LONGEVITY with Nathalie Niddam

Latest Episodes:

Why You Need to Optimize Your Hormones BEFORE anything else with Caleb Greer FNP-C - the best kept secret in functional medicine Nov 13, 2020

Show notes

In my opinion Caleb Greer is one of the best kept secrets in Functional Medicine. One of his many superpowers is his ability to take the best from the world of conventional medicine and marry it to Functional practice to get his patients the results that they seek. From hormone optimization to peptides, personalized nutrition to the judicious use of pharmaceutical compounds when they are called for - Caleb covers it all - which is why Caleb and I will often collaborate on optimizing clients' results…this podcast is just an intro - stay tuned for more episodes where we dive deep into various topics. For today, we start with hormone optimization.

Please note that this content is intended for information purposes only and is not intended to substitute professional medical advice, diagnosis or treatment. Before changing your diet or using any new supplement make sure to consult with your health care provider. Always seek the advice of your physician or health care provider with any questions or concerns you may have regarding a medical condition before you make any changes.

Deep Dive into Molecular Hydrogen with Alex Tarnava Nov 09, 2020

Show notes

Alex Tarnava of HRW

https://drinkhrw.com/

Promo Code: Longevity10 to get 10% off your purchase

0:11 Alex Tarnava and DrinkHRW

1:06 DrinkHRW aims to get messaging right and put forth an honest and accurate voice

02:52 How Alex Tarnava got into molecular hydrogen

04:09 From fit to sick

08:26 Hydrogen as a viable option to regulate inflammatory response

10:12 Hydrogen Testing

10:56 Getting the right amount of molecular hydrogen

11:15 Cautionary tale about molecular hydrogen products

12:34 What drove Alex to create HRW

15:44 Initial stages for hydrogen tablet

16:49 What it takes to scale production

21:27 Marketing the Hydrogen tablets

21:42 Alex's Ethical requirements: doing good rather than just making money

22:20 Clinical outreach program

22:38 The underlying issue on pharmaceutical and supplemental research

26:14 How much you need to use to dissolve your Hydrogen tablets and why...

28:42 Dissolution kinetics when mixing hydrogen tablets with

29:36 How to get the highest dose of hydrogen

29:59 Hydrogen is most effective during intermittent high dosing

Molecular Hydrogen and….

32:29 Metabolic syndrome

32:49 Multiple research and clinical trials about the benefits

34:12 Rodents, hydrogen treatments, and Parkinson's Disease

39:25 Traumatic Brain Injury

41:02 Oxidative stress, inflammation, insulin sensitivity

44:44 Molecular hydrogen as a selective antioxidant?

46:19 Restoring proper functions in the critical systems in our body and not as a pharmacological agent

47:12 Molecular Hydrogen and Fasting

48:48 The need for better evidence about Fasting in the Biohacking community

51:40 Panacea contributes to the reluctance of researchers to publish studies

52:25 The need for a cultural shift within biohacking and integrative medicine

53:08 There's no toxic dose of molecular hydrogen

55:11 Bath tablets: absorbing hydrogen through the skin

57:43 Why adding lemon to your hydrogen is a good idea beyond taste

58:23 Topical application for molecular hydrogen

59:47 Alex's new project: Myjourney. and biohacking

1:01:36 About wearable technologies

1:06:29 The goal of Myjourney.

1:09:18 Helping researchers explore the best benefits of various biohacks via myjourney. research grants

1:09:56 Data privacy and community collaboration

Links: https://drinkhrw.com/

Save 10% off your with promo code: Longevity10

@drinkhrw (Instagram)

Please note that this content is intended for information purposes only and is not intended to substitute professional medical advice, diagnosis or treatment. Before changing your diet or using any new supplement make sure to consult with your care provider. Always seek the advice of your physician or care provider with any questions or concerns you may have regarding a medical condition before you make any changes.

Cellular Senescence, Why the Goldilocks Approach is the ONLY way to go and SELANK: more than just another brain peptide Nov 02, 2020

Show notes

Dr. Seeds is a board-certified orthopedic surgeon and physician specializing in all aspects of sports medicine and total joint treatments. With over 22 years of experience, Dr. Seeds is focused on providing the most innovative results to those seeking to maximize their performance, relieve injuries, and live a healthy lifestyle.

Please note that this content is intended for information purposes only and is not intended to substitute professional medical advice, diagnosis or treatment. Peptides are for the most part classified as research chemicals so should not be used on humans. Before changing your diet or using any new supplement make sure to consult with your health care provider. Always seek the advice of your physician or health care provider with any questions or concerns you may have regarding a medical condition before you make any changes.

