Longevity Optimization with Kayla Barnes-Lentz

Latest Episodes:

Dr. Laura Briden - This Is The Biggest Health Crisis Of Our Time Sep 18, 2025

Show notes

Today I’m joined by Dr. Lara Briden, a naturopathic doctor, best-selling author, and internationally recognized expert in women’s hormones for a wide-ranging conversation on cycle health and why ovulation is a vital sign of wellbeing.

We talked about how monthly ovulation creates hormones that support bones, metabolism, and brain function, and what happens when that rhythm is disrupted by stress, restrictive eating, or birth control. Dr. Briden explains why natural estradiol and progesterone are so protective, how they differ from synthetic hormones, and what that means for both younger women and women approaching perimenopause.

She also shares her perspective on missing periods, hypothalamic amenorrhea, and the four functional types of PCOS, along with the growing role of insulin resistance in hormone imbalance. We talk about how to track ovulation, what lab markers to look for, and why restoring cycles is one of the most powerful steps for long-term health.

Chapters

00:49 - Ovulation as a vital sign of female health

02:57 - Impact of hormonal birth control on ovulation and hormones

07:51 - Benefits of natural estrogen and progesterone

09:47 - Perimenopause and importance of hormones in young women

11:49 - Benefits of estradiol and progesterone

17:37 - Dysregulated or missing periods

19:50 - Anovulatory cycles and tracking ovulation

22:50 - Lag time for menstrual cycle disruption and recovery

26:50 - Differentiating between hypothalamic amenorrhea and PCOS

31:18 - Four different types of PCOS

36:25 - Lab markers for insulin resistance

58:53 - Recommendations for managing insulin-resistant PCOS

Dr. Briden socials + website

Website: ⁠https://www.larabriden.com/about/⁠

Instagram: ⁠@larabriden⁠

Kayla's social + website:

Instagram: ⁠https://www.instagram.com/kaylabarnes/⁠

TikTok: ⁠https://www.tiktok.com/@femalelongevity⁠

Twitter: ⁠https://x.com/femalelongevity⁠

Website: ⁠https://www.kaylabarnes.com/⁠

Follow Her Female Protocol: ⁠https://www.protocol.kaylabarnes.com/⁠

Become a Member of Kayla's Female Longevity Membership: ⁠https://kayla-barnes-lentz.circle.so/checkout/become-a-member⁠

Exploring the Future of Health and Technology with Dr. Ja-Nae Duane Sep 14, 2025

Show notes

Join us in this insightful episode as we sit down with Dr. Ja-Nae Duane, a behavioral scientist, futurist, and bestselling author. We delve into the intersection of exponential technology, human systems, and the future of health. Discover how Dr. Duane's journey from opera singer to futurist informs her mission to improve life for a billion people.

Chapters:

Introduction to Dr. Janaye Duane (0:00 - 2:30)
- Overview of Dr. Duane's background and mission.
From Opera Singer to Futurist (2:31 - 10:00)
- Dr. Duane shares her career journey and the transition to futurism.
The Impact of COVID-19 (10:01 - 18:00)
- Discussion on how the pandemic has shifted scenario planning and work dynamics.
Biohacking and Longevity (18:01 - 30:00)
- Exploring future trends in biohacking and longevity medicine.
Ethical Considerations in AI (30:01 - 40:00)
- Delving into the ethical implications of AI in healthcare.
Practical Tools for Growth (40:01 - 50:00)
- Exercises and tools for personal and professional development.
Conclusion and Future Outlook (50:01 - End)
- Final thoughts and the importance of ongoing conversations about health and technology.

Brigid Titgemeier, MS - The Diet Myth: Why “Healthy Eating” Is Making Women Sicker Sep 11, 2025

Show notes

Brigid Titgemeier, a functional medicine dietitian and founder of Being Brigid Nutrition, has seen countless women walk into her clinic exhausted, bloated, and frustrated despite eating all the right foods. She knows that feeling firsthand, too. Instead of blaming willpower or cutting out everything you love, Brigid discovered how simple, personalized nutrition changes could completely shift energy, hormones, and mood.

