attached to our favorite ideas & preferred conclusions.
    • Wisdom comes from an iterative, trial-and-error process of learning and unlearning. Letting go of pre-conceived notions can be painful, but pain is information.

    Sometimes modern discoveries teach us we must unlearn received wisdom. Other times, modern information overload & historical chauvinism cause us to forget ancient wisdom which stills applies. The framework for learning that I embody is inspired by three Ancient Greek maxims inscribed in the Temple of Apollo at Delphi:

    • “Γνῶθι σεαυτόν” (Know thyself)
    • “Μηδὲν ἄγαν” (Nothing in excess)
    • “Ἐγγύα πάρα δ Ἄτα” (Certainty brings insanity)
    Advertise

    Copyright: © 2025 Nick Jikomes

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    Latest Episodes:
    Shamanism, Human Culture & the Evolution of Religion | Manvir Singh | Episode 219 Apr 04, 2025
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    Short Summary: A detailed examination of shamanism with anthropologist Manvir Singh, blending evolutionary theory and vivid storytelling.

    About the guest: Manvir Singh, PhD is an anthropologist at the University of California, Davis. His new book, "Shamanism: The Timeless Religion," comes out on May 25, 2025.

    Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Full transcript and other information on Substack.

    Episode Summary: Dr. Manvir Singh discusses shamanism’s role as a universal human practice, exploring its roots in cultural evolution, cognitive tendencies, and persistence across history and modern society. They discuss how shamans use altered states to address uncertainty—like healing or divination—while examining shamanism’s interplay with centralized religion, its psychological benefits, and parallels in today’s world, from tech gurus to medical placebos.

    Key Takeaways:

    • Shamanism is a widespread cultural practice involving specialists who enter altered states to engage with unseen forces, often for healing or managing uncertainty.
    • It’s not an archaic precursor to modern religion but a recurring expression of spiritual beliefs & practices, competing with other forms.
    • Techniques vary widely—dance, music, psychedelics—but only about half of shamans historically used psychoactive substances.
    • Modern parallels include tech CEOs and money managers who project exceptionalism to influence others, echoing shamanic charisma without trance.
    • Open-label placebos (where patients know it’s fake) still work, suggesting rituals alone can trigger healing, much like shamanic practices.
    • Singh sees shamanism as a cognitive technology, not inherently good or bad, shaping how we cope with chaos across cultures and time.

    Related episode:

    • M&M #86: Shamanism, Psychedelics, Social Behavior, Religion & Evolution of Human Culture | Michael Winkelman

    *Not medical advice.


    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    Chemical Exposures, Neurodegenerative Disease & Exposomics | Gary Miller | Episode 218 Mar 31, 2025
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    Short Summary: How environmental chemical exposures affect neurodegenerative disease and health.

    About the guest: Gary Miller, PhD is a Professor of Environmental Health Sciences at Columbia University. His research bridges pharmacology, toxicology, and neuroscience to explore neurodegeneration, particularly Parkinson’s and Alzheimer’s diseases.

    Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Full transcript and other information on Substack.

    Episode Summary: Dr. Gary Miller talks about neurodegenerative diseases like Parkinson’s and Alzheimer’s, exploring their age-driven nature, early detection challenges, and environmental risk factors such as pesticide exposure and head trauma. They discuss the emerging field of exposomics—studying lifetime chemical exposures—and its potential to uncover links between pollutants, diet, and disease, while highlighting protective factors like caffeine and nicotine, and the role of technology in advancing prevention and treatment.

    Key Takeaways:

    • Neurodegenerative diseases like Parkinson’s & Alzheimer’s worsen with age, but early intervention could slow progression & improve quality of life.
    • Parkinson’s symptoms often appear after significant dopamine neuron loss, but subtle signs like handwriting changes or gait issues might be detectable earlier.
    • Environmental factors, including pesticides & air pollution, increase neurodegeneration risk, while caffeine and nicotine surprisingly lower Parkinson’s incidence.
    • The exposome—total lifetime exposure to chemicals—offers a new lens to study health, revealing how pollutants & diet interact with our biology.
    • Ultra-processed foods & common chemicals like PFAS (in packaging) raise exposure levels, but simple steps like air filters or less processed diets can help reduce risks.