Repair Peptides: TB500 vs Thymosin Beta 4, they are NOT the same Oct 29, 2020

Show notes

Thymosin Beta 4 and TB500 - are they one and the same? NO! We are BACK!!! In the peptide world these two peptides are often referred to interchangeably....as if they were one. And yet - they are most certainly not! In this short interview Jean-Francois Tremblay from CanLabs explains how they are related but quite different and how they may work together in certain scenarios.

Remember - none of this information is to be used as medical advice ...there is a LOT we do not know about peptides hence peptides are still rated as "research chemicals" so before you even think of using these please consult with a medical professional to assess any risks.

5:00 Amino acids 17-23

6:30 Anti-fibrotic

7:00 Why people interchange TB500 and Thymosin Beta 4

9:00 If you want a tan just take melanotan2

9:10 For sensory effect take this peptide

9:30 If you want more take this peptide

9:50 "Moron proof" peptides

12:30 Neuro benefits of Thymosin Beta 4

14:15 Used for race horses

15:20 Number of peptides in Thymosin Beta 4 chain.

15:45 How to double names and peptides: the number

23:00 The of peptides

23:50 Cost effective

26:00 TB4 pills and the issue of digesting

27:30 How peptides digested work with leaky gut better in the beginning

31:40 BPC-157 is an orally available peptide

32:40 TB500 hones in on musculoskeletal system

https://www.canlabresearch.com/

Please note that this content is intended for information purposes only and is not intended to substitute professional medical advice, diagnosis or treatment. Peptides are for the most part classified as research chemicals so should not be used on humans. Before changing your diet or using any new supplement make sure to consult with your care provider. Always seek the advice of your physician or care provider with any questions or concerns you may have regarding a medical condition before you make any changes.

Find Out How Fast (or Slowly) You're Aging with Épi-Age & Dr Moshe Szyf Oct 26, 2020

Show notes

Dr. Szyf is a pioneer in the field of epigenetics, he holds a PhD from the celebrated Hebrew University, a postdoctoral fellowship in Genetics at Harvard Medical School, a Professorship at McGill University and a Chair in Pharmacology at GlaxoSmithKline.

5:33 DNA as the operating system of our lives

6:14 Disease causes disruption in the DNA

6:41 DNA methylation gives us an insight into what's going on in our DNA

7:07 Epi Age testing can tell us how many years we've been living in this world, and may give insight into how many years we may have left

8:02 Chronological age and epigenetic age can be good indicators for life span

11:17 Epi Age is a lifestyle product

12:59 Identifying the markers for aging

14:23 How Epi Age is different

17:05 What are the most effective ways to slow down the clock?

17:29 Behaviours that can help slow down the clock

18:28 epiAging app

19:51 epiAge test results tell you what you're DNA thinks of what you're doing

22:21 The first step in slowing down the clock is to get to a state of balance

23:58 Using AI to derive some conclusions from an individual result against a general lifestyle model

24:30 The great revolution will come from mathematics and technology to capture the complexity of humans

26:24 The idea of sharing -- creating a "Waze" of health

27:08 Health data safety and privacy

28:06 Balancing privacy and sharing -- learning about diseases without consequences to the individual

29:00 Sharing public methylation data can help save millions of lives

31:19 Firewalled personal data and medical data -a solution to protect the individual

32:25 Goal: To get the best solutions to prevent anyone to hack the database

33:41 The collaboration between Epi-Age and users

36:41 The best way to use the Epi-Age test

40:25 Transferring the responsibility of health from your doctor to yourself

40:45 Experience as a teacher

41:10 Trial, error, and scientific truth

41:36 Self-empowerment and the biohacking movement

43:22 Technology empowers people about medicine

44:37 epiAge app as a source of information for lifestyle trends

48:11 Environmental influence on genetics

49:38 The impact of your mental environment on your health

50:02 Listen to your own clock

Ordering tests: Epi-Age.com

Use Promo code Longevity to get 10% off the cost of your test….

Link to Dr Szyf's Ted Talk: https://youtu.be/38OUCtzkT4Q

Dr Amber ND - Peptide Expert - Mitochondrial Peptides for Ultimate Cellular Energy Oct 16, 2020

Show notes

Dr. Amber is an A4M trained peptide expert and Naturopathic Doctor practicing out of beautiful California. In this episode we talk about two peptides that address mitochondria and why that's an amazing place to start with peptides. Dr. Amber uses the term "forgot" which you'll learn why towards the end of the show, and how to remind your body of proper signaling and why peptides are so amazing!