In this episode, she shares why common advice like “just eat clean” or “go low-carb” often backfires, and what really moves the needle when it comes to gut health, hormone balance, and long-term vitality. We also talked about the hype around weight-loss drugs, overlooked biomarkers that reveal hidden stress in the body, and why your microbiome might hold the biggest key to feeling better.

If you’ve ever wondered why eating healthy doesn’t always feel healthy, this conversation will give you the clarity and hope you’ve been missing.

Chapters

00:00 Introduction

00:02:59 - Introduction of Brigid Tegemeier

00:05:08 - The three biggest nutrition myths.

00:05:56 - Myth 1: Just eating a variety of whole foods is enough for improving overall health.

00:07:04 - Myth 2: A low carb lifestyle works well for every single person.

00:07:32 - Myth 3: The obsession with protein is always beneficial.

00:08:24 - Why individuals might not see results even if they're doing everything for their health.

00:15:09 - How long it should take to see results

00:18:15 - GLP1 medications for weight loss.

00:22:59 - Establishing a good baseline for diet, focusing on fiber diversity and prebiotic sources.

00:29:36 - Recommendations for protein intake for women.

00:30:35 - Carbohydrate intake and its impact on female hormones and stress response.

01:09:54 - Seed oils and the balance of Omega 6s to Omega 3s.

Guest’s socials + website

LinkedIn: https://www.linkedin.com/in/brigid-titgemeier-b437574b

Website: https://beingbrigid.com/

Instagram: @beingbrigid

Kayla's social + website:

Instagram: https://www.instagram.com/kaylabarnes/

TikTok: https://www.tiktok.com/@femalelongevity

Twitter: https://x.com/femalelongevity

Website: https://www.kaylabarnes.com/

Follow Her Female Protocol: https://www.protocol.kaylabarnes.com/

Become a Member of Kayla's Female Longevity Membership: https://kayla-barnes-lentz.circle.so/checkout/become-a-member

Dr. Matt Kaeberlein, PhD - Why We Age + Interventions to Slow Aging Sep 04, 2025

Show notes

What if aging wasn’t just something that happens to us, but something science could actually slow down? That’s the question at the heart of today’s conversation with Dr. Matt Kaeberlein, who’s a leading scientist and longevity researcher at the University of Washington.

Dr. Kaeberlein has spent decades decoding the biology of aging, from cellular mechanisms to practical strategies that could extend not just how long we live, but how well we live. In this episode, we talked about surprising connections between aging and brain health, and looked into the research around lithium and Alzheimer’s to see what the latest science is telling us about extending healthspan.

It is an informative discussion on whether aging itself can be slowed or reversed. If you’re curious about how close we really are to changing the rules of aging, this could be worth a watch.

Chapters:

00:00 – Introduction & The Biology of Aging Across Species

10:57 – The Struggles of Change, GLP-1 Drugs & The Power of Sleep

14:33 – The Hallmarks of Aging

21:52 – Funding Issues

23:22 – The Truth About Anti-Aging Drugs

27:22 – Biological Age Testing

48:23 – Biomarkers, Advanced Testing & The Limits of Diagnostics

01:02:50 – Micronutrient Testing and Supplements

01:07:11 – NAD, Smarter Longevity Choices

01:18:05 – Lithium’s Secret Role in Aging and Memory Loss

01:27:00 – Foundations of Longevity

01:57:37 - Ovarian Aging

02:01:02 – Closing Thoughts & Where to Find the Guest

Guest’s socials + website:

YouTube: https://www.youtube.com/@optispan

X: https://x.com/mkaeberlein?lang=en

Website: https://www.optispan.life/

Kayla's social + website:

Instagram: https://www.instagram.com/kaylabarnes/

TikTok: https://www.tiktok.com/@femalelongevity

Twitter: https://x.com/femalelongevity

Website: https://www.kaylabarnes.com/

Follow Her Female Protocol: https://www.protocol.kaylabarnes.com/

Become a Member of Kayla's Female Longevity Membership: https://kayla-barnes-lentz.circle.so/checkout/become-a-member

The Fertility Formula with Dr. Natalie Crawford Aug 28, 2025

Show notes

Join us in this powerful episode as we sit down with Dr. Natalie Crawford, a double board-certified OB/GYN and reproductive endocrinologist. We explore her personal journey with recurrent pregnancy loss, the rising rates of infertility, and the impact of inflammation, toxins, and lifestyle on reproductive health. Discover how Dr. Crawford is reshaping fertility care and empowering women to understand their bodies, advocate for their health, and make informed choices about their future.