    Related episode:

    • M&M #145: Epigenetics, Hormones, Endocrine Disruptors, Microplastics, Xenoestrogens, Obesogens & Obesity, Inheritance of Acquired Characteristics | Bruce Blumberg

    *Not medical advice.


    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    Communication & Social Cognition in Elephants & Animals | Mickey Pardo | Episode 217 Mar 27, 2025
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    Short Summary: Do elephants and other animals have language-like abilities, such as the ability to use individual names to refer to themselves and others?

    About the guest: Michael Pardo, PhD studies animal behavior at Cornell University, where he focused on animal communication and cognition. His work includes extensive field research with African elephants in Kenya.

    Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Full transcript and other information on Substack.

    Episode Summary: Michael Pardo, PhD talks about his research on animal communication, focusing on whether African savanna elephants use vocal "names" to address each other. They explore the broader context of vocal communication across species like dolphins, parrots, and marmosets, discussing how these systems compare to human language and what they reveal about its evolution. Dr. Pardo shares details of his fieldwork in Kenya, elephant social structures, and their behaviors like mourning the dead, while also touching on the challenges and joys of studying animals in their natural habitats.

    Key Takeaways:

    • Elephants may use unique vocal rumbles to address specific individuals.
    • Dolphins use signature whistles as "calling cards," sometimes imitating others’ whistles to get their attention, hinting at a form of naming.
    • Elephant society features female-led family groups and dispersing males.
    • Elephants show intriguing behaviors like visiting carcasses and covering them with dirt, suggesting an awareness of death uncommon in most animals.
    • Human language evolution may have evolved gradually from simpler communication systems, as seen in various species, rather than emerging suddenly.
    • Studying less charismatic animals like chickens could uncover surprisingly complex communication, broadening our understanding of cognition in nature.

    Related episode:

    • M&M #20: Language, Symbolic Cognition, Evolution, Origins of the Human Mind | Terrence Deacon

    *Not medical advice.


    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    Can Aspirin Prevent Cancer Metastasis? | Rahul Roychoudhuri | Episode 216 Mar 23, 2025
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    Short Summary: The science of cancer and immunity with Dr. Roychoudhuri, blending cutting-edge research with everyday implications like aspirin’s role in fighting tumor metastasis.

    About the guest: Rahul Roychoudhuri, PhD is a Professor of Cancer Immunology at the University of Cambridge. His research bridges basic science and clinical applications, focusing on immune responses to cancer development and spread.

    Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Full transcript and other information on Substack.

    Episode Summary: The immune system’s role in detecting and fighting cancer, particularly how cancer cells evade immunity through selection pressures and microenvironment manipulation. They explore cancer initiation via mutations and inflammation, metastasis mechanics, and a surprising link between low-dose aspirin and reduced cancer spread, spotlighting new research on T cells and thromboxane. The discussion ties in dietary fats, aspirin’s anti-inflammatory and anti-clotting effects, and the potential for new therapies to prevent metastasis.

    Key Takeaways:

    • The immune system constantly surveils and eliminates early cancer cells, but surviving cancers evolve to dodge detection.
    • Inflammation can both spark cancer growth and be exploited by tumors to suppress helpful immune responses.
    • Cancer metastasis, responsible for ~90% of cancer deaths, involves cells breaking off, traveling, and adapting to new sites.
    • New research shows aspirin may curb metastasis by lowering thromboxane, a lipid-derived blood clotting factor.
    • Human data hints aspirin reduces metastasis risk in cancers like breast and colorectal, but trials are ongoing.
    • Daily low-dose aspirin (75-100 mg) is used for heart health, yet its cancer benefits need more study. 600 mg per day has been observed to reduce metastasis rates in colon cancer patients, but chronic use of that dose carries some risk (ulcers, bleeding).