1:30 Why we start with MITOCHONDRIA

2:15 Theory of aging

3:15 A4M

5:25 The issue with the thought of "getting energy from energy drinks" you are an energy factory

6:45 Why issues show up in the brain and heart first

9:00 The link between Fibromyalgia and mitochondrial dysfunction

10:00 Inflammation, why it needs to be addressed first so that one can then add things like peptides to help with repair

11:00 How common analgesics (pain relief pills) negatively affect mitochondria

12:30 How blue light negatively affects melatonin production

13:10 Things that damage the mitochondria.

13:20 How to create new mitochondria

13:45 Why sleep is so important

15:00 Ways to mitigate damage, there are amazing things you can do :)

15:20 Computer software to reduce blue light and protect your eyes and mitochondria

16:30 Offset the positive ions with negative ions by going to a natural body of water or grounding

17:00 Red light can upregulate production of ATP and mitochondria

19:30 Cold water exposure

21:30 Why Nathalie likes cold lakes over a tub 😂

22:15 Our cells make waste naturally, not including environmental factors, that's normal. This is why we need to support detoxification

23:00 Leveraging hormetic stressors. LDN and adaptation principle to your benefit.

23:40 Molecular hydrogen, because we need oxidation, but this works almost like an adaptogen

24:45 HIIT workouts for the win!

25:00 Cell senescence

27:00 SS31

28:20 May be useful for - cardiac issues, insulin/pancreatic dysfunction, depression, fibromyalgia, chronic fatigue, anti-aging.

30:15 Amount needed of SS31.

33:00 Our bodies make these peptides, but often "need instructions" or a reminder...

34:30 How the wrong peptide at the wrong time can do more harm than good, and the right peptide at the right time can really do wonders and promote signaling that the body really needed and "forgot" about.

37:00 Melanotan

39:00 Nutrition is incredibly important, but here's why you often need help from peptides

40:10 5-Amino-1MQ (capsule, no needle use)

41:50 How 5-Amino-1MQ keeps your NAD around longer

42:50 L-carnitine

43:30 Dosing of 5-Amino-1MQ

44:00 How some people react very different, triggering more anxiety

46:00 Sublingual NAD powder that Nathalie loves

47:10 The placebo of peptides and supplements and the power of belief

48:45 The issue with digesting supplements

49:15 Leaky gut

50:30 NAD The patch versus IV, and why you can get more from the patch!

52:30 Kisspeptin peptide, for men vs. women, "kiss-54" "kiss-10"

55:45 Natural increase of testosterone

56:00 Why Dr. Amber uses the term "forgot"...and how to remind your body of proper signaling

57:00 And why you should avoid exogenous testosterone for as long as possible

57:45 Kiss-54

https://www.instagram.com/doctorambernd/

drambernd.com

Dr. Elizabeth Yurth Peptide Expert - DSIP Sleep Peptide, Hormones and The Shocking Truth about Melatonin Oct 06, 2020

Show notes

Dr. Yurth is on the cutting edge helping her clients prevent joint replacement with the use of peptides, hormones and preventative medicine. She's an expert on circadian rhythm and how to fix yours with peptides and other biohacks!

http://boulderlongevity.com/

3:13 Dr. Yurth Background

12:00 industry is about lifelong learning and questioning what we thought we knew

14:00 Take responsibility for your own

15:00 Why Nathalie and Dr. Yurth would rather spend money on their than a fancy

16:00 How you shouldn't expect a peptide to do ALL of the work for you

19:00 Peptides and your Circadian rhythm and deep and REM sleep.

20:54 The best time to have surgery

22:00 The Clock Gene

22:29 How do we fix the circadian rhythm in you

24:50 How this sleep tracker shows you the impact of your actions

25:50 How to increase deep sleep time "the brain cleanout time"

26:21 If you're frustrated that these biohacks aren't "helping you"

26:10 Sleep quality vs. quantity, and how too much sleep can be bad, and what really matters most

28:55 How DSIP could be better for some people in the morning for sleep that night, and great for some in the evening.

31:50 Muscle building

34:30 The other benefits of melatonin

37:33 Stacking and why you should give something a chance

38:30 Biohacking for night shift workers, must biohack

40:25 Why you should take melatonin, and if you're a slow metabolizer of melatonin listen to this!