Chapters:

00:00 – Introduction

02:15 – Dr. Crawford’s personal fertility journey & miscarriages

07:07 – Discovering inflammation, toxins & celiac connection

09:56 – Rising infertility rates & sperm count decline12:18 – Cycle tracking, wearables & hormone testing

15:11 – AMH testing & why it’s controversial

20:14 – Fertility testing, anatomy & semen analysis

26:26 – Patient stories & whole-body fertility approach

34:17 – Environmental toxins & endocrine disruptors

40:09 – Egg quality, biological age & lifestyle factors

46:28 – Advanced strategies: red light therapy, IVF testing, add-ons

56:00 – Birth control myths & fertility impact

01:04:09 – Menopause, genetics & shifting timelines

01:12:01 – Fertility myths & misconceptions

01:16:07 – Prenatal vitamins, folate vs. methylfolate debate

01:21:18 – PCOS explained & why diagnosis matters

01:28:36 – Closing thoughts, book & where to find Dr. Crawford

*Dr. Natalie Crawford's Socials:*YouTube: https://www.youtube.com/@NatalieCrawfordMD/videosIG: https://www.instagram.com/nataliecrawfordmdTikTok: https://www.tiktok.com/@UCRZamIB-DWuVPJuc0bKhwzg Website: https://www.nataliecrawfordmd.com/X: https://x.com/ncrawfordmd?lang=enFacebook: https://www.facebook.com/nataliecrawfordmd/Podcast: https://podcasts.apple.com/us/podcast/as-a-woman/id1449553339*Kayla's social + website:*Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter: https://x.com/femalelongevityWebsite: https://www.kaylabarnes.comFollow Her Female Protocol: https://www.protocol.kaylabarnes.comBecome a Member of Kayla's Female Longevity Membership: https://kayla-barnes-lentz.circle.so/..

Dr. Bill Rawls, MD - Cellular Healing: Lyme, Mold & The Chronic Illness Solution Aug 21, 2025

Show notes

Today I’m joined by Dr. Bill Rawls, a board-certified physician and bestselling author, for a wide-ranging conversation on chronic illness, healing, and what it really takes to protect long-term health. We dive into the challenges people face when conventional medicine falls short, the role of lifestyle and environment in recovery, and the surprising power of natural approaches to restore balance in the body.Dr. Rawls also shares insights on resilience, aging, and why true wellness depends on going deeper than symptom management.

If you’ve ever struggled with confusing health issues or wondered why the body sometimes fails to heal, this episode offers clarity, empowerment, and tools you can begin applying right away.

Chapters:00:00 – Introduction02:03 – When Medicine Doesn’t Have the Answers07:12 – A Personal Turning Point13:14 – Rethinking What “Chronic” Really Means19:22 – The Body’s Hidden Defenses24:55 – How Stress Shapes Illness31:20 – A Smarter Way to Approach Healing38:04 – Restoring Balance Naturally44:50 – Building Resilience for the Long TermDr. Bill Rawls IG + website:IG: https://www.instagram.com/rawlsmd/?hl=enWebsite: https://rawlsmd.com/Resources: https://rawlsmd.com/resources/ Kayla's social + website:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter: https://x.com/femalelongevityWebsite: https://www.kaylabarnes.comFollow Her Female Protocol: https://www.protocol.kaylabarnes.comBecome a Member of Kayla's Female Longevity Membership: ;https://kayla-barnes-lentz.circle.so/checkout/become-a-member