    *Not medical advice.


    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    Cancer Metabolism: Sugar, Fructose, Lipids & Fasting | Gary Patti | Episode 215 Mar 18, 2025
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    How dietary fructose affects the growth rate of cancer.

    About the guest: Gary Patti, PhD is a professor at Washington University in St. Louis, holding appointments in chemistry, medicine, and genetics

    Episode Summary: Nick Jikomes talks to Dr. Patti, exploring how cancer cells metabolize sugars like glucose and fructose, focusing on a recent study showing fructose indirectly boosts tumor growth in mice via liver-produced lipids called LPCs. The discussion covers cancer biology basics, Warburg effect, tumor microenvironments, and systemic metabolic impacts of cancer, while also touching on dietary implications, fasting, and the complexities of nutrient use in cancer progression.

    Key Takeaways:

    • Cancer cells often rely heavily on glucose, excreting it as lactate even when oxygen is available (Warburg effect), but take up more than their mitochondria can handle.
    • In a study, high fructose diets accelerated tumor growth in mice by 4x, not because cancer cells use fructose directly, but because the liver converts it to LPCs, which tumors use to build membranes.
    • Tumors are not just cancer cells; they recruit healthy cells in their microenvironment, and their metabolic effects ripple across the entire body, altering distant tissues.
    • Excessive fructose consumption may worsen tumor growth, but cutting it poses little risk and could benefit cancer patients, pending human studies.
    • Fasting may reduce cancer initiation risk in animals, but its effect on existing tumors is less clear and could worsen wasting (cachexia) in late stages.
    • The body tightly regulates blood glucose via the liver, so simply cutting dietary glucose won’t starve tumors, highlighting cancer’s metabolic adaptability.

    Related episode:

    • M&M #200: Dietary Fats & Seed Oils in Inflammation, Colon Cancer

    *Not medical advice.


    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    Gut Microbiome Plasticity | Peter Turnbaugh | Episode 214 Mar 14, 2025
    Show notes

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    Short Summary: How diet shapes the gut microbiome and impacts health, with microbiologist Dr. Peter Turnbaugh breaking down the complex science.

    About the guest: Peter Turnbaugh, PhD is a professor of microbiology and immunology at the University of California, San Francisco, where he leads a lab studying the gut microbiome’s role in nutrition and drug response.

    Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Full transcript and other information on Substack.

    Episode Summary: Nick talks to Peter Turnbaugh discuss the pitfalls of oversimplified diet labels in research, Turnbaugh’s studies comparing plant-based and animal-based diets in humans, and how these shifts rapidly alter gut microbes and short-chain fatty acid profiles.

    Key Takeaways:

    • The term “high-fat diet” in research is often misleading, as it can include high carbs and vary widely, complicating study comparisons.
    • In a 2014 study, switching humans to a plant-based (high-fiber) or animal-based (ketogenic, no-fiber) diet changed their gut microbiome within one day, showing its remarkable adaptability.
    • Ketogenic diets reduce Bifidobacterium in the gut, which may lower inflammation-linked immune cells (Th17), potentially aiding conditions like multiple sclerosis.
    • Short-chain fatty acids (e.g., butyrate) don’t just come from fiber; they persist even on zero-fiber ketogenic diets, hinting at alternative microbial pathways.
    • Gut microbes can activate or deactivate drugs, like antibiotics or digoxin, suggesting microbiomes may explain why drugs work differently across individuals.
    • Ketone bodies like BHB alone can mimic some ketogenic diet effects on the microbiome and immunity, simplifying research and hinting at therapeutic potential.

    Related episode:

    • M&M #203: Metagenomics, Microbiome Transmission, Gut Microbiome in Health & Disease | Nicola Segata

    *Not medical advice.


    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    Causes of Diabetes: Insulin, Mitochondria, Genetics, Metabolism | Scott Soleimanpour | Episode 213 Mar 10, 2025
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    Short Summary: The science of diabetes with Dr. Scott Soleimanpour, blending personal insights and cutting-edge research that gets into mitochondrial biology and more.