46:15 How most disease can be linked back to circadian rhythm

50:39 How being breast fed vs. bottle fed and how timing of feeding affects children

54:30 Neuropathy

56:07 Kidney function

56:24 Fibromyalgia

59:32 Pulsing: turning on, turning off, turning on, turning off

59:55 How long to try a peptide for

http://boulderlongevity.com/

https://www.instagram.com/dryurth/

Hack Light, Mitigate EMF's to Upgrade Your Health with PrimalHacker Thaddeus Owen Sep 25, 2020

Show notes

Thaddeus Owen the co founder and owner of PrimalHacker has been deep diving into how light and EMF's affect our health and physiology for almost as long as I've known him. He is a wealth of information on the topic and in this episode we deep dive into the many issues impacting our health and, more importantly what we can do about it. For the most part we stick to easy and free interventions you can apply starting today - and we even mention a peptide in our conversation! PrimalHacker sells a curated selection of items that can help you to live a healthier light life including Blue Blockers, Red Lights and more - all at incredibly affordable prices. PLUS you can use Promo Code NAT10 to get an extra 10% off your entire purchase! Please note that this video is for information purposes only and that none of the information in this video is intended as medical advice. Please consult with your health provider before starting any new intervention and especially if you have a medical condition.

Peptides for Fat Loss w/ CanLab: Setmelanotide, AOD 9604, FRAG17691, Tesamorelin, CJC 1295 NO Dac Sep 25, 2020

Show notes

In this Interview, Jean-Francois Tremblay, owner of CanLab and I dig in to one of the new darlings of the peptide world - Tesamorelin and a less known but possibly just as effective other option - Setmelanotide - an offshoot of the better known Melantonan 2. We also cover AOD 9604, FRAG 17691 and CJC1295 ...and why you probably want to avoid the version with DAC (drug affinity complex)... We start with a chat about how if you're after lasting results there's really no way to avoid optimizing your diet, moving more, optimizing sleep etc... but these peptides might just help to speed things along and ease some of the bumps along the way.

Show Notes:

Keto Calorie

Peptides Help with Fat Loss Body Recomposition Growth Hormone unregulated by Fat Loss peptides like FRAG 17691 or AOD9604 (just one amino acid difference) help to mobilize fatty acids in the fat cell – but need to be in calorie/energy deficit for it to stay out

Consistency and sticking to your plan is the ultimate secret sauce…

Why Canlab combines Frag and AOD 9604 More about Frag and AOD….are they the same or different? AOD lacks one tyrosine…means that it lasts longer…whereas Frag uses more up front and gets metabolized faster…..

Tesamorelin…..what it does….

The skinny on Tesamorelin….it's not about Tesa it's about the growth hormone release….

Re Muscle Gains attributed to Peptides….in studies re old people it's about bringing back muscle you once had…. Hormone replacement therapy is at the foundation of reclaiming muscle mass GH good for muscle sustaining (vs growth) and tissue repair (but doesn't hold a candle to BPC and TB4)

Tesamorelin – origins – where it came from originally….very close to CJC 1295 (Mod IGRF 121 is actually CJC 1295 without dac). and other Growth Hormone Secretagogues.

The difference between Tesa and CJC not really all that great….why some people may be promoting Tesa over CJC 1295 the magic is in the dose.

Difference about with Dac and without Dac. With Dac too many peaks of growth hormone (similar to MK 677….increases risk of insulin resistance…..why is the Dac long lasting…binds to albumin in the blood ….which is problematic as there may have been relationship to blood cancer seen in certain studies….so better to use without DAC…just use multiple times a day if necessary

Post workout (3) is a good time…but pre bed(1), pre workout and first thing in the morning (2) are all better

Setmelanotide – another derivative of alpha MSH (Melanotan, melanotan 2, PT141) Basically prioritizes appetite suppression over tanning and sexual enhancement..they all create a tan just to varying degrees…. SM get appetite curbing (some sexual stim)…increases metabolic rate by about 6%, without increasing HR or BP…. On average can expect about 1 lb a week fat loss…. Many reports of people using it with good results – safe track record…..Clinical studies went for 12 months

Do not start at full dose of 1.5mg a day….start at .5 1-2 days then 1.0mg for a couple of days and then increase to full dose to avoid possible /nausea In studies – they changed nothing else….and saw results but it's likely that as people lost weight they may have started to move more etc…

At this point best method for most peptides is SubQ over oral….Intranasal may work but need to use higher dose (aka PT141 1 mg is SubQ and 2mg is IntraNasal)

Tesofensine – not a peptide acts on dopamine and AC receptors in the brain so needs to be used with great caution Please note that this video is intended for information purposes only and is not intended to substitute professional medical advice, diagnosis or treatment. Peptides are for the most part classified as research chemicals so should not be used on humans. Before changing your diet or using any new supplement make sure to consult with your care provider. Always seek the advice of your physician or care provider with any questions or concerns you may have regarding a medical condition.

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