Dr. Brooke Stubbs - Foundational Female Health Pillars Aug 07, 2025

Show notes

Today I’m joined by Dr. Brooke Stubbs, a double board-certified physician in internal and lifestyle medicine, for a deep dive into inflammation, what drives it, how it shows up in the body, and why so many women are silently affected by it. We explore how gut dysfunction, hormone imbalances, poor sleep, and emotional stress contribute to chronic symptoms like fatigue, bloating, brain fog, and burnout. Dr. Stubbs shares why inflammation is often overlooked in conventional care—and how a functional, root-cause approach can lead to lasting healing.She also explains how food, movement, stress management, and environment can either fuel or reduce disease over time.If you’ve ever felt dismissed by the medical system or frustrated by vague symptoms, this conversation offers clarity, empowerment, and science-backed tools to take your health into your own hands.This episode is brought to you by Seed. Save 25% off Seed: https://seed.com/daily-synbiotic?utm_source=ambassador&utm_medium=podcast&utm_campaign=kaylabarnes&utm_term=25p&promo_code=KAYLABARNES25Chapters:

00:00 – Introduction02:57 – Women Are Being Misdiagnosed (Here’s Why)09:10 – How Ultra-Processed Foods Hijack Your Biology15:05 – The Gut-Brain-Immune Axis Is Real (And Powerful)21:23 – Environmental Toxins Are Disrupting Your Hormones27:02 – Longevity Medicine Isn’t Just for Men33:10 – Debunking “Plant-Based Is Always Healthier”39:18 – Your Nervous System Is a Missing Piece44:56 – What Dr. Stubbs Actually Eats in a Day_______________Dr. Brooke Stubbs + WebsiteIG: / brookiestubbsmd Website: https://brookestubbsmd.com/Kayla Socials + WebsiteInstagram: / kaylabarnes TikTok: / femalelongevity Twitter: https://x.com/femalelongevityWebsite: https://www.kaylabarnes.comFollow Her Female Protocol: https://www.protocol.kaylabarnes.comBecome a Member of Kayla's Female Longevity Membership: https://kayla-barnes-lentz.circle.so/checkout/become-a-memberkayla-barnes-lentz.circle.so/checkout/become-a-member

Nick Norwitz, MD, PhD - Exploring Metabolic Health Jul 31, 2025

Show notes

In this conversation, I sit down with Nick to unpack the deeper science behind GLP-1s and metabolic health. We explore how compounds like Tirzepatide and GLP-1 agonists go beyond weight loss, influencing everything from cardiovascular elasticity and neuroinflammation to mood, cognition, and gut-brain signaling. We also discuss lesser-known drivers of real change, like adiponectin, MPO, and the surprising effects of statins on inflammation.But the conversation doesn’t stop with human health. We dive into the behavioral power of the microbiome, how dogs might reduce childhood allergies, and whether AI can actually translate what your pet is thinking. If you’re curious about fat loss, brain health, and the future of metabolic science, this episode offers a perspective you won’t find anywhere else.*Chapters:*0:00 – Meet Dr. Nick: From Patient to Pioneer06:50 – The Problem with "Evidence-Based Medicine"10:15 – Why Nick Left the Medical System13:10 – Can YouTube Have a Bigger Impact Than Hospitals?16:30 – What Is Metabolic Health & Why Does It Matter?19:00 – Mental Health, Depression & Metabolism24:15 – Brain Hacks That Actually Work40:00 – Improving Metabolic Flexibility Naturally46:00 – Gut-Brain Connection & Fiber Myths*Nick's Socials + Website*IG: https://www.linkedin.com/in/nicknorwitz/Youtube channel: https://www.youtube.com/channel/UCLTZUJSEulehPtF_ytFiU_AWebsite: https://www.nicknorwitz.com*Kayla's Socials + Website*Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter: https://x.com/femalelongevityWebsite: https://www.kaylabarnes.comFollow Her Female Protocol: https://www.protocol.kaylabarnes.comBecome a Member of Kayla's Female Longevity Membership: https://kayla-barnes-lentz.circle.so/checkout/become-a-member

Dr. Amy Killen, MD - Perimenopause, Menopause, Vaginal Dryness, and Health Politics Jul 24, 2025

Show notes

In this conversation, Kayla and Dr. Amy Killen discuss the critical aspects of women's hormonal health, emphasizing the importance of estrogen, the impact of menopause, and the need for accurate information regarding hormone therapy. She highlights the significance of bone health, the role of lifestyle in hormonal balance, and emerging treatments that can enhance women's health. The discussion also touches on the intersection of women's health and environmental policy, as well as the evolving relationship between doctors and patients in the age of technology.