    About the guest: Scott Soleimanpour, MD, is a physician-scientist at the University of Michigan, where he runs a lab studying pancreatic beta cell biology and mitochondrial quality control in diabetes.

    Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Full transcript and other information on Substack.

    Episode Summary: Nick Jikomes interviews Dr. Scott Soleimanpour about the biology of diabetes, exploring the pancreas’s dual role in digestion and blood sugar regulation via beta cells, which produce insulin. They discuss type 1 diabetes as an autoimmune condition with rising incidence and complex beta cell issues, and type 2 as a progressive disease tied to beta cell failure, not just obesity. The conversation covers mitochondrial function in beta cells, lifestyle factors like diet, and the limits of current treatments, offering practical advice for prevention and management.

    Key Takeaways:

    • The pancreas has two parts: the exocrine (98%) makes digestive enzymes, while the endocrine (1-2%) regulates blood sugar with hormones like insulin from beta cells.
    • Type 1 diabetes involves autoimmunity and intrinsic beta cell defects, with rates increasing due to environmental factors, not just genetics.
    • Type 2 diabetes hinges on beta cell dysfunction, not obesity alone—only 1 in 5 overweight people develop it, showing other factors matter.
    • Beta cells are energy-intensive and long-lived, relying on mitochondria; stress from overwork (e.g., excess insulin demand) can lead to failure.
    • Current diabetes drugs don’t rejuvenate beta cells; only TZDs (rarely used) preserve function, highlighting a gap in treatment.

    Related episode:

    • M&M #140: Obesogens, Oxidative Stress, Dietary Sugars & Fats, Statins, Diabetes & the True Causes of Metabolic Dysfunction & Chronic Disease | Robert Lustig

    *Not medical advice.


    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    How Science Works: Meta-Research, Publishing, Reproducibility, Peer Review, Funding | John Ioannidis | Episode 212 Mar 05, 2025
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    Short Summary: A rare, insider’s look at the messy realities of scientific research with Stanford’s Dr. John Ioannidis. The good, the bad, and the ugly about how scientific research actually works.

    About the guest: John Ioannidis, MD, PhD is a professor at Stanford University in medicine, epidemiology, population health, and biomedical data science, with an MD from the University of Athens and a PhD from Harvard in biostatistics. He directs the Meta-Research Innovation Center at Stanford (METRICS), focusing on improving research methods and practices. Renowned for his paper “Why Most Published Research Findings Are False,” he’s among the most cited scientists globally, tackling biases and reproducibility in science.

    Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Full transcript and other information on Substack.

    Key Takeaways:

    • Science’s “replication crisis” isn’t new—it’s baked into how tough and bias-prone research is, hitting all fields, not just “soft” ones like psychology.
    • Ioannidis’s famous claim, “most published findings are false,” holds up: stats show many “significant” results are flukes due to weak studies or bias.
    • Peer review’s a mixed bag—only a third of papers improve, and unpaid, tired reviewers miss a lot, letting shaky stuff slip through.
    • Publishing’s a $30 billion game with 50,000+ journals; big players like Elsevier rake in huge profits from subscriptions and fees, often over $10,000 per paper.
    • Researchers game the system—think fake co-authorships or citation cartels—boosting metrics like the H-index, which tracks papers with matching citation counts.
    • Ioannidis’s early COVID-19 fatality rate (0.2-0.3%) was spot-on but sparked a firestorm as politics warped science into “clan warfare.”
    • NIH funding’s clogged by red tape and favors older researchers, starving young innovators and risky ideas that could shake things up.
    • He’s building tools like a public database of scientist stats (4 million downloads!) to spotlight gaming and push for transparent, fair research.

    *Not medical advice.


    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    Short-Chain Fatty Acids, Diabetes Subtypes & Wearable HealthTech | Michael Snyder | Episode 211 Mar 01, 2025
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    Short Summary: Personalized health monitoring with Professor Michael Snyder, blending cutting-edge science with practical tips and actionable insights.