Dr. Amy Killen, MD is a leading expert in anti-aging and regenerative medicine, specializing in skin rejuvenation, sexual optimization, and longevity. A former ER physician, she now focuses on cutting-edge therapies like stem cells, PRP, and exosomes to help people look and feel their best. Dr. Killen is the founder of the HOP Box, Humanout Health and a global speaker on biohacking and sexual health.

Chapters

00:00 Understanding Women's Hormonal Health

02:49 The Importance of Bone Health in Women

05:37 Navigating Hormone Therapy and Misinformation

08:43 The Role of Hormones in Disease Prevention

11:43 Testing and Monitoring Hormone Levels

14:38 The Impact of Lifestyle on Hormonal Health

17:37 Emerging Treatments and Technologies for Women's Health

20:17 The Intersection of Women's Health and Environmental Policy

23:10 The Future of Doctor-Patient Relationships

26:11 Closing Thoughts on Women's Health and Longevity

Ovarian Longevity (How AI can predict and more) Jul 17, 2025

Show notes

In this episode, we explore the intersection of ovarian health, menopause, and AI technology with Kiran, the founder of TimelessBioTech. The conversation delves into the importance of ovarian longevity for women's health, the predictive tools being developed to forecast menopause timing, and the various interventions that can support ovarian health. Kiran shares insights on hormonal balance, the role of lifestyle factors, and the future of personalized health strategies for women. The discussion emphasizes the need for targeted solutions and the potential for AI to revolutionize women's health care.

Timeless Biotech Website

Kiran's email for investors, clinics, and companies looking to invest in or work with Timeless: Kiiran@timelessbiotech.com

This episode is brought to you by OneSkin, the longevity scientists behind the first topical peptide scientifically proven to reverse skin aging—now bringing their expertise to your scalp.

If you care about aging well, you can’t ignore your hair. The health of your scalp directly impacts the strength, thickness, and lifespan of every strand.

That’s why OneSkin created their new OS-01 HAIR, the first scalp serum powered by a longevity peptide designed to optimize follicle health, balance the scalp, and extend the healthspan of your hair follicles.

In their clinical study, OS-01 HAIR showed significant improvements in hair density, thickness, and overall scalp health—all by targeting follicle aging at the root.

I’ve been using it myself and I’m genuinely impressed. It’s lightweight, fragrance-free, and backed by science—not fluff.

If you're serious about keeping your hair vibrant and resilient as you age, I highly recommend giving OneSkin's OS-01 HAIR a try.

Head to oneskin.co/KAYLA for 15% off your order.

About Kiran

Kiran Kumar is the Founder & CEO of Timeless Biotech, an early-stage ovarian longevity company that has prototyped the first-ever time-to-menopause predictor and ovarian age clock.

Kiran is a Biotechnology Bioengineer from UC San Diego, and has contributed to research in ML-powered diagnostics.

Kiran has worked in numerous longevity and wellness startups such as FOXO Technologies, OneSkin, and Timeline where she authored. research-backed content

Kiran’s work sits at the intersection of Physiology, AI, and Longevity.

Chapters

00:00 Introduction to Ovarian Longevity and AI Solutions

02:44 The Importance of Ovarian Health in Longevity

05:38 Understanding Menopause and Ovarian Aging

08:48 Predictive Tools for Menopause Timing

11:32 Interventions for Ovarian Longevity

14:31 The Role of Hormones in Ovarian Health

17:25 Innovative Approaches to Hormonal Balance

20:14 The Future of Ovarian Health Technologies

22:58 Personalized Health Strategies for Women

25:31 Conclusion and Future Directions