    About the guest: Michael Snyder, PhD is a Professor of Genetics at Stanford University School of Medicine. He directs the Center for Genomics and Personalized Medicine, which focuses on big data and health innovation. Snyder holds a PhD from Caltech and completed postdoctoral work at Stanford. His career has spanned yeast genomics to human health profiling. Currently, he leads research on advanced molecular and wearable technologies while spinning off companies like Q Bio to translate findings into real-world health solutions.

    Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Full transcript and other information on Substack.

    Episode Summary: Nick talks to Dr. Michael Snyder about transforming medicine through personalized health monitoring, leveraging tools like wearables, continuous glucose monitors, and deep molecular profiling. They explore how diet, microbiome, and genetics shape metabolic health, delving into Snyder’s research on diabetes subtypes, short-chain fatty acids, and aging patterns. The conversation also covers practical technologies available today, like smartwatches and home blood tests, and their potential to catch diseases early and extend healthy lifespans.

    Key Takeaways:

    • Medicine is shifting from sick care to proactive health care using comprehensive data from wearables and molecular profiling.
    • Diabetes has many subtypes, not just type 1 or 2, and treatments like drugs or diet should match an individual’s specific profile.
    • Dietary fiber boosts gut health by producing short-chain fatty acids, which influence gene expression and may reduce leaky gut risks.
    • Aging isn’t linear—big changes spike in the 40s and 60s, varying by person (e.g., heart, kidneys, metabolism), offering chances to adjust lifestyles early.
    • Wearables like fitness watches can detect illnesses (e.g., COVID, Lyme) days before symptoms by tracking heart rate shifts.
    • Continuous glucose monitors reveal surprising food responses, guiding personalized diets.

    *Not medical advice.

    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


    Public Health & Trust in Science in the Post-COVID Era | Martin Kulldorff | 210 Feb 26, 2025
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    Short Summary: Insider’s look at the COVID-19 pandemic response from a seasoned epidemiologist, unraveling myths and lessons with straightforward science.

    About the guest: Martin Kulldorff, PhD is an epidemiologist and biostatistician with decades of experience in infectious disease monitoring and vaccine safety. He was formerly a professor at Harvard Medical School.

    Note: Podcast episodes are fully available to paid subscribers on the M&M Substack. Partial versions are available elsewhere. Full transcript and other information on Substack.

    Episode Summary: Dr. Martin Kulldorff discusses the COVID pandemic response, reflecting on the controversial Great Barrington Declaration, which opposed lockdowns in favor of protecting the vulnerable. They explore the virus’s fatality rates, asymptomatic spread, and vaccine efficacy, contrasting textbook epidemiology with real-world decisions. He critiques institutional failures, like the CDC’s misleading claims. He shares optimism for future pandemics with better leadership and public awareness.

    Key Takeaways:

    • Lockdowns ignored basic public health principles, causing collateral damage like missed cancer screenings, while Sweden’s focused protection approach led to lower excess mortality.
    • Early data showed COVID’s risk was 1000x higher for older people, yet lockdowns didn’t prioritize them, unlike textbook strategies.
    • Asymptomatic spread made containment impossible, unlike Ebola, where isolation works due to clear symptoms.
    • Natural immunity was downplayed despite 2500 years of evidence, leading to wasted vaccines on those already immune.
    • CDC falsely claimed vaccines stopped transmission, eroding trust when people got sick anyway, fueling vaccine skepticism.
    • mRNA vaccine boosters lack proper trials, and their long-term effects need rigorous study, not assumptions.
    • Kulldorff’s new Journal of the Academy of Public Health pushes open peer review to rebuild trust in science.

    Related episode:

    • M&M #100: Infectious Disease, Epidemiology, Pandemics, Health Policy, COVID, Politicization of Science | Jay Bhattacharya

    *Not medical advice.


    Support the show

    Support my work:

    • Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.
    • Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.

    For all the ways you can support my efforts.